Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challe...With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.展开更多
Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2...Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.展开更多
Ischemic stroke therapy has long been dominated by strategies aimed at restoring cerebral blood flow. Yet, accumulating evidence suggests that neuronal survival and functional recovery depend not only on reperfusion, ...Ischemic stroke therapy has long been dominated by strategies aimed at restoring cerebral blood flow. Yet, accumulating evidence suggests that neuronal survival and functional recovery depend not only on reperfusion, but also on the resolution of postischemic immune dysregulation. This study(Chen et al., Prog Biochem Biophys, 2026, 53(3): 697-710. DOI:10.3724/j.pibb.2025.0541) a dvances this emerging paradigm by proposing a therapeutic strategy that integrates lesion-specific delivery with active modulation of the inflammatory microenvironment.展开更多
Objectives:Glioblastoma multiforme(GBM)is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation.Brother of the Regulator of Imprinted Sites(BORIS/CTCFL)has been implic...Objectives:Glioblastoma multiforme(GBM)is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation.Brother of the Regulator of Imprinted Sites(BORIS/CTCFL)has been implicated in oncogenic transcriptional programs in several cancers,but its role in GBM remains poorly defined.This study aimed to characterize BORIS-associated transcriptional programs in GBM and to assess their functional relevance using integrative computational and experimental approaches.Methods:Transcriptomic data from The Cancer Genome Atlas(TCGA)-GBM and Genotype-Tissue Expression(GTex)brain cortex were analyzed following batch correction,differential expression analysis,and gene ontology enrichment.TCGA-GBM samples were stratified into BORIS-high and BORIS-low expression quartiles to identify BORIS-associated gene signatures.BORIS chromatin occupancy was examined by Chromatin immunoprecipitation combined with sequencing(ChIP-seq)in U87MG cells,followed by functional annotation of BORIS-bound genes.Experimental validation included BORIS overexpression,RT-qPCR,immunoblotting,ChIP-qPCR,and functional assays assessing proliferation,clonogenic survival,and migration.Results:BORIS was significantly upregulated in GBM compared with normal brain tissue and was associated with transcriptional programs related to development,metabolism,and cell signaling.Quartilebased analysis identified BORIS-associated differentially expressed genes,including CD36 and FBN2.ChIP-seq revealed BORIS binding at promoter-proximal regions,with ChIP-qPCR confirming occupancy at CD36 and FBN2 regulatory regions.BORIS overexpression increased CD36 and FBN2 expression and was associated with reduced proliferation,enhanced clonogenic survival,and increased migratory capacity.Conclusion:These findings indicate that BORIS is associated with transcriptional and phenotypic programs linked to GBM aggressiveness and may represent a candidate for further investigation as a biomarker or therapeutic target in GBM.展开更多
Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigeneti...Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation.展开更多
Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of N...Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of NF membranes is intrinsically constrained by the morphology and structure of the polyamide(PA) selective layer.This issue arises because NF membranes typically exhibit relatively smooth nodular structures,which theoretically impede efficient water transport.In this study,we enhanced the formation of nanobubbles by synergistically regulating with surfactant and low temperatures,resulting in the fabrication of PA NF membranes with a crumpled morphology.We observed that lower temperatures promote enhanced gas solubility in the aqueous phase,facilitating increased nanobubble formation through the foaming effect of surfactant sodium dodecylbenzene sulfonate(SDBS).Consequently,this resulted in the creation of PA NF membranes with more crumpled structures and superior performance,with pure water permeance reaching 36.25 ± 0.42 L m^(-2)h^(-1)bar^(-1),representing an improvement of 14.47 L m^(-2)h^(-1)bar^(-1)compared to the control group.Additionally,it maintains a high Na_(2)SO_(4) rejection rate of97.00 % ± 0.58 %.The PA NF membranes produced by eliminating nanobubbles and free interfaces exhibited a smooth structure,whereas introducing nanobubbles(through Na HCO_(3) addition,N_(2) pressurization,and ultrasonication) resulted in the formation of crumpled membranes.This emphasized that the large amount of nanobubbles generated by SDBS and low temperature in the interfacial process played a critical role in shaping crumpled PA NF membranes and enhancing membrane performance.This approach has the potential to provide valuable insights into customizing the structural design of TFC PA NF membranes,contributing to further advancements in this field.展开更多
Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptabillity of rapeseed(Brassica napus L.).Strategically advancing flowering time can reduce the risk of yield losses due t...Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptabillity of rapeseed(Brassica napus L.).Strategically advancing flowering time can reduce the risk of yield losses due to extreme climatic conditions and facilitate the cultivation of subsequent crops on the same land,thereby enhancing overall agricultural efficiency.In this review,we synthesize current information on flowering time regulation in rapeseed through an integrated analysis of its genetic,hormonal,and environmental dimensions,emphasizing their crosstalk and implications for yield.We consolidate multi-omics evidence from population genetics,functional genomics,and systems biology to create a haplotype-based framework that overcomes the trade-off between flowering time and yield,providing support for the precision breeding of early-maturing cultivars.The insights presented here could inform future research on flowering time regulation and guide strategies for increasing rapeseed productivity.展开更多
Parasitic interface side reactions and uncontrollable Zn deposition seriously erode the cycling performance of aqueous zinc ion batteries,thus impeding the large-scale application.Herein,an organic acid molecule with ...Parasitic interface side reactions and uncontrollable Zn deposition seriously erode the cycling performance of aqueous zinc ion batteries,thus impeding the large-scale application.Herein,an organic acid molecule with a unique molecular structure,camphorsulfonic acid(CSA),is first proposed to remodel the interface microenvironment as an electrolyte additive.The proton provided by CSA can neutralize the hydroxide ions generated by side reactions and inhibit the accumulation of alkaline by-products.The sulfonic acid groups are firmly adsorbed on the Zn anode surface,thereby enabling the regulation of interfacial species.Specifically,oxygen-containing functional groups combined with hydrophobic rigid carbon rings achieve a water-poor interface environment and promote the transfer of Zn^(2+),providing a suitable environment for Zn deposition.As a result,Zn//Zn symmetrical battery can run for over 2800 h(2 mA cm^(-2)-2 mAh cm^(-2)),demonstrating 28-times lifespan compared to the battery without CSA.Furthermore,Zn//KVO full cell presents excellent performance of 800 cycles at 3 A g^(-1).Besides,the pouch cell with CSA can also operate a capacity of 153.8 mAh after 60 cycles at 0.5 A g^(-1) with96.5%capacity retention rate.This work provides an organism-inspired additive selection for stabilizing the interface chemistry of the Zn anode.展开更多
Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-...Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-line self-recovery of unbalanced vibration faults in a rotor system,a self-recovery regulation method based on the grey wolf optimization-adaptive linear quadratic regulator(GWO-ALQR)is proposed.First,a self-recovery regulation system for unbalanced vibrations was constructed,with the state-space equation of the control system obtained and discretized based on the dynamic equation of the rotor-bearing system.Subsequently,a self-recovery regulation method for unbalanced vi-brations based on GWO-ALQR was designed based on the state-space equation.In this method,the parameters of the control system are optimized using grey wolf optimization(GwO),with the working conditions identified on-line.The optimization parameters were selected independently,while the control commands were generated through a linear quadratic regulator(LQR)to control the action of the actuator to achieve self-recovery of the unbalanced vibration.The experimental results indicate that the unbalanced vibration of the rotor system can be restrained below the expected vibration threshold by the self-recovery regulation system based on GWO-ALQR and the final vibration suppression effect can exceed 70%.展开更多
Hard carbon(HC)remains a leading anode candidate for sodium-ion storage,yet its application is hindered by low initial Coulombic efficiency(ICE)and limited plateau capacity due to uncontrolled defect density and open ...Hard carbon(HC)remains a leading anode candidate for sodium-ion storage,yet its application is hindered by low initial Coulombic efficiency(ICE)and limited plateau capacity due to uncontrolled defect density and open porosity.Here,we propose a scalable dual-regulation strategy that simultaneously tunes pore mouth size and defect chemistry to enhance sodium storage performance.Using phenol-formaldehyde resin as the carbon precursor and phosphorus pentoxide(P_(2)O_(5))as a bifunctional sacrificial template and dopant source,we synthesize phosphorus-functionalized hard carbon(PF-PHC)featuring a high density of closed pores with well-confined sub-nanometer pore entrances.The in-situ sublimation of P_(2)O_(5) during pyrolysis promotes the formation of closed-pore architectures,while residual phosphorus atoms effectively passivate vacancy-type defects,thereby reducing irreversible Na+adsorption and mitigating excessive solid electrolyte interphase(SEI)formation.As a result,PF-PHC achieves an ICE of 89.3%and a plateau capacity of 289 mAh g^(−1).In-situ characterizations reveal that regulating pore mouth dimensions decouples Na+and solvent access,enabling highly selective ion transport and stable interfacial chemistry.Sodium-ion hybrid capacitors(SIHCs)assembled based on PF-PHC deliver exceptional rate performance and outstanding long-term cycling stability,retaining 98.2%after 10,000 cycles at 2 A g^(−1).This study establishes pore mouth engineering as a robust and scalable design principle for advancing next-generation HC-based sodium storage materials.展开更多
Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the ad...Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the adsorption layer and the ambiguous mechanisms of action.In this study,a highly stable Vani molecular brush additive was designed.The additive effectively inhibits H_(2) generation by targeting and anchoring H+in the inner Helmholtz layer,and reduces the water activity by constructing an enhanced hydrogen bonding network through the interaction with water molecules,thus inhibiting the parasitic side reactions on the zinc anode.In addition,the dynamic interfacial molecular layer can regulate and buffer the interfacial Zn^(2+)for highly reversible plating/stripping.Experiments show that the symmetric cell cycle life is as long as 3760 h at a Vani content of only 2×10^(-3) g L^(-1) with a current density of5 mA cm^(-2).The cycle life of the Zn‖MnO_(2) and Zn‖Zn_(0.58)V_(2)O_(5) H_(2)O full battery is significantly improved.This study deepens the understanding of the working mechanism of the zinc electrode interface and provides new ideas for non-sacrififcial trace additive design.展开更多
This article utilizes Katherine Mansfield’s short story The Garden Party as the research object to explore the narrative generation conditions of ethical experience in the text. Through a close analysis of the novel...This article utilizes Katherine Mansfield’s short story The Garden Party as the research object to explore the narrative generation conditions of ethical experience in the text. Through a close analysis of the novel’s narrative structure and key scenes, the article argues that ethical discomfort does not evolve into enduring moral judgments within the text;rather, it is continually managed and deferred through the interplay of aesthetic order, familial discourse, and the distribution of social roles. The novel eschews a linear trajectory of ethical awakening, instead crafting a narrative mechanism that keeps ethical experience palpable yet inarticulable. The female subject is given the role of sensing ethical incongruity, but lacks the narrative position from which to articulate it as judgment. Consequently, ethics remains confined to the level of personalization and unimplementability. Far from a narrative of moral growth or awakening, The Garden Party exposes why ethical judgment has become structurally unrealizable in modern narratives.展开更多
Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditio...Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li^(+)solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li_(3)N-Li_(2)S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO_(2)//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering.展开更多
Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of de...Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.展开更多
The development of robust anode-electrolyte interfaces(AEI)with enhanced compatibility and mechanical strength is critical for regulating zinc-ion nucleation kinetics,suppressing dendrite formation,and advancing zinc-...The development of robust anode-electrolyte interfaces(AEI)with enhanced compatibility and mechanical strength is critical for regulating zinc-ion nucleation kinetics,suppressing dendrite formation,and advancing zinc-ion battery commercialization.To address persistent interface degradation during battery cycling,we propose a novel manufacturing strategy utilizing digital-light-processing(DLP)3D printing.This approach enables programmable regulation of gel-polymer electrolyte(GPE)structures through layer-by-layer photopolymerization,achieving precision regulation of macro-microstructures and interfacial stresses.The DLP-manufactured GPEs feature cross-scale structures combining dense porous networks with smooth surface topography,providing abundant electrochemical active sites and stable interfacial contact.Multiphase-field simulations integrated with in-situ/ex-situ characterizations reveal stress-enhanced zinc deposition mechanisms,where optimized interfacial stress eliminates AEI contact instability,ensuring rapid mass transfer between electrode and electrolyte.Under regulated interface stress,the symmetrical cell demonstrates stability exceeding 2000 hours,and the full cell retains 91.72%capacity after 8000 ultralong cycles,with reliable operation under extreme temperature conditions(-10℃/60℃).The precise regulation of interfacial stresses establishes stable AEI configurations,demonstrating a transformative approach to durable zinc-ion battery design.展开更多
