Diamonds were formed in the mantle lithosphere,mostly at depths of 150~200km in the centres of Precambrian cratons,the buoyant ancient cores of continents.From there they were normally transported into the upper crust...Diamonds were formed in the mantle lithosphere,mostly at depths of 150~200km in the centres of Precambrian cratons,the buoyant ancient cores of continents.From there they were normally transported into the upper crust in kimberlite pipes whose diamonds are largely colourless and light yellow related to trace element N(Ia type),although brown,green,and more rarely blue-coloured diamonds are related to lattice defect and trace amounts of H,more rarely B and Ni.Pink diamonds are extremely rare in the approximately 90 diamondiferous pipes mined globally.Although small quantities have been discovered elsewhere,about 90%have been mined from the ca.1.3Ga Argyle diamond pipe in Western Australia,with the Arkhangelskaya diamond pipe in Russia the only other significant source.The pink colour at both Argyle and Arkhangelskaya is unrelated to trace elements and instead results from absorption of light from nanoscale(550nm)defects related to shear stress and plastic deformation.Macroscopically,defects are shown by glide planes,lamellae,and grain lines imposed on the originally colourless diamonds derived from their mantle source.The key question is why these defects were uniquely acquired in diamonds in the Argyle and Arkhangelskaya pipes.Unlike most diamondiferous pipes,Argyle is a rare diamondiferous volatile-rich lamproite pipe that was emplaced into the multiply deformed and rifted NNE-trending Halls Creek Orogen on the margin of the Kimberley Craton.Similarly,Arkhangelskaya in the Devonian Lomonosov kimberlite cluster is a volatile-rich low-Ti type kimberlite,a close relative to lamproite,that was emplaced into the multiply deformed Lapland-Kola Orogen on the rifted margin of the Kola Craton.These craton margins are underlain by subduction-induced volatile-enriched metasomatized mantle lithosphere in contrast to the more primeval mantle under craton centres.It is thus likely that shear stresses were exacerbated at Argyle and Arkangelskaya by rapid vertical emplacement of the anomalous volatile-enriched magmas at supercritical pressures and temperatures,that induced catastrophic phase separation of these volatiles and'mini seismic events'during rapid pressure drops during ascent from 200km depth to the surface.Such a mechanism is consistent with the presence of strongly resorbed and plastically deformed small brown industrial diamonds in the Argyle pipe.From a China perspective,it is potentially important that at 1.3Ga the alkaline Argyle pipe in northern Australia is placed adjacent to the North China Craton(NCC),with numerous world-class mineral deposits including the giant ca.1.4~1.2Ga alkaline Bayan Obo REE system on its margin.However,it is the southeastern margin of the Yangtze Craton and the Jiangnan Orogen with their lamproite pipes derived from metasomatized mantle lithosphere that present the most prospective regions for pink diamond occurrences.展开更多
The formation of Caosiyao giant porphyry Mo deposit is related to three granitic porphyries:coarse-grained granite porphyry(CG),fine-grained granite porphyry(FG),and giant plagioclase phenocryst bearing granite porphy...The formation of Caosiyao giant porphyry Mo deposit is related to three granitic porphyries:coarse-grained granite porphyry(CG),fine-grained granite porphyry(FG),and giant plagioclase phenocryst bearing granite porphyry(PG).To investigate the mineralization significance of three porphyries,Microthermometry,Laser micro-Raman Spectra,and H-O-He-Ar isotope analyses of fluid inclusions were conducted.Intermediate density with high temperatures(>550℃)and moderate-low salinities(~10 wt.%)characterizes CG-related initial exsolved fluids.Vapor-rich and brine phases separated from the initial fluid following a continuous decrease in pressure and temperature,inducing molybdenite precipitation.FG-related initial fluids are characterized by high temperatures(>550℃)and salinities(>65 wt.%).The mixing of low-salinity fluids led to a rapid decrease in the salinity of FG-related fluid,promoting the deposit of the Mo element.The lead-zinc mineralization is closely related to the FG-related fluid,and the addition of meteoric fluid induced the formation of galena and sphalerite.The ore-forming fluid related to the PG is CO_(2)-rich and accompanied by the addition of mantle-derived He-Ar.The presence of CO_(2) did not contribute to the solubility of Mo,resulting in the absence of a considerable amount of molybdenite.展开更多
The authors extend the marginal coordinate test for predictor contribution(Cook,2004)to the case with multivariate responses.Instead of explicitly specifying the link functions between the responses and the predictors...The authors extend the marginal coordinate test for predictor contribution(Cook,2004)to the case with multivariate responses.Instead of explicitly specifying the link functions between the responses and the predictors,an asymptotic test is proposed under the normality assumption of the predictors as well as an asymmetry assumption about the unknown regression mean function.When these assumptions are violated,the asymptotic test with elliptical trimming and clustering is still valid with desirable numerical performances.展开更多
Ecosystems along the eastern margin of the Qinghai-Tibet Plateau(EQTP)are highly fragile and extremely sensitive to climate change and human disturbances.To quantitatively assess climate-induced ecosystem responses,th...Ecosystems along the eastern margin of the Qinghai-Tibet Plateau(EQTP)are highly fragile and extremely sensitive to climate change and human disturbances.To quantitatively assess climate-induced ecosystem responses,this study proposes a Climate-Induced Productivity Index(CIPI)based on the Super Slack-Based Measure(Super-SBM)model using remote sensing data from 2001 to 2020.The results reveal persistently low CIPI values(0.47-0.53)across major ecosystem types,indicating widespread vulnerability to climatic variability.Among these ecosystems,forests exhibit the highest CIPI(0.55),followed by shrublands(0.54),croplands(0.53),grasslands(0.51),and barelands(0.43).The Theil index analysis further demonstrates significant intra-group disparities,suggesting that extreme climatic events amplify CIPI heterogeneity.Moreover,the dominant environmental drivers differ among ecosystem types:the Palmer Drought Severity Index(PDSI)primarily constrains grassland productivity,solar radiation(SRAD)strongly influences shrub and cropland systems,whereas subsurface factors exert greater control in forested regions.This study provides a quantitative framework for evaluating climate-ecosystem interactions and offers a scientific basis for long-term ecological monitoring and security planning across the EQTP.展开更多
Based on the plate tectonics theory,the sedimentary environment of paleotectonics along the passive continental margins on both sides of the South Atlantic Ocean was reconstructed using the paleomagnetic,regional geol...Based on the plate tectonics theory,the sedimentary environment of paleotectonics along the passive continental margins on both sides of the South Atlantic Ocean was reconstructed using the paleomagnetic,regional geological,and seismic data,and the intrinsic relationships of hydrocarbon distribution in the passive continental margin basins and the differential hydrocarbon accumulation patterns were analyzed.Results show that basins on both sides of the South Atlantic experienced two major extensional phases—rift and depression—and four evolutionary stages:the Early Cretaceous Berriasian-Barremian intracontinental rift stage,the Early Cretaceous Aptian-Albian intercontinental rift to initial drift transition stage,the Late Cretaceous-Paleogene drift-related marine transgressive depression stage,and the Neogene-Quaternary drift-related marine regressive depression stage.According to basin architecture and superposition style,the passive-margin basins are classified into two principal types:rift-continental marginal depression composite and continental marginal depression-dominated.The basins in the study area were further divided into six types based on the development degree of salt tectonics and the type of dominant sand bodies,i.e.salt-free rift-continental marginal gravity-flow composite type,salt-free rift-continental marginal delta composite type,salt-bearing rift-continental marginal gravity flow composite type,delta-dominated salt-bearing rift-continental marginal delta composite type,gravity-flow-dominated continental marginal depression type,and delta-dominated continental marginal depression type.The salt-free rift-continental marginal gravity flow and delta composite basins are mainly distributed in the southern segment.The salt-bearing rift-continental marginal gravity flow and delta composite basins are mainly distributed in the central segment.The gravity-flow-dominated continental marginal depression basins are mainy distributed in the northern segment.The delta-dominated passive-margin depression basins are distributed in three segments from north to south.In different types of basins,distinctive depositional systems and source-reservoir-caprock assemblages were formed in each upper/lower structure layer.The superimposition and evolution of multi-phase prototype basins result in the orderly hydrocarbon accumulation vertically and laterally,which are“segmented along-strike,zoned across-strike,and layered vertically”.展开更多
