It’s a golden season of harvest during which it was a fine autumn weather with the pale clouds and a light breeze blowing in September in Beijing. The China International Economic and Trade Arbitration Commission and...It’s a golden season of harvest during which it was a fine autumn weather with the pale clouds and a light breeze blowing in September in Beijing. The China International Economic and Trade Arbitration Commission and China Maritime Arbitration Commission held a forum of arbitrators on 26 to 28 September 2001s dealing with arbitrate work in a beautiful landscape place, Kuan Gou, a suburb in Beijing. Mr. Yu Xiaosong, the Chair- man of China Council for Promotion of International Trade/China Chamber of International Commerce, China Intemational Economic and Trade Arbitration Commission and China Maritime Arbitration Commission, gave a talk at the forum stressed that the development of arbitration cause in China should be marched with ticccccccccmes and adapted to the fast development in the situations both of home and abroad. Mr. Yu Xaosong’s talk put forward a kind of principles for the development of the arbitration cause in China, a part of which, we publish part of it here as a reference for the arbitrate circle colleagues.展开更多
Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated R...Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated RING finger protein 2(March2) is the highest among all March family members,with an increasing trend during odontoblast differentiation.In mouse incisors and molars,MARCH2 is moderately expressed in the undifferentiated dental papilla cells and strongly expressed in the odontoblasts.Knockdown and overexpression experiments demonstrate that MARCH2 inhibits odontoblastic differentiation of mouse dental papilla cells(mDPCs).Additionally,both March2 deficient mice and mice with odontoblast specific knockdown of March2 exhibit the phenotype of increased dentin thickness,accelerated dentin deposition as well as elevated expression levels of odontoblast markers compared with control littermates.Therefore,MARCH2 plays an inhibitory role in odontoblast differentiation.Mechanistically,MARCH2 interacts with protein tyrosine phosphatase receptor delta(PTPRD) and facilitates its K27-linked polyubiquitination and subsequent degradation,which is dependent on the ligase activity of MARCH2.The presence of MARCH2promotes the translocation of PTPRD from the cell membrane to the lysosome,thereby enhancing its degradation via the lysosomal pathway.Further experiments show that knockdown of endogenous Ptprd impairs odontoblastic differentiation of mDPCs.Ptprd and March2 double knockdown in mDPCs apparently reversed the enhanced odontoblastic differentiation by knockdown of March2 alone,indicating that MARCH2 inhibits odontoblastic differentiation by promoting PTPRD degradation.This study unveils a novel mechanism where an E3 ubiquitin ligase regulates odontoblast differentiation through post-translational modification of a membrane protein,highlighting a promising direction for future exploration.展开更多
At 11:00 p.m. on January 13, 2026, floodlights illuminated the launch pad at the Hainan Commercial Space Launch Site in Wenchang,south China’s Hainan Province. A Long March-8A (CZ-8A) carrier rocket lifted off with a...At 11:00 p.m. on January 13, 2026, floodlights illuminated the launch pad at the Hainan Commercial Space Launch Site in Wenchang,south China’s Hainan Province. A Long March-8A (CZ-8A) carrier rocket lifted off with a steady roar, its exhaust lighting up the night sky as it delivered a satellite into its designated orbit.The development of China’s first commercial space launch site has been striking. Since its inaugural launch in2024, it has completed 11 missions in less than 14 months—each a success.展开更多
目的:探讨过表达MARCH2对肝细胞癌HUH7细胞自噬水平和生长的影响及其机制。方法:MTS和EDU检测MARCH2过表达的肝细胞癌HUH7细胞的生长情况。流式细胞术检测MARCH2过表达的肝细胞癌HUH7细胞凋亡、细胞周期的情况。Western blot和激光共聚...目的:探讨过表达MARCH2对肝细胞癌HUH7细胞自噬水平和生长的影响及其机制。方法:MTS和EDU检测MARCH2过表达的肝细胞癌HUH7细胞的生长情况。流式细胞术检测MARCH2过表达的肝细胞癌HUH7细胞凋亡、细胞周期的情况。Western blot和激光共聚焦法检测MARCH2过表达的肝细胞癌HUH7细胞自噬水平。结果:MTS和EDU检测表明,MARCH2的过表达促进了肝细胞癌HUH7的生长。流式细胞术检测表明,MARCH2过表达对肝细胞癌HUH7细胞凋亡和细胞周期没有明显影响。进一步的实验表明,MARCH2过表达损害了肝细胞癌HUH7的自噬。用常见的自噬诱导剂雷帕霉素挽救自噬可以使肝细胞癌HUH7的增殖率恢复到控制水平。结论:我们的数据表明,MARCH2通过抑制自噬在肿瘤发展过程中起着至关重要的作用。因此,MARCH2是一种有前景的肿瘤治疗新靶点。