Hi,everyone!I started loving economics and money when I was only seven.When I was nine,I tried managing money for the fi rst time.I learned a lot from itmaybe even more than I learn in school!It all began after I read...Hi,everyone!I started loving economics and money when I was only seven.When I was nine,I tried managing money for the fi rst time.I learned a lot from itmaybe even more than I learn in school!It all began after I read a book about how kids can succeed with money.I felt excited and asked my mom for some money to start.She gave me 5,000 yuan.I spent a lot of time learning online about investing and saving.One day,I found something called online financial management,and I wanted to try it.展开更多
Colonoscopy represents a safe procedure that is widely used in medical practice either to diagnose or treat various gastrointestinal diseases.During the last few years,the incidence rate of perforations in colonoscopi...Colonoscopy represents a safe procedure that is widely used in medical practice either to diagnose or treat various gastrointestinal diseases.During the last few years,the incidence rate of perforations in colonoscopic procedures has increased,especially in therapeutic colonoscopies.The recent advancements in endoscopic techniques and gastrointestinal tumoral resection procedures such as endoscopic mucosal resection,endoscopic full-thickness resection,and endoscopic submucosal dissection(ESD)could be a risk factor for this increased risk.The incidence rate of mortality of serious colonoscopic perforations is 7.1%.The management plan for these perforations starts with conservative treatment in mild cases,endoscopic closure,and surgical management in severe cases.Recently,endoluminal vacuum therapy was found to be effective in the management of colorectal perforations and this has been reported in multiple case reports.This editorial provides an overview of the current guidelines for the management of iatrogenic colorectal perforations.These insights are from the perspectives of endoscopists and gastroenterologists.We also present a management algorithm based on the guidelines of the European Society of Gastrointestinal Endoscopy,the American Gastroenterological Association,and the World Society of Emergency Surgery.We also discussed in brief the use of endoluminal vacuum therapy in colorectal perforations.展开更多
Machine picking in cotton is an emerging practice in India,to solve the problems of labour shortages and production costs increasing.Cotton production has been declining in recent years;however,the high density planti...Machine picking in cotton is an emerging practice in India,to solve the problems of labour shortages and production costs increasing.Cotton production has been declining in recent years;however,the high density planting system(HDPS)offers a viable method to enhance productivity by increasing plant populations per unit area,optimizing resource utilization,and facilitating machine picking.Cotton is an indeterminate plant that produce excessive vegeta-tive growth in favorable soil fertility and moisture conditions,which posing challenges for efficient machine picking.To address this issue,the application of plant growth retardants(PGRs)is essential for controlling canopy architecture.PGRs reduce internode elongation,promote regulated branching,and increase plant compactness,making cotton plants better suited for machine picking.PGRs application also optimizes photosynthates distribution between veg-etative and reproductive growth,resulting in higher yields and improved fibre quality.The integration of HDPS and PGRs applications results in an optimal plant architecture for improving machine picking efficiency.However,the success of this integration is determined by some factors,including cotton variety,environmental conditions,and geographical variations.These approaches not only address yield stagnation and labour shortages but also help to establish more effective and sustainable cotton farming practices,resulting in higher cotton productivity.展开更多
Artificial intelligence(AI)is transforming gastroenterology by enhancing diagnostic accuracy,enabling personalized treatment,and improving disease management efficiency.This review explored the evolution and applicati...Artificial intelligence(AI)is transforming gastroenterology by enhancing diagnostic accuracy,enabling personalized treatment,and improving disease management efficiency.This review explored the evolution and application of core AI technologies,including machine learning,deep learning,and neural networks,that underpin modern computational advancements in the field.These tools have demonstrated significant success in detecting premalignant and malignant lesions and in managing gastrointestinal bleeding,colorectal cancer,and Helicobacter pylori infection.AI also supports the diagnosis and treatment of liver and pancreatic diseases.Its use is expanding in functional gastrointestinal disorders such as irritable bowel syndrome with emerging applications in pediatric gastroenterology.In addition AI enables advanced risk stratification and addresses persistent challenges in conventional diagnostic and therapeutic approaches,including interobserver variability and inefficiencies in care delivery.However,integration into routine clinical practice faces several barriers,including data privacy concerns,algorithmic bias,limited model interpretability,regulatory gaps,and interoperability issues with existing healthcare infrastructure.Future directions include real-time procedural guidance,multi-omic prediction models,minimally invasive surgical automation,and drug discovery.Achieving the full potential of AI will require ethical governance,regulatory clarity,and sustained interdisciplinary collaboration.展开更多