Vaccination is the preferred strategy for preventing infections such as influenza in elderly individuals;however,its efficacy is often suboptimal due in part to age-related declines in immune function.In this study,we...Vaccination is the preferred strategy for preventing infections such as influenza in elderly individuals;however,its efficacy is often suboptimal due in part to age-related declines in immune function.In this study,we discovered that the infusion of mesenchymal stromal cells(MSCs)restored defects in the splenic stromal cell network and lymphocyte architecture in aged mice while also increasing specific antibody levels following vaccine immunization.This significantly protected aging mice from influenza infection.Mechanistically,the delivered MSCs localized in the splenic marginal zones,where they positioned themselves near marginal reticular cells(MRCs)and stimulated MRC proliferation,partially through the action of vascular endothelial growth factor A(VEGFA).This MSC‒MRC interaction orchestrated the reconstruction of the stromal network,thereby restoring lymphocyte homeostasis and germinal center reactions.Importantly,the MSC-mediated enhancement of the vaccine response was further validated in aged cynomolgus monkeys.Collectively,our findings provide new insights into the application of MSCs in addressing age-related immune decline and highlight splenic MRCs as critical therapeutic targets.展开更多
The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sal...The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.展开更多
Based on a set of high-resolution 3D seismic data from the northern continental margin of the South China Sea,the lithospheric structure,thinning mechanisms and related syn-rift tectonic deformation response processes...Based on a set of high-resolution 3D seismic data from the northern continental margin of the South China Sea,the lithospheric structure,thinning mechanisms and related syn-rift tectonic deformation response processes in the crustal necking zone in the deepwater area of the Pearl River Mouth Basin were systematically analyzed,and the petroleum geological significance was discussed.The necking zone investigated in the study is located in the Baiyun Sag and Kaiping Sag in the deepwater area of the Pearl River Mouth Basin.These areas show extreme crustal thinned geometries of central thinning and flank thickening,characterized by multi-level and multi-dipping detachment fault systems.The necking zone exhibits pronounced lateral heterogeneity in structural architectures,which can be classified into four types of thinned crustal architectures,i.e.the wedge-shaped extremely thinned crustal architecture in the Baiyun Main Sub-sag,dumbbell-shaped moderately thinned crustal architecture in the Baiyun West Sub-sag,box-shaped weakly thinned crustal architecture in eastern Baiyun Sag,and metamorphic core complex weakly thinned crustal architecture in the Kaiping Sag.This shows great variations in the degree and style of crustal thinning,types of detachment faults,distribution of syn-rift sedimentary sequences,and intensity of magmatism.The thinning of the necking zone is controlled by the heterogeneous rheological stratification of lithosphere,intensity of mantle-derived magmatism,and deformation modes of detachment faults.The syn-rift tectonic deformation of the necking zone evolved through three phases,i.e.uniform stretching during the early Wenchang Formation deposition period,necking during the late Wenchang Formation deposition period,and hyperextension during the Enping Formation deposition period.The crustal thinning extent and architectural differentiation in these phases were primarily controlled by three distinct mechanisms,i.e.the pure shear deformation activation of pre-existing thrust faults,the simple shear deformation of crust-mantle and inter-crust detachment faults,and differential coupling of lower crustal flow and ductile domes with main detachment faults.The hydrocarbon accumulation and enrichment in the necking zone exhibit marked spatial heterogeneity.Four distinct crustal thinned architecture-hydrocarbon accumulation models were identified in this study.The hydrocarbon accumulations in the shallow part exhibit significant correlations with their deep crustal thinned architectures.The unique lithospheric structure and deformation process predominantly control the favorable hydrocarbon accumulation zones with excellent source-fault-ridge-sand configurations,which is critical to reservoir-forming.The most promising exploration targets are mainly identified on the uplift zones and their seaward-dipping flanks associated with the middle and lower crustal domes.This research provides additional insights into lithospheric thinning-breakup process at intermediate continental margins of marine sedimentary basins,being significant for guiding the deepwater petroleum exploration in the Pearl River Mouth Basin.展开更多
The Litang fault zone is an important seismogenic structure along the southeastern margin of the Tibetan Plateau.It caused the M71/4 earthquake in Litang in 1948 AD.The fault zone intersects the Sichuan-Xizang transpo...The Litang fault zone is an important seismogenic structure along the southeastern margin of the Tibetan Plateau.It caused the M71/4 earthquake in Litang in 1948 AD.The fault zone intersects the Sichuan-Xizang transportation corridor and poses a serious risk to its safe operation.This study,utilizing high-resolution remote sensing interpretation,field geological verification,UAV photogrammetry,UAV LiDAR,paleoearthquake trench excavation,and AMS^(14)C and OSL dating methods,reveals the geometric structure,slip rates,paleoearthquake sequence,and earthquake rupture segmentation of the Litang fault zone;analyzes the rupture distribution range of the 1729 AD Litang earthquake and estimates its magnitude.The study indicates that the Litang fault zone is a relatively immature strike-slip fault,which has developed as a new active fault zone within the Northwestern Sichuan sub-block during the southeastward material migration of the southeastern margin of the Tibetan Plateau.This reflects a transformation in the deformation model of the Northwestern Sichuan sub-block crust from the‘Rigid Block’model to the‘Continuous Deformation’model.展开更多
The Cambrian platform margin in the Tarim Basin boasts favorable source-reservoir-cap assemblages,making it a significant target for hydrocarbon exploration in ultra-to extra-deep facies-controlled for-mations.Of the ...The Cambrian platform margin in the Tarim Basin boasts favorable source-reservoir-cap assemblages,making it a significant target for hydrocarbon exploration in ultra-to extra-deep facies-controlled for-mations.Of the three major basins in western China,Tarim is the only basin with large-scale platform margin where no exploration breakthrough has been achieved yet.This study determines the vertical and lateral differential evolution of the platform margin(in the Manxi area hereafter referred to as the Cambrian Manxi platform margin)through fine-scale sequence stratigraphic division and a segmented analysis.The platform margin can be divided into the Yuqi,Tahe,Shunbei,and Gucheng segments,from north to south,based on the development of different ancient landforms and the evolutionary process of the platform.The Yuqi and Shunbei segments exhibit relatively low-elevation ancient landforms.Both segments were in a submarine buildup stage during the Early Cambrian,resulting in overall limited scales of their reservoirs.The Gucheng segment features the highest-elevation ancient landforms and accordingly limited accommodation spaces.As a result,the rapid lateral migration of high-energy facies zones leads to the development of large-scale reservoirs with only limited thicknesses.In contrast,the Tahe segment,exhibiting comparatively high-elevation ancient landforms,is identified as the most favorable segment for the formation of large-scale reservoirs.The cap rocks of the platform margin are dominated by back-reef dolomitic flats and tight carbonate rocks formed in transgressive periods.A comprehensive evaluation of source rocks,reservoirs,and cap rocks indicates that the Tahe segment boasts the optimal hydrocarbon accumulation conditions along the platform margin.In this segment,the Shayilike Formation transgressive deposits and the high-energy mound-shoal complexes along the platform margin of the Wusonggeer Formation constitute the optimal reservoir-cap rock assemblage,establishing this segment as the most promising target for hydrocarbon exploration in the platform margin.展开更多
