Autism spectrum disorder(ASD)is an early-onset neurodevelopmental disorder marked by persistent deficits in social communication and interaction,alongside restricted,repetitive patterns of behaviors(RRB),interests,or ...Autism spectrum disorder(ASD)is an early-onset neurodevelopmental disorder marked by persistent deficits in social communication and interaction,alongside restricted,repetitive patterns of behaviors(RRB),interests,or activities.It often co-occurs with various neuropsychiatric disorders,though their frequency varies widely due to unclear boundaries between the core features of ASD and common comorbidities.Catatonia,increasingly noted in neurodevelopmental conditions like ASD,shares striking similarities with ASD in symptomatology,brain mech-anisms,and treatment responses,prompting the question of whether it is a core feature of ASD or a distinct condition.This paper delved into this overlap,ex-ploring the relationship between catatonia and ASD through a narrative review of peer-reviewed literature from 1943 to 2024,sourced from PubMed and psy-chiatric journals.Focusing on ASD diagnostic evolution,symptom overlap with catatonia,and shared neurobiological and therapeutic characteristics,we used thematic analysis to synthesize findings into key areas such as historical nosology,phenomenological overlap,neurobiological parallels,and treatment response.The evidence revealed weak support for separating catatonia from overlapping RRB features of ASD,suggesting that some RRB might align more with comorbid catatonia than intrinsic ASD traits.However,this idea needs further validation through rigorous clinical trials.Clarifying this relationship could refine diagnostic approaches and open doors to targeted treatments,potentially improving out-comes for those affected.展开更多
This article centers on The Call of the Wild,an English novel by American author Jack London,alongside two Chinese translations by Dajie Liu and Menglin Zhang,and Rongyue Liu.Seventy sentences containing motion events...This article centers on The Call of the Wild,an English novel by American author Jack London,alongside two Chinese translations by Dajie Liu and Menglin Zhang,and Rongyue Liu.Seventy sentences containing motion events and their corresponding translations were randomly selected for analysis.The study focuses on the primary elements of motion events-manner,path,and ground-and examines their Chinese translations through the lens of Skopos theory.Skopos theory emphasizes whether translators can adopt appropriate translation strategies according to various contextual factors during the translation process.Compared to verb-framed languages,satellite-framed languages possess a richer vocabulary for manner verbs,express more detailed manner information,use more satellite words to indicate paths,and incorporate more background information.Verb-framed languages,by contrast,typically express manner information only when necessary and tend to include less background information.The analysis reveals that both Chinese translations embody the core principle of Skopos theory:translation strategies are determined by their purpose.To fulfill the novel’s translation objectives,the translators adeptly adjust their strategies for motion event components based on different contextual needs.It is noted that the Chinese translations do not fully retain the characteristics of English as a typical satellite-framed language.This observation aligns with Skopos theory’s purpose-oriented approach,which prioritizes translation goals over strict adherence to source text characteristics.展开更多
Table manners are important in manycultures.Inmost countries,youwait untileveryone has food before eating.Youalso don't put your elbows on the table.It's not polite to eat too fast.And youshouldn't talk wi...Table manners are important in manycultures.Inmost countries,youwait untileveryone has food before eating.Youalso don't put your elbows on the table.It's not polite to eat too fast.And youshouldn't talk with food in yourmouth orchew with your mouth open.展开更多
This paper analyzes the unique business etiquette under specific culture of different countries, the similarities and differences of business etiquette among China and main English-speaking countries, i.e. Britain, Am...This paper analyzes the unique business etiquette under specific culture of different countries, the similarities and differences of business etiquette among China and main English-speaking countries, i.e. Britain, America, are discussed. Better understanding of how cultural differences influence the operations of international business is the most essential for people who look for standard of excellence.展开更多
Grice's maxims,which define the conditions for efficient spoken communication,can be adapted to the teaching of writing by providing both teachers and writers with a way of understanding successful and unsuccessfu...Grice's maxims,which define the conditions for efficient spoken communication,can be adapted to the teaching of writing by providing both teachers and writers with a way of understanding successful and unsuccessful written correspondence in mono-and cross-cultural settings.A survey of lay readers' responses to a sample letter which show that,while there are individual differences in the way these maxims are interpreted,readers expect clarity,brevity,and sincerity,and writing which fails to meet these expectations will be unfavorably received.Also discussed are the issues of contrastive rhetoric,and ways of helping writers to position themselves in relation to their real or imagined reader.展开更多
Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists ...Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.展开更多
The lethality of a semi-preformed fragment warhead is closely related to the expand velocity and spatial distribution of the fragments from ruptured metal casing. The topic of how to improve the utilization of charge ...The lethality of a semi-preformed fragment warhead is closely related to the expand velocity and spatial distribution of the fragments from ruptured metal casing. The topic of how to improve the utilization of charge of have been drawing great attention from researchers and designer in this filed. In present paper,in order to investigate the influence of charge initiation manners on the scattering characteristics of semi-preformed fragment warhead, the numerical simulations and experimental test are conducted.Firstly, the influence of grid density on numerical results is investigated, and a proper numerical model with relatively high accuracy and effectiveness is determined. Then. numerical simulations of three kinds of different initiation position of a semi-preformed fragment warhead are carried out. An experimental test of the explosion of a semi-preformed fragment warhead is carried out. By comparing and analyzing the numerical results and experimental data, it is found that the initiation manners have great influence on scattering characteristics of semi-preformed fragment warhead. The researcher work of this paper would provide an effective alternative method to optimize the design of warhead.展开更多
Prior to 2005 China’s mental health services were provided in the same manner as the other types of health services in the country. The hospital was the center of the service delivery network so medica staff only pro...Prior to 2005 China’s mental health services were provided in the same manner as the other types of health services in the country. The hospital was the center of the service delivery network so medica staff only provided services to those who came to the hospital and there was no continuity between hospita services and community services. This delivery system did not provide preventive services and was not展开更多
The evaluation method on steering is based on qualitative manner in existence, which causes the result inaccurate and fuzziness. It reduces the efficiency of process execution. So the method by quantitative manner for...The evaluation method on steering is based on qualitative manner in existence, which causes the result inaccurate and fuzziness. It reduces the efficiency of process execution. So the method by quantitative manner for the shape-shifting robot in different configurations is proposed. Comparing to traditional evaluation method, the most important aspects which can influence the steering abilities of the robot in different configurations are researched in detail, including the energy, angular velocity, time and space. In order to improve the robustness of system, the ideal and slippage conditions are all considered by mathematical model. Comparing to the traditional weighting confirming method, the extent of robot steering method is proposed by the combination of subjective and objective weighting method. The subjective weighting method can show more preferences of the experts and is based on five-grade scale. The objective weighting method is based on information entropy to determine the factors. By the sensors fixed on the robot, the contract force between track grouser and ground, the intrinsic motion characteristics of robot are obtained and the experiment is done to prove the algorithm which is proposed as the robot in different common configurations. Through the method proposed in the article, fuzziness and inaccurate of the evaluation method has been solved, so the operators can choose the most suitable configuration of the robot to fulfil the different tasks more quickly and simply.展开更多
A systematic study was undertaken to investigate the effects of the manganese incorporation manner on the textural properties, bulk and surface phase compositions, reduction/carburization behaviors, and surface basici...A systematic study was undertaken to investigate the effects of the manganese incorporation manner on the textural properties, bulk and surface phase compositions, reduction/carburization behaviors, and surface basicity of an iron-based Fischer-Tropsch synthesis （FTS） catalyst. The catalyst samples were characterized by N2 physisorption, X-ray photoelectron spectroscopy （XPS）, H2 （or CO） temperature-programmed reduction （TPR）, CO2 temperature-programmed desorption （TPD）, and M5ssbauer spectroscopy. The FTS performance of the catalysts was studied in a slurry-phase continuously stirred tank reactor （CSTR）. The characterization results indicated that the manganese promoter incorporated by using the coprecipitation method could improve the dispersion of iron oxide, and decrease the size of the iron oxide crystallite. The manganese incorporated with the impregnation method is enriched on the catalyst＇s surface. The manganese promoter added with the impregnation method suppresses the reduction and carburization of the catalyst in H2, CO, and syngas because of the excessive enrichment of manganese on the catalyst surface. The catalyst added manganese using the coprecipitation method has the highest CO conversion （51.9%） and the lowest selectivity for heavy hydrocarbons （C12＋）.展开更多
