When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene express...When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).展开更多
In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily ...In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.展开更多
On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings...On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings are obtained. The results gained by caleulation in the paper are consistent with that measured in the field. And this provides a basis for the roadway sidepacking support design.展开更多
Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the q...Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.展开更多
Homeostasis in internal environment and cellular metabolism ensures cells’ functions to be stable in living organisms. Neuronal spike encoding in the brain needs to be precise
In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.
Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at t...Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.展开更多
As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Bene...As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Benefiting from a flurry of consumption-stimulating policies and measures,China’s online retail sales surpassed RMB 14 trillion in the January-November period,a year-on-year increase of 7.4 percent.Imports and exports maintained steady growth,climbing by 4.9 percent year-on-year in renminbi terms.Value-added industrial output also expanded 5.8 percent year-on-year.The volume of express delivery parcels reached a new high of 150 billion and is expected to grow higher still given the new-year festivities ahead.展开更多
China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history....China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history.The Beijing Summit of the Forum on China-Africa Cooperation(FOCAC),held in September 2024,elevated bilateral ties between China and African countries with diplomatic relations with China to a strategic level.It also redefined China-Africa relations as an“all-weather China-Africa community with a shared future for the new era.”This signifies that China and Africa will remain steadfast friends and close development partners,regardless of changes in the international landscape.展开更多
The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastr...The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastructure construction,mineral resource development,and agriculture.The two sides have maintained a high degree of political mutual trust and have cooperated closely in international affairs.Cultural exchanges and people-to-people contacts have expanded,and both nations continue to work together to further deepen their partnership.展开更多
China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s....China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s.The past decade has witnessed steadily improving relations between the two countries.Their cultural exchange,especially in theatrical arts,has become increasingly fruitful in three distinct ways.展开更多
With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chines...With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).展开更多
Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade ...Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade depends on optimal recognition of tumor cells through the activation of receptors on antitumor effector immune cells,such as CD8^(+)T cells and NK cells.Therefore,sufficient and maintained expression levels of activating receptors on these effector immune cells are essential for antitumor immunity and checkpoint blockade immunotherapy.展开更多
Rheumatoid arthritis(RA)is a systemic autoimmune disease in which synovial fibroblasts(SFs)maintain chronic inflammation by secreting proinflammatory mediators,leading to joint destruction.While the role of proinflamm...Rheumatoid arthritis(RA)is a systemic autoimmune disease in which synovial fibroblasts(SFs)maintain chronic inflammation by secreting proinflammatory mediators,leading to joint destruction.While the role of proinflammatory mediators in this process is well-established,the contribution of non-inflammatory regulators in SFs to joint pathology remains poorly understood.In this study,we investigated the non-inflammatory role of SFs in RA using a co-culture model,and found that SFs from RA patients promote apoptosis of human chondrocytes.Mechanistic investigations reveal that SFs can secrete small extracellular vesicles(sEVs),which are taken up by chondrocytes and induce chondrocyte apoptosis in both normal chondrocytes and chondrocytes from patients with RA.sEV-derived miRNA 15-29148 are identified as key signaling molecules mediating the apoptosis effects of chondrocytes.Further studies reveal that SF-derived miRNA 15-29148 targeting CIAPIN1 results in increased chondrocyte apoptosis.We further demonstrate that SF-derived miRNA 15-29148 is transferred to chondrocytes,exacerbating cartilage damage in vivo.Moreover,chondrocyte-specific aptamer-modified polyamidoamine nanoparticles not only ameliorated RA but also prevented its onset.This study suggests that,in RA,the secretion of specific sEV-miRNAs from SFs plays a crucial role in promoting chondrocyte apoptosis,potentially through non-inflammatory regulation,and that sEV-miRNA inhibition in SFs may represent an early preventive treatment strategy for cartilage degradation in RA.展开更多
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental...Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.展开更多
Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE pr...Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.展开更多
Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formu...Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formula φ_N(x) in the展开更多
In life,we are bound to encounter various difficulties and setbacks.However,it is of great significance to maintain a positive attitude when were facing these challenges.For me,this lesson was deeply impressed upon me...In life,we are bound to encounter various difficulties and setbacks.However,it is of great significance to maintain a positive attitude when were facing these challenges.For me,this lesson was deeply impressed upon me during a particularly tough period.展开更多
If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishe...If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishes to the people around them,and maintain friendships.展开更多
基金supported by the National Key R&D Program of China(2019YFA0802501)the National Natural Science Foundation of China(31770843,31971231)。
文摘When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).
文摘In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.
文摘On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings are obtained. The results gained by caleulation in the paper are consistent with that measured in the field. And this provides a basis for the roadway sidepacking support design.
文摘Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.
基金granted by National Award for Outstanding Young Scientist (30325021)National Basic Research Program (2006CB500804)+1 种基金NSFC (30870517 and 30621130077)CAS Program for Knowledge Innovation (KSCX2-YWR-39)
文摘Homeostasis in internal environment and cellular metabolism ensures cells’ functions to be stable in living organisms. Neuronal spike encoding in the brain needs to be precise
文摘In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.