Objective:Microscopically positive resection margins(R1)in gastric cancer have been associated with poor outcomes,but evidence regarding its prognostic significance across different stages remains inconsistent.This st...Objective:Microscopically positive resection margins(R1)in gastric cancer have been associated with poor outcomes,but evidence regarding its prognostic significance across different stages remains inconsistent.This study investigated the impact of R1 resection on survival outcomes and evaluated the prognostic significance of detailed pathological characteristics of margin involvement.Methods:This retrospective study analyzed 10,165 patients who underwent curative-intent gastrectomy for gastric cancer between 2007 and 2021.Propensity score matching was performed at a 1:3 ratio between R1(n=45)and R0(n=130)cases.For R1 margins,detailed pathological assessment included involvement length,proportion,depth,and histological features.Survival outcomes were evaluated across all stages,and the impact of subsequent resection was analyzed.Results:After propensity score matching,R1 resection showed significantly lower 5-year overall survival rates compared to R0 resection across all stages(stageⅠ:60.0%vs.90.9%,P=0.008;stageⅡ:40.0%vs.83.3%,P=0.001;stageⅢ:20.0%vs.35.4%,P<0.001).In R1 cases,tumor involvement length≤1 cm(P<0.001),proportion≤10%(P=0.012),and mucosal-only involvement(P=0.004)were associated with better survival.Patients who underwent subsequent resection to achieve R0 status showed better survival than those with persistent R1 resection(53.8%vs.26.7%,P<0.001)and comparable survival to matched R0 cases(53.8%vs.46.9%,P=0.320).Conclusions:R1 resection significantly impairs survival across all stages of gastric cancer,with the extent and depth of microscopic involvement influencing prognosis.When R1 status is discovered postoperatively,subsequent resection should be considered to improve survival outcomes.展开更多
The trace element selenium(Se)occurs naturally throughout the earth.Se deficiency has been linked to impaired breast health and other diseases in human and animals.Compared to severe Se deficiency,marginal dietary Se ...The trace element selenium(Se)occurs naturally throughout the earth.Se deficiency has been linked to impaired breast health and other diseases in human and animals.Compared to severe Se deficiency,marginal dietary Se deficiency accusers more frequently in low-Se regions.Therefore,to investigate the Se status and inflammatory response of the mammary gland under marginal dietary Se levels,an lipopolysaccharide(LPS)induced mouse mastitis model was established.Mice were fed with moderate Se diet(0.087 mg•kg^(-1) Se),adequate Se diet(0.15 mg•kg^(-1) Se)or excessive Se diet(1.5 mg•kg^(-1) Se)for 60 days.Se status and inflammatory factors were investigated.Results showed that the Se status of mammary gland correlated with dietary Se levels.Marginal Se deficiency exacerbated mammary tissue histopathology;increased the mRNA level of inflammatory genes tumor necrosis factor alpha(TNF-α),interleukin-1β(IL-1β)and cyclooxygenase-2(COX-2);and enhanced the phosphorylation of NF-κB p65 in mammary gland tissues.Supplementation of Se in diet higher than recommended levels reduced the inflammatory reaction of mammary glands in LPS-induced mastitis model and provided a protective effect.展开更多
Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysi...Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysis of the main source rocks,reservoirs,and vertical migration pathways within the Rovuma(RB)and Tanzania(TB)basins in East Africa utilizing drilling,logging,seismic,and geochemical data.The results indicate that the enhanced preservation conditions of the Lower Jurassic source rocks in the southwest could lead to the discovery of large natural gas fields in the southern TB and RB.The primary reservoir is a deep-water turbidite sandstone.Due to topographic differences,the expanse of the turbidite sandstones in the RB is significantly larger than those in Tanzania.The main vertical migration pathways are the western boundary fault zone of the Kerimbas Graben(WBFZ)and the Seagap fault zone(SFZ).In the RB,natural gas migrates vertically along the WBFZ and preferentially accumulates in the deep-water turbidite sandstones of the footwall under the control of the fluid potential.Conversely,in the southern TB,the deep natural gas first migrates upward along the SFZ,then moves along the shallow branch faults in the sandstones on both sides of the SFZ.展开更多
Marginal Fisher analysis(MFA)stands out as a prominent dimensionality reduction algorithm,striving to minimize within-class scatter while maximizing the separability between marginal data points.However,MFA and its va...Marginal Fisher analysis(MFA)stands out as a prominent dimensionality reduction algorithm,striving to minimize within-class scatter while maximizing the separability between marginal data points.However,MFA and its variants require substantial computational resources when dealing with large-scale data.To address this,we propose quantum algorithms for MFA(called QMFA).QMFA is composed of two core processes:the first is the efficient construction of the weight matrices for the intrinsic and penalty graphs,and the second is solving the generalized eigenvalue problem(GEP)using the block-encoding technique.Compared to classical MFA,the proposed QMFA achieves a polynomial acceleration in the number of samples and exponential acceleration in the dimensionality.Additionally,we investigate quantum algorithms for different variants of MFA.Specifically,for enhanced MFA and multiple MFA,we address the construction of the related weight matrix,which differs from that in standard MFA.For kernel MFA,we solve the GEP associated with the corresponding kernel matrix.The proposed quantum algorithms achieve a speedup equivalent to that of QMFA.展开更多
Recently,Luolai Group released its Q12025 quarterly report.As a leading Chinese home textile enterprise listed on the Shenzhen Stock Exchange in 2009,the company covers the research,design,production,and sales of home...Recently,Luolai Group released its Q12025 quarterly report.As a leading Chinese home textile enterprise listed on the Shenzhen Stock Exchange in 2009,the company covers the research,design,production,and sales of home textile products,and has multiple brands covering different consumer markets.It has expanded its online and offline comprehensive multichannel sales system and is committed to creating a win-win home furnishings and textile industry ecosystem.展开更多
Magmatism at continental margins is of great significance in understanding the continental rifting.We present a twodimensional P-wave velocity model derived from an ocean bottom seismometer experiment,conducted across...Magmatism at continental margins is of great significance in understanding the continental rifting.We present a twodimensional P-wave velocity model derived from an ocean bottom seismometer experiment,conducted across the middle northern continental margin of the South China Sea(SCS).The detailed velocity structures reveal significant heterogeneities extending from the continental shelf to the continent-ocean transition zone.The crust exhibits its greatest thickness below the continental shelf,measuring~23 km and gradually thins to~13 km at the distal margin.Furthermore,a narrow and distinct continent-ocean transition with only 40-km width is revealed.We also observe a high-velocity layer within the transition zone,reaching thickness of up to 4 km,characterized by P-wave velocities ranging from 7.0 km/s to 7.6 km/s in the lower crust.Based on the syn-rift melt generation using decompression melting model,we ascertain that syn-rift magmatism cannot fully account for the observed thick high-velocity layer.By integrating findings from previous geophysical and geochemical studies presenting extensive volcanic edifice on the seafloor at the northern margin,as well as ocean-island-basalt-type magmaticsamples in the SCS area,we propose that post-rifting magmatism associated with the Hainan Plume may have influenced theformation of the high-velocity lower crust within the transition zone and the northern margin of the SCS can thus be recognizedas magma-poor type margin.展开更多