In this editorial,we discuss the article by Singh et al published in World Journal of Nephrology,stating the need for timely adjustments in inflammatory bowel disease(IBD)patients'long-term management plans.IBD is...In this editorial,we discuss the article by Singh et al published in World Journal of Nephrology,stating the need for timely adjustments in inflammatory bowel disease(IBD)patients'long-term management plans.IBD is chronic and lifelong,with recurrence and remission cycles,including ulcerative colitis and Crohn's disease.It's exact etiology is unknown but likely multifactorial.Related to gut flora and immune issues.Besides intestinal symptoms,IBD can also affect various extrain-testinal manifestations such as those involving the skin,joints,eyes and urinary system.The anatomical proximity of urinary system waste disposal to that of the alimentary canal makes early detection and the differentiation of such symptoms very difficult.Various studies show that IBD and it's first-line drugs have nephro-toxicity,impacting the patients'life quality.Existing guidelines give very few references for kidney lesion monitoring.Singh et al's plan aims to improve treatment management for IBD patients with glomerular filtration rate decline,specifically those at risk.Most of IBD patients are young and they need lifelong therapy.So early therapy cessation,taking into account drug side effects,can be helpful.Artificial intelligence-driven diagnosis and treatment has a big potential for management improvements in IBD and other chronic diseases.展开更多
BACKGROUND Children with autism spectrum disorder(ASD)face unique challenges in maintaining oral health due to sensory sensitivities,communication difficulties,and behavioral barriers.These factors,along with limited ...BACKGROUND Children with autism spectrum disorder(ASD)face unique challenges in maintaining oral health due to sensory sensitivities,communication difficulties,and behavioral barriers.These factors,along with limited access to ASD-trained dental professionals,increase their risk of dental caries,periodontal disease,bruxism,and other oral health issues.Despite growing awareness of these challenges,a comprehensive synthesis of evidence-based solutions remains lacking.AIM To review synthesizes existing research on dental problems in ASD,barriers to care,management strategies,and future directions for improved oral health outcomes.METHODS A systematic search of PubMed,Cochrane Library,and Scopus was conducted using predefined search terms.Related to ASD,dental health,and management strategies.Inclusion criteria encompassed studies focusing on children with ASD,dental health issues,and interventions.Data extraction included study design,participant characteristics,key findings,and intervention outcomes.The quality of studies was assessed using appropriate tools such as the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale.A narrative synthesis approach,incorporating thematic analysis,was utilized to evaluate the findings.RESULTS A total of 165 studies met the inclusion criteria.Children with ASD exhibited a higher prevalence of dental caries,gingivitis,bruxism,and malocclusion compared to neurotypical peers.Barriers to dental care included sensory sensitivities,communication difficulties,financial constraints,and a shortage of ASD-trained dental professionals.Effective interventions included desensitization programs,behavioral therapy,digital applications,and interdiscip-linary collaboration.Parental education and professional training were crucial for improving oral health outcomes.CONCLUSION Tailored dental care strategies,including sensory adaptations,behavioral interventions,and interdisciplinary collaboration,are essential for children with ASD.Standardized guidelines and long-term studies are needed to refine evidence-based protocols.Future research should explore digital interventions and probiotic applications in ASD dental care.展开更多
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)management requires sustainable lifestyle modifications.This study aimed to evaluate the effectiveness of the RESET care plan,a comprehensive program that is an integ...BACKGROUND Non-alcoholic fatty liver disease(NAFLD)management requires sustainable lifestyle modifications.This study aimed to evaluate the effectiveness of the RESET care plan,a comprehensive program that is an integrated personalized diet,exercise,and cognitive behavior therapy,delivered via MyTatva’s digital health application enabled through a body composition analyzer(BCA)and smartwatch.AIM To evaluates the effectiveness of the comprehensive program delivered via My-Tatva’s digital health app enabled through internet of thing devices.METHODS This retrospective observational study analyzed deidentified data from 22 par-ticipants enrolled in the MyTatva RESET care program.Participants were divided into three groups:Group A,diet plan;Group B,diet+exercise plan;and Group C,diet+exercise+cognitive behavioral therapy plan.Participants were provided with a BCA and smartwatch for continuous monitoring of anthropometric para-meters.Statistical analysis,including one-way ANOVA and post-hoc Tukey’s Honest Significant Difference test,was conducted to compare mean changes in anthropometric parameters across the groups.INTRODUCTION Non-alcoholic fatty liver disease(NAFLD)has emerged as a global health burden,affecting approximately 1 in 4 in-dividuals worldwide.NAFLD ranges from simple steatosis(fat accumulation)to non-alcoholic steatohepatitis(NASH),and its global prevalence in the general population is estimated between 6.3%and 33%,with NASH affecting 3-5%[1,2].Obesity is a major risk factor of NAFLD,with studies showing that the likelihood of developing NAFLD increases 5-fold at a body mass index(BMI)of 30-32.5 kg/m²and up to 14-fold at BMI of 37.5-40 kg/m²compared to a BMI of 20-22.5 kg/m²[3,4].Effective NAFLD management requires both dietary and physical activity modifications.Healthy weight loss with sustained muscle mass plays a pivotal role,with a reduction of 3%-5%decreasing hepatic steatosis,5%-7%improving NASH conditions,and 10%or more needed to reverse hepatic fibrosis[5].Management also normalizes elevated liver enzymes(aspartate aminotransferase and alanine aminotransferase),enhances insulin sensitivity,and thereby reduces cardiovascular risk by improving endothelial function and increasing cardiorespiratory fitness[6].However,diet or exercise alone is often not as effective as a combined approach.Integrating both balanced dietary changes and increased physical activity yields more sustainable improvements in NAFLD and overall metabolic health[1,7].Traditional intervention methods usually involve in-person consultations,which often lack real-time and continuous patient monitoring.The recommendation of drastic changes in diet and exercise can also be overwhelming for patients,leading to low adherence rates.Many patients struggle to maintain these changes in the long-term due to a lack of con-tinuous motivational support[8,9].In recent years,the health ecosystem has witnessed a significant shift toward digital health platforms,which complement pharmacological treatments in chronic disease management,and increase scala-bility.These platforms provide continuous monitoring and personalized support,helping to bridge the gap between health care setups and patients[10].Recent digital advances enable internet of things(IoT)devices to be integrated into such management plans to track health metrics,to address the limitations of traditional methods[11,12].The MyTatva digital health application offers the RESET plan,a novel comprehensive approach for NAFLD mana-gement by integrating personalized support from nutrition,physiotherapy,and cognitive behavioral therapy(CBT)coaches.We aimed to evaluate the effectiveness of the RESET plan by analyzing the reduction in anthropometric para-meters across three different digital intervention groups.展开更多
