Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong P...Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–2019.For suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-thalassemia.Among them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study population.Our results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control strategies.We demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.展开更多
Background:Even though various research has demonstrated the connection between consanguinity and health issues,consanguineous marriage still common in Egypt with high prevalence rate 35.3%,23.5%in semi-urban and 17.7...Background:Even though various research has demonstrated the connection between consanguinity and health issues,consanguineous marriage still common in Egypt with high prevalence rate 35.3%,23.5%in semi-urban and 17.7%in urban areas.Methods:This study was conducted on 434native Arabic-speaking Egyptians children(3-10 years)who visited Special Needs Clinic at National Research Centre,among one year presenting with a hearing or/and language problem.They were subjected to psychometric assessment,Conners'Parent Rating Scales-Revised,Autism Diagnostic Interview Revised,Childhood Autism Rating Scale,audiological assessment,and Arabic Preschool Language Scale-4.Participants were classified into 6 subgroups according to the cause of language delay.We estimated the frequency and degree of consanguinity in each group and the association between consanguinity and hearing and language problems.Results:The prevalence of the consanguineous marriage in all participants(n=434)was31.6%with the mean inbreeding coefficient of 0.01208.First cousins'marriages were the most common type of consanguineous marriages(50.3%of consanguineous marriages).Among all participants in the 6 subgroups(n=434),language delay secondary to cognitive delay showed the highest percentage of consanguineous marriages(35%)followed by autism spectrum disorder(32.8%).No significant association between consanguinity and language problems.Among the 78 participants with sensorineural hearing loss,35.9%of consanguineous couples(no.=28 cases)were reported versus 64.1%of non-consanguineous couples(no.=50 cases).Conclusions:The Frequency of consanguineous marriages in our participants was 31.6%which was close to that reported in Egyptian population.Absence of significant association between consanguinity and language problems warrants further investigation and point to the role of genetic-environment interplay in cases of language delay.展开更多
This article attempts to trace the status and many manifestations of erōs in Xenophon’s ethical and political thought.It examines its meaning in the narrow sense of“love and desire”and the broad sense of“affectiv...This article attempts to trace the status and many manifestations of erōs in Xenophon’s ethical and political thought.It examines its meaning in the narrow sense of“love and desire”and the broad sense of“affective feelings and friendship in the life of the family and the polis.”The principal goal is to demonstrate the remarkable coherence of Xenophon’s concept of erōs despite the diversity of the types of manifestation and visible differences in framing between male-male and male-female relationships.In addition,it will be shown that the principle of self-mastery as a vital criterion for the evaluation of sexual conduct is subordinated to what Xenophon perceives as the primary purpose of sexual intercourse:the procreation of progeny.展开更多
美国加利福尼亚州同性婚姻立法风波自In re Marriage案至2009年5月26日Strauss v.Horton案审结虽已告一段落,但斗争并未结束。这场风波是美国同性婚姻合法化论争的一个缩影。它不仅全面地反映出同性婚姻支持者和反对者的观点,同时也反...美国加利福尼亚州同性婚姻立法风波自In re Marriage案至2009年5月26日Strauss v.Horton案审结虽已告一段落,但斗争并未结束。这场风波是美国同性婚姻合法化论争的一个缩影。它不仅全面地反映出同性婚姻支持者和反对者的观点,同时也反映了同性恋运动的一个斗争策略。他们所争取的至少在很大程度上并不是更多的权利,而是一个"名份",更准确地说是一个同等对待的态度。展开更多
Jane Austen begins Pride and Prejudice with "It is a truth universally acknowledged that, a single man in possession of a good fortune, must be in want of a wife."Hence, there is no doubt that marriage will ...Jane Austen begins Pride and Prejudice with "It is a truth universally acknowledged that, a single man in possession of a good fortune, must be in want of a wife."Hence, there is no doubt that marriage will be a central concern of Pride and Prejudice. In this novel, Austen depicted several types of marriage: Elizabeth and Darcy’s marriage which emphasized equality and independence, Jane and Bingley’s marriage for love’s sake, Charlotte Lucas and Mr. Collins’ practical marriage and the rash marriage between Lydia and Wickham. This thesis is focused on the practical marriage between Charlotte Lucas and Mr. Collins while further explores the reasons behind their pragmatism.展开更多
