Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.Ho...Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.However,the ferroptosis accompanied with down-regulation of glutathione peroxidase 4(GPX4)lead to CD36-mediated tumor-infiltrating CD8^(+)T cells uptaking fatty acids,resulting in the negative action on immunotherapeutic efficacy.Herein,the albumin nanoparticles,abbreviated as LHS NPs,were designed by co-assembly of hemin,linoleic acid-cystamine,and a CD36 inhibitor sulfosuccinimide oleate,to bi-directionally manipulated ferroptosis in tumor and CD8^(+)T cells for TNBC therapy.LHS NPs exerted more efficient reactive oxygen species generation,glutathione depletion and malondialdehyde production by the combinatory strategy of classical and non-classical ferroptosis modes,which amplified the positive action on ferroptosis in tumor cells.Meanwhile,LHS manipulated the negative action of ferroptosis by inhibiting the CD36 mediated-lipid peroxidation in CD8^(+)T cells,thereby activating the immunotherapeutic efficacy with the improvements on induction of immunogenic cell death,proliferation of CD4+CD8^(+)T cells and natural killer cells,alleviation immunosuppressive regulatory T cells and myeloid-derived suppressor cells,and repolarization of the M2-to M1-phenotype tumor-associated macrophages.Thus,LHS NPs demonstrated an improved antitumor efficacy in suppressing the tumor growth and lungmetastasis of 4T1-tumormice.Our work gives novel insights for the bi-directionally manipulating ferroptosis in tumor and CD8^(+)T cells on TNBC chemoimmunotherapy.展开更多
Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorr...Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorrhage and vasospasm.Post injury,secondary damage is caused by ischemia,展开更多
The control of nuclear fuel manipulator crane （MC） drive system is essential for its running and other systems are designed surrounding the drive system.This paper gives a brief introduction to the composition and f...The control of nuclear fuel manipulator crane （MC） drive system is essential for its running and other systems are designed surrounding the drive system.This paper gives a brief introduction to the composition and function of MC,analyses its drive mode and control method and applies PLC to control its frequency transducer directly to help the motor work more stable.Based on the control requirements of bridge,trolley,Hoist,the control system of bridge applies a drive mode with 2-drag2 drive model on both sides and a multi-control method to realize simultaneous runningof two sides,1-drag-1 model on through-going axes and closed loop control method finish the precise location of trolley,and the using of 1-drag-1 model drive mode and closed loop control method solves the protect control difficulty of hoist which stops/starts repeatedly and changes speed.展开更多
BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair loss.AA appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis...BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair loss.AA appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune diseases.For this reason,preclinical and case studies of AA and related diseases using MSCs have been conducted.CASE SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the scalp.She was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 mo.The AA gradually improved 3 mo after the first round.The patient was cured,and AA did not recur.Case 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the scalp.She was given two rounds of MM-UC-MSCs over 1 mo.The AA immediately improved after the first round.The patient was cured,and AA did not recur.Case 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 mo.Her hair began to grow about 3 mo after the first round.The patient was cured,and alopecia universalis did not recur.CONCLUSION MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases.展开更多
BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal keratinocytes.About 2%of the world’s population suffers from psoriasis b...BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal keratinocytes.About 2%of the world’s population suffers from psoriasis but there are no clear therapeutics yet.Recently,mesenchymal stem cells(MSCs)have been regarded as a therapeutic alternative for autoimmune diseases,as they possess immunosuppressive effects without risks.Human umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity,which has many advantages in treating immune diseases.CASE SUMMARY The patient was a 47-year-old male,diagnosed with psoriasis in 1995.He had received various treatments for 25 years,but the psoriatic condition was not significantly improved.He was given three rounds of minimally manipulated umbilical cord-derived MSCs over 2 wk.The erythema gradually disappeared.Three months after the 1st round,all erythema completely disappeared,and the psoriasis did not recur.CONCLUSION Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis.展开更多
BACKGROUND Stroke is one of the major causes of disability and death worldwide.Some treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neurona...BACKGROUND Stroke is one of the major causes of disability and death worldwide.Some treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the brain.Recently,mesenchymal stem cells(MSCs)have been studied as a therapeutic alternative for stroke,and various preclinical and case studies have been reported.CASE SUMMARY A 55-year-old man suffered an acute stroke,causing paralysis in the left upper and lower limbs.He intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs(MM-UC-MSCs)twice with an 8-d interval.At 65 wk after transplantation,the patient returned to his previous occupation as a veterinarian with no adverse reactions.CONCLUSION MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke.展开更多
