SaintMalo,a historic French port on the English Channel coast,is famous for having the highest tides in Europe,with breakwater defenses barely keeping giant waves from hitting residential buildings.Seeing SaintMalo at...SaintMalo,a historic French port on the English Channel coast,is famous for having the highest tides in Europe,with breakwater defenses barely keeping giant waves from hitting residential buildings.Seeing SaintMalo at low tide and then again at high tide is like looking at two completely different towns.The buildings and the way they are laid out are the same,but the existence of a beach as wide as the eye can see at one point,and the complete lack thereof just a few hours later,is truly strange.And not only does the ocean come in hard at high tide,but it's strong as well,with giant waves pounding against the waterfront and splashing up to the tops of exposed buildings.展开更多
Steatotic liver disease(SLD)is an emerging liver disease,whereas chronic viral hepatitis is the renowned cause of chronic liver disease leading to cirrhosis and hepatocellular carcinoma(HCC).The impact of coexisting S...Steatotic liver disease(SLD)is an emerging liver disease,whereas chronic viral hepatitis is the renowned cause of chronic liver disease leading to cirrhosis and hepatocellular carcinoma(HCC).The impact of coexisting SLD in chronic hepatitis B(CHB)on liverrelated events(LREs)in the long term is still debated.This study aims to compare all-cause mortality and LRE between CHB patients with and without SLD.This retrospective study included CHB patients who underwent transient elastography between 2014 and 2021 at a tertiary-care hospital.Exclusion criteria were those without controlled attenuated parameter(CAP)results,interquartile range/median of liver stiffness measurement(LSM)>30%,follow-up time<6 months,and without hepatitis B virus DNA data during follow-up.SLD was defined as CAP≥248 dB/m,significant liver fibrosis(SF)as LSM≥7 kPa,and cirrhosis as LSM≥11 kPa or imaging evidence.LRE was defined as the development of HCC and/or cirrhosis complications.Among 532 patients(median follow-up 4.3 years),SLD was present in 161(30.2%)patients,SF was found in 186(34.5%)patients,and 104(19.6%)patients had cirrhosis at baseline.SF was insignificantly more common in SLD patients(40.1%vs 32.4%,P=0.068).Long-term outcomes showed SF,not SLD,was independently associated with higher LRE development with an adjusted HR of 13.85(95%confidence interval[CI]:3.06-62.76,P<0.001),while the adjusted HR of SLD was 0.49(95%CI:0.16-1.53,P=0.22).In conclusion,SLD commonly coexists with CHB patients.CHB patients with SLD were more likely to have SF at baseline,albeit not significantly.Long-term HCC and cirrhosis complications development are associated with SF but not SLD status.展开更多
文摘SaintMalo,a historic French port on the English Channel coast,is famous for having the highest tides in Europe,with breakwater defenses barely keeping giant waves from hitting residential buildings.Seeing SaintMalo at low tide and then again at high tide is like looking at two completely different towns.The buildings and the way they are laid out are the same,but the existence of a beach as wide as the eye can see at one point,and the complete lack thereof just a few hours later,is truly strange.And not only does the ocean come in hard at high tide,but it's strong as well,with giant waves pounding against the waterfront and splashing up to the tops of exposed buildings.
基金funded by the Gastroenterological Association of Thailand.
文摘Steatotic liver disease(SLD)is an emerging liver disease,whereas chronic viral hepatitis is the renowned cause of chronic liver disease leading to cirrhosis and hepatocellular carcinoma(HCC).The impact of coexisting SLD in chronic hepatitis B(CHB)on liverrelated events(LREs)in the long term is still debated.This study aims to compare all-cause mortality and LRE between CHB patients with and without SLD.This retrospective study included CHB patients who underwent transient elastography between 2014 and 2021 at a tertiary-care hospital.Exclusion criteria were those without controlled attenuated parameter(CAP)results,interquartile range/median of liver stiffness measurement(LSM)>30%,follow-up time<6 months,and without hepatitis B virus DNA data during follow-up.SLD was defined as CAP≥248 dB/m,significant liver fibrosis(SF)as LSM≥7 kPa,and cirrhosis as LSM≥11 kPa or imaging evidence.LRE was defined as the development of HCC and/or cirrhosis complications.Among 532 patients(median follow-up 4.3 years),SLD was present in 161(30.2%)patients,SF was found in 186(34.5%)patients,and 104(19.6%)patients had cirrhosis at baseline.SF was insignificantly more common in SLD patients(40.1%vs 32.4%,P=0.068).Long-term outcomes showed SF,not SLD,was independently associated with higher LRE development with an adjusted HR of 13.85(95%confidence interval[CI]:3.06-62.76,P<0.001),while the adjusted HR of SLD was 0.49(95%CI:0.16-1.53,P=0.22).In conclusion,SLD commonly coexists with CHB patients.CHB patients with SLD were more likely to have SF at baseline,albeit not significantly.Long-term HCC and cirrhosis complications development are associated with SF but not SLD status.