Doris Lessing is a British writer and novelist. This paper focuses on marriage in Lessing’s To Room Nineteen. In this story, Lessing legitimizes the depression that besets many women who work at home through her narr...Doris Lessing is a British writer and novelist. This paper focuses on marriage in Lessing’s To Room Nineteen. In this story, Lessing legitimizes the depression that besets many women who work at home through her narrative technique and the character of Susan.展开更多
Marriage is a very important part in one's life.But different countries have different wedding ceremonies because of the culture difference.western wedding is simple while Chinese wedding is complex.No matter you ...Marriage is a very important part in one's life.But different countries have different wedding ceremonies because of the culture difference.western wedding is simple while Chinese wedding is complex.No matter you choose the Chinese style or the western style,you should marry the one you love best,and then you can enjoy a beautiful life.展开更多
At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that ...At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that marriage is the most important thing to women.Sometimes it even equals to men's career at that time.It seems like once a woman married to a rich single man,she succeed in her lifetime"career".The question is what is the standard of that"succeed"? Married to a rich man,or the man you really love,or a man you had a crush on? Everyone keep these questions in mind since very early time,and different people have different opinions.In her short life,Jane Austin,the great novelist,composed six novels and created lot of female characters.Women in her novel had different attitudes toward marriage.Speaking of marriage,Pride and Prejudice must be the most representative work of it,and it is also Jane's masterpiece.Through the different type of marriage of Mr.Bennet's daughters,we can find the Jane's atti tude towards marriage.In this article the author will discuss this issue based on Pride and Prejudice.展开更多
Pride and Prejudice is the masterpiece of Jane Austen.In her novel,through description of four marriages,Jane Austen expressed such views on marriage:marriages based on economics or superficial qualities such as lust,...Pride and Prejudice is the masterpiece of Jane Austen.In her novel,through description of four marriages,Jane Austen expressed such views on marriage:marriages based on economics or superficial qualities such as lust,money,and appearance will inevitably lead to unhappiness,while those based on mutual understanding and true love will be happy and stable.展开更多
Austin’s work-Pride and prejudice, demonstrates three key factors of marriage, namely, a certain economic condition is the guarantee to maintain a happy family, and Love is the foundation of a happy marriage, a ratio...Austin’s work-Pride and prejudice, demonstrates three key factors of marriage, namely, a certain economic condition is the guarantee to maintain a happy family, and Love is the foundation of a happy marriage, a rational and serious attitude towards the matrimonial issue.展开更多
Pride and Prejudice enjoys a worldwide appreciation for its readers. By showing different notions held by people in getting married, the author mainly intends to evoke the moral standards and principles beyond simple ...Pride and Prejudice enjoys a worldwide appreciation for its readers. By showing different notions held by people in getting married, the author mainly intends to evoke the moral standards and principles beyond simple love stories and instruct people's prudence in getting married.展开更多
In the history of English literature,the story of the three sisters,Charlotte(1816~1855),Emily(1818~1848)and Anne(1820~1849),is one of the most important and the saddest pages.They were the daughters of a poor clergym...In the history of English literature,the story of the three sisters,Charlotte(1816~1855),Emily(1818~1848)and Anne(1820~1849),is one of the most important and the saddest pages.They were the daughters of a poor clergyman in the little village of Haworth,Yorkshire,in northern England.Their mother died in 1821.展开更多
1.Is the belief that marriage is between a man and a woman—until recently common even in liberal circles—now presumed so bigoted as to deserve no consideration,even when the exercise of this belief does not actually...1.Is the belief that marriage is between a man and a woman—until recently common even in liberal circles—now presumed so bigoted as to deserve no consideration,even when the exercise of this belief does not actually keep gays from marrying？（Washington News,Feb.24,2014）翻译：婚姻是男女之间的结合,这种观念直到最近就算在思想开明的圈子里都很常见。即便这种观念并不妨碍同性恋者结婚,如今难道也被认为古板而不值得考虑吗？展开更多