A single particle magneto-confined in a one-dimensional （1D） quantum wire experiences a harmonic potential, and imposing a sharply focused laser beam on an appropriate site shapes a δ potential. The theoretical inv...A single particle magneto-confined in a one-dimensional （1D） quantum wire experiences a harmonic potential, and imposing a sharply focused laser beam on an appropriate site shapes a δ potential. The theoretical investigation has demonstrated that for a sufficiently strong δ pulse the quantum motional stationary state of the particle is one of the eigenstates of the free harmonic oscillator, and it is determined by the site of the laser beam uniquely, namely a quantum state is admissible if and only if the laser site is one of its nodes. The numerical computation shows that all the nodes of the lower energy states with quantum numbers n ≤ 20, except the coordinate origin, are mutually different. So we can manipulate the multiphoton transitions between the quantum states by adjusting the position of the laser δ pulse and realize the transition from an unknown higher excitation state to a required lower energy state.展开更多
The use of magnetic nanoparticles （MNPs） for the manipulation of biological objects, including proteins, genes, cellular organelles, bacteria, cells, and organs, are reviewed. MNPs are popular candidates for control...The use of magnetic nanoparticles （MNPs） for the manipulation of biological objects, including proteins, genes, cellular organelles, bacteria, cells, and organs, are reviewed. MNPs are popular candidates for controlling and probing biological objects with a magnetic force. In the past decade, progress in the synthesis and surface engineering of MNPs has further enhanced this popularity.展开更多
The kagome ferrimagnet TbMn_(6)Sn_(6),featuring a pristine Mn kagome lattice,has emerged as a candidate Chern magnet with a large intrinsic anomalous Hall effect(AHE).While chemical substitution can modulate its prope...The kagome ferrimagnet TbMn_(6)Sn_(6),featuring a pristine Mn kagome lattice,has emerged as a candidate Chern magnet with a large intrinsic anomalous Hall effect(AHE).While chemical substitution can modulate its properties,hydrostatic pressure provides a disorder-free route to manipulate electronic and magnetic interactions.Herein,we investigate the effects of hydrostatic pressure on electrical and magneto-transport in TbMn6Sn6 up to 18.3 GPa.Pressure significantly enhances hysteresis in the magnetoresistance and Hall responses,causing a concurrent monotonic coercive field increase,suggesting the enhancement of interlayer magnetic couplings in a robust c-axis ferrimagnetic order.The intrinsic anomalous Hall conductivity increases considerably from 129.5 S·cm^(−1) at ambient pressure conditions to 448.7 S·cm^(−1) at 14.0 GPa—an enhancement of 247%that is unprecedented among pressure-tuned kagome magnets.Based on density functional theory calculations,we reveal that pressure induces multiple gap openings near the Fermi level,giving rise to pronounced Berry curvature hotspots that may contribute to the AHE.Our results show that pressure can be used to enhance the intrinsic topological responses of this kagome magnet.展开更多
Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under ext...Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment.展开更多
Professor Zhan Hongsheng(詹红生),as the national representative inheritor of Shanghai Shi’s Orthopedics and Traumatology,has led his team in long-term dedication to the research of Chinese spinal manipulative medicin...Professor Zhan Hongsheng(詹红生),as the national representative inheritor of Shanghai Shi’s Orthopedics and Traumatology,has led his team in long-term dedication to the research of Chinese spinal manipulative medicine.He has achieved outstanding accomplishments in areas such as school inheritance,theoretical construction,technological innovation,standard establishment,scientific research translation,and talent cultivation,thereby advancing the modernization,standardization,and internationalization of Chinese spinal manipulative medicine.展开更多
Single-cell biomechanics and electrophysiology measuring tools have transformed biological research over the last few decades,which enabling a comprehensive and nuanced understanding of cellular behavior and function....Single-cell biomechanics and electrophysiology measuring tools have transformed biological research over the last few decades,which enabling a comprehensive and nuanced understanding of cellular behavior and function.Despite their high-quality information content,these single-cell measuring techniques suffer from laborious manual processing by highly skilled workers and extremely low throughput(tens of cells per day).Recently,numerous researchers have automated the measurement of cell mechanical and electrical signals through robotic localization and control processes.While these efforts have demonstrated promising progress,critical challenges persist,including human dependency,learning complexity,in-situ measurement,and multidimensional signal acquisition.To identify key limitations and highlight emerging opportunities for innovation,in this review,we comprehensively summarize the key steps of robotic technologies in single-cell biomechanics and electrophysiology.We also discussed the prospects and challenges of robotics and automation in biological research.By bridging gaps between engineering,biology,and data science,this work aims to stimulate interdisciplinary research and accelerate the translation of robotic single-cell technologies into practical applications in the life sciences and medical fields.展开更多
Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limita...Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limitations of inferior transparency,unsatisfactory flexibility,and scarce functionality greatly hinder their practical applications.Here,a multifunctional,all-flexible and slef-cleaning electrothermal-actuated(SETA)module with superior transparency is developed by sandwiching the hydrophobic SiO_(2) nanoparticles decorated silver nanowires thin-film heater and the thermo-responsive hydrogel.Through loading/discharging an electric stimulus of 5 V,the optical visibility of SETA could be in situ switched between an opaque state(T_(550)=11.0%)and a transparent state(T_(550)=84.9%)relying on the dynamically collapsed and swollen transition of hydrogel on planar and three-dimensional curved surfaces.Moreover,SETA chipset is able to repel diverse liquids,including organic and inorganic species,showcasing an excellent self-cleaning capability.Lastly,all-in-one multifunctionalities,including pixelated display,thermal regulation,defogging,and self-cleaning on a single SETA chipset,are successfully deployed.Compared to the previous windows,the current SETA chipset is more competent for optical switching in reality,owing to its portable,energy-efficient,flexible,highly-transparent,and on-demand manipulating advantages.This work provides inspirations for self-cleaning greenhouse,tunable optics,intelligent vehicles,and so on.展开更多
Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response ...Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response of an underwater manipulator subjected to pulsating flow,focusing on how different postures affect the behavior of the system.The effects of pulsating parameters and manipulator arrangement on the hydrodynamic coefficient,vibration response,motion trajectory,and vortex shedding behaviors were analyzed.Results indicated that the cross flow vibration displacement in pulsating flow increased by 32.14%compared to uniform flow,inducing a shift in the motion trajectory from a crescent shape to a sideward vase shape.In the absence of interference between the upper and lower arms,the lift coefficient of the manipulator substantially increased with rising pulsating frequency,reaching a maximum increment of 67.0%.This increase in the lift coefficient led to a 67.05%rise in the vibration frequency of the manipulator in the in-line direction.As the pulsating amplitude increased,the drag coefficient of the underwater manipulator rose by 36.79%,but the vibration frequency in the cross-flow direction decreased by 56.26%.Additionally,when the upper and lower arms remained in a state of mutual interference,the cross-flow vibration amplitudes of the upper and lower arms were approximately 1.84 and 4.82 times higher in a circular-elliptical arrangement compared to an elliptical-circular arrangement,respectively.Consequently,the flow field shifted from a P+S pattern to a disordered pattern,disrupting the regularity of the motion trajectory.展开更多
Soft robotic manipulators represent a rapidly evolving field characterized by inherent compliance,adaptability,and safe interactions within unstructured environments.Over the past decade(2015-2025),significant advance...Soft robotic manipulators represent a rapidly evolving field characterized by inherent compliance,adaptability,and safe interactions within unstructured environments.Over the past decade(2015-2025),significant advancements have trans-formed their capabilities through novel designs inspired by biological systems,advanced modeling frameworks,sophisti-cated control strategies,and integration into diverse real-world applications.Recent innovations in multifunctional mate-rials and emerging actuation technologies have markedly expanded manipulator performance,reliability,and dexterity.Concurrently,developments in modeling have progressed from simplified geometric methods toward highly accurate physics-based and hybrid data-driven approaches,substantially improving real-time prediction and controllability.Coupled with these developments,adaptive and robust control strategies-including learning-based techniques-have enabled unprec-edented autonomy and precision in challenging application domains such as Minimally Invasive Surgery(MIS),precision agriculture,deep-sea exploration,disaster recovery,and space missions.Despite these remarkable strides,key challenges remain,notably regarding scalability,long-term material durability,robust integrated sensing,and standardized evaluation procedures.This review comprehensively synthesizes recent advances,critically evaluates state-of-the-art methodologies,and systematically identifies existing gaps to provide a clear roadmap and targeted research directions,guiding future developments toward the broader adoption and optimal utilization of soft robotic manipulators.展开更多