Accurate determination of lung cancer margins at the molecular level is of great significance to determine the optimal extent of resection during surgical operation and reduce the risk of postoperative recurrence.In t...Accurate determination of lung cancer margins at the molecular level is of great significance to determine the optimal extent of resection during surgical operation and reduce the risk of postoperative recurrence.In this study,internal extractive electrospray ionization mass spectrometry(i EESI-MS)was used to trace potential molecular tumor margins in lung cancer tissue.Molecular differential model for the determination of lung cancer tumor margin was established via partial least-squares discriminant analysis(PLS-DA)of iEESI-MS data collected from lung tissue pieces within cancer tumor area and iEESI-MS data collected from lung tissue pieces outside cancer tumor area.Proof-of-concept data demonstrate that the developed molecular differential model yields ca.1-2 mm wider potential molecular tumor margin of a lung cancer compared to the conventional histological analysis,showing promising potential of iEESI-MS to increase the accuracy of tumor margins determination and lower risk of lung cancer postoperative recurrence.Furthermore,our results revealed that creatine and taurine showed positive correlations with lung cancer.展开更多
Previous studies have indicated that sediment gravity flow deposits developed in lacustrine active extensional rift basins are primarily influenced by tectonics and to a lesser extent by climate.Our present work revea...Previous studies have indicated that sediment gravity flow deposits developed in lacustrine active extensional rift basins are primarily influenced by tectonics and to a lesser extent by climate.Our present work reveals that climate can obscure the effect of tectonic subsidence by regulating sediment supply;conversely,tectonics can impede the sedimentary manifestation of climatic impacts.Here a case study has been presented to assess the impact of climate-modulated rapid lake-level rise and tectonic subsidence on the development of coarse-grained gravity flow deposits in the Dongying rift margin of the Bohai Bay Basin,eastern China.The lithofacies analysis reveals frequent bed amalgamation,abundant thick massive coarse-grained deposits,widespread cross bedding and plant fragments,and incomplete composite bed formed by high-energy erosion,indicating that the hyperpycnal flow is an important mechanism driving the deposition of these coarse-grained sediments.Detailed sequence stratigraphic analysis and sediment dispersal pattern suggest that the long-striped nearshore subaqueous fan systems induced by outburst-flood hyperpycnal flow distributed along the border fault,are primarily controlled by long-term tectonics,while the rapid rise of lake level driven by short-term climate change possibly intensifies seasonal flood-generated hyperpycnal flow occurrences and consequently promotes the basinal fan progradation.The maximum scale of these coarse-grained gravity flow deposits of the basinal fan systems are typically attained during the transgressive systems tract,which deviates from the classical sequence stratigraphic model.Furthermore,it presented a continuous transition from the proximal to the distal part,encompassing traction flows and turbidity currents during the periods of relatively stable tectonics.Nevertheless,gravel-rich debris flows appear to predominate the dispersion of coarse-grained sediments during periods characterized by intense tectonic activity.The coarse-grained gravity flow deposits in the lacustrine rift margin reported here,challenge the traditional beliefs:this study suggests that subaqueous deposits abundantly preserved in the transgressive setting.展开更多
In order to better realize the development of cultural tourism products in Yuncheng County,this paper analyzed Water Margin cultural tourism resources,market demand and product design in Yuncheng County using the RMP(...In order to better realize the development of cultural tourism products in Yuncheng County,this paper analyzed Water Margin cultural tourism resources,market demand and product design in Yuncheng County using the RMP(Resource-Market-Product)theory,summarized existing problems in the development of Water Margin cultural tourism in Yuncheng County,and proposed countermeasures for its development.It is expected to achieve the integration of Water Margin culture and the tourism industry under the broader context of cultural and tourism integration,provide richly diverse and distinctive tourism products and services,and promote the economic development of the tourist destination.展开更多
The composition and sedimentary controlling effect of the coal measure gas-bearing(CMG)system of the Jurassic Xishanyao Formation in the southern margin of the Junggar Basin(SJB)are analysed based on core observations...The composition and sedimentary controlling effect of the coal measure gas-bearing(CMG)system of the Jurassic Xishanyao Formation in the southern margin of the Junggar Basin(SJB)are analysed based on core observations,sample tests,and logging data.The results show that the lithological associations of the SJB can be classified into 6 types based on sediment supply strengths and sealing abilities,while the gas shows of CMG reservoirs vary greatly among different lithological associations.Due to the diversified coal-forming environment and multistage coal accumulation,superimposed CMG systems are generally developed in the SJB,and their types include:superimposed unattached CMG systems,multilayer unified CMG systems,and superimposed mixed CMG systems.Furthermore,sedimentary controls on the vertical and regional distributions of different types of CMG systems are discussed according to the sedimentary facies of single wells and well cross-sections and the corresponding data of well log,gas logging,and gas contents.Shore shallow lake environments in the Fukang,Miquan,and northern Liuhuanggou areas were favourable for forming superimposed unattached CMG systems.Braided river environments in the Houxia and the southern Liuhuanggou areas usually formed multilayer unified CMG systems.Braided river delta environments in the Manasi,Hutubi,and eastern Sikeshu areas generally developed multilayer unified CMG systems and superimposed mixed CMG systems.For different types of superimposed CMG systems,the number of gas-bearing units,coal seam gas content,vertical hydraulic connectivity and lateral continuity vary considerably,which makes it necessary to tailor the CMG co-production plan to the type of CMG system.展开更多
文摘Diamonds were formed in the mantle lithosphere,mostly at depths of 150~200km in the centres of Precambrian cratons,the buoyant ancient cores of continents.From there they were normally transported into the upper crust in kimberlite pipes whose diamonds are largely colourless and light yellow related to trace element N(Ia type),although brown,green,and more rarely blue-coloured diamonds are related to lattice defect and trace amounts of H,more rarely B and Ni.Pink diamonds are extremely rare in the approximately 90 diamondiferous pipes mined globally.Although small quantities have been discovered elsewhere,about 90%have been mined from the ca.1.3Ga Argyle diamond pipe in Western Australia,with the Arkhangelskaya diamond pipe in Russia the only other significant source.The pink colour at both Argyle and Arkhangelskaya is unrelated to trace elements and instead results from absorption of light from nanoscale(550nm)defects related to shear stress and plastic deformation.Macroscopically,defects are shown by glide planes,lamellae,and grain lines imposed on the originally colourless diamonds derived from their mantle source.The key question is why these defects were uniquely acquired in diamonds in the Argyle and Arkhangelskaya pipes.Unlike most diamondiferous pipes,Argyle is a rare diamondiferous volatile-rich lamproite pipe that was emplaced into the multiply deformed and rifted NNE-trending Halls Creek Orogen on the margin of the Kimberley Craton.Similarly,Arkhangelskaya in the Devonian Lomonosov kimberlite cluster is a volatile-rich low-Ti type kimberlite,a close relative to lamproite,that was emplaced into the multiply deformed Lapland-Kola Orogen on the rifted margin of the Kola Craton.These craton margins are underlain by subduction-induced volatile-enriched metasomatized mantle lithosphere in contrast to the more primeval mantle under craton centres.It is thus likely that shear stresses were exacerbated at Argyle and Arkangelskaya by rapid vertical emplacement of the anomalous volatile-enriched magmas at supercritical pressures and temperatures,that induced catastrophic phase separation of these volatiles and'mini seismic events'during rapid pressure drops during ascent from 200km depth to the surface.Such a mechanism is consistent with the presence of strongly resorbed and plastically deformed small brown industrial diamonds in the Argyle pipe.From a China perspective,it is potentially important that at 1.3Ga the alkaline Argyle pipe in northern Australia is placed adjacent to the North China Craton(NCC),with numerous world-class mineral deposits including the giant ca.1.4~1.2Ga alkaline Bayan Obo REE system on its margin.However,it is the southeastern margin of the Yangtze Craton and the Jiangnan Orogen with their lamproite pipes derived from metasomatized mantle lithosphere that present the most prospective regions for pink diamond occurrences.
