Background: Research has shown that high-sensitivity C-reactive protein (hs-CRP) is a major inflammatory marker for prediction of acute coronary syndrome (ACS). Myeloperoxidase (MPO) also plays an important role in at...Background: Research has shown that high-sensitivity C-reactive protein (hs-CRP) is a major inflammatory marker for prediction of acute coronary syndrome (ACS). Myeloperoxidase (MPO) also plays an important role in atherosclerosis initiation and development. In present study, the major adverse cardiovascular events (MACEs) of patients with coronary heart disease (CHD) were investigated. Methods: MPO, hs-CRP and ACS-related risk factors from 201 ACS (78 AMI and 123 UAP) and 210 non-ACS (84 SAP and 126 non-CHD) patients confirmed by coronary angiography were detected, and the data were analyzed with receiver operating characteristic (ROC) curve and Spearman’s correlation coefficients. MACEs of 285 CHD patients were investigated during the 4-year period follow-up from March 2010 to May 2014. Results: The areas under ROC curve for diagnosing ACS were 0.888 (95% CI 0.843 - 0.933) for MPO, and 0.862 (95% CI 0.815-0.910) for hs-CRP, respectively. There were significantly correlations between MPO and hs-CRP in both ACS and non-ACS groups. Regarding to ACS patients, both MPO and hs-CRP were positively correlated with BMI, TC, TG, LDL-C and Hcy. Prospective study demonstrated that the incidences of MACEs associated significantly with elevated MPO baseline level (yes vs no, OR 7.383, 95% CI 4.095 - 13.309) and high hs-CRP baseline level (yes vs no, OR 4.186, 95% CI 2.469 - 7.097) in CHD patients. Conclusions: The present study provides the epidemiological evidence that elevated baseline MPO and hs-CRP levels are both valuable predictors of MACEs in CHD patients. MPO and hs-CRP would prompt the progression of atherosclerosis and development from SAP to ACS.展开更多
Resistin is a member of the family of cysteine-rich secretary proteins called resistin-like molecules (RELMs). It is suggested to be involved in inflammatory conditions and atherosclerosis. We have established a signi...Resistin is a member of the family of cysteine-rich secretary proteins called resistin-like molecules (RELMs). It is suggested to be involved in inflammatory conditions and atherosclerosis. We have established a significant correlation between serum resistin levels and coronary artery disease (CAD) in a study was performed between 2011 and 2012 in our institute in two hundred fourteen patients (164 CAD patients and 50 controls). Then the CAD patients were followed up to investigate the relationship between increased serum resistin levels and major adverse cardiac events (MACE) between 2012 and 2016. One hundred fifty-five of 164 patients (95%) were followed up and 9 patients lost to follow up. There were 39 MACE (25%) in four years of follow-up.?There were 16 in-hospital deaths due to cardiac causes, 8 revascularization procedures, and 15 re-hospitalization due to acute coronary syndrome (ACS) or heart failure (HF). The patients with MACE had similar serum resistin level (median: 71.37 pg/ml) compared to patients without MACE (median: 80.23 pg/ml) (p > 0.05).展开更多
Based on an analysis of major recent social events in China,such as the 2008 Beijing Olympic Games,2010 Shanghai World Expo,2014 Nanjing Youth Olympic Games,and 2014 Beijing Asia Pacific Economic Cooperation Conferenc...Based on an analysis of major recent social events in China,such as the 2008 Beijing Olympic Games,2010 Shanghai World Expo,2014 Nanjing Youth Olympic Games,and 2014 Beijing Asia Pacific Economic Cooperation Conference,mandatory,temporary,and indemnificatory quantitative policies aimed at protecting air quality,which were carried out by both central and local governments,made substantial contributions to changes and improvements in air quality.To some extent,the findings show that command and control measures play a significant role in protecting air quality,while the law and economic and voluntary environmental safeguard measures do not during major social events.Therefore,it reminds us the air quality could and will improve not only during major social events but also in the regular days if we implement appropriate environmental policies and safeguard measures.展开更多
目的探讨动态心电图参数联合心肌梗死溶栓疗法(TIMI)危险评分对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后发生主要不良心血管事件(MACE)的预测价值。方法选取2021年7月至2024年6月于连云港市第一人民医院就诊的S...目的探讨动态心电图参数联合心肌梗死溶栓疗法(TIMI)危险评分对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后发生主要不良心血管事件(MACE)的预测价值。方法选取2021年7月至2024年6月于连云港市第一人民医院就诊的STEMI患者119例,根据术后1年随访期内是否发生MACE分为发生组(24例)和未发生组(95例)。比较两组一般临床资料、动态心电图参数;采用多因素Logistic回归分析STEMI患者PCI术后发生MACE的影响因素;采用ROC曲线分析动态心电图参数[包括24 h QT间期变异性(24 h QTV)、窦性心搏RR间期的标准差(SDNN)等]、TIMI危险评分对STEMI患者PCI术后发生MACE的预测价值。结果发生组年龄、Killip心功能分级≥Ⅱ级、TIMI危险评分高于未发生组(P<0.05)。发生组24 h QTV、SDNN水平低于未发生组(P<0.001)。多因素Logistic回归分析显示,年龄、TIMI危险评分是STEMI患者PCI术后发生MACE的独立危险因素,24 h QTV、SDNN是STEMI患者PCI术后发生MACE的独立保护因素(OR=2.098,95%CI:1.022~4.307,P=0.044;OR=2.869,95%CI:1.267~6.497,P=0.012;OR=0.355,95%CI:0.159~0.795,P=0.012;OR=0.376,95%CI:0.174~0.813,P=0.013)。ROC曲线分析显示,24 h QTV、SDNN、TIMI危险评分预测STEMI患者PCI术后发生MACE的曲线下面积分别为0.762、0.740、0.761,联合检测预测的曲线下面积为0.930,显著优于单独检测(P<0.05)。结论动态心电图参数24 h QTV、SDNN及TIMI危险评分均是STEMI患者PCI术后发生MACE的独立影响因素,联合检测可较好地预测STEMI患者PCI术后MACE的发生。展开更多