Droplet-based microfluidics have drawn much attention in recent years and have been successfully applied in biochemical analysis,material synthesis,and biomedical engineering.Precise and flexible manipulations of drop...Droplet-based microfluidics have drawn much attention in recent years and have been successfully applied in biochemical analysis,material synthesis,and biomedical engineering.Precise and flexible manipulations of droplets are the basis of various applications.Numerous techniques have been introduced to achieve on-demand control of droplets,including electric,magnetic,acoustic,optical,and thermal methods.Among these,the combination of acoustics and microfluidics(termed acoustofluidics)has shown great potential and advantages in droplet manipulation as it is non-invasive,high-precision,low-cost,easily integrated,and biocompatible.Here,we summarize recent works on acoustofluidic manipulations of droplet-based microfluidics.This paper is structured into three main sections.First,the commonly used acoustic devices in acoustofluidics and their working principles are introduced.Such acoustic devices include interdigital transducers,Lamb wave resonators,and bulk acoustic resonators,and generate acoustic waves with frequencies ranging from kilohertz to gigahertz.Second,the forces and effects involved in droplet manipulations using acoustofluidics are analyzed.Third,the manipulation processes of droplet microfluidics using various acoustofluidic techniques are summarized and compared with other methods,including droplet generation,mixing,splitting,fusion,sorting,transportation,and internal particle patterning.Finally,current challenges and future prospects for acoustofluidic manipulation techniques for droplet-based microfluidics are discussed.展开更多
The safe driving and operation of trains is a necessary condition for ensuring the safe operation of trains.In particular,heavy-haul trains are characterized by the difficulty in driving and operation.Considering the ...The safe driving and operation of trains is a necessary condition for ensuring the safe operation of trains.In particular,heavy-haul trains are characterized by the difficulty in driving and operation.Considering the uncertainties in train driving and operation,this paper analyzes the relationship between the safety of heavy-haul electric locomotive hauled trains and driving and operation.It studies the auxiliary intelligent driving safety operation control methods.Through K-means to identify the characteristics of drivers'driving manipulation,the hidden Markov model adaptively adjusts the train driving and operation sequence,and conducts auxiliary driving reconstruction for heavy-haul locomotive driving and operation.Based on the train running curve and the locomotive traction/braking characteristics,it smoothly controls the exertion of the traction/braking force of heavy-haul locomotives,thereby optimizing the driving safety control of heavy-haul trains in the vehicle-environment-track system.Finally,the train operation simulation and optimized driving verification are carried out by simulating some track sections.The results show that the proposed method can correct and pre-optimize driving operations,improving the smoothness of heavy-haul trains by approximately 10%.It verifies the effectiveness of the proposed train assisted driving control reconstruction method,facilitating the smooth and safe operation of heavy-haul trains.展开更多
Octopuses,due to their flexible arms,marvelous adaptability,and powerful suckers,are able to effortlessly grasp and disengage various objects in the marine surrounding without causing devastation.However,manipulating ...Octopuses,due to their flexible arms,marvelous adaptability,and powerful suckers,are able to effortlessly grasp and disengage various objects in the marine surrounding without causing devastation.However,manipulating delicate objects such as soft and fragile foods underwater require gentle contact and stable adhesion,which poses a serious challenge to now available soft grippers.Inspired by the sucker infundibulum structure and flexible tentacles of octopus,herein we developed a hydraulically actuated hydrogel soft gripper with adaptive maneuverability by coupling multiple hydrogen bond-mediated supramolecular hydrogels and vat polymerization three-dimensional printing,in which hydrogel bionic sucker is composed of a tunable curvature membrane,a negative pressure cavity,and a pneumatic chamber.The design of the sucker structure with the alterable curvature membrane is conducive to realize the reliable and gentle switchable adhesion of the hydrogel soft gripper.As a proof-of-concept,the adaptive hydrogel soft gripper is capable of implement diversified underwater tasks,including gingerly grasping fragile foods like egg yolks and tofu,as well as underwater robots and vehicles that station-keeping and crawling based on switchable adhesion.This study therefore provides a transformative strategy for the design of novel soft grippers that will render promising utilities for underwater exploration soft robotics.展开更多
基金supported by the National Nature Science Foundation of China(NO.82260699)the Science and Technology Leading Talents of Ningxia(NO.2022GKLRLX011)the West Light Foundation of The Chinese Academy of Sciences(the Science and Technology Department of Ningxia,Department of Science and Technology Cooperation[2021]NO.2).