Aims: To investigate the effects and mechanisms of overexpression of MARCH2 on autophagy levels and growth of hepatocellular carcinoma HUH7 cells. Methods: MTS and EDU were used to detect the growth of MARCH2 overexpressing hepatocellular carcinoma HUH7 cells. Flow cytometry was used to detect apoptosis and cell cycle in MARCH2 overexpressing hepatocellular carcinoma HUH7 cells. Western blot and laser confocal microscopy were used to detect the autophagy levels in MARCH2 overexpressing HUH7 hepatocellular carcinoma cells. Results: In this study, MTS and EDU assays showed that the overexpression of MARCH2 promoted the growth of hepatocellular carcinoma HUH7 cells. Flow cytometry detection illustrated that MARCH2 overexpression had no obvious effect on the hepatocellular carcinoma HUH7 cell apoptosis and cell cycle. Further experiments displayed that MARCH2 overexpression impaired the autophagy of hepatocellular carcinoma HUH7 cells. Rescued autophagy with the common autophagy inducer rapamycin can bring the proliferation rate of hepatocellular carcinoma HUH7 cells back to the control level. Conclusions: Our data indicates that MARCH2 plays an essential role in the progression of tumor development through inhibiting autophagy. Therefore, MARCH2 is an attractive novel target for tumor therapy.展开更多
Physics informed neural networks(PINNs)are a deep learning approach designed to solve partial differential equations(PDEs).Accurately learning the initial conditions is crucial when employing PINNs to solve PDEs.Howev...Physics informed neural networks(PINNs)are a deep learning approach designed to solve partial differential equations(PDEs).Accurately learning the initial conditions is crucial when employing PINNs to solve PDEs.However,simply adjusting weights and imposing hard constraints may not always lead to better learning of the initial conditions;sometimes it even makes it difficult for the neural networks to converge.To enhance the accuracy of PINNs in learning the initial conditions,this paper proposes a novel strategy named causally enhanced initial conditions(CEICs).This strategy works by embedding a new loss in the loss function:the loss is constructed by the derivative of the initial condition and the derivative of the neural network at the initial condition.Furthermore,to respect the causality in learning the derivative,a novel causality coefficient is introduced for the training when selecting multiple derivatives.Additionally,because CEICs can provide more accurate pseudo-labels in the first subdomain,they are compatible with the temporal-marching strategy.Experimental results demonstrate that CEICs outperform hard constraints and improve the overall accuracy of pre-training PINNs.For the 1D-Korteweg–de Vries,reaction and convection equations,the CEIC method proposed in this paper reduces the relative error by at least 60%compared to the previous methods.展开更多
The International Textile Manufac-turers Federation(ITMF),has releasedthe results of its Global Textile IndustrySurvey(GTIS)for March 2025.Thissurvey,conducted regularly across allkey regions and segments of the texti...The International Textile Manufac-turers Federation(ITMF),has releasedthe results of its Global Textile IndustrySurvey(GTIS)for March 2025.Thissurvey,conducted regularly across allkey regions and segments of the textilevalue chain,revealed a complex pictureof a deteriorated business situation,cau-tious op timism,regional divergence,andongoing structural challenges.展开更多
Sent out at 1:31am GMT+8 on May 29 by a Long March-3B carrier rocket from the Xichang Satellite Launch Center in Sichuan province,China,Tianwen-2,the second mission of China’s Planetary Exploration Program,correctly ...Sent out at 1:31am GMT+8 on May 29 by a Long March-3B carrier rocket from the Xichang Satellite Launch Center in Sichuan province,China,Tianwen-2,the second mission of China’s Planetary Exploration Program,correctly entered the transfer trajectory toward an asteroid named 2016HO3 after flying for 18 minutes.Its solar wings unfolded properly,signaling a successful start,and primed for the next stage of its mission.展开更多
50.2% On March 6, the China Federation of Commerce released the China Retail Industry Sentiment Index (CRPI) of 50.2% in March, up 0.1%f rom the previous month.66.74 billion According to Fu Jinling, Director of the Ec...50.2% On March 6, the China Federation of Commerce released the China Retail Industry Sentiment Index (CRPI) of 50.2% in March, up 0.1%f rom the previous month.66.74 billion According to Fu Jinling, Director of the Economic Construction Department of the Ministry of Finance, in 2025, the central finance will arrange RMB 66.74 billion of employment subsidies.展开更多