Cytokines provided locally at tbe tumor site mayinitiate an effective anti-tumor immune responsewhich leads to rejection of a tumor which otherwisegrows progressively. Experimentillly, this can betested by gene transf...Cytokines provided locally at tbe tumor site mayinitiate an effective anti-tumor immune responsewhich leads to rejection of a tumor which otherwisegrows progressively. Experimentillly, this can betested by gene transfer into cultured tumor cellsfollowed by the analysis of the tumorigenicity of suchgenetically engincered cells. This approach allows展开更多
This study investigated how the mode in which the reading-writing integrated continuation task was conducted modulates the effects of second language(L2) syntactic alignment, through the English motion event construct...This study investigated how the mode in which the reading-writing integrated continuation task was conducted modulates the effects of second language(L2) syntactic alignment, through the English motion event construction with manner verbs. Ninety Chinese students were assigned to either of the two experimental groups or a control group, and they all experienced a pretest, an alignment phase and a posttest. In the alignment phase, the two experimental groups completed a reading-writing integrated continuation task but in different modes. For the multi-turn mode,participants reconstructed a picture story by continuing the episodes extracted from the story with one episode presented and continued at a time;for the single-turn mode, the first half of the same picture story was presented as a chunk, and then participants read and continued it. Results show that L2 learners aligned with the target structure in completing the story, and the alignment effect was retained in the posttest conducted after a delay of two weeks. Moreover, syntactic alignment was modulated by task mode with the multi-turn group exhibiting stronger immediate and longterm alignment effects. We conclude that the continuation task is a fruitful context for L2 structural alignment, and the magnitude of alignment effect hinges on interactive intensity.展开更多
We report a case of a 56-year-old woman with intrahepatic biliary cystadenoma(IBC)accompanying a tumor embolus in the extrahepatic bile duct,who was admitted to our department on October 13,2008.Imaging showed an asym...We report a case of a 56-year-old woman with intrahepatic biliary cystadenoma(IBC)accompanying a tumor embolus in the extrahepatic bile duct,who was admitted to our department on October 13,2008.Imaging showed an asymmetry dilation of the biliary tree,different bile signals in the biliary tree,a multiloculated lesion and an extrahepatic bile duct lesion with internal septation.A regular left hemihepatectomy en bloc was performed with resection of the entire tumor,during which a tumor embolus protruding into the extrahepatic bile duct and originating from biliary duct of segment 4 was revealed.Microscopically,the multiloculated tumor was confirmed to be a biliary cystadenoma with an epithelial lining composed of biliary-type cuboidal cells and surrounded by an ovarian-like stroma.An aggressive en bloc resection was recommended for the multiloculated lesion.Imaging workup,clinicians and surgeons need to be aware of this different presentation.展开更多
We investigated whether Nd_2O_3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar macrophages.Cell viability assessed by the MTT assay revealed that Nd_2O_3 was toxic in a dose-depe...We investigated whether Nd_2O_3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar macrophages.Cell viability assessed by the MTT assay revealed that Nd_2O_3 was toxic in a dose-dependent manner, but not in a time-dependent manner. An ELISA analysis indicated that exposure to Nd203 caused cell damage and enhanced synthesis and release of inflammatory chemokines. A Western blot analysis showed that protein expression levels of caspase-3, nuclear factor-KB （NF-KB） and its inhibitor IKB increased significantly in response to Nd203 treatment. Both NF-KB and caspase-3 signaling were activated, suggesting that both pathways are involved in Nd203 cytotoxicity.展开更多
The active ingredient of ginseng,ginsenosides Rg1,has been shown to scavenge free radicals and improve antioxidant capacity.This study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma ce...The active ingredient of ginseng,ginsenosides Rg1,has been shown to scavenge free radicals and improve antioxidant capacity.This study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma cells injured by H2O2.Ginsenosides Rg1 at different concentrations（50 and 100 μM） was used to treat H2O2（150 μM）-injured SH-SY5 Y cells.Results demonstrated that ginsenoside Rg1 elevated the survival rate of SH-SY5 Y cells injured by H2O2,diminished the amount of leaked lactate dehydrogenase,and increased superoxide dismutase activity.Ginsenoside Rg1 effectively suppressed caspase-3 immunoreactivity,and contributed to heat shock protein 70 gene expression,in a dose-dependent manner.These results indicate that ginsenoside Rg1 has protective effects on SH-SY5 Y cells injured by H2O2 and that its mechanism of action is associated with anti-oxidation and the inhibition of apoptosis.展开更多