基金financially supported by the National Natural Science Foundation of China(No.42102084)the Special Research Fund of Natural Science(Special Post)of Guizhou University(No.2020[27])Guizhou Provincial Science and Technology Projects(No.ZK[2022]041)。
文摘The formation of Caosiyao giant porphyry Mo deposit is related to three granitic porphyries:coarse-grained granite porphyry(CG),fine-grained granite porphyry(FG),and giant plagioclase phenocryst bearing granite porphyry(PG).To investigate the mineralization significance of three porphyries,Microthermometry,Laser micro-Raman Spectra,and H-O-He-Ar isotope analyses of fluid inclusions were conducted.Intermediate density with high temperatures(>550℃)and moderate-low salinities(~10 wt.%)characterizes CG-related initial exsolved fluids.Vapor-rich and brine phases separated from the initial fluid following a continuous decrease in pressure and temperature,inducing molybdenite precipitation.FG-related initial fluids are characterized by high temperatures(>550℃)and salinities(>65 wt.%).The mixing of low-salinity fluids led to a rapid decrease in the salinity of FG-related fluid,promoting the deposit of the Mo element.The lead-zinc mineralization is closely related to the FG-related fluid,and the addition of meteoric fluid induced the formation of galena and sphalerite.The ore-forming fluid related to the PG is CO_(2)-rich and accompanied by the addition of mantle-derived He-Ar.The presence of CO_(2) did not contribute to the solubility of Mo,resulting in the absence of a considerable amount of molybdenite.
文摘The authors extend the marginal coordinate test for predictor contribution(Cook,2004)to the case with multivariate responses.Instead of explicitly specifying the link functions between the responses and the predictors,an asymptotic test is proposed under the normality assumption of the predictors as well as an asymmetry assumption about the unknown regression mean function.When these assumptions are violated,the asymptotic test with elliptical trimming and clustering is still valid with desirable numerical performances.
基金National Key R&D Program of China,No.2022YFF1302401National Natural Science Foundation of China,No.42271007。
文摘Ecosystems along the eastern margin of the Qinghai-Tibet Plateau(EQTP)are highly fragile and extremely sensitive to climate change and human disturbances.To quantitatively assess climate-induced ecosystem responses,this study proposes a Climate-Induced Productivity Index(CIPI)based on the Super Slack-Based Measure(Super-SBM)model using remote sensing data from 2001 to 2020.The results reveal persistently low CIPI values(0.47-0.53)across major ecosystem types,indicating widespread vulnerability to climatic variability.Among these ecosystems,forests exhibit the highest CIPI(0.55),followed by shrublands(0.54),croplands(0.53),grasslands(0.51),and barelands(0.43).The Theil index analysis further demonstrates significant intra-group disparities,suggesting that extreme climatic events amplify CIPI heterogeneity.Moreover,the dominant environmental drivers differ among ecosystem types:the Palmer Drought Severity Index(PDSI)primarily constrains grassland productivity,solar radiation(SRAD)strongly influences shrub and cropland systems,whereas subsurface factors exert greater control in forested regions.This study provides a quantitative framework for evaluating climate-ecosystem interactions and offers a scientific basis for long-term ecological monitoring and security planning across the EQTP.
基金Supported by the China National Science and Technology Major Project(2025ZD400801)CNPC Science and Technology Major Project(2023ZZ07-01)。
文摘Based on the plate tectonics theory,the sedimentary environment of paleotectonics along the passive continental margins on both sides of the South Atlantic Ocean was reconstructed using the paleomagnetic,regional geological,and seismic data,and the intrinsic relationships of hydrocarbon distribution in the passive continental margin basins and the differential hydrocarbon accumulation patterns were analyzed.Results show that basins on both sides of the South Atlantic experienced two major extensional phases—rift and depression—and four evolutionary stages:the Early Cretaceous Berriasian-Barremian intracontinental rift stage,the Early Cretaceous Aptian-Albian intercontinental rift to initial drift transition stage,the Late Cretaceous-Paleogene drift-related marine transgressive depression stage,and the Neogene-Quaternary drift-related marine regressive depression stage.According to basin architecture and superposition style,the passive-margin basins are classified into two principal types:rift-continental marginal depression composite and continental marginal depression-dominated.The basins in the study area were further divided into six types based on the development degree of salt tectonics and the type of dominant sand bodies,i.e.salt-free rift-continental marginal gravity-flow composite type,salt-free rift-continental marginal delta composite type,salt-bearing rift-continental marginal gravity flow composite type,delta-dominated salt-bearing rift-continental marginal delta composite type,gravity-flow-dominated continental marginal depression type,and delta-dominated continental marginal depression type.The salt-free rift-continental marginal gravity flow and delta composite basins are mainly distributed in the southern segment.The salt-bearing rift-continental marginal gravity flow and delta composite basins are mainly distributed in the central segment.The gravity-flow-dominated continental marginal depression basins are mainy distributed in the northern segment.The delta-dominated passive-margin depression basins are distributed in three segments from north to south.In different types of basins,distinctive depositional systems and source-reservoir-caprock assemblages were formed in each upper/lower structure layer.The superimposition and evolution of multi-phase prototype basins result in the orderly hydrocarbon accumulation vertically and laterally,which are“segmented along-strike,zoned across-strike,and layered vertically”.