Managing the value of the organization is taking place based on factors forming it. It is becoming possible thanks to such managing operations of the organization, when in the end an image in accordance with expectati...Managing the value of the organization is taking place based on factors forming it. It is becoming possible thanks to such managing operations of the organization, when in the end an image in accordance with expectations, giving the state back to the value of organizations is being got. Creating the goodwill is based among others on immaterial factors, which although they are becoming impossible to include in balance, are taken hold in time value of the organization. Creation of the value of an organization may be based on the organizational culture. The article presents the essence of value management and organization characterized the factors affecting the formation of organizational culture, ways of dealing with an organization aimed at consolidating and strengthening the organizational culture. Sometimes organizations feel the need to change the culture in order to achieve increased efficiency and ensure the success of the company to implement the necessary changes. Therefore, the rest of this article presents the elements to ensure a smooth implementation and consolidation of cultural change.展开更多
The reduction of wasteful variation within the supp ly chain is naturally suited to high and stable volumes, as epitomised in the lean practices of the automotive industry. However, with the growth of innovative pr od...The reduction of wasteful variation within the supp ly chain is naturally suited to high and stable volumes, as epitomised in the lean practices of the automotive industry. However, with the growth of innovative pr oducts, typically characterised by lower volumes and uncertain demand, it is als o important to develop strategies to effectively manage the externally imposed v ariation resulting from volatile market demand. Such strategies often come under the banner of quick response or agile supply. System variation is the common denominator, for whereas lean strategies emphasis e the need for stability and the reduction of wasteful supply chain variation, a gile emphasises the need to respond to externally imposed demand variation. Simi larly, lean supply is closely associated with level scheduling and investing in inventory to decouple demand variation from the supply chain, whereas, agile sup ply is associated with investing in responsive capacity as inventory requirement s cannot be effectively predicted. This distinction between lean and agile supply, highlights a trade-off between investing in responsive capacity and decoupling inventory, which is closely related to the conflicting manufacturing tasks of fast response and low cost. The implications of this conflict have been more widely felt in recent years, as companies have opted to outsource manufacture to low cost overseas suppliers. T he rationale is to reduce manufacturing costs, but the trade-off is a dramatic loss of responsive capacity with higher dependency on decoupling inventory. As with lean and agile supply, the trade-off implications of such choices need to be acknowledged, conceptually understood and then separate out or otherwise r esolved. This paper introduces the business need before exploring the significance of var iation and the concept of managing variation in a delivery system using responsi ve capacity and decoupling inventory. These concepts will then be used to unpack the lean and agile paradigms before applying the thinking to a more detailed in dustrial case concerning offshore supply decisions. The paper concludes with som e reflections.展开更多
The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transport...The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter （DAT）, the diffusion of DA and its metabolism by mono-amine oxidase （MAO） and cate- chol-O-methyl transferase （COMT）. DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis （Popolo et al., 2004; Reimer et al., 2013） and neuroregeneration （Hoglinger et al., 2004; Yang et al., 2008）. These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.展开更多
The research topic of this article"Managing and measuring business networks in Russia"has been under consideration in three successive research projects oriented to Russian business to business(B2B)networks....The research topic of this article"Managing and measuring business networks in Russia"has been under consideration in three successive research projects oriented to Russian business to business(B2B)networks.The projects have been accomplished by HAMK,VTT Technical Research Centre of Finland,and Tampere University of Technology(TUT).Russian experts from The Higher School of Economics in Moscow and the Graduate School of Management in St.Petersburg were involved in these projects.We asked how managing and measuring B2B networks should be developed,when a company becomes established to Russian market.Both qualitative and quantitative analytical methods were used.Results concerning performance measurement presented in this article are based on data which was collected using survey and a questionnaire.Methodical triangulation was carried out as both research instruments produced 17 full answers for questions concerning performance measurement.Wider results are based on about 200 face-to-face interviews and answers for questionnaires.Results indicate that in Russia the management and leadership models as well as the company performance measurement should be adjusted to Russian traditions.Networked companies have difficulties in applying matrix type organizations in Russia,as management practices are based traditionally on authoritarian leadership.However,clear and specific targets should be set for projects and strategic business areas.Targets and bonuses should be agreed on with managers and staff throughout the company and the business network.Personal networks,within project stake-holders,have more emphasis in Russia than in Finland,because personal relations to authorities',and organizations are needed at every stage of the project.Therefore,managing SMEs working in B2B networks is challenging in Russia.In this article,a method for setting and implementing strategic targets for a business networked company is presented.Understanding networked performance measurement indicators will enable successful business for all networked partners in the long tenn.展开更多
