BACKGROUND This case report enhances the medical literature by presenting a rare instance of primary esophageal mucoepidermoid carcinoma(MEC),highlighting its unique histological features and the challenges in diagnos...BACKGROUND This case report enhances the medical literature by presenting a rare instance of primary esophageal mucoepidermoid carcinoma(MEC),highlighting its unique histological features and the challenges in diagnosis that can arise due to its similarities with other esophageal cancers.CASE SUMMARY A 58-year-old female presented with dysphagia and was initially misdiagnosed with squamous cell carcinoma.Upon further evaluation,upper gastrointestinal endoscopy revealed a 1.5 cm lesion in the distal esophagus.The patient underwent partial esophagectomy,and histopathological examination confirmed the diagnosis of primary esophageal MEC with no lymph node metastasis.The patient has been under observation for 5 months post-surgery without adjuvant therapy.CONCLUSION Awareness of MEC is essential for accurate diagnosis and management due to its rarity and potential for misdiagnosis.展开更多
目的:研究MAML1在肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)组织中的表达,阐明其对ICC早期诊断的作用。方法:在癌症基因图集数据库(the cancer genome atlas,TCGA)中分析MAML1基因,运用免疫组织化学(immunohistochemistry,I...目的:研究MAML1在肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)组织中的表达,阐明其对ICC早期诊断的作用。方法:在癌症基因图集数据库(the cancer genome atlas,TCGA)中分析MAML1基因,运用免疫组织化学(immunohistochemistry,IHC)技术分析MAML1在ICC组织及正常胆管组织的表达差异,阐述MAML1基因在ICC发生、发展进程的作用。结果:ICC组织中MAML1的mRNA表达量上升(P<0.05);在病理分级低的ICC组织中,MAML1的蛋白表达量高,相反,在病理分级高的组织中,MAMAL1蛋白表达量低。结论:MAML1在ICC中可能起着促癌基因的作用,临床上根据ICC组织中MAML1表达量的差异,可辅助鉴别ICC病理分级,能为临床工作者提供针对ICC患者制定个性化的治疗方案提供重要依据。展开更多
文摘BACKGROUND This case report enhances the medical literature by presenting a rare instance of primary esophageal mucoepidermoid carcinoma(MEC),highlighting its unique histological features and the challenges in diagnosis that can arise due to its similarities with other esophageal cancers.CASE SUMMARY A 58-year-old female presented with dysphagia and was initially misdiagnosed with squamous cell carcinoma.Upon further evaluation,upper gastrointestinal endoscopy revealed a 1.5 cm lesion in the distal esophagus.The patient underwent partial esophagectomy,and histopathological examination confirmed the diagnosis of primary esophageal MEC with no lymph node metastasis.The patient has been under observation for 5 months post-surgery without adjuvant therapy.CONCLUSION Awareness of MEC is essential for accurate diagnosis and management due to its rarity and potential for misdiagnosis.
文摘目的:研究MAML1在肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)组织中的表达,阐明其对ICC早期诊断的作用。方法:在癌症基因图集数据库(the cancer genome atlas,TCGA)中分析MAML1基因,运用免疫组织化学(immunohistochemistry,IHC)技术分析MAML1在ICC组织及正常胆管组织的表达差异,阐述MAML1基因在ICC发生、发展进程的作用。结果:ICC组织中MAML1的mRNA表达量上升(P<0.05);在病理分级低的ICC组织中,MAML1的蛋白表达量高,相反,在病理分级高的组织中,MAMAL1蛋白表达量低。结论:MAML1在ICC中可能起着促癌基因的作用,临床上根据ICC组织中MAML1表达量的差异,可辅助鉴别ICC病理分级,能为临床工作者提供针对ICC患者制定个性化的治疗方案提供重要依据。
