To study protective effects of Qingshen Compound on experimental anti-glomerular basement membrane antibody （AGBM-Ab） nephritis model in rats,an experimental Masugi nephritis model was established in Sprague-Dawley...To study protective effects of Qingshen Compound on experimental anti-glomerular basement membrane antibody （AGBM-Ab） nephritis model in rats,an experimental Masugi nephritis model was established in Sprague-Dawley（SD） rats by a single-dose injection of prepared rabbit anti-rat glomerular basement membrane（GBM） serum into sublingual vein and then effects of Qingshen Compound on urine volume,urinary protein level,blood urea nitrogen （BUN）,creatinine （Cr）,albumin （Alb）,triglycerides （TG）,cholesterol （CHO） and histopathological changes were investigated.After successive daily three-dosage oral administration to rat groups （9.4,4.7,2.3 g·kg-1） for 8 weeks,Qingshen Compound was proved effective on increasing urine volume and Alb content,and decreasing levels of urinary protein,BUN,Cr and TG.Furthermore,high and middle dosages （9.4,4.7 g·kg-1） could improve histopathological healing of the model.In summary,Qingshen Compound has shown protective effects on experimental Masugi nephritis model in rats.展开更多
文摘To study protective effects of Qingshen Compound on experimental anti-glomerular basement membrane antibody （AGBM-Ab） nephritis model in rats,an experimental Masugi nephritis model was established in Sprague-Dawley（SD） rats by a single-dose injection of prepared rabbit anti-rat glomerular basement membrane（GBM） serum into sublingual vein and then effects of Qingshen Compound on urine volume,urinary protein level,blood urea nitrogen （BUN）,creatinine （Cr）,albumin （Alb）,triglycerides （TG）,cholesterol （CHO） and histopathological changes were investigated.After successive daily three-dosage oral administration to rat groups （9.4,4.7,2.3 g·kg-1） for 8 weeks,Qingshen Compound was proved effective on increasing urine volume and Alb content,and decreasing levels of urinary protein,BUN,Cr and TG.Furthermore,high and middle dosages （9.4,4.7 g·kg-1） could improve histopathological healing of the model.In summary,Qingshen Compound has shown protective effects on experimental Masugi nephritis model in rats.