Floods have always had and will continue to have significant consequences for society. In May 2014, there was widespread flooding in the Balkans affecting Bosnia and Herzegovina, Croatia and Serbia. The aim of this ar...Floods have always had and will continue to have significant consequences for society. In May 2014, there was widespread flooding in the Balkans affecting Bosnia and Herzegovina, Croatia and Serbia. The aim of this article is to show that resilient and proactive health systems that anticipate needs and challenges are more likely to reduce risks and respond effectively during emergencies, saving lives and alleviating human suffering. The method draws on multiple sources of information, including a Balkan case study questionnaire survey with public health professionals involved in response to floods (n = 18) from three affected countries, and focus group discussion results (n = 43) presented at the meeting on “Prevention, preparedness and response to reduce or avoid health effects of flood events”, held in Bonn, Germany, in October 2015. The proposed range of measures to protect population health, organized around flood prevention, preparedness, response and recovery listed issues and considerations largely corresponds to the identified needs by Member State requests, following the Balkan country experiences. The consideration of lessons for early warning, preparedness and response and the integration of research results would lead to improved preparedness measures to better prevent flooding risks. Experiences in the WHO European Region point to a need to shift the emphasis from disaster response to long-term risk management.展开更多
In Indonesia, open unemployment until August 2011 was 7,700,086. Although this number has decreased compared with the number of unemployed in February 2011, which is 8,117,631, but the decline is not very significant....In Indonesia, open unemployment until August 2011 was 7,700,086. Although this number has decreased compared with the number of unemployed in February 2011, which is 8,117,631, but the decline is not very significant. Unemployment occurs because labor forces are not absorbed into employment. One way to reduce unemployment is to open their own employment or become entrepreneurs. In fact, the government of Indonesia has made some efforts to the growth of new entrepreneurs, for example, by providing funding for student entrepreneurship program to a number of universities in Indonesia. However, efforts by the government are useless if there is no intention in the individual itself, and there are five factors driving intention in entrepreneurship, which invest, creativity, market opportunity, autonomy, status. Meanwhile, some researchers have conducted research about factor which driving the entrepreneurial intention. The result of that research shows that the most encouraging factor is the creativity. However, creativity must be managed properly in order to give optimal results This article wants to analyze the management of creativity among entrepreneurs in order to give optimal results. The research was conducted among young entrepreneurs, which are still a college student or had graduated from college. The total informants for this research are five informants from three private universities/colleges. This research used interview to collect data. This study attempted to process qualitative data obtained from interviews with young entrepreneurs. The result of this research is all of the respondents use some techniques to maintain and enhance creativity, such as ＂allow you to creative＂, ＂think out of the box＂, and ＂be persistent＂. From the findings of this study, it also can be seen that the young entrepreneurs are able to overcome the barriers to creativity, ＂believing that I am not creative＇展开更多
WHENEVER high-level conversations turn to national or regional strategies for managing water-related climate impacts,many are compelled to look again and again to China as a model for imagining and then creating a sus...WHENEVER high-level conversations turn to national or regional strategies for managing water-related climate impacts,many are compelled to look again and again to China as a model for imagining and then creating a sustainable future for all of humanity.Why?Because as China goes,so goes the world.展开更多
Facing the challenges of an increasing world population, a changing climate and ever depleting resources, agricultural intensification （Keating et al. 2010） is one of the few options for meeting the demand of food s...Facing the challenges of an increasing world population, a changing climate and ever depleting resources, agricultural intensification （Keating et al. 2010） is one of the few options for meeting the demand of food security. It is necessary to apply a dynamic and systematic approach to effectively man- age the complex agri-eco production and green processing systems. Indeed, farming systems approach for appropriate technology development and simulation modeling is a result of adopting the system thinking by the agricultural research community （Norman et al. 1995）.展开更多