3D traveltime calculation is widely used in seismic exploration technologies such as seismic migration and tomography. The fast marching method （FMM） is useful for calculating 3D traveltime and has proven to be effi...3D traveltime calculation is widely used in seismic exploration technologies such as seismic migration and tomography. The fast marching method （FMM） is useful for calculating 3D traveltime and has proven to be efficient and stable. However, it has low calculation accuracy near the source, which thus gives it low overall accuracy. This paper proposes a joint traveltime calculation method to solve this problem. The method firstly employs the wavefront construction method （WFC）, which has a higher calculation accuracy than FMM in calculating traveltime in the small area near the source, and secondly adopts FMM to calculate traveltime for the remaining grid nodes. Due to the increase in calculation precision of grid nodes near the source, this new algorithm is shown to have good calculation precision while maintaining the high calculation efficiency of FMM, which is employed in most of the computational area. Results are verified using various numerical models.展开更多
文摘It’s a golden season of harvest during which it was a fine autumn weather with the pale clouds and a light breeze blowing in September in Beijing. The China International Economic and Trade Arbitration Commission and China Maritime Arbitration Commission held a forum of arbitrators on 26 to 28 September 2001s dealing with arbitrate work in a beautiful landscape place, Kuan Gou, a suburb in Beijing. Mr. Yu Xiaosong, the Chair- man of China Council for Promotion of International Trade/China Chamber of International Commerce, China Intemational Economic and Trade Arbitration Commission and China Maritime Arbitration Commission, gave a talk at the forum stressed that the development of arbitration cause in China should be marched with ticccccccccmes and adapted to the fast development in the situations both of home and abroad. Mr. Yu Xaosong’s talk put forward a kind of principles for the development of the arbitration cause in China, a part of which, we publish part of it here as a reference for the arbitrate circle colleagues.
基金supported by grants from the National Natural Science Foundation of China (82370913,82170914 to Guohua Yuan and 82270947 to Guobin Yang)the National Natural Science Foundation of China Key Program (82230029 to Z.C)+1 种基金the Fundamental Research Funds for the Central Universities (2042022dx0003)the Innovation Project of Municipal Science and Technology Bureau (2023020201010170) to Guohua Yuan。
文摘Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated RING finger protein 2(March2) is the highest among all March family members,with an increasing trend during odontoblast differentiation.In mouse incisors and molars,MARCH2 is moderately expressed in the undifferentiated dental papilla cells and strongly expressed in the odontoblasts.Knockdown and overexpression experiments demonstrate that MARCH2 inhibits odontoblastic differentiation of mouse dental papilla cells(mDPCs).Additionally,both March2 deficient mice and mice with odontoblast specific knockdown of March2 exhibit the phenotype of increased dentin thickness,accelerated dentin deposition as well as elevated expression levels of odontoblast markers compared with control littermates.Therefore,MARCH2 plays an inhibitory role in odontoblast differentiation.Mechanistically,MARCH2 interacts with protein tyrosine phosphatase receptor delta(PTPRD) and facilitates its K27-linked polyubiquitination and subsequent degradation,which is dependent on the ligase activity of MARCH2.The presence of MARCH2promotes the translocation of PTPRD from the cell membrane to the lysosome,thereby enhancing its degradation via the lysosomal pathway.Further experiments show that knockdown of endogenous Ptprd impairs odontoblastic differentiation of mDPCs.Ptprd and March2 double knockdown in mDPCs apparently reversed the enhanced odontoblastic differentiation by knockdown of March2 alone,indicating that MARCH2 inhibits odontoblastic differentiation by promoting PTPRD degradation.This study unveils a novel mechanism where an E3 ubiquitin ligase regulates odontoblast differentiation through post-translational modification of a membrane protein,highlighting a promising direction for future exploration.
文摘At 11:00 p.m. on January 13, 2026, floodlights illuminated the launch pad at the Hainan Commercial Space Launch Site in Wenchang,south China’s Hainan Province. A Long March-8A (CZ-8A) carrier rocket lifted off with a steady roar, its exhaust lighting up the night sky as it delivered a satellite into its designated orbit.The development of China’s first commercial space launch site has been striking. Since its inaugural launch in2024, it has completed 11 missions in less than 14 months—each a success.
