When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene express...When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).展开更多
In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily ...In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.展开更多
On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings...On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings are obtained. The results gained by caleulation in the paper are consistent with that measured in the field. And this provides a basis for the roadway sidepacking support design.展开更多
Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the q...Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.展开更多
In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.
Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at t...Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.展开更多
With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chines...With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).展开更多
Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade ...Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade depends on optimal recognition of tumor cells through the activation of receptors on antitumor effector immune cells,such as CD8^(+)T cells and NK cells.Therefore,sufficient and maintained expression levels of activating receptors on these effector immune cells are essential for antitumor immunity and checkpoint blockade immunotherapy.展开更多
Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formu...Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formula φ_N(x) in the展开更多
Tooth morphogenesis is orchestrated by a complex interplay of signaling pathways and transcription factors that control cell proliferation,apoptosis,and differentiation,with the Wnt/β-catenin signaling pathway playin...Tooth morphogenesis is orchestrated by a complex interplay of signaling pathways and transcription factors that control cell proliferation,apoptosis,and differentiation,with the Wnt/β-catenin signaling pathway playing a pivotal role.However,the comprehensive regulatory mechanisms of Wnt/β-catenin signaling remain largely unclear.Smad7,a key antagonist of the TGF-βsuperfamily,is essential for maintaining tissue homeostasis and ensuring proper cellular function.Our previous study has demonstrated that Smad7 knockout in mice leads to impaired proliferative property of tooth germ cells,resulting in small molars.Here,we identified SMAD7 expression in human dental papilla and dental pulp,colocalized with β-CATENIN and cell proliferationrelated proteins.RNA sequencing analysis revealed a significant reduction in Wnt signaling activity in Smad7-deficient mouse tooth germs.Using lentivirus transfection,we established SMAD7-knockdown human dental papilla stem cells,which manifested remarkably blunt proliferation rate,along with diminished Wnt signaling activity.In vivo transplantation investigations further revealed the indispensable role of SMAD7 in dentin formation.Mechanistically,we revealed that β-CATENIN interacts with P-SMAD2/3 and SMAD7 through co-immunoprecipitation and yeast two-hybrid assays.Inhibition of TGF-β pathway or disruption of SMAD7/β-CATENIN transcription factor complex formation potently impacted Wnt/β-catenin activities,indicating both direct and indirect regulatory mechanisms.These findings highlight the critical role of SMAD7 in the proliferation and diffe rentiation of human dental stem cells,which could contribute to dental tissue regeneration and engineering.展开更多
Microglia cells are the resident innate immune cells of the central nervous system(CNS)(Paolicelli et al.,2022).They play a pivotal role in CNS development and in maintaining homeostasis during adulthood.Microglia are...Microglia cells are the resident innate immune cells of the central nervous system(CNS)(Paolicelli et al.,2022).They play a pivotal role in CNS development and in maintaining homeostasis during adulthood.Microglia are being extensively studied for their involvement in CNS disorders,ranging from autoimmune diseases such as multiple sclerosis to neurodegenerative and psychiatric conditions,as well as stroke and brain tumors(Paolicelli et al.,2022).展开更多
The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. Th...The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.展开更多
Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for sign...Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.展开更多
In the year 2010,the exports and imports of Chinese textile machinery maintained rapid growth,owing to the industrial upgrading and a strong recovery in demand.
In 2007,the national economy kept steady and fast growth with the features of rapid economic growth,optimized structure,increased efficiency and improved livelihood of the people. According to preliminary estimation,t...In 2007,the national economy kept steady and fast growth with the features of rapid economic growth,optimized structure,increased efficiency and improved livelihood of the people. According to preliminary estimation,the gross domestic product (GDP)for the year was 24,661.9 billion yuan,up by 11.4 percent,or 0.3 percentage point higher than that in the previous year,represent-展开更多
HUNAN Province at one time was known as Chudi, which means the land of Chu. Every year, when the floods would come to Chudi, the local people would carry their stores out of the high mountains using a technique they c...HUNAN Province at one time was known as Chudi, which means the land of Chu. Every year, when the floods would come to Chudi, the local people would carry their stores out of the high mountains using a technique they called "fang pai," or rafting. It took about six months to carry a raftload of goods down the mountain,展开更多
As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Bene...As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Benefiting from a flurry of consumption-stimulating policies and measures,China’s online retail sales surpassed RMB 14 trillion in the January-November period,a year-on-year increase of 7.4 percent.Imports and exports maintained steady growth,climbing by 4.9 percent year-on-year in renminbi terms.Value-added industrial output also expanded 5.8 percent year-on-year.The volume of express delivery parcels reached a new high of 150 billion and is expected to grow higher still given the new-year festivities ahead.展开更多
The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastr...The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastructure construction,mineral resource development,and agriculture.The two sides have maintained a high degree of political mutual trust and have cooperated closely in international affairs.Cultural exchanges and people-to-people contacts have expanded,and both nations continue to work together to further deepen their partnership.展开更多
China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history....China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history.The Beijing Summit of the Forum on China-Africa Cooperation(FOCAC),held in September 2024,elevated bilateral ties between China and African countries with diplomatic relations with China to a strategic level.It also redefined China-Africa relations as an“all-weather China-Africa community with a shared future for the new era.”This signifies that China and Africa will remain steadfast friends and close development partners,regardless of changes in the international landscape.展开更多
China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s....China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s.The past decade has witnessed steadily improving relations between the two countries.Their cultural exchange,especially in theatrical arts,has become increasingly fruitful in three distinct ways.展开更多
基金supported by the National Key R&D Program of China(2019YFA0802501)the National Natural Science Foundation of China(31770843,31971231)。
文摘When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).