文摘Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.However,the ferroptosis accompanied with down-regulation of glutathione peroxidase 4(GPX4)lead to CD36-mediated tumor-infiltrating CD8^(+)T cells uptaking fatty acids,resulting in the negative action on immunotherapeutic efficacy.Herein,the albumin nanoparticles,abbreviated as LHS NPs,were designed by co-assembly of hemin,linoleic acid-cystamine,and a CD36 inhibitor sulfosuccinimide oleate,to bi-directionally manipulated ferroptosis in tumor and CD8^(+)T cells for TNBC therapy.LHS NPs exerted more efficient reactive oxygen species generation,glutathione depletion and malondialdehyde production by the combinatory strategy of classical and non-classical ferroptosis modes,which amplified the positive action on ferroptosis in tumor cells.Meanwhile,LHS manipulated the negative action of ferroptosis by inhibiting the CD36 mediated-lipid peroxidation in CD8^(+)T cells,thereby activating the immunotherapeutic efficacy with the improvements on induction of immunogenic cell death,proliferation of CD4+CD8^(+)T cells and natural killer cells,alleviation immunosuppressive regulatory T cells and myeloid-derived suppressor cells,and repolarization of the M2-to M1-phenotype tumor-associated macrophages.Thus,LHS NPs demonstrated an improved antitumor efficacy in suppressing the tumor growth and lungmetastasis of 4T1-tumormice.Our work gives novel insights for the bi-directionally manipulating ferroptosis in tumor and CD8^(+)T cells on TNBC chemoimmunotherapy.
文摘Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorrhage and vasospasm.Post injury,secondary damage is caused by ischemia,
基金Supported by the National High Technology Research and Development Program of China(No.SQ2010AA0401265006)
文摘The control of nuclear fuel manipulator crane （MC） drive system is essential for its running and other systems are designed surrounding the drive system.This paper gives a brief introduction to the composition and function of MC,analyses its drive mode and control method and applies PLC to control its frequency transducer directly to help the motor work more stable.Based on the control requirements of bridge,trolley,Hoist,the control system of bridge applies a drive mode with 2-drag2 drive model on both sides and a multi-control method to realize simultaneous runningof two sides,1-drag-1 model on through-going axes and closed loop control method finish the precise location of trolley,and the using of 1-drag-1 model drive mode and closed loop control method solves the protect control difficulty of hoist which stops/starts repeatedly and changes speed.
文摘BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair loss.AA appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune diseases.For this reason,preclinical and case studies of AA and related diseases using MSCs have been conducted.CASE SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the scalp.She was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 mo.The AA gradually improved 3 mo after the first round.The patient was cured,and AA did not recur.Case 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the scalp.She was given two rounds of MM-UC-MSCs over 1 mo.The AA immediately improved after the first round.The patient was cured,and AA did not recur.Case 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 mo.Her hair began to grow about 3 mo after the first round.The patient was cured,and alopecia universalis did not recur.CONCLUSION MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases.
文摘BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal keratinocytes.About 2%of the world’s population suffers from psoriasis but there are no clear therapeutics yet.Recently,mesenchymal stem cells(MSCs)have been regarded as a therapeutic alternative for autoimmune diseases,as they possess immunosuppressive effects without risks.Human umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity,which has many advantages in treating immune diseases.CASE SUMMARY The patient was a 47-year-old male,diagnosed with psoriasis in 1995.He had received various treatments for 25 years,but the psoriatic condition was not significantly improved.He was given three rounds of minimally manipulated umbilical cord-derived MSCs over 2 wk.The erythema gradually disappeared.Three months after the 1st round,all erythema completely disappeared,and the psoriasis did not recur.CONCLUSION Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis.
文摘BACKGROUND Stroke is one of the major causes of disability and death worldwide.Some treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the brain.Recently,mesenchymal stem cells(MSCs)have been studied as a therapeutic alternative for stroke,and various preclinical and case studies have been reported.CASE SUMMARY A 55-year-old man suffered an acute stroke,causing paralysis in the left upper and lower limbs.He intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs(MM-UC-MSCs)twice with an 8-d interval.At 65 wk after transplantation,the patient returned to his previous occupation as a veterinarian with no adverse reactions.CONCLUSION MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke.
基金Project supported by the National Natural Science Foundation of China （Grant No 10575034）, and the Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics of China （Grant No T152504）.
文摘A single particle magneto-confined in a one-dimensional （1D） quantum wire experiences a harmonic potential, and imposing a sharply focused laser beam on an appropriate site shapes a δ potential. The theoretical investigation has demonstrated that for a sufficiently strong δ pulse the quantum motional stationary state of the particle is one of the eigenstates of the free harmonic oscillator, and it is determined by the site of the laser beam uniquely, namely a quantum state is admissible if and only if the laser site is one of its nodes. The numerical computation shows that all the nodes of the lower energy states with quantum numbers n ≤ 20, except the coordinate origin, are mutually different. So we can manipulate the multiphoton transitions between the quantum states by adjusting the position of the laser δ pulse and realize the transition from an unknown higher excitation state to a required lower energy state.