Neural stem cells（NSCs） proliferation can be influenced by repetitive transcranial magnetic stimulation（r TMS） in vivo via micro RNA-106b-25 cluster,but the underlying mechanisms are poorly understood. This study ...Neural stem cells（NSCs） proliferation can be influenced by repetitive transcranial magnetic stimulation（r TMS） in vivo via micro RNA-106b-25 cluster,but the underlying mechanisms are poorly understood. This study investigated the involvement of micro RNA-106b-25 cluster in the proliferation of NSCs after repetitive magnetic stimulation（r MS） in vitro. NSCs were stimulated by r MS（200/400/600/800/1000 pulses per day,with 10 Hz frequency and 50% maximum machine output） over a 3-day period. NSCs proliferation was detected by using ki-67 and Ed U staining. Ki-67,p21,p57,cyclin D1,cyclin E,cyclin A,cdk2,cdk4 proteins and mi R-106 b,mi R-93,mi R-25 m RNAs were detected by Western blotting and q RT-PCR,respectively. The results showed that r MS could promote NSCs proliferation in a dose-dependent manner. The proportions of ki-67＋ and Edu＋ cells in 1000 pulses group were 20.65% and 4.00%,respectively,significantly higher than those in control group（9.25%,2.05%）. The expression levels of mi R-106 b and mi R-93 were significantly upregulated in 600–1000 pulses groups compared with control group（P〈0.05 or 0.01 for all）. The expression levels of p21 protein were decreased significantly in 800/1000 pulses groups,and those of cyclin D1,cyclin A,cyclin E,cdk2 and cdk4 were obviously increased after r MS as compared with control group（P〈0.05 or 0.01 for all）. In conclusion,our findings suggested that r MS enhances the NSCs proliferation in vitro in a dose-dependent manner and mi R-106b/p21/cdks/cyclins pathway was involved in the process.展开更多
The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a co...The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a coordinated laboratory response in the Ministry of Health(MOH)network with credible laboratories capable of providing accurate and reliable results in a timely manner to enable effective public health measures展开更多
Liver fibrosis is an important health problem that can further progress into cirrhosis or liver cancer,and result in significant morbidity and mortality. Inhibiting proliferation and inducing apoptosis of hepatic stel...Liver fibrosis is an important health problem that can further progress into cirrhosis or liver cancer,and result in significant morbidity and mortality. Inhibiting proliferation and inducing apoptosis of hepatic stellate cells（HSCs） may be the key point to reverse liver fibrosis. At present,anti-fibrosis drugs are rare. Kinetin is a type of plant-derived cytokinin which has been reported to control differentiation and induce apoptosis of human cells. In this study,the HSCs were incubated with different concentrations of kinetin. The proliferation of rat HSCs was measured by MTT assay,cell cycle and apoptosis were analyzed by flow cytometry,and the apoptosis was examined by TUNEL method. The expression of Bcl-2 and Bax proteins was detected by immunocytochemistry staining. It was found that kinetin could markedly inhibit proliferation of HSCs. In a concentration range of 2 to 8 μg/m L,the inhibitory effects of kinetin on proliferation of HSCs were increased with the increased concentration and the extension of time（P〈0.01）. Flow cytometry indicated that kinetin could inhibit the DNA synthesis from G0/G1 to S phase in a dose-dependent manner（P〈0.01）. The apoptosis rates of the HSCs treated with 8,4 and 2 μg/m L kinetin（25.62%±2.21%,15.31%±1.9% and 6.18%±1.23%,respectively） were increased significantly compared with the control group（3.81%±0.93%）（P〈0.01）. All the DNA frequency histogram in kinetin-treated groups showed obvious hypodiploid peak（sub-G1 peak）,and with the increase of kinetin concentrations,the apoptosis rate of HSCs also showed a trend of increase. It was also found that kinetin could down-regulate the expression of Bcl-2,and up-regulate the expression of Bax,leading to the decreased ratio of Bcl-2/Bax significantly. The kinetin-induced apoptosis of HSCs was positively correlated with the expression of Bax,and negatively with the expression of Bcl-2. It was concluded that kinetin can inhibit activation and proliferation of HSCs by interrupting the cell cycle at G1/S restriction point and inducing apoptosis of HSCs via reducing the ratio of Bcl-2/Bax.展开更多
Cytokines are believed to be involved in a “vicious circle” of progressive interactions in bone metastasis. Iguratimod is a novel anti-rheumatic drug which is reported to have the capability of anti-cytokines. In th...Cytokines are believed to be involved in a “vicious circle” of progressive interactions in bone metastasis. Iguratimod is a novel anti-rheumatic drug which is reported to have the capability of anti-cytokines. In this study, a rat model was constructed to investigate the effect of iguratimod on bone metastasis and it was found that iguratimod alleviated cancer-induced bone destruction. To further explore whether an anti-tumor activity of iguratimod contributes to the effect of bone resorption suppression, two human breast cancer cell lines MDA-MB-231 and MCF-7 were studied. The effect of iguratimod on tumor proliferation was detected by CCK-8 assay and flow cytometry. The effects of iguratimod on migration and invasion of cancer cells were determined by wound-healing and Transwell assays. Results showed that high dose（30 μg/m L） iguratimod slightly suppressed the proliferation of cancer cells but failed to inhibit their migration and invasion capacity. Interestingly, iguratimod decreased the transcription level of IL-6 in MDA-MB-231 cells in a concentration-dependent manner. Moreover, iguratimod partially impaired NF-κB signaling by suppressing the phosphorylation of NF-κB p65 subunit. Our findings indicated that iguratimod may alleviate bone destruction by partially decreasing the expression of IL-6 in an NF-κB-dependent manner, while it has little effect on the tumor proliferation and invasion.展开更多