If we want to enhance the medical level of modern hospital,we not only need to make the career morality and professional capability of the medical staff,but also require the perfection of the governance institution of...If we want to enhance the medical level of modern hospital,we not only need to make the career morality and professional capability of the medical staff,but also require the perfection of the governance institution of hospital in accordance with the development of society.That said,the medical staff will provide the patients with the best service,which is significant to the development of hospital.In addition,every hospital should conduct deepening reform of public hospital comprehensively to respond to call of the government.And the hospital should also put forward professional and comprehensive managing system based on the concrete conditions of the hospital.That is how the hospital can serve the people better.That said,this article focuses on how to promote the system of managing the modern hospital.展开更多
A creating effective strategic alliance is a useful method for the global expansion of intemational companies and managing strategic alliances is an important research project to the success of strategic alliances. Th...A creating effective strategic alliance is a useful method for the global expansion of intemational companies and managing strategic alliances is an important research project to the success of strategic alliances. This paper focuses on the practical problems of strategic alliances in China and explores how to manage such alliances. This research aims to introduce the basic background of strategic alliances, analyze the primary reason for the current situation of strategic alliances, and discuss the advantages and disadvantages of strategic alliances, then give the successful factors managing strategic alliances and discuss what should be done in future research about strategic alliances.展开更多
文摘Hi,everyone!I started loving economics and money when I was only seven.When I was nine,I tried managing money for the fi rst time.I learned a lot from itmaybe even more than I learn in school!It all began after I read a book about how kids can succeed with money.I felt excited and asked my mom for some money to start.She gave me 5,000 yuan.I spent a lot of time learning online about investing and saving.One day,I found something called online financial management,and I wanted to try it.
文摘Colonoscopy represents a safe procedure that is widely used in medical practice either to diagnose or treat various gastrointestinal diseases.During the last few years,the incidence rate of perforations in colonoscopic procedures has increased,especially in therapeutic colonoscopies.The recent advancements in endoscopic techniques and gastrointestinal tumoral resection procedures such as endoscopic mucosal resection,endoscopic full-thickness resection,and endoscopic submucosal dissection(ESD)could be a risk factor for this increased risk.The incidence rate of mortality of serious colonoscopic perforations is 7.1%.The management plan for these perforations starts with conservative treatment in mild cases,endoscopic closure,and surgical management in severe cases.Recently,endoluminal vacuum therapy was found to be effective in the management of colorectal perforations and this has been reported in multiple case reports.This editorial provides an overview of the current guidelines for the management of iatrogenic colorectal perforations.These insights are from the perspectives of endoscopists and gastroenterologists.We also present a management algorithm based on the guidelines of the European Society of Gastrointestinal Endoscopy,the American Gastroenterological Association,and the World Society of Emergency Surgery.We also discussed in brief the use of endoluminal vacuum therapy in colorectal perforations.
文摘Machine picking in cotton is an emerging practice in India,to solve the problems of labour shortages and production costs increasing.Cotton production has been declining in recent years;however,the high density planting system(HDPS)offers a viable method to enhance productivity by increasing plant populations per unit area,optimizing resource utilization,and facilitating machine picking.Cotton is an indeterminate plant that produce excessive vegeta-tive growth in favorable soil fertility and moisture conditions,which posing challenges for efficient machine picking.To address this issue,the application of plant growth retardants(PGRs)is essential for controlling canopy architecture.PGRs reduce internode elongation,promote regulated branching,and increase plant compactness,making cotton plants better suited for machine picking.PGRs application also optimizes photosynthates distribution between veg-etative and reproductive growth,resulting in higher yields and improved fibre quality.The integration of HDPS and PGRs applications results in an optimal plant architecture for improving machine picking efficiency.However,the success of this integration is determined by some factors,including cotton variety,environmental conditions,and geographical variations.These approaches not only address yield stagnation and labour shortages but also help to establish more effective and sustainable cotton farming practices,resulting in higher cotton productivity.
文摘Artificial intelligence(AI)is transforming gastroenterology by enhancing diagnostic accuracy,enabling personalized treatment,and improving disease management efficiency.This review explored the evolution and application of core AI technologies,including machine learning,deep learning,and neural networks,that underpin modern computational advancements in the field.These tools have demonstrated significant success in detecting premalignant and malignant lesions and in managing gastrointestinal bleeding,colorectal cancer,and Helicobacter pylori infection.AI also supports the diagnosis and treatment of liver and pancreatic diseases.Its use is expanding in functional gastrointestinal disorders such as irritable bowel syndrome with emerging applications in pediatric gastroenterology.In addition AI enables advanced risk stratification and addresses persistent challenges in conventional diagnostic and therapeutic approaches,including interobserver variability and inefficiencies in care delivery.However,integration into routine clinical practice faces several barriers,including data privacy concerns,algorithmic bias,limited model interpretability,regulatory gaps,and interoperability issues with existing healthcare infrastructure.Future directions include real-time procedural guidance,multi-omic prediction models,minimally invasive surgical automation,and drug discovery.Achieving the full potential of AI will require ethical governance,regulatory clarity,and sustained interdisciplinary collaboration.