文摘目的:探讨过表达MARCH2对肝细胞癌HUH7细胞自噬水平和生长的影响及其机制。方法:MTS和EDU检测MARCH2过表达的肝细胞癌HUH7细胞的生长情况。流式细胞术检测MARCH2过表达的肝细胞癌HUH7细胞凋亡、细胞周期的情况。Western blot和激光共聚焦法检测MARCH2过表达的肝细胞癌HUH7细胞自噬水平。结果:MTS和EDU检测表明,MARCH2的过表达促进了肝细胞癌HUH7的生长。流式细胞术检测表明,MARCH2过表达对肝细胞癌HUH7细胞凋亡和细胞周期没有明显影响。进一步的实验表明,MARCH2过表达损害了肝细胞癌HUH7的自噬。用常见的自噬诱导剂雷帕霉素挽救自噬可以使肝细胞癌HUH7的增殖率恢复到控制水平。结论:我们的数据表明,MARCH2通过抑制自噬在肿瘤发展过程中起着至关重要的作用。因此,MARCH2是一种有前景的肿瘤治疗新靶点。Aims: To investigate the effects and mechanisms of overexpression of MARCH2 on autophagy levels and growth of hepatocellular carcinoma HUH7 cells. Methods: MTS and EDU were used to detect the growth of MARCH2 overexpressing hepatocellular carcinoma HUH7 cells. Flow cytometry was used to detect apoptosis and cell cycle in MARCH2 overexpressing hepatocellular carcinoma HUH7 cells. Western blot and laser confocal microscopy were used to detect the autophagy levels in MARCH2 overexpressing HUH7 hepatocellular carcinoma cells. Results: In this study, MTS and EDU assays showed that the overexpression of MARCH2 promoted the growth of hepatocellular carcinoma HUH7 cells. Flow cytometry detection illustrated that MARCH2 overexpression had no obvious effect on the hepatocellular carcinoma HUH7 cell apoptosis and cell cycle. Further experiments displayed that MARCH2 overexpression impaired the autophagy of hepatocellular carcinoma HUH7 cells. Rescued autophagy with the common autophagy inducer rapamycin can bring the proliferation rate of hepatocellular carcinoma HUH7 cells back to the control level. Conclusions: Our data indicates that MARCH2 plays an essential role in the progression of tumor development through inhibiting autophagy. Therefore, MARCH2 is an attractive novel target for tumor therapy.
基金supported by the National Natural Science Foundation of China(Grant Nos.1217211 and 12372244).
文摘Physics informed neural networks(PINNs)are a deep learning approach designed to solve partial differential equations(PDEs).Accurately learning the initial conditions is crucial when employing PINNs to solve PDEs.However,simply adjusting weights and imposing hard constraints may not always lead to better learning of the initial conditions;sometimes it even makes it difficult for the neural networks to converge.To enhance the accuracy of PINNs in learning the initial conditions,this paper proposes a novel strategy named causally enhanced initial conditions(CEICs).This strategy works by embedding a new loss in the loss function:the loss is constructed by the derivative of the initial condition and the derivative of the neural network at the initial condition.Furthermore,to respect the causality in learning the derivative,a novel causality coefficient is introduced for the training when selecting multiple derivatives.Additionally,because CEICs can provide more accurate pseudo-labels in the first subdomain,they are compatible with the temporal-marching strategy.Experimental results demonstrate that CEICs outperform hard constraints and improve the overall accuracy of pre-training PINNs.For the 1D-Korteweg–de Vries,reaction and convection equations,the CEIC method proposed in this paper reduces the relative error by at least 60%compared to the previous methods.
文摘The International Textile Manufac-turers Federation(ITMF),has releasedthe results of its Global Textile IndustrySurvey(GTIS)for March 2025.Thissurvey,conducted regularly across allkey regions and segments of the textilevalue chain,revealed a complex pictureof a deteriorated business situation,cau-tious op timism,regional divergence,andongoing structural challenges.
文摘Sent out at 1:31am GMT+8 on May 29 by a Long March-3B carrier rocket from the Xichang Satellite Launch Center in Sichuan province,China,Tianwen-2,the second mission of China’s Planetary Exploration Program,correctly entered the transfer trajectory toward an asteroid named 2016HO3 after flying for 18 minutes.Its solar wings unfolded properly,signaling a successful start,and primed for the next stage of its mission.
文摘50.2% On March 6, the China Federation of Commerce released the China Retail Industry Sentiment Index (CRPI) of 50.2% in March, up 0.1%f rom the previous month.66.74 billion According to Fu Jinling, Director of the Economic Construction Department of the Ministry of Finance, in 2025, the central finance will arrange RMB 66.74 billion of employment subsidies.
基金supported by NSFC(Nos.41274120,41404085,and 41504084)
文摘3D traveltime calculation is widely used in seismic exploration technologies such as seismic migration and tomography. The fast marching method （FMM） is useful for calculating 3D traveltime and has proven to be efficient and stable. However, it has low calculation accuracy near the source, which thus gives it low overall accuracy. This paper proposes a joint traveltime calculation method to solve this problem. The method firstly employs the wavefront construction method （WFC）, which has a higher calculation accuracy than FMM in calculating traveltime in the small area near the source, and secondly adopts FMM to calculate traveltime for the remaining grid nodes. Due to the increase in calculation precision of grid nodes near the source, this new algorithm is shown to have good calculation precision while maintaining the high calculation efficiency of FMM, which is employed in most of the computational area. Results are verified using various numerical models.