文摘Autism spectrum disorder(ASD)is an early-onset neurodevelopmental disorder marked by persistent deficits in social communication and interaction,alongside restricted,repetitive patterns of behaviors(RRB),interests,or activities.It often co-occurs with various neuropsychiatric disorders,though their frequency varies widely due to unclear boundaries between the core features of ASD and common comorbidities.Catatonia,increasingly noted in neurodevelopmental conditions like ASD,shares striking similarities with ASD in symptomatology,brain mech-anisms,and treatment responses,prompting the question of whether it is a core feature of ASD or a distinct condition.This paper delved into this overlap,ex-ploring the relationship between catatonia and ASD through a narrative review of peer-reviewed literature from 1943 to 2024,sourced from PubMed and psy-chiatric journals.Focusing on ASD diagnostic evolution,symptom overlap with catatonia,and shared neurobiological and therapeutic characteristics,we used thematic analysis to synthesize findings into key areas such as historical nosology,phenomenological overlap,neurobiological parallels,and treatment response.The evidence revealed weak support for separating catatonia from overlapping RRB features of ASD,suggesting that some RRB might align more with comorbid catatonia than intrinsic ASD traits.However,this idea needs further validation through rigorous clinical trials.Clarifying this relationship could refine diagnostic approaches and open doors to targeted treatments,potentially improving out-comes for those affected.
基金Humanities and Social Sciences Research Project of China’s Ministry of Education(23YJCZH242)Major Humanities and Social Sciences Research Projects in Zhejiang Higher Education Institutions(2024QN069)Hangzhou Collaborative Innovation Institute of Language Services,Hangzhou City University,China。
文摘This article centers on The Call of the Wild,an English novel by American author Jack London,alongside two Chinese translations by Dajie Liu and Menglin Zhang,and Rongyue Liu.Seventy sentences containing motion events and their corresponding translations were randomly selected for analysis.The study focuses on the primary elements of motion events-manner,path,and ground-and examines their Chinese translations through the lens of Skopos theory.Skopos theory emphasizes whether translators can adopt appropriate translation strategies according to various contextual factors during the translation process.Compared to verb-framed languages,satellite-framed languages possess a richer vocabulary for manner verbs,express more detailed manner information,use more satellite words to indicate paths,and incorporate more background information.Verb-framed languages,by contrast,typically express manner information only when necessary and tend to include less background information.The analysis reveals that both Chinese translations embody the core principle of Skopos theory:translation strategies are determined by their purpose.To fulfill the novel’s translation objectives,the translators adeptly adjust their strategies for motion event components based on different contextual needs.It is noted that the Chinese translations do not fully retain the characteristics of English as a typical satellite-framed language.This observation aligns with Skopos theory’s purpose-oriented approach,which prioritizes translation goals over strict adherence to source text characteristics.
文摘Table manners are important in manycultures.Inmost countries,youwait untileveryone has food before eating.Youalso don't put your elbows on the table.It's not polite to eat too fast.And youshouldn't talk with food in yourmouth orchew with your mouth open.
文摘This paper analyzes the unique business etiquette under specific culture of different countries, the similarities and differences of business etiquette among China and main English-speaking countries, i.e. Britain, America, are discussed. Better understanding of how cultural differences influence the operations of international business is the most essential for people who look for standard of excellence.
文摘Grice's maxims,which define the conditions for efficient spoken communication,can be adapted to the teaching of writing by providing both teachers and writers with a way of understanding successful and unsuccessful written correspondence in mono-and cross-cultural settings.A survey of lay readers' responses to a sample letter which show that,while there are individual differences in the way these maxims are interpreted,readers expect clarity,brevity,and sincerity,and writing which fails to meet these expectations will be unfavorably received.Also discussed are the issues of contrastive rhetoric,and ways of helping writers to position themselves in relation to their real or imagined reader.
文摘Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.