基金supported by grants from the National Key Research and Development Program of China,Stem Cell and Translational Research(2022YFA1104100,2022YFA1105000,2018YFA0801404)the National Natural Science Foundation of China(82570270,82270230,32130046,82171617,82471689,82170540,82471462,82270566)+8 种基金the Guangdong Basic and Applied Basic Research Foundation(2023B1515020119)the Key Research and Development Program of Guangdong Province(2023B1111050006)the Key Scientific and Technological Program of Guangzhou City(2023B01J1002,202206080002)the Pioneering Talents Project of the Guangzhou Development Zone(2021-L029)the Guangdong Special Support Program(2019BT02Y276)the Shenzhen Science and Technology Program(KJZD20230923114504008)the Sanming Project of Medicine in Shenzhen Nanshan(SZSM2021034008)the Science and Technology Planning Project of Gaozhou(20240619111622)the Special Funds for the Cultivation of Guangdong College Students'Scientific and Technological Innovation(pdjh2025ak003).
文摘Vaccination is the preferred strategy for preventing infections such as influenza in elderly individuals;however,its efficacy is often suboptimal due in part to age-related declines in immune function.In this study,we discovered that the infusion of mesenchymal stromal cells(MSCs)restored defects in the splenic stromal cell network and lymphocyte architecture in aged mice while also increasing specific antibody levels following vaccine immunization.This significantly protected aging mice from influenza infection.Mechanistically,the delivered MSCs localized in the splenic marginal zones,where they positioned themselves near marginal reticular cells(MRCs)and stimulated MRC proliferation,partially through the action of vascular endothelial growth factor A(VEGFA).This MSC‒MRC interaction orchestrated the reconstruction of the stromal network,thereby restoring lymphocyte homeostasis and germinal center reactions.Importantly,the MSC-mediated enhancement of the vaccine response was further validated in aged cynomolgus monkeys.Collectively,our findings provide new insights into the application of MSCs in addressing age-related immune decline and highlight splenic MRCs as critical therapeutic targets.
文摘The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.
基金Supported by the Prospective Basic Research Project of CNOOC China Limited(KJQZ-2023-2001)Major Science and Technology Project of CNOOC(KJGG2022-0103-03).
文摘Based on a set of high-resolution 3D seismic data from the northern continental margin of the South China Sea,the lithospheric structure,thinning mechanisms and related syn-rift tectonic deformation response processes in the crustal necking zone in the deepwater area of the Pearl River Mouth Basin were systematically analyzed,and the petroleum geological significance was discussed.The necking zone investigated in the study is located in the Baiyun Sag and Kaiping Sag in the deepwater area of the Pearl River Mouth Basin.These areas show extreme crustal thinned geometries of central thinning and flank thickening,characterized by multi-level and multi-dipping detachment fault systems.The necking zone exhibits pronounced lateral heterogeneity in structural architectures,which can be classified into four types of thinned crustal architectures,i.e.the wedge-shaped extremely thinned crustal architecture in the Baiyun Main Sub-sag,dumbbell-shaped moderately thinned crustal architecture in the Baiyun West Sub-sag,box-shaped weakly thinned crustal architecture in eastern Baiyun Sag,and metamorphic core complex weakly thinned crustal architecture in the Kaiping Sag.This shows great variations in the degree and style of crustal thinning,types of detachment faults,distribution of syn-rift sedimentary sequences,and intensity of magmatism.The thinning of the necking zone is controlled by the heterogeneous rheological stratification of lithosphere,intensity of mantle-derived magmatism,and deformation modes of detachment faults.The syn-rift tectonic deformation of the necking zone evolved through three phases,i.e.uniform stretching during the early Wenchang Formation deposition period,necking during the late Wenchang Formation deposition period,and hyperextension during the Enping Formation deposition period.The crustal thinning extent and architectural differentiation in these phases were primarily controlled by three distinct mechanisms,i.e.the pure shear deformation activation of pre-existing thrust faults,the simple shear deformation of crust-mantle and inter-crust detachment faults,and differential coupling of lower crustal flow and ductile domes with main detachment faults.The hydrocarbon accumulation and enrichment in the necking zone exhibit marked spatial heterogeneity.Four distinct crustal thinned architecture-hydrocarbon accumulation models were identified in this study.The hydrocarbon accumulations in the shallow part exhibit significant correlations with their deep crustal thinned architectures.The unique lithospheric structure and deformation process predominantly control the favorable hydrocarbon accumulation zones with excellent source-fault-ridge-sand configurations,which is critical to reservoir-forming.The most promising exploration targets are mainly identified on the uplift zones and their seaward-dipping flanks associated with the middle and lower crustal domes.This research provides additional insights into lithospheric thinning-breakup process at intermediate continental margins of marine sedimentary basins,being significant for guiding the deepwater petroleum exploration in the Pearl River Mouth Basin.
基金supported by the National Natural Science Foundation of China(No.42177184)。
文摘The Litang fault zone is an important seismogenic structure along the southeastern margin of the Tibetan Plateau.It caused the M71/4 earthquake in Litang in 1948 AD.The fault zone intersects the Sichuan-Xizang transportation corridor and poses a serious risk to its safe operation.This study,utilizing high-resolution remote sensing interpretation,field geological verification,UAV photogrammetry,UAV LiDAR,paleoearthquake trench excavation,and AMS^(14)C and OSL dating methods,reveals the geometric structure,slip rates,paleoearthquake sequence,and earthquake rupture segmentation of the Litang fault zone;analyzes the rupture distribution range of the 1729 AD Litang earthquake and estimates its magnitude.The study indicates that the Litang fault zone is a relatively immature strike-slip fault,which has developed as a new active fault zone within the Northwestern Sichuan sub-block during the southeastward material migration of the southeastern margin of the Tibetan Plateau.This reflects a transformation in the deformation model of the Northwestern Sichuan sub-block crust from the‘Rigid Block’model to the‘Continuous Deformation’model.
基金funded by SINOPEC Science and Technology Research Program (project Nos:P24226, P24077)Northwest Oil Field Company,SINOPEC.
文摘The Cambrian platform margin in the Tarim Basin boasts favorable source-reservoir-cap assemblages,making it a significant target for hydrocarbon exploration in ultra-to extra-deep facies-controlled for-mations.Of the three major basins in western China,Tarim is the only basin with large-scale platform margin where no exploration breakthrough has been achieved yet.This study determines the vertical and lateral differential evolution of the platform margin(in the Manxi area hereafter referred to as the Cambrian Manxi platform margin)through fine-scale sequence stratigraphic division and a segmented analysis.The platform margin can be divided into the Yuqi,Tahe,Shunbei,and Gucheng segments,from north to south,based on the development of different ancient landforms and the evolutionary process of the platform.The Yuqi and Shunbei segments exhibit relatively low-elevation ancient landforms.Both segments were in a submarine buildup stage during the Early Cambrian,resulting in overall limited scales of their reservoirs.The Gucheng segment features the highest-elevation ancient landforms and accordingly limited accommodation spaces.As a result,the rapid lateral migration of high-energy facies zones leads to the development of large-scale reservoirs with only limited thicknesses.In contrast,the Tahe segment,exhibiting comparatively high-elevation ancient landforms,is identified as the most favorable segment for the formation of large-scale reservoirs.The cap rocks of the platform margin are dominated by back-reef dolomitic flats and tight carbonate rocks formed in transgressive periods.A comprehensive evaluation of source rocks,reservoirs,and cap rocks indicates that the Tahe segment boasts the optimal hydrocarbon accumulation conditions along the platform margin.In this segment,the Shayilike Formation transgressive deposits and the high-energy mound-shoal complexes along the platform margin of the Wusonggeer Formation constitute the optimal reservoir-cap rock assemblage,establishing this segment as the most promising target for hydrocarbon exploration in the platform margin.