基金supported by the Nanyang Technological University Start-Up Grant, Singaporethe Singapore MOE AcRF Tier 1 Research Fund
文摘The use of magnetic nanoparticles （MNPs） for the manipulation of biological objects, including proteins, genes, cellular organelles, bacteria, cells, and organs, are reviewed. MNPs are popular candidates for controlling and probing biological objects with a magnetic force. In the past decade, progress in the synthesis and surface engineering of MNPs has further enhanced this popularity.
基金supported by the National Key R&D Program of China (Grant Nos.2023YFA1406002 and 2020YFA0308801)the National Natural Science Foundation of China (NSFC) (Grant Nos.12321004,12174025,12074041,and 12204045)+7 种基金the CAS Superconducting Research Project (Grant No.SCZX-0101)the Fundamental Research Funds for the Central Universities (Grant No.2243300003)the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0302800)supported by the Synergetic Extreme Condition User Facility (SECUF)Analysis & Testing center in Beijing Institute of Technologysupport from the Beijing Institute of Technology Research Fund Program (Grant No.2023CX01027)support from the Beijing Institute of Technology Research Fund Program for Young Scholarssupport from the Beijing Institute of Technology Laboratory Research Project (Grant No.2023BITSYB07)。
文摘The kagome ferrimagnet TbMn_(6)Sn_(6),featuring a pristine Mn kagome lattice,has emerged as a candidate Chern magnet with a large intrinsic anomalous Hall effect(AHE).While chemical substitution can modulate its properties,hydrostatic pressure provides a disorder-free route to manipulate electronic and magnetic interactions.Herein,we investigate the effects of hydrostatic pressure on electrical and magneto-transport in TbMn6Sn6 up to 18.3 GPa.Pressure significantly enhances hysteresis in the magnetoresistance and Hall responses,causing a concurrent monotonic coercive field increase,suggesting the enhancement of interlayer magnetic couplings in a robust c-axis ferrimagnetic order.The intrinsic anomalous Hall conductivity increases considerably from 129.5 S·cm^(−1) at ambient pressure conditions to 448.7 S·cm^(−1) at 14.0 GPa—an enhancement of 247%that is unprecedented among pressure-tuned kagome magnets.Based on density functional theory calculations,we reveal that pressure induces multiple gap openings near the Fermi level,giving rise to pronounced Berry curvature hotspots that may contribute to the AHE.Our results show that pressure can be used to enhance the intrinsic topological responses of this kagome magnet.
基金financial support of the National Key R&D Program of China(Grant Nos.2024YFB4607402 and 2016YFA0200500)National Natural Science Foundation of China(NSFC,Grant Nos.61975213,61475164 and 61205194)International Partnership Program of Chinese Academy of Sciences(GJHZ2021130)。
文摘Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment.
文摘Professor Zhan Hongsheng(詹红生),as the national representative inheritor of Shanghai Shi’s Orthopedics and Traumatology,has led his team in long-term dedication to the research of Chinese spinal manipulative medicine.He has achieved outstanding accomplishments in areas such as school inheritance,theoretical construction,technological innovation,standard establishment,scientific research translation,and talent cultivation,thereby advancing the modernization,standardization,and internationalization of Chinese spinal manipulative medicine.
基金the National Natural Science Foundation of China[62525301,62127811,62433019]the New Cornerstone Science Foundation through the XPLORER PRIZEthe financial support by the China Postdoctoral Science Foundation[GZB20240797].
文摘Single-cell biomechanics and electrophysiology measuring tools have transformed biological research over the last few decades,which enabling a comprehensive and nuanced understanding of cellular behavior and function.Despite their high-quality information content,these single-cell measuring techniques suffer from laborious manual processing by highly skilled workers and extremely low throughput(tens of cells per day).Recently,numerous researchers have automated the measurement of cell mechanical and electrical signals through robotic localization and control processes.While these efforts have demonstrated promising progress,critical challenges persist,including human dependency,learning complexity,in-situ measurement,and multidimensional signal acquisition.To identify key limitations and highlight emerging opportunities for innovation,in this review,we comprehensively summarize the key steps of robotic technologies in single-cell biomechanics and electrophysiology.We also discussed the prospects and challenges of robotics and automation in biological research.By bridging gaps between engineering,biology,and data science,this work aims to stimulate interdisciplinary research and accelerate the translation of robotic single-cell technologies into practical applications in the life sciences and medical fields.