基金supported by the Joint Foundation project for Young Scientists of Ministry of Education(6141A02033108)National Natural Science Foundation of China(11502180)
文摘The lethality of a semi-preformed fragment warhead is closely related to the expand velocity and spatial distribution of the fragments from ruptured metal casing. The topic of how to improve the utilization of charge of have been drawing great attention from researchers and designer in this filed. In present paper,in order to investigate the influence of charge initiation manners on the scattering characteristics of semi-preformed fragment warhead, the numerical simulations and experimental test are conducted.Firstly, the influence of grid density on numerical results is investigated, and a proper numerical model with relatively high accuracy and effectiveness is determined. Then. numerical simulations of three kinds of different initiation position of a semi-preformed fragment warhead are carried out. An experimental test of the explosion of a semi-preformed fragment warhead is carried out. By comparing and analyzing the numerical results and experimental data, it is found that the initiation manners have great influence on scattering characteristics of semi-preformed fragment warhead. The researcher work of this paper would provide an effective alternative method to optimize the design of warhead.
文摘Prior to 2005 China’s mental health services were provided in the same manner as the other types of health services in the country. The hospital was the center of the service delivery network so medica staff only provided services to those who came to the hospital and there was no continuity between hospita services and community services. This delivery system did not provide preventive services and was not
基金Supported by National Key Technology R&D Program of China(Grant No.2014BAK12B01)
文摘The evaluation method on steering is based on qualitative manner in existence, which causes the result inaccurate and fuzziness. It reduces the efficiency of process execution. So the method by quantitative manner for the shape-shifting robot in different configurations is proposed. Comparing to traditional evaluation method, the most important aspects which can influence the steering abilities of the robot in different configurations are researched in detail, including the energy, angular velocity, time and space. In order to improve the robustness of system, the ideal and slippage conditions are all considered by mathematical model. Comparing to the traditional weighting confirming method, the extent of robot steering method is proposed by the combination of subjective and objective weighting method. The subjective weighting method can show more preferences of the experts and is based on five-grade scale. The objective weighting method is based on information entropy to determine the factors. By the sensors fixed on the robot, the contract force between track grouser and ground, the intrinsic motion characteristics of robot are obtained and the experiment is done to prove the algorithm which is proposed as the robot in different common configurations. Through the method proposed in the article, fuzziness and inaccurate of the evaluation method has been solved, so the operators can choose the most suitable configuration of the robot to fulfil the different tasks more quickly and simply.
基金Foundation item:the National Natural Science Foundation of China(20590360)the Natural Science Foundation of Shanxi Province(2006021014)+1 种基金the National Outstanding Young Scientists Foundation of China(20625620)National Key Basic Research Program of China(973 Program)(2007CB216401).
文摘A systematic study was undertaken to investigate the effects of the manganese incorporation manner on the textural properties, bulk and surface phase compositions, reduction/carburization behaviors, and surface basicity of an iron-based Fischer-Tropsch synthesis （FTS） catalyst. The catalyst samples were characterized by N2 physisorption, X-ray photoelectron spectroscopy （XPS）, H2 （or CO） temperature-programmed reduction （TPR）, CO2 temperature-programmed desorption （TPD）, and M5ssbauer spectroscopy. The FTS performance of the catalysts was studied in a slurry-phase continuously stirred tank reactor （CSTR）. The characterization results indicated that the manganese promoter incorporated by using the coprecipitation method could improve the dispersion of iron oxide, and decrease the size of the iron oxide crystallite. The manganese incorporated with the impregnation method is enriched on the catalyst＇s surface. The manganese promoter added with the impregnation method suppresses the reduction and carburization of the catalyst in H2, CO, and syngas because of the excessive enrichment of manganese on the catalyst surface. The catalyst added manganese using the coprecipitation method has the highest CO conversion （51.9%） and the lowest selectivity for heavy hydrocarbons （C12＋）.
文摘Cytokines provided locally at tbe tumor site mayinitiate an effective anti-tumor immune responsewhich leads to rejection of a tumor which otherwisegrows progressively. Experimentillly, this can betested by gene transfer into cultured tumor cellsfollowed by the analysis of the tumorigenicity of suchgenetically engincered cells. This approach allows
文摘This study investigated how the mode in which the reading-writing integrated continuation task was conducted modulates the effects of second language(L2) syntactic alignment, through the English motion event construction with manner verbs. Ninety Chinese students were assigned to either of the two experimental groups or a control group, and they all experienced a pretest, an alignment phase and a posttest. In the alignment phase, the two experimental groups completed a reading-writing integrated continuation task but in different modes. For the multi-turn mode,participants reconstructed a picture story by continuing the episodes extracted from the story with one episode presented and continued at a time;for the single-turn mode, the first half of the same picture story was presented as a chunk, and then participants read and continued it. Results show that L2 learners aligned with the target structure in completing the story, and the alignment effect was retained in the posttest conducted after a delay of two weeks. Moreover, syntactic alignment was modulated by task mode with the multi-turn group exhibiting stronger immediate and longterm alignment effects. We conclude that the continuation task is a fruitful context for L2 structural alignment, and the magnitude of alignment effect hinges on interactive intensity.