Background:Maternal mental health literacy is a cognitive resource that may support preschoolers’emotional development,yet its influence on emotional regulation and the related mechanisms remains unclear.This study e...Background:Maternal mental health literacy is a cognitive resource that may support preschoolers’emotional development,yet its influence on emotional regulation and the related mechanisms remains unclear.This study examined whether maternal depressive mood and democratic parenting form a chain pathway linking maternal mental health literacy to preschoolers’emotional regulation ability.Methods:Mothers of 544 preschoolers in China’s Mainland completed an online questionnaire that assessed maternal mental health literacy,depressive mood,democratic parenting,and child emotional regulation.Structural path analysis was conducted with child age and gender controlled.Indirect effects were tested using 5000 bootstrap samples.Results:Maternal mental health literacy did not directly predict preschoolers’emotional regulation.Three indirect effects were significant.The pathway through depressive mood had an effect of 0.005,the pathway through democratic parenting had an effect of 0.004,and the chain pathway through depressive mood and democratic parenting had an effect of 0.002.All confidence intervals excluded 0.Conclusion:Maternal mental health literacy influences preschoolers’emotional regulation only through maternal depressive mood and democratic parenting,indicating that cognitive resources affect child emotional outcomes through emotional and behavioral processes rather than a direct pathway.展开更多
Cation disordering is a common issue in Ni-rich cathodes that significantly degrades cycle life and compromises safety.The cubic rock-salt phase formation and the slow oxidation kinetics of Ni^(2+)during solid-state s...Cation disordering is a common issue in Ni-rich cathodes that significantly degrades cycle life and compromises safety.The cubic rock-salt phase formation and the slow oxidation kinetics of Ni^(2+)during solid-state sintering are widely recognized as the principal causes of these structural defects.To solve this issue,a topotactic soft-chemical precursor engineering strategy is proposed for use in aqueous solution.By utilizing the layered structure of the precursor,this method allows for selective proton extraction and efficient Ni^(2+)oxidation,along with rapid Li+intercalation to form a layered lithiated intermediate.This intermediate crystallizes without further phase transitions during subsequent heat treatment,preventing structural defects caused by complex phase evolution and slow ion diffusion.The resulting cathode exhibits a long-range ordered layered structure and a uniform phase distribution,enabling efficient Li+insertion and extraction.Electrochemical tests reveal a high discharge capacity of 229.6 mAh g^(−1)and an initial coulombic efficiency of 95.77%at 0.1 C,greatly exceeding the performance of a conventionally synthesized cathode(210.3 mAh g^(−1),88.93%).Improved Li^(+)transport kinetics reduces phase-transition hysteresis and alleviates stress concentration,resulting in better cycling stability with a capacity retention of 85.3%after 300 cycles,compared to 61.5%for the conventional sample.This work presents a scalable and effective synthesis route for Ni-rich cathodes with reduced structural disorder and extended lifespan,providing valuable insights into how the regulation of intermediate phases influences electrochemical performance in high-performance Ni-rich cathodes.展开更多
Molecular engineering has demonstrated significant potential in modulating the crystallization and interfacial defect passivation of perovskite films.However,the deprotonation of conventional organic ammonium under li...Molecular engineering has demonstrated significant potential in modulating the crystallization and interfacial defect passivation of perovskite films.However,the deprotonation of conventional organic ammonium under light or thermal stress compromises the long-term operational stability of perovskite solar cells(PSCs).Here,we designed two multifunctional deprotonation-resistant cycloalkyl amidines with different heteroatoms,tetrahydro-2H-pyran-4-carboximidamide hydroiodide(TPCAI)and tetrahydro-2H-t hiopyran-4-carboximidamide hydroiodide(TTCAI),which were used to precisely regulate the crystallization process and interfacial properties of perovskite films.The larger dipole moment and enhanced electronic properties of sulfur-substituted TTCAI than TPCAI strengthen its interaction with the perovskite lattice.This interaction markedly slows down the crystallization rate,promotes preferential growth along the(100)crystal plane,reduces defect density,and effectively suppresses non-radiative recombination.TTCAI meanwhile construction of passivation layers on the surface and grain boundaries of the perovskite film through multiple hydrogen-bond interactions,passivates grain boundary defects,which significantly improves the film's environmental stability.Consequently,the TTCAI-modified device achieved a high efficiency of 25.58%,and the unencapsulated device retained 92%of its initial efficiency after 1200 h of storage at 65℃ under air(RH 30–65%).This study provides new insights into the rational design of multifunctional amidine ligands toward achieving efficient and stable PSCs.展开更多
BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this ...BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.展开更多
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
基金supported by the Science and Technology Development Project of Jilin Province(Project No.YDZJ202301ZYTS284).