基金supported by the National Key Research and Development Program of China(Grant No.2024YFB4610700)the Fundamental Research Funds for the Central Universities(Grant No.JZ2025HGTG0269)+4 种基金the National Natural Science Foundation of China(Grant Nos.52005475,62305321)the Natural Science Foundation of Anhui Province(Grant Nos.JZ2024AKZR0561,2308085QE167)Major Scientific and Technological Projects in Anhui Province(Grant No.202203a05020014)Opening Project of the Key Laboratory of Bionic Engineering(Ministry of Education)Jilin University(Grant No.K202204)。
文摘Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limitations of inferior transparency,unsatisfactory flexibility,and scarce functionality greatly hinder their practical applications.Here,a multifunctional,all-flexible and slef-cleaning electrothermal-actuated(SETA)module with superior transparency is developed by sandwiching the hydrophobic SiO_(2) nanoparticles decorated silver nanowires thin-film heater and the thermo-responsive hydrogel.Through loading/discharging an electric stimulus of 5 V,the optical visibility of SETA could be in situ switched between an opaque state(T_(550)=11.0%)and a transparent state(T_(550)=84.9%)relying on the dynamically collapsed and swollen transition of hydrogel on planar and three-dimensional curved surfaces.Moreover,SETA chipset is able to repel diverse liquids,including organic and inorganic species,showcasing an excellent self-cleaning capability.Lastly,all-in-one multifunctionalities,including pixelated display,thermal regulation,defogging,and self-cleaning on a single SETA chipset,are successfully deployed.Compared to the previous windows,the current SETA chipset is more competent for optical switching in reality,owing to its portable,energy-efficient,flexible,highly-transparent,and on-demand manipulating advantages.This work provides inspirations for self-cleaning greenhouse,tunable optics,intelligent vehicles,and so on.
基金Supported by the National Natural Science Foundation of China(No.51905211)A Project of the“20 Regulations for New Universities”Funding Program of Jinan(No.202228116).
文摘Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response of an underwater manipulator subjected to pulsating flow,focusing on how different postures affect the behavior of the system.The effects of pulsating parameters and manipulator arrangement on the hydrodynamic coefficient,vibration response,motion trajectory,and vortex shedding behaviors were analyzed.Results indicated that the cross flow vibration displacement in pulsating flow increased by 32.14%compared to uniform flow,inducing a shift in the motion trajectory from a crescent shape to a sideward vase shape.In the absence of interference between the upper and lower arms,the lift coefficient of the manipulator substantially increased with rising pulsating frequency,reaching a maximum increment of 67.0%.This increase in the lift coefficient led to a 67.05%rise in the vibration frequency of the manipulator in the in-line direction.As the pulsating amplitude increased,the drag coefficient of the underwater manipulator rose by 36.79%,but the vibration frequency in the cross-flow direction decreased by 56.26%.Additionally,when the upper and lower arms remained in a state of mutual interference,the cross-flow vibration amplitudes of the upper and lower arms were approximately 1.84 and 4.82 times higher in a circular-elliptical arrangement compared to an elliptical-circular arrangement,respectively.Consequently,the flow field shifted from a P+S pattern to a disordered pattern,disrupting the regularity of the motion trajectory.
基金Open access funding provided by The Science,Technology&Innovation Funding Authority(STDF)in cooperation with The Egyptian Knowledge Bank(EKB).
文摘Soft robotic manipulators represent a rapidly evolving field characterized by inherent compliance,adaptability,and safe interactions within unstructured environments.Over the past decade(2015-2025),significant advancements have trans-formed their capabilities through novel designs inspired by biological systems,advanced modeling frameworks,sophisti-cated control strategies,and integration into diverse real-world applications.Recent innovations in multifunctional mate-rials and emerging actuation technologies have markedly expanded manipulator performance,reliability,and dexterity.Concurrently,developments in modeling have progressed from simplified geometric methods toward highly accurate physics-based and hybrid data-driven approaches,substantially improving real-time prediction and controllability.Coupled with these developments,adaptive and robust control strategies-including learning-based techniques-have enabled unprec-edented autonomy and precision in challenging application domains such as Minimally Invasive Surgery(MIS),precision agriculture,deep-sea exploration,disaster recovery,and space missions.Despite these remarkable strides,key challenges remain,notably regarding scalability,long-term material durability,robust integrated sensing,and standardized evaluation procedures.This review comprehensively synthesizes recent advances,critically evaluates state-of-the-art methodologies,and systematically identifies existing gaps to provide a clear roadmap and targeted research directions,guiding future developments toward the broader adoption and optimal utilization of soft robotic manipulators.