Pride and Prejudice is a masterpiece by Juan Austen.Generally,Austen is considered one of the two major novelists of the Romantic period in the history of British literature,the other is Walter Scott.But her view of l...Pride and Prejudice is a masterpiece by Juan Austen.Generally,Austen is considered one of the two major novelists of the Romantic period in the history of British literature,the other is Walter Scott.But her view of life is totally realistic.She shows the readers the daily life of middle class.This paper investigates different kinds of love and marriages in Pride and Prejudice with feminism,and comes to the conclusion that Jane Austen is a romantic writer as well as a realistic writer.展开更多
This essay aims to discuss and analyse Jane Eyre and Mr. Rochester's attitude towards love and marriage. Struggling for theequality of human dignity crosses through their love from beginning to end. Therefore, we ...This essay aims to discuss and analyse Jane Eyre and Mr. Rochester's attitude towards love and marriage. Struggling for theequality of human dignity crosses through their love from beginning to end. Therefore, we can draw a conclusion--True love and happymarriage are based upon the equality of human dignity between a couple.展开更多
Marriage is usually associated with happiness and harmony. But in Shakespear's Measure for Measure, it seems it is infused with power of law. Is it a clear-cut punishment or reward? Its qualities revolve around th...Marriage is usually associated with happiness and harmony. But in Shakespear's Measure for Measure, it seems it is infused with power of law. Is it a clear-cut punishment or reward? Its qualities revolve around the individual situations in which it occurs, which is interpreted and deployed by characters in the play in different ways.展开更多
基金the Data quality evaluation study of the national free preconception eugenics health screening program[No.C2018033]。
文摘Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–2019.For suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-thalassemia.Among them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study population.Our results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control strategies.We demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.
文摘Background:Even though various research has demonstrated the connection between consanguinity and health issues,consanguineous marriage still common in Egypt with high prevalence rate 35.3%,23.5%in semi-urban and 17.7%in urban areas.Methods:This study was conducted on 434native Arabic-speaking Egyptians children(3-10 years)who visited Special Needs Clinic at National Research Centre,among one year presenting with a hearing or/and language problem.They were subjected to psychometric assessment,Conners'Parent Rating Scales-Revised,Autism Diagnostic Interview Revised,Childhood Autism Rating Scale,audiological assessment,and Arabic Preschool Language Scale-4.Participants were classified into 6 subgroups according to the cause of language delay.We estimated the frequency and degree of consanguinity in each group and the association between consanguinity and hearing and language problems.Results:The prevalence of the consanguineous marriage in all participants(n=434)was31.6%with the mean inbreeding coefficient of 0.01208.First cousins'marriages were the most common type of consanguineous marriages(50.3%of consanguineous marriages).Among all participants in the 6 subgroups(n=434),language delay secondary to cognitive delay showed the highest percentage of consanguineous marriages(35%)followed by autism spectrum disorder(32.8%).No significant association between consanguinity and language problems.Among the 78 participants with sensorineural hearing loss,35.9%of consanguineous couples(no.=28 cases)were reported versus 64.1%of non-consanguineous couples(no.=50 cases).Conclusions:The Frequency of consanguineous marriages in our participants was 31.6%which was close to that reported in Egyptian population.Absence of significant association between consanguinity and language problems warrants further investigation and point to the role of genetic-environment interplay in cases of language delay.
文摘This article attempts to trace the status and many manifestations of erōs in Xenophon’s ethical and political thought.It examines its meaning in the narrow sense of“love and desire”and the broad sense of“affective feelings and friendship in the life of the family and the polis.”The principal goal is to demonstrate the remarkable coherence of Xenophon’s concept of erōs despite the diversity of the types of manifestation and visible differences in framing between male-male and male-female relationships.In addition,it will be shown that the principle of self-mastery as a vital criterion for the evaluation of sexual conduct is subordinated to what Xenophon perceives as the primary purpose of sexual intercourse:the procreation of progeny.