文摘Background: Research has shown that high-sensitivity C-reactive protein (hs-CRP) is a major inflammatory marker for prediction of acute coronary syndrome (ACS). Myeloperoxidase (MPO) also plays an important role in atherosclerosis initiation and development. In present study, the major adverse cardiovascular events (MACEs) of patients with coronary heart disease (CHD) were investigated. Methods: MPO, hs-CRP and ACS-related risk factors from 201 ACS (78 AMI and 123 UAP) and 210 non-ACS (84 SAP and 126 non-CHD) patients confirmed by coronary angiography were detected, and the data were analyzed with receiver operating characteristic (ROC) curve and Spearman’s correlation coefficients. MACEs of 285 CHD patients were investigated during the 4-year period follow-up from March 2010 to May 2014. Results: The areas under ROC curve for diagnosing ACS were 0.888 (95% CI 0.843 - 0.933) for MPO, and 0.862 (95% CI 0.815-0.910) for hs-CRP, respectively. There were significantly correlations between MPO and hs-CRP in both ACS and non-ACS groups. Regarding to ACS patients, both MPO and hs-CRP were positively correlated with BMI, TC, TG, LDL-C and Hcy. Prospective study demonstrated that the incidences of MACEs associated significantly with elevated MPO baseline level (yes vs no, OR 7.383, 95% CI 4.095 - 13.309) and high hs-CRP baseline level (yes vs no, OR 4.186, 95% CI 2.469 - 7.097) in CHD patients. Conclusions: The present study provides the epidemiological evidence that elevated baseline MPO and hs-CRP levels are both valuable predictors of MACEs in CHD patients. MPO and hs-CRP would prompt the progression of atherosclerosis and development from SAP to ACS.
文摘Resistin is a member of the family of cysteine-rich secretary proteins called resistin-like molecules (RELMs). It is suggested to be involved in inflammatory conditions and atherosclerosis. We have established a significant correlation between serum resistin levels and coronary artery disease (CAD) in a study was performed between 2011 and 2012 in our institute in two hundred fourteen patients (164 CAD patients and 50 controls). Then the CAD patients were followed up to investigate the relationship between increased serum resistin levels and major adverse cardiac events (MACE) between 2012 and 2016. One hundred fifty-five of 164 patients (95%) were followed up and 9 patients lost to follow up. There were 39 MACE (25%) in four years of follow-up.?There were 16 in-hospital deaths due to cardiac causes, 8 revascularization procedures, and 15 re-hospitalization due to acute coronary syndrome (ACS) or heart failure (HF). The patients with MACE had similar serum resistin level (median: 71.37 pg/ml) compared to patients without MACE (median: 80.23 pg/ml) (p > 0.05).
基金sponsored by National Social Science Fund [grant number 13&ZD172]
文摘Based on an analysis of major recent social events in China,such as the 2008 Beijing Olympic Games,2010 Shanghai World Expo,2014 Nanjing Youth Olympic Games,and 2014 Beijing Asia Pacific Economic Cooperation Conference,mandatory,temporary,and indemnificatory quantitative policies aimed at protecting air quality,which were carried out by both central and local governments,made substantial contributions to changes and improvements in air quality.To some extent,the findings show that command and control measures play a significant role in protecting air quality,while the law and economic and voluntary environmental safeguard measures do not during major social events.Therefore,it reminds us the air quality could and will improve not only during major social events but also in the regular days if we implement appropriate environmental policies and safeguard measures.
文摘目的探讨动态心电图参数联合心肌梗死溶栓疗法(TIMI)危险评分对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后发生主要不良心血管事件(MACE)的预测价值。方法选取2021年7月至2024年6月于连云港市第一人民医院就诊的STEMI患者119例,根据术后1年随访期内是否发生MACE分为发生组(24例)和未发生组(95例)。比较两组一般临床资料、动态心电图参数;采用多因素Logistic回归分析STEMI患者PCI术后发生MACE的影响因素;采用ROC曲线分析动态心电图参数[包括24 h QT间期变异性(24 h QTV)、窦性心搏RR间期的标准差(SDNN)等]、TIMI危险评分对STEMI患者PCI术后发生MACE的预测价值。结果发生组年龄、Killip心功能分级≥Ⅱ级、TIMI危险评分高于未发生组(P<0.05)。发生组24 h QTV、SDNN水平低于未发生组(P<0.001)。多因素Logistic回归分析显示,年龄、TIMI危险评分是STEMI患者PCI术后发生MACE的独立危险因素,24 h QTV、SDNN是STEMI患者PCI术后发生MACE的独立保护因素(OR=2.098,95%CI:1.022~4.307,P=0.044;OR=2.869,95%CI:1.267~6.497,P=0.012;OR=0.355,95%CI:0.159~0.795,P=0.012;OR=0.376,95%CI:0.174~0.813,P=0.013)。ROC曲线分析显示,24 h QTV、SDNN、TIMI危险评分预测STEMI患者PCI术后发生MACE的曲线下面积分别为0.762、0.740、0.761,联合检测预测的曲线下面积为0.930,显著优于单独检测(P<0.05)。结论动态心电图参数24 h QTV、SDNN及TIMI危险评分均是STEMI患者PCI术后发生MACE的独立影响因素,联合检测可较好地预测STEMI患者PCI术后MACE的发生。