文摘Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.
文摘As 2024 comes to an end,the pickup in consumption and robust growth in a range of sectors have bolstered confidence that the Chinese economy is right on track to meet the preset growth rate of around five percent.Benefiting from a flurry of consumption-stimulating policies and measures,China’s online retail sales surpassed RMB 14 trillion in the January-November period,a year-on-year increase of 7.4 percent.Imports and exports maintained steady growth,climbing by 4.9 percent year-on-year in renminbi terms.Value-added industrial output also expanded 5.8 percent year-on-year.The volume of express delivery parcels reached a new high of 150 billion and is expected to grow higher still given the new-year festivities ahead.
文摘China-Africa relations maintained their upward trajectory in 2024,with new plans for future cooperation taking shape.Chinese President Xi Jinping described the China-Africa partnership as being at its best in history.The Beijing Summit of the Forum on China-Africa Cooperation(FOCAC),held in September 2024,elevated bilateral ties between China and African countries with diplomatic relations with China to a strategic level.It also redefined China-Africa relations as an“all-weather China-Africa community with a shared future for the new era.”This signifies that China and Africa will remain steadfast friends and close development partners,regardless of changes in the international landscape.
文摘The year 2025 marks the 45th anniversary of the establishment of diplomatic relations between China and Zimbabwe.During this period,China-Zimbabwe economic cooperation has deepened,especially in the fields of infrastructure construction,mineral resource development,and agriculture.The two sides have maintained a high degree of political mutual trust and have cooperated closely in international affairs.Cultural exchanges and people-to-people contacts have expanded,and both nations continue to work together to further deepen their partnership.
文摘China and Vietnam have maintained close theatrical exchange.A group of Vietnamese students studied at the Central Academy of Drama and the National Academy of Chinese Theatre Arts(NACTA)of China in the 1950s and’60s.The past decade has witnessed steadily improving relations between the two countries.Their cultural exchange,especially in theatrical arts,has become increasingly fruitful in three distinct ways.
文摘With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).
基金This work was supported by the National Key R&D Program of China(2020YFA0710802)the Natural Science Foundation of China(reference number 82071768).
文摘Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade depends on optimal recognition of tumor cells through the activation of receptors on antitumor effector immune cells,such as CD8^(+)T cells and NK cells.Therefore,sufficient and maintained expression levels of activating receptors on these effector immune cells are essential for antitumor immunity and checkpoint blockade immunotherapy.
基金the National Natural Science Foundation of China(82372412)the Social Development Project of Jiangsu Province(BE2022701)+4 种基金the Top Talent Support Program for Young and Middle-aged People of the Wuxi Health Committee(BJ2020044,BJ2020057,HB2020043)the Fundamental Research Funds of the Health and Family Planning Commission of Wuxi(M202024)the Special Program for Translational Medicine Research of the Wuxi Translational Medicine Center(2020DHYB07,2020DHYB03)the Key Special Project of Precision Medicine of the Wuxi Health Commission(J202101)peking union medical college hospital talent cultivation program(UHB50192).
文摘Rheumatoid arthritis(RA)is a systemic autoimmune disease in which synovial fibroblasts(SFs)maintain chronic inflammation by secreting proinflammatory mediators,leading to joint destruction.While the role of proinflammatory mediators in this process is well-established,the contribution of non-inflammatory regulators in SFs to joint pathology remains poorly understood.In this study,we investigated the non-inflammatory role of SFs in RA using a co-culture model,and found that SFs from RA patients promote apoptosis of human chondrocytes.Mechanistic investigations reveal that SFs can secrete small extracellular vesicles(sEVs),which are taken up by chondrocytes and induce chondrocyte apoptosis in both normal chondrocytes and chondrocytes from patients with RA.sEV-derived miRNA 15-29148 are identified as key signaling molecules mediating the apoptosis effects of chondrocytes.Further studies reveal that SF-derived miRNA 15-29148 targeting CIAPIN1 results in increased chondrocyte apoptosis.We further demonstrate that SF-derived miRNA 15-29148 is transferred to chondrocytes,exacerbating cartilage damage in vivo.Moreover,chondrocyte-specific aptamer-modified polyamidoamine nanoparticles not only ameliorated RA but also prevented its onset.This study suggests that,in RA,the secretion of specific sEV-miRNAs from SFs plays a crucial role in promoting chondrocyte apoptosis,potentially through non-inflammatory regulation,and that sEV-miRNA inhibition in SFs may represent an early preventive treatment strategy for cartilage degradation in RA.
基金supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL)5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL)the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。
文摘Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.
基金supported by core funding provided by Temasek Life Sciences Laboratory(to CTO)。
文摘Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.
文摘Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formula φ_N(x) in the
文摘In life,we are bound to encounter various difficulties and setbacks.However,it is of great significance to maintain a positive attitude when were facing these challenges.For me,this lesson was deeply impressed upon me during a particularly tough period.
文摘If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishes to the people around them,and maintain friendships.