文摘美国加利福尼亚州同性婚姻立法风波自In re Marriage案至2009年5月26日Strauss v.Horton案审结虽已告一段落,但斗争并未结束。这场风波是美国同性婚姻合法化论争的一个缩影。它不仅全面地反映出同性婚姻支持者和反对者的观点,同时也反映了同性恋运动的一个斗争策略。他们所争取的至少在很大程度上并不是更多的权利,而是一个"名份",更准确地说是一个同等对待的态度。
文摘Jane Austen begins Pride and Prejudice with "It is a truth universally acknowledged that, a single man in possession of a good fortune, must be in want of a wife."Hence, there is no doubt that marriage will be a central concern of Pride and Prejudice. In this novel, Austen depicted several types of marriage: Elizabeth and Darcy’s marriage which emphasized equality and independence, Jane and Bingley’s marriage for love’s sake, Charlotte Lucas and Mr. Collins’ practical marriage and the rash marriage between Lydia and Wickham. This thesis is focused on the practical marriage between Charlotte Lucas and Mr. Collins while further explores the reasons behind their pragmatism.
文摘Doris Lessing is a British writer and novelist. This paper focuses on marriage in Lessing’s To Room Nineteen. In this story, Lessing legitimizes the depression that besets many women who work at home through her narrative technique and the character of Susan.
文摘Marriage is a very important part in one's life.But different countries have different wedding ceremonies because of the culture difference.western wedding is simple while Chinese wedding is complex.No matter you choose the Chinese style or the western style,you should marry the one you love best,and then you can enjoy a beautiful life.
文摘At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that marriage is the most important thing to women.Sometimes it even equals to men's career at that time.It seems like once a woman married to a rich single man,she succeed in her lifetime"career".The question is what is the standard of that"succeed"? Married to a rich man,or the man you really love,or a man you had a crush on? Everyone keep these questions in mind since very early time,and different people have different opinions.In her short life,Jane Austin,the great novelist,composed six novels and created lot of female characters.Women in her novel had different attitudes toward marriage.Speaking of marriage,Pride and Prejudice must be the most representative work of it,and it is also Jane's masterpiece.Through the different type of marriage of Mr.Bennet's daughters,we can find the Jane's atti tude towards marriage.In this article the author will discuss this issue based on Pride and Prejudice.
文摘Pride and Prejudice is the masterpiece of Jane Austen.In her novel,through description of four marriages,Jane Austen expressed such views on marriage:marriages based on economics or superficial qualities such as lust,money,and appearance will inevitably lead to unhappiness,while those based on mutual understanding and true love will be happy and stable.
文摘Austin’s work-Pride and prejudice, demonstrates three key factors of marriage, namely, a certain economic condition is the guarantee to maintain a happy family, and Love is the foundation of a happy marriage, a rational and serious attitude towards the matrimonial issue.
文摘Pride and Prejudice enjoys a worldwide appreciation for its readers. By showing different notions held by people in getting married, the author mainly intends to evoke the moral standards and principles beyond simple love stories and instruct people's prudence in getting married.
文摘In the history of English literature,the story of the three sisters,Charlotte(1816~1855),Emily(1818~1848)and Anne(1820~1849),is one of the most important and the saddest pages.They were the daughters of a poor clergyman in the little village of Haworth,Yorkshire,in northern England.Their mother died in 1821.
文摘1.Is the belief that marriage is between a man and a woman—until recently common even in liberal circles—now presumed so bigoted as to deserve no consideration,even when the exercise of this belief does not actually keep gays from marrying？（Washington News,Feb.24,2014）翻译：婚姻是男女之间的结合,这种观念直到最近就算在思想开明的圈子里都很常见。即便这种观念并不妨碍同性恋者结婚,如今难道也被认为古板而不值得考虑吗？
文摘Pride and Prejudice is a masterpiece by Juan Austen.Generally,Austen is considered one of the two major novelists of the Romantic period in the history of British literature,the other is Walter Scott.But her view of life is totally realistic.She shows the readers the daily life of middle class.This paper investigates different kinds of love and marriages in Pride and Prejudice with feminism,and comes to the conclusion that Jane Austen is a romantic writer as well as a realistic writer.
文摘This essay aims to discuss and analyse Jane Eyre and Mr. Rochester's attitude towards love and marriage. Struggling for theequality of human dignity crosses through their love from beginning to end. Therefore, we can draw a conclusion--True love and happymarriage are based upon the equality of human dignity between a couple.
文摘Marriage is usually associated with happiness and harmony. But in Shakespear's Measure for Measure, it seems it is infused with power of law. Is it a clear-cut punishment or reward? Its qualities revolve around the individual situations in which it occurs, which is interpreted and deployed by characters in the play in different ways.