文摘In this editorial,we discuss the article by Singh et al published in World Journal of Nephrology,stating the need for timely adjustments in inflammatory bowel disease(IBD)patients'long-term management plans.IBD is chronic and lifelong,with recurrence and remission cycles,including ulcerative colitis and Crohn's disease.It's exact etiology is unknown but likely multifactorial.Related to gut flora and immune issues.Besides intestinal symptoms,IBD can also affect various extrain-testinal manifestations such as those involving the skin,joints,eyes and urinary system.The anatomical proximity of urinary system waste disposal to that of the alimentary canal makes early detection and the differentiation of such symptoms very difficult.Various studies show that IBD and it's first-line drugs have nephro-toxicity,impacting the patients'life quality.Existing guidelines give very few references for kidney lesion monitoring.Singh et al's plan aims to improve treatment management for IBD patients with glomerular filtration rate decline,specifically those at risk.Most of IBD patients are young and they need lifelong therapy.So early therapy cessation,taking into account drug side effects,can be helpful.Artificial intelligence-driven diagnosis and treatment has a big potential for management improvements in IBD and other chronic diseases.
文摘BACKGROUND Children with autism spectrum disorder(ASD)face unique challenges in maintaining oral health due to sensory sensitivities,communication difficulties,and behavioral barriers.These factors,along with limited access to ASD-trained dental professionals,increase their risk of dental caries,periodontal disease,bruxism,and other oral health issues.Despite growing awareness of these challenges,a comprehensive synthesis of evidence-based solutions remains lacking.AIM To review synthesizes existing research on dental problems in ASD,barriers to care,management strategies,and future directions for improved oral health outcomes.METHODS A systematic search of PubMed,Cochrane Library,and Scopus was conducted using predefined search terms.Related to ASD,dental health,and management strategies.Inclusion criteria encompassed studies focusing on children with ASD,dental health issues,and interventions.Data extraction included study design,participant characteristics,key findings,and intervention outcomes.The quality of studies was assessed using appropriate tools such as the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale.A narrative synthesis approach,incorporating thematic analysis,was utilized to evaluate the findings.RESULTS A total of 165 studies met the inclusion criteria.Children with ASD exhibited a higher prevalence of dental caries,gingivitis,bruxism,and malocclusion compared to neurotypical peers.Barriers to dental care included sensory sensitivities,communication difficulties,financial constraints,and a shortage of ASD-trained dental professionals.Effective interventions included desensitization programs,behavioral therapy,digital applications,and interdiscip-linary collaboration.Parental education and professional training were crucial for improving oral health outcomes.CONCLUSION Tailored dental care strategies,including sensory adaptations,behavioral interventions,and interdisciplinary collaboration,are essential for children with ASD.Standardized guidelines and long-term studies are needed to refine evidence-based protocols.Future research should explore digital interventions and probiotic applications in ASD dental care.
文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)management requires sustainable lifestyle modifications.This study aimed to evaluate the effectiveness of the RESET care plan,a comprehensive program that is an integrated personalized diet,exercise,and cognitive behavior therapy,delivered via MyTatva’s digital health application enabled through a body composition analyzer(BCA)and smartwatch.AIM To evaluates the effectiveness of the comprehensive program delivered via My-Tatva’s digital health app enabled through internet of thing devices.METHODS This retrospective observational study analyzed deidentified data from 22 par-ticipants enrolled in the MyTatva RESET care program.Participants were divided into three groups:Group A,diet plan;Group B,diet+exercise plan;and Group C,diet+exercise+cognitive behavioral therapy plan.Participants were provided with a BCA and smartwatch for continuous monitoring of anthropometric para-meters.Statistical analysis,including one-way ANOVA and post-hoc Tukey’s Honest Significant Difference test,was conducted to compare mean changes in anthropometric parameters across the groups.INTRODUCTION Non-alcoholic fatty liver disease(NAFLD)has emerged as a global health burden,affecting approximately 1 in 4 in-dividuals worldwide.NAFLD ranges from simple steatosis(fat accumulation)to non-alcoholic steatohepatitis(NASH),and its global prevalence in the general population is estimated between 6.3%and 33%,with NASH affecting 3-5%[1,2].Obesity is a major risk factor of NAFLD,with studies showing that the likelihood of developing NAFLD increases 5-fold at a body mass index(BMI)of 30-32.5 kg/m²and up to 14-fold at BMI of 37.5-40 kg/m²compared to a BMI of 20-22.5 kg/m²[3,4].Effective NAFLD management requires both dietary and physical activity modifications.Healthy weight loss with sustained muscle mass plays a pivotal role,with a reduction of 3%-5%decreasing hepatic steatosis,5%-7%improving NASH conditions,and 10%or more needed to reverse hepatic fibrosis[5].Management also normalizes elevated liver enzymes(aspartate aminotransferase and alanine aminotransferase),enhances insulin sensitivity,and thereby reduces cardiovascular risk by improving endothelial function and increasing cardiorespiratory fitness[6].However,diet or exercise alone is often not as effective as a combined approach.Integrating both balanced dietary changes and increased physical activity yields more sustainable improvements in NAFLD and overall metabolic health[1,7].Traditional intervention methods usually involve in-person consultations,which often lack real-time and continuous patient monitoring.The recommendation of drastic changes in diet and exercise can also be overwhelming for patients,leading to low adherence rates.Many patients struggle to maintain these changes in the long-term due to a lack of con-tinuous motivational support[8,9].In recent years,the health ecosystem has witnessed a significant shift toward digital health platforms,which complement pharmacological treatments in chronic disease management,and increase scala-bility.These platforms provide continuous monitoring and personalized support,helping to bridge the gap between health care setups and patients[10].Recent digital advances enable internet of things(IoT)devices to be integrated into such management plans to track health metrics,to address the limitations of traditional methods[11,12].The MyTatva digital health application offers the RESET plan,a novel comprehensive approach for NAFLD mana-gement by integrating personalized support from nutrition,physiotherapy,and cognitive behavioral therapy(CBT)coaches.We aimed to evaluate the effectiveness of the RESET plan by analyzing the reduction in anthropometric para-meters across three different digital intervention groups.