文摘We report a case of a 56-year-old woman with intrahepatic biliary cystadenoma(IBC)accompanying a tumor embolus in the extrahepatic bile duct,who was admitted to our department on October 13,2008.Imaging showed an asymmetry dilation of the biliary tree,different bile signals in the biliary tree,a multiloculated lesion and an extrahepatic bile duct lesion with internal septation.A regular left hemihepatectomy en bloc was performed with resection of the entire tumor,during which a tumor embolus protruding into the extrahepatic bile duct and originating from biliary duct of segment 4 was revealed.Microscopically,the multiloculated tumor was confirmed to be a biliary cystadenoma with an epithelial lining composed of biliary-type cuboidal cells and surrounded by an ovarian-like stroma.An aggressive en bloc resection was recommended for the multiloculated lesion.Imaging workup,clinicians and surgeons need to be aware of this different presentation.
基金supported by the National Natural Science Foundation of China[No.81660532,81260426]the Natural Science Foundation of Inner Mongolia[No.2016MS(LH)0822]+2 种基金the Science and Technology Plan Project in Inner Mongolia[No.201502080]the Doctoral Scientific Research Foundation of Baotou Medical College[BSJJ201621]the Scientific Research Foundation of Baotou Medical College[BYJJ-YF201613]
文摘We investigated whether Nd_2O_3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar macrophages.Cell viability assessed by the MTT assay revealed that Nd_2O_3 was toxic in a dose-dependent manner, but not in a time-dependent manner. An ELISA analysis indicated that exposure to Nd203 caused cell damage and enhanced synthesis and release of inflammatory chemokines. A Western blot analysis showed that protein expression levels of caspase-3, nuclear factor-KB （NF-KB） and its inhibitor IKB increased significantly in response to Nd203 treatment. Both NF-KB and caspase-3 signaling were activated, suggesting that both pathways are involved in Nd203 cytotoxicity.
基金supported by the Research and Development Project Fund of Science and Technology Plan Program of Science and Technology Bureau of Beijing of China,No.Z111107067311022
文摘The active ingredient of ginseng,ginsenosides Rg1,has been shown to scavenge free radicals and improve antioxidant capacity.This study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma cells injured by H2O2.Ginsenosides Rg1 at different concentrations（50 and 100 μM） was used to treat H2O2（150 μM）-injured SH-SY5 Y cells.Results demonstrated that ginsenoside Rg1 elevated the survival rate of SH-SY5 Y cells injured by H2O2,diminished the amount of leaked lactate dehydrogenase,and increased superoxide dismutase activity.Ginsenoside Rg1 effectively suppressed caspase-3 immunoreactivity,and contributed to heat shock protein 70 gene expression,in a dose-dependent manner.These results indicate that ginsenoside Rg1 has protective effects on SH-SY5 Y cells injured by H2O2 and that its mechanism of action is associated with anti-oxidation and the inhibition of apoptosis.
基金supported by grants from the National Natural Science Foundation of China(No.81071601,and No.81171858)
文摘Neural stem cells（NSCs） proliferation can be influenced by repetitive transcranial magnetic stimulation（r TMS） in vivo via micro RNA-106b-25 cluster,but the underlying mechanisms are poorly understood. This study investigated the involvement of micro RNA-106b-25 cluster in the proliferation of NSCs after repetitive magnetic stimulation（r MS） in vitro. NSCs were stimulated by r MS（200/400/600/800/1000 pulses per day,with 10 Hz frequency and 50% maximum machine output） over a 3-day period. NSCs proliferation was detected by using ki-67 and Ed U staining. Ki-67,p21,p57,cyclin D1,cyclin E,cyclin A,cdk2,cdk4 proteins and mi R-106 b,mi R-93,mi R-25 m RNAs were detected by Western blotting and q RT-PCR,respectively. The results showed that r MS could promote NSCs proliferation in a dose-dependent manner. The proportions of ki-67＋ and Edu＋ cells in 1000 pulses group were 20.65% and 4.00%,respectively,significantly higher than those in control group（9.25%,2.05%）. The expression levels of mi R-106 b and mi R-93 were significantly upregulated in 600–1000 pulses groups compared with control group（P〈0.05 or 0.01 for all）. The expression levels of p21 protein were decreased significantly in 800/1000 pulses groups,and those of cyclin D1,cyclin A,cyclin E,cdk2 and cdk4 were obviously increased after r MS as compared with control group（P〈0.05 or 0.01 for all）. In conclusion,our findings suggested that r MS enhances the NSCs proliferation in vitro in a dose-dependent manner and mi R-106b/p21/cdks/cyclins pathway was involved in the process.