文摘Objective:Microscopically positive resection margins(R1)in gastric cancer have been associated with poor outcomes,but evidence regarding its prognostic significance across different stages remains inconsistent.This study investigated the impact of R1 resection on survival outcomes and evaluated the prognostic significance of detailed pathological characteristics of margin involvement.Methods:This retrospective study analyzed 10,165 patients who underwent curative-intent gastrectomy for gastric cancer between 2007 and 2021.Propensity score matching was performed at a 1:3 ratio between R1(n=45)and R0(n=130)cases.For R1 margins,detailed pathological assessment included involvement length,proportion,depth,and histological features.Survival outcomes were evaluated across all stages,and the impact of subsequent resection was analyzed.Results:After propensity score matching,R1 resection showed significantly lower 5-year overall survival rates compared to R0 resection across all stages(stageⅠ:60.0%vs.90.9%,P=0.008;stageⅡ:40.0%vs.83.3%,P=0.001;stageⅢ:20.0%vs.35.4%,P<0.001).In R1 cases,tumor involvement length≤1 cm(P<0.001),proportion≤10%(P=0.012),and mucosal-only involvement(P=0.004)were associated with better survival.Patients who underwent subsequent resection to achieve R0 status showed better survival than those with persistent R1 resection(53.8%vs.26.7%,P<0.001)and comparable survival to matched R0 cases(53.8%vs.46.9%,P=0.320).Conclusions:R1 resection significantly impairs survival across all stages of gastric cancer,with the extent and depth of microscopic involvement influencing prognosis.When R1 status is discovered postoperatively,subsequent resection should be considered to improve survival outcomes.
基金Supported by the Natural Science Foundation of the Heilongjiang Province of China(C2016003)China Postdoctoral Science Foundation(2015M581415)Heilongjiang Postdoctoral Fund(LBH-Z15005)。
文摘The trace element selenium(Se)occurs naturally throughout the earth.Se deficiency has been linked to impaired breast health and other diseases in human and animals.Compared to severe Se deficiency,marginal dietary Se deficiency accusers more frequently in low-Se regions.Therefore,to investigate the Se status and inflammatory response of the mammary gland under marginal dietary Se levels,an lipopolysaccharide(LPS)induced mouse mastitis model was established.Mice were fed with moderate Se diet(0.087 mg•kg^(-1) Se),adequate Se diet(0.15 mg•kg^(-1) Se)or excessive Se diet(1.5 mg•kg^(-1) Se)for 60 days.Se status and inflammatory factors were investigated.Results showed that the Se status of mammary gland correlated with dietary Se levels.Marginal Se deficiency exacerbated mammary tissue histopathology;increased the mRNA level of inflammatory genes tumor necrosis factor alpha(TNF-α),interleukin-1β(IL-1β)and cyclooxygenase-2(COX-2);and enhanced the phosphorylation of NF-κB p65 in mammary gland tissues.Supplementation of Se in diet higher than recommended levels reduced the inflammatory reaction of mammary glands in LPS-induced mastitis model and provided a protective effect.
基金financially supported by the National Natural Science Foundation of China(Grant No.42002150)the Open Foundation of Cooperative Innovation Center of Unconventional Oil and Gas,Yangtze University(Ministry of Education&Hubei Province,Grant No.UOG2024-12)+1 种基金the Open Foundation Project of the Key Laboratory of Polar Geology and Marine Mineral Resources(China University of Geosciences,Beijing,China),Ministry of Education(Grant No.PGMR-2023-201)the National Key Research Program of China(Grant No.2017ZX05032-002)。
文摘Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysis of the main source rocks,reservoirs,and vertical migration pathways within the Rovuma(RB)and Tanzania(TB)basins in East Africa utilizing drilling,logging,seismic,and geochemical data.The results indicate that the enhanced preservation conditions of the Lower Jurassic source rocks in the southwest could lead to the discovery of large natural gas fields in the southern TB and RB.The primary reservoir is a deep-water turbidite sandstone.Due to topographic differences,the expanse of the turbidite sandstones in the RB is significantly larger than those in Tanzania.The main vertical migration pathways are the western boundary fault zone of the Kerimbas Graben(WBFZ)and the Seagap fault zone(SFZ).In the RB,natural gas migrates vertically along the WBFZ and preferentially accumulates in the deep-water turbidite sandstones of the footwall under the control of the fluid potential.Conversely,in the southern TB,the deep natural gas first migrates upward along the SFZ,then moves along the shallow branch faults in the sandstones on both sides of the SFZ.
基金supported by the National Natural Science Foundation of China(Grant Nos.62372048,62371069,62272056,and U25B2014)。
文摘Marginal Fisher analysis(MFA)stands out as a prominent dimensionality reduction algorithm,striving to minimize within-class scatter while maximizing the separability between marginal data points.However,MFA and its variants require substantial computational resources when dealing with large-scale data.To address this,we propose quantum algorithms for MFA(called QMFA).QMFA is composed of two core processes:the first is the efficient construction of the weight matrices for the intrinsic and penalty graphs,and the second is solving the generalized eigenvalue problem(GEP)using the block-encoding technique.Compared to classical MFA,the proposed QMFA achieves a polynomial acceleration in the number of samples and exponential acceleration in the dimensionality.Additionally,we investigate quantum algorithms for different variants of MFA.Specifically,for enhanced MFA and multiple MFA,we address the construction of the related weight matrix,which differs from that in standard MFA.For kernel MFA,we solve the GEP associated with the corresponding kernel matrix.The proposed quantum algorithms achieve a speedup equivalent to that of QMFA.
文摘Recently,Luolai Group released its Q12025 quarterly report.As a leading Chinese home textile enterprise listed on the Shenzhen Stock Exchange in 2009,the company covers the research,design,production,and sales of home textile products,and has multiple brands covering different consumer markets.It has expanded its online and offline comprehensive multichannel sales system and is committed to creating a win-win home furnishings and textile industry ecosystem.
基金supported by the Guangdong Pearl River Talent Program(No.017TZ07Z066)the Second Tibetan Plateau Scientific Expedition and Research Program(No.2019QZKK0701)+4 种基金the Southern Marine Laboratory(Zhuhai)Innovative R&D Program(No.311021003)the National Natural Science Foundation of China(No.42106067)the Natural Science Foundation of Guangdong Province,China(No.2022A1515010090)Shanghai Sheshan National Geophysical Observatory(No.SSOP202102)Guangzhou Science and Technology Planning Project(No.202102020456).