文摘Managing the value of the organization is taking place based on factors forming it. It is becoming possible thanks to such managing operations of the organization, when in the end an image in accordance with expectations, giving the state back to the value of organizations is being got. Creating the goodwill is based among others on immaterial factors, which although they are becoming impossible to include in balance, are taken hold in time value of the organization. Creation of the value of an organization may be based on the organizational culture. The article presents the essence of value management and organization characterized the factors affecting the formation of organizational culture, ways of dealing with an organization aimed at consolidating and strengthening the organizational culture. Sometimes organizations feel the need to change the culture in order to achieve increased efficiency and ensure the success of the company to implement the necessary changes. Therefore, the rest of this article presents the elements to ensure a smooth implementation and consolidation of cultural change.
文摘The reduction of wasteful variation within the supp ly chain is naturally suited to high and stable volumes, as epitomised in the lean practices of the automotive industry. However, with the growth of innovative pr oducts, typically characterised by lower volumes and uncertain demand, it is als o important to develop strategies to effectively manage the externally imposed v ariation resulting from volatile market demand. Such strategies often come under the banner of quick response or agile supply. System variation is the common denominator, for whereas lean strategies emphasis e the need for stability and the reduction of wasteful supply chain variation, a gile emphasises the need to respond to externally imposed demand variation. Simi larly, lean supply is closely associated with level scheduling and investing in inventory to decouple demand variation from the supply chain, whereas, agile sup ply is associated with investing in responsive capacity as inventory requirement s cannot be effectively predicted. This distinction between lean and agile supply, highlights a trade-off between investing in responsive capacity and decoupling inventory, which is closely related to the conflicting manufacturing tasks of fast response and low cost. The implications of this conflict have been more widely felt in recent years, as companies have opted to outsource manufacture to low cost overseas suppliers. T he rationale is to reduce manufacturing costs, but the trade-off is a dramatic loss of responsive capacity with higher dependency on decoupling inventory. As with lean and agile supply, the trade-off implications of such choices need to be acknowledged, conceptually understood and then separate out or otherwise r esolved. This paper introduces the business need before exploring the significance of var iation and the concept of managing variation in a delivery system using responsi ve capacity and decoupling inventory. These concepts will then be used to unpack the lean and agile paradigms before applying the thinking to a more detailed in dustrial case concerning offshore supply decisions. The paper concludes with som e reflections.
文摘The mechanisms for the regulation of synaptic dopamine （DA） include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter （DAT）, the diffusion of DA and its metabolism by mono-amine oxidase （MAO） and cate- chol-O-methyl transferase （COMT）. DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis （Popolo et al., 2004; Reimer et al., 2013） and neuroregeneration （Hoglinger et al., 2004; Yang et al., 2008）. These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.
基金TEKES--the Finnish Funding Agency for Technology and Innovation(2006-2009)also Regional Council of Paijät-Häme by applying the South Finland ERDF Programme allocation for ROCKET-project(2010-2012).