基金funded by the operational budget of the Disease Control Division,Ministry of Health,Malaysia
文摘The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a coordinated laboratory response in the Ministry of Health(MOH)network with credible laboratories capable of providing accurate and reliable results in a timely manner to enable effective public health measures
基金supported by a grant from Hubei Natural Science Foundation of China(No.2013CFB135)
文摘Liver fibrosis is an important health problem that can further progress into cirrhosis or liver cancer,and result in significant morbidity and mortality. Inhibiting proliferation and inducing apoptosis of hepatic stellate cells（HSCs） may be the key point to reverse liver fibrosis. At present,anti-fibrosis drugs are rare. Kinetin is a type of plant-derived cytokinin which has been reported to control differentiation and induce apoptosis of human cells. In this study,the HSCs were incubated with different concentrations of kinetin. The proliferation of rat HSCs was measured by MTT assay,cell cycle and apoptosis were analyzed by flow cytometry,and the apoptosis was examined by TUNEL method. The expression of Bcl-2 and Bax proteins was detected by immunocytochemistry staining. It was found that kinetin could markedly inhibit proliferation of HSCs. In a concentration range of 2 to 8 μg/m L,the inhibitory effects of kinetin on proliferation of HSCs were increased with the increased concentration and the extension of time（P〈0.01）. Flow cytometry indicated that kinetin could inhibit the DNA synthesis from G0/G1 to S phase in a dose-dependent manner（P〈0.01）. The apoptosis rates of the HSCs treated with 8,4 and 2 μg/m L kinetin（25.62%±2.21%,15.31%±1.9% and 6.18%±1.23%,respectively） were increased significantly compared with the control group（3.81%±0.93%）（P〈0.01）. All the DNA frequency histogram in kinetin-treated groups showed obvious hypodiploid peak（sub-G1 peak）,and with the increase of kinetin concentrations,the apoptosis rate of HSCs also showed a trend of increase. It was also found that kinetin could down-regulate the expression of Bcl-2,and up-regulate the expression of Bax,leading to the decreased ratio of Bcl-2/Bax significantly. The kinetin-induced apoptosis of HSCs was positively correlated with the expression of Bax,and negatively with the expression of Bcl-2. It was concluded that kinetin can inhibit activation and proliferation of HSCs by interrupting the cell cycle at G1/S restriction point and inducing apoptosis of HSCs via reducing the ratio of Bcl-2/Bax.
基金supported by grants from the National Natural Science Foundation of China(Nos.81372852 and 81202095)
文摘Cytokines are believed to be involved in a “vicious circle” of progressive interactions in bone metastasis. Iguratimod is a novel anti-rheumatic drug which is reported to have the capability of anti-cytokines. In this study, a rat model was constructed to investigate the effect of iguratimod on bone metastasis and it was found that iguratimod alleviated cancer-induced bone destruction. To further explore whether an anti-tumor activity of iguratimod contributes to the effect of bone resorption suppression, two human breast cancer cell lines MDA-MB-231 and MCF-7 were studied. The effect of iguratimod on tumor proliferation was detected by CCK-8 assay and flow cytometry. The effects of iguratimod on migration and invasion of cancer cells were determined by wound-healing and Transwell assays. Results showed that high dose（30 μg/m L） iguratimod slightly suppressed the proliferation of cancer cells but failed to inhibit their migration and invasion capacity. Interestingly, iguratimod decreased the transcription level of IL-6 in MDA-MB-231 cells in a concentration-dependent manner. Moreover, iguratimod partially impaired NF-κB signaling by suppressing the phosphorylation of NF-κB p65 subunit. Our findings indicated that iguratimod may alleviate bone destruction by partially decreasing the expression of IL-6 in an NF-κB-dependent manner, while it has little effect on the tumor proliferation and invasion.