文摘Magmatism at continental margins is of great significance in understanding the continental rifting.We present a twodimensional P-wave velocity model derived from an ocean bottom seismometer experiment,conducted across the middle northern continental margin of the South China Sea(SCS).The detailed velocity structures reveal significant heterogeneities extending from the continental shelf to the continent-ocean transition zone.The crust exhibits its greatest thickness below the continental shelf,measuring~23 km and gradually thins to~13 km at the distal margin.Furthermore,a narrow and distinct continent-ocean transition with only 40-km width is revealed.We also observe a high-velocity layer within the transition zone,reaching thickness of up to 4 km,characterized by P-wave velocities ranging from 7.0 km/s to 7.6 km/s in the lower crust.Based on the syn-rift melt generation using decompression melting model,we ascertain that syn-rift magmatism cannot fully account for the observed thick high-velocity layer.By integrating findings from previous geophysical and geochemical studies presenting extensive volcanic edifice on the seafloor at the northern margin,as well as ocean-island-basalt-type magmaticsamples in the SCS area,we propose that post-rifting magmatism associated with the Hainan Plume may have influenced theformation of the high-velocity lower crust within the transition zone and the northern margin of the SCS can thus be recognizedas magma-poor type margin.
基金supported by Jiangxi Provincial International Science and Technology Cooperation Project(Nos.20203BDH80W010 and 20232BBH80012)the National Natural Science Foundation of China(Nos.82160410 and 81860379)+1 种基金Foundation of Jiangxi Provincial Department of Science and Technology(No.20212ACB206018)Key Research and Development Program of Jiangxi Province(No.20223BBG71009)。
文摘Accurate determination of lung cancer margins at the molecular level is of great significance to determine the optimal extent of resection during surgical operation and reduce the risk of postoperative recurrence.In this study,internal extractive electrospray ionization mass spectrometry(i EESI-MS)was used to trace potential molecular tumor margins in lung cancer tissue.Molecular differential model for the determination of lung cancer tumor margin was established via partial least-squares discriminant analysis(PLS-DA)of iEESI-MS data collected from lung tissue pieces within cancer tumor area and iEESI-MS data collected from lung tissue pieces outside cancer tumor area.Proof-of-concept data demonstrate that the developed molecular differential model yields ca.1-2 mm wider potential molecular tumor margin of a lung cancer compared to the conventional histological analysis,showing promising potential of iEESI-MS to increase the accuracy of tumor margins determination and lower risk of lung cancer postoperative recurrence.Furthermore,our results revealed that creatine and taurine showed positive correlations with lung cancer.
基金supported by the National Natural Science Foundation of China(Nos.42172109,41872113,42172108)China National Petroleum Corporation-China University of Petroleum(Beijing)strategic cooperation science and technology project(ZLZX2020-02)+2 种基金Science Foundation of China University of Petroleum(Beijing)(Nos.2462020BJRC002,2462020YXZZ020)Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX1166)Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202201511).
文摘Previous studies have indicated that sediment gravity flow deposits developed in lacustrine active extensional rift basins are primarily influenced by tectonics and to a lesser extent by climate.Our present work reveals that climate can obscure the effect of tectonic subsidence by regulating sediment supply;conversely,tectonics can impede the sedimentary manifestation of climatic impacts.Here a case study has been presented to assess the impact of climate-modulated rapid lake-level rise and tectonic subsidence on the development of coarse-grained gravity flow deposits in the Dongying rift margin of the Bohai Bay Basin,eastern China.The lithofacies analysis reveals frequent bed amalgamation,abundant thick massive coarse-grained deposits,widespread cross bedding and plant fragments,and incomplete composite bed formed by high-energy erosion,indicating that the hyperpycnal flow is an important mechanism driving the deposition of these coarse-grained sediments.Detailed sequence stratigraphic analysis and sediment dispersal pattern suggest that the long-striped nearshore subaqueous fan systems induced by outburst-flood hyperpycnal flow distributed along the border fault,are primarily controlled by long-term tectonics,while the rapid rise of lake level driven by short-term climate change possibly intensifies seasonal flood-generated hyperpycnal flow occurrences and consequently promotes the basinal fan progradation.The maximum scale of these coarse-grained gravity flow deposits of the basinal fan systems are typically attained during the transgressive systems tract,which deviates from the classical sequence stratigraphic model.Furthermore,it presented a continuous transition from the proximal to the distal part,encompassing traction flows and turbidity currents during the periods of relatively stable tectonics.Nevertheless,gravel-rich debris flows appear to predominate the dispersion of coarse-grained sediments during periods characterized by intense tectonic activity.The coarse-grained gravity flow deposits in the lacustrine rift margin reported here,challenge the traditional beliefs:this study suggests that subaqueous deposits abundantly preserved in the transgressive setting.
基金Sponsored by Research Project of Inner Mongolia Autonomous Region Center for the Theoretical System of Socialism with Chinese Characteristics(2024ZZB018).
文摘In order to better realize the development of cultural tourism products in Yuncheng County,this paper analyzed Water Margin cultural tourism resources,market demand and product design in Yuncheng County using the RMP(Resource-Market-Product)theory,summarized existing problems in the development of Water Margin cultural tourism in Yuncheng County,and proposed countermeasures for its development.It is expected to achieve the integration of Water Margin culture and the tourism industry under the broader context of cultural and tourism integration,provide richly diverse and distinctive tourism products and services,and promote the economic development of the tourist destination.
基金financially supported by the National Natural Science Foundation of China(Nos.41772132,41502157,41530314)the key project of the National Science&Technology(No.2016ZX05043-001)+1 种基金the Fundamental Research Funds for the Central Universities(No.2652019095)the China Postdoctoral Science Foundation(No.2021M692998)。
文摘The composition and sedimentary controlling effect of the coal measure gas-bearing(CMG)system of the Jurassic Xishanyao Formation in the southern margin of the Junggar Basin(SJB)are analysed based on core observations,sample tests,and logging data.The results show that the lithological associations of the SJB can be classified into 6 types based on sediment supply strengths and sealing abilities,while the gas shows of CMG reservoirs vary greatly among different lithological associations.Due to the diversified coal-forming environment and multistage coal accumulation,superimposed CMG systems are generally developed in the SJB,and their types include:superimposed unattached CMG systems,multilayer unified CMG systems,and superimposed mixed CMG systems.Furthermore,sedimentary controls on the vertical and regional distributions of different types of CMG systems are discussed according to the sedimentary facies of single wells and well cross-sections and the corresponding data of well log,gas logging,and gas contents.Shore shallow lake environments in the Fukang,Miquan,and northern Liuhuanggou areas were favourable for forming superimposed unattached CMG systems.Braided river environments in the Houxia and the southern Liuhuanggou areas usually formed multilayer unified CMG systems.Braided river delta environments in the Manasi,Hutubi,and eastern Sikeshu areas generally developed multilayer unified CMG systems and superimposed mixed CMG systems.For different types of superimposed CMG systems,the number of gas-bearing units,coal seam gas content,vertical hydraulic connectivity and lateral continuity vary considerably,which makes it necessary to tailor the CMG co-production plan to the type of CMG system.