文摘The research topic of this article"Managing and measuring business networks in Russia"has been under consideration in three successive research projects oriented to Russian business to business(B2B)networks.The projects have been accomplished by HAMK,VTT Technical Research Centre of Finland,and Tampere University of Technology(TUT).Russian experts from The Higher School of Economics in Moscow and the Graduate School of Management in St.Petersburg were involved in these projects.We asked how managing and measuring B2B networks should be developed,when a company becomes established to Russian market.Both qualitative and quantitative analytical methods were used.Results concerning performance measurement presented in this article are based on data which was collected using survey and a questionnaire.Methodical triangulation was carried out as both research instruments produced 17 full answers for questions concerning performance measurement.Wider results are based on about 200 face-to-face interviews and answers for questionnaires.Results indicate that in Russia the management and leadership models as well as the company performance measurement should be adjusted to Russian traditions.Networked companies have difficulties in applying matrix type organizations in Russia,as management practices are based traditionally on authoritarian leadership.However,clear and specific targets should be set for projects and strategic business areas.Targets and bonuses should be agreed on with managers and staff throughout the company and the business network.Personal networks,within project stake-holders,have more emphasis in Russia than in Finland,because personal relations to authorities',and organizations are needed at every stage of the project.Therefore,managing SMEs working in B2B networks is challenging in Russia.In this article,a method for setting and implementing strategic targets for a business networked company is presented.Understanding networked performance measurement indicators will enable successful business for all networked partners in the long tenn.
文摘Floods have always had and will continue to have significant consequences for society. In May 2014, there was widespread flooding in the Balkans affecting Bosnia and Herzegovina, Croatia and Serbia. The aim of this article is to show that resilient and proactive health systems that anticipate needs and challenges are more likely to reduce risks and respond effectively during emergencies, saving lives and alleviating human suffering. The method draws on multiple sources of information, including a Balkan case study questionnaire survey with public health professionals involved in response to floods (n = 18) from three affected countries, and focus group discussion results (n = 43) presented at the meeting on “Prevention, preparedness and response to reduce or avoid health effects of flood events”, held in Bonn, Germany, in October 2015. The proposed range of measures to protect population health, organized around flood prevention, preparedness, response and recovery listed issues and considerations largely corresponds to the identified needs by Member State requests, following the Balkan country experiences. The consideration of lessons for early warning, preparedness and response and the integration of research results would lead to improved preparedness measures to better prevent flooding risks. Experiences in the WHO European Region point to a need to shift the emphasis from disaster response to long-term risk management.
文摘In Indonesia, open unemployment until August 2011 was 7,700,086. Although this number has decreased compared with the number of unemployed in February 2011, which is 8,117,631, but the decline is not very significant. Unemployment occurs because labor forces are not absorbed into employment. One way to reduce unemployment is to open their own employment or become entrepreneurs. In fact, the government of Indonesia has made some efforts to the growth of new entrepreneurs, for example, by providing funding for student entrepreneurship program to a number of universities in Indonesia. However, efforts by the government are useless if there is no intention in the individual itself, and there are five factors driving intention in entrepreneurship, which invest, creativity, market opportunity, autonomy, status. Meanwhile, some researchers have conducted research about factor which driving the entrepreneurial intention. The result of that research shows that the most encouraging factor is the creativity. However, creativity must be managed properly in order to give optimal results This article wants to analyze the management of creativity among entrepreneurs in order to give optimal results. The research was conducted among young entrepreneurs, which are still a college student or had graduated from college. The total informants for this research are five informants from three private universities/colleges. This research used interview to collect data. This study attempted to process qualitative data obtained from interviews with young entrepreneurs. The result of this research is all of the respondents use some techniques to maintain and enhance creativity, such as ＂allow you to creative＂, ＂think out of the box＂, and ＂be persistent＂. From the findings of this study, it also can be seen that the young entrepreneurs are able to overcome the barriers to creativity, ＂believing that I am not creative＇
文摘WHENEVER high-level conversations turn to national or regional strategies for managing water-related climate impacts,many are compelled to look again and again to China as a model for imagining and then creating a sustainable future for all of humanity.Why?Because as China goes,so goes the world.
文摘Facing the challenges of an increasing world population, a changing climate and ever depleting resources, agricultural intensification （Keating et al. 2010） is one of the few options for meeting the demand of food security. It is necessary to apply a dynamic and systematic approach to effectively man- age the complex agri-eco production and green processing systems. Indeed, farming systems approach for appropriate technology development and simulation modeling is a result of adopting the system thinking by the agricultural research community （Norman et al. 1995）.
文摘If we want to enhance the medical level of modern hospital,we not only need to make the career morality and professional capability of the medical staff,but also require the perfection of the governance institution of hospital in accordance with the development of society.That said,the medical staff will provide the patients with the best service,which is significant to the development of hospital.In addition,every hospital should conduct deepening reform of public hospital comprehensively to respond to call of the government.And the hospital should also put forward professional and comprehensive managing system based on the concrete conditions of the hospital.That is how the hospital can serve the people better.That said,this article focuses on how to promote the system of managing the modern hospital.
文摘A creating effective strategic alliance is a useful method for the global expansion of intemational companies and managing strategic alliances is an important research project to the success of strategic alliances. This paper focuses on the practical problems of strategic alliances in China and explores how to manage such alliances. This research aims to introduce the basic background of strategic alliances, analyze the primary reason for the current situation of strategic alliances, and discuss the advantages and disadvantages of strategic alliances, then give the successful factors managing strategic alliances and discuss what should be done in future research about strategic alliances.