文摘In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.
文摘On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings are obtained. The results gained by caleulation in the paper are consistent with that measured in the field. And this provides a basis for the roadway sidepacking support design.
文摘Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.
文摘In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.
文摘Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.
文摘With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).
基金This work was supported by the National Key R&D Program of China(2020YFA0710802)the Natural Science Foundation of China(reference number 82071768).
文摘Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade depends on optimal recognition of tumor cells through the activation of receptors on antitumor effector immune cells,such as CD8^(+)T cells and NK cells.Therefore,sufficient and maintained expression levels of activating receptors on these effector immune cells are essential for antitumor immunity and checkpoint blockade immunotherapy.
文摘Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formula φ_N(x) in the
基金supported by the National Key Research and Development Program of China to W.Tian (2022YFA1104400)the National Natural Science Foundation of China to T.Chen (82100959)a grant from the Sichuan Science and Technology Program to Z.Liu (2024YFFK0068)。
文摘Tooth morphogenesis is orchestrated by a complex interplay of signaling pathways and transcription factors that control cell proliferation,apoptosis,and differentiation,with the Wnt/β-catenin signaling pathway playing a pivotal role.However,the comprehensive regulatory mechanisms of Wnt/β-catenin signaling remain largely unclear.Smad7,a key antagonist of the TGF-βsuperfamily,is essential for maintaining tissue homeostasis and ensuring proper cellular function.Our previous study has demonstrated that Smad7 knockout in mice leads to impaired proliferative property of tooth germ cells,resulting in small molars.Here,we identified SMAD7 expression in human dental papilla and dental pulp,colocalized with β-CATENIN and cell proliferationrelated proteins.RNA sequencing analysis revealed a significant reduction in Wnt signaling activity in Smad7-deficient mouse tooth germs.Using lentivirus transfection,we established SMAD7-knockdown human dental papilla stem cells,which manifested remarkably blunt proliferation rate,along with diminished Wnt signaling activity.In vivo transplantation investigations further revealed the indispensable role of SMAD7 in dentin formation.Mechanistically,we revealed that β-CATENIN interacts with P-SMAD2/3 and SMAD7 through co-immunoprecipitation and yeast two-hybrid assays.Inhibition of TGF-β pathway or disruption of SMAD7/β-CATENIN transcription factor complex formation potently impacted Wnt/β-catenin activities,indicating both direct and indirect regulatory mechanisms.These findings highlight the critical role of SMAD7 in the proliferation and diffe rentiation of human dental stem cells,which could contribute to dental tissue regeneration and engineering.
文摘Microglia cells are the resident innate immune cells of the central nervous system(CNS)(Paolicelli et al.,2022).They play a pivotal role in CNS development and in maintaining homeostasis during adulthood.Microglia are being extensively studied for their involvement in CNS disorders,ranging from autoimmune diseases such as multiple sclerosis to neurodegenerative and psychiatric conditions,as well as stroke and brain tumors(Paolicelli et al.,2022).
文摘The rise of the aging population parallels the rapidly increasing cases of neurological disorders. This puts pressure on scientists and physicians to find novel methods that can prevent and treat neurodegeneration. The brain is made up of a complex network of different cell types that work in tandem to maintain systemic homeostasis.
基金supported by the National Natural Science Foundation of China(NSFC/RGC/JRF N_HKU735/21)Research Grant Council of Hong Kong,China(17102120,17108821,17103922,C1024-22GF,C7074-21G)+1 种基金Health and Medical Research Fund(HMRF 09200966)(to CSWL)FRQS Postdoctoral Fellowship(to AHKF).
文摘Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.
文摘In the year 2010,the exports and imports of Chinese textile machinery maintained rapid growth,owing to the industrial upgrading and a strong recovery in demand.
文摘In 2007,the national economy kept steady and fast growth with the features of rapid economic growth,optimized structure,increased efficiency and improved livelihood of the people. According to preliminary estimation,the gross domestic product (GDP)for the year was 24,661.9 billion yuan,up by 11.4 percent,or 0.3 percentage point higher than that in the previous year,represent-
文摘HUNAN Province at one time was known as Chudi, which means the land of Chu. Every year, when the floods would come to Chudi, the local people would carry their stores out of the high mountains using a technique they called "fang pai," or rafting. It took about six months to carry a raftload of goods down the mountain,
文摘As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Benefiting from a flurry of consumption-stimulating policies and measures,China’s online retail sales surpassed RMB 14 trillion in the January-November period,a year-on-year increase of 7.4 percent.Imports and exports maintained steady growth,climbing by 4.9 percent year-on-year in renminbi terms.Value-added industrial output also expanded 5.8 percent year-on-year.The volume of express delivery parcels reached a new high of 150 billion and is expected to grow higher still given the new-year festivities ahead.
文摘The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastructure construction,mineral resource development,and agriculture.The two sides have maintained a high degree of political mutual trust and have cooperated closely in international affairs.Cultural exchanges and people-to-people contacts have expanded,and both nations continue to work together to further deepen their partnership.
文摘China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history.The Beijing Summit of the Forum on China-Africa Cooperation(FOCAC),held in September 2024,elevated bilateral ties between China and African countries with diplomatic relations with China to a strategic level.It also redefined China-Africa relations as an“all-weather China-Africa community with a shared future for the new era.”This signifies that China and Africa will remain steadfast friends and close development partners,regardless of changes in the international landscape.
文摘China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s.The past decade has witnessed steadily improving relations between the two countries.Their cultural exchange,especially in theatrical arts,has become increasingly fruitful in three distinct ways.