基金financial support from the National Natural Science Foundation of China(NSFC):Grant Nos.22427807 and 62174119Tianjin National Key Laboratory Major Project No.24ZXZSSS00290.
文摘Droplet-based microfluidics have drawn much attention in recent years and have been successfully applied in biochemical analysis,material synthesis,and biomedical engineering.Precise and flexible manipulations of droplets are the basis of various applications.Numerous techniques have been introduced to achieve on-demand control of droplets,including electric,magnetic,acoustic,optical,and thermal methods.Among these,the combination of acoustics and microfluidics(termed acoustofluidics)has shown great potential and advantages in droplet manipulation as it is non-invasive,high-precision,low-cost,easily integrated,and biocompatible.Here,we summarize recent works on acoustofluidic manipulations of droplet-based microfluidics.This paper is structured into three main sections.First,the commonly used acoustic devices in acoustofluidics and their working principles are introduced.Such acoustic devices include interdigital transducers,Lamb wave resonators,and bulk acoustic resonators,and generate acoustic waves with frequencies ranging from kilohertz to gigahertz.Second,the forces and effects involved in droplet manipulations using acoustofluidics are analyzed.Third,the manipulation processes of droplet microfluidics using various acoustofluidic techniques are summarized and compared with other methods,including droplet generation,mixing,splitting,fusion,sorting,transportation,and internal particle patterning.Finally,current challenges and future prospects for acoustofluidic manipulation techniques for droplet-based microfluidics are discussed.
基金Project(U2034211)supported by the National Natural Science Foundation of ChinaProject(20232ACE01013)supported by the Major Scientific and Technological Research and Development Special Project of Jiangxi Province,China。
文摘The safe driving and operation of trains is a necessary condition for ensuring the safe operation of trains.In particular,heavy-haul trains are characterized by the difficulty in driving and operation.Considering the uncertainties in train driving and operation,this paper analyzes the relationship between the safety of heavy-haul electric locomotive hauled trains and driving and operation.It studies the auxiliary intelligent driving safety operation control methods.Through K-means to identify the characteristics of drivers'driving manipulation,the hidden Markov model adaptively adjusts the train driving and operation sequence,and conducts auxiliary driving reconstruction for heavy-haul locomotive driving and operation.Based on the train running curve and the locomotive traction/braking characteristics,it smoothly controls the exertion of the traction/braking force of heavy-haul locomotives,thereby optimizing the driving safety control of heavy-haul trains in the vehicle-environment-track system.Finally,the train operation simulation and optimized driving verification are carried out by simulating some track sections.The results show that the proposed method can correct and pre-optimize driving operations,improving the smoothness of heavy-haul trains by approximately 10%.It verifies the effectiveness of the proposed train assisted driving control reconstruction method,facilitating the smooth and safe operation of heavy-haul trains.
基金the financial support from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0470303)the National Key Research and Development Program of China (2022YFB4600101)+5 种基金the National Natural Science Foundation of China (52175201)the Research Program of Science and Technology Department of Gansu Province (24JRRA059, 24JRRA044, and 24YFFA014)the Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai (AMGM2024F12)the Major Program (ZYFZFX-2) of the Lanzhou Institute of Chemical Physics, CASthe Special Research Assistant Project of the Chinese Academy of Sciencesthe Oasis Scholar of Shihezi University
文摘Octopuses,due to their flexible arms,marvelous adaptability,and powerful suckers,are able to effortlessly grasp and disengage various objects in the marine surrounding without causing devastation.However,manipulating delicate objects such as soft and fragile foods underwater require gentle contact and stable adhesion,which poses a serious challenge to now available soft grippers.Inspired by the sucker infundibulum structure and flexible tentacles of octopus,herein we developed a hydraulically actuated hydrogel soft gripper with adaptive maneuverability by coupling multiple hydrogen bond-mediated supramolecular hydrogels and vat polymerization three-dimensional printing,in which hydrogel bionic sucker is composed of a tunable curvature membrane,a negative pressure cavity,and a pneumatic chamber.The design of the sucker structure with the alterable curvature membrane is conducive to realize the reliable and gentle switchable adhesion of the hydrogel soft gripper.As a proof-of-concept,the adaptive hydrogel soft gripper is capable of implement diversified underwater tasks,including gingerly grasping fragile foods like egg yolks and tofu,as well as underwater robots and vehicles that station-keeping and crawling based on switchable adhesion.This study therefore provides a transformative strategy for the design of novel soft grippers that will render promising utilities for underwater exploration soft robotics.