文摘With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.
文摘Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.
文摘Ischemic stroke therapy has long been dominated by strategies aimed at restoring cerebral blood flow. Yet, accumulating evidence suggests that neuronal survival and functional recovery depend not only on reperfusion, but also on the resolution of postischemic immune dysregulation. This study(Chen et al., Prog Biochem Biophys, 2026, 53(3): 697-710. DOI:10.3724/j.pibb.2025.0541) a dvances this emerging paradigm by proposing a therapeutic strategy that integrates lesion-specific delivery with active modulation of the inflammatory microenvironment.
基金supported by the Secretaría de Ciencia,Humanidades,Tecnología e Innovación(SECIHTI),Fondo Ciencia Básica y de Frontera 2025(CBF-2025-G-97)to E.Soto-Reyes and PRODEP(511/2023-3066-1599)SECIHTI,Fondo de Ciencia de Frontera 2023(CF-2023-G398)to C.Sámano+2 种基金supported by the Departamen to de Ciencias Naturales(DCN),División de Ciencias Naturales e Ingeniería(DCNI),UAM,Unidad Cuajimalpa,through Divisional Project Number 101S243-23 to E.Soto-Reyes and 123 S289-25 to C.Sámanoa master student from Programa de Maestría y Doctorado en Ciencias Bio-químicas,Universidad Nacional Autónoma deMéxico(UNAM)and received a fellowship(CVU number 1184475)fromSecretaría de Ciencia,Humanidades,Tecnología e Innovación(SECIHTI),Mexicoa postdoctoral fellow at the Universidad Autónoma Metropolitana-Cuajimalpa(UAM-C)and received a fellowship(CVU number 588333)from SECIHTI,Mexico.
文摘Objectives:Glioblastoma multiforme(GBM)is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation.Brother of the Regulator of Imprinted Sites(BORIS/CTCFL)has been implicated in oncogenic transcriptional programs in several cancers,but its role in GBM remains poorly defined.This study aimed to characterize BORIS-associated transcriptional programs in GBM and to assess their functional relevance using integrative computational and experimental approaches.Methods:Transcriptomic data from The Cancer Genome Atlas(TCGA)-GBM and Genotype-Tissue Expression(GTex)brain cortex were analyzed following batch correction,differential expression analysis,and gene ontology enrichment.TCGA-GBM samples were stratified into BORIS-high and BORIS-low expression quartiles to identify BORIS-associated gene signatures.BORIS chromatin occupancy was examined by Chromatin immunoprecipitation combined with sequencing(ChIP-seq)in U87MG cells,followed by functional annotation of BORIS-bound genes.Experimental validation included BORIS overexpression,RT-qPCR,immunoblotting,ChIP-qPCR,and functional assays assessing proliferation,clonogenic survival,and migration.Results:BORIS was significantly upregulated in GBM compared with normal brain tissue and was associated with transcriptional programs related to development,metabolism,and cell signaling.Quartilebased analysis identified BORIS-associated differentially expressed genes,including CD36 and FBN2.ChIP-seq revealed BORIS binding at promoter-proximal regions,with ChIP-qPCR confirming occupancy at CD36 and FBN2 regulatory regions.BORIS overexpression increased CD36 and FBN2 expression and was associated with reduced proliferation,enhanced clonogenic survival,and increased migratory capacity.Conclusion:These findings indicate that BORIS is associated with transcriptional and phenotypic programs linked to GBM aggressiveness and may represent a candidate for further investigation as a biomarker or therapeutic target in GBM.
基金funded by grants from the sub-project of Liaoning Province Germplasm Innovation Grain Storage and Technology Special Program(Grant No.2023JH1/10200003)National Natural Science Foundation of China(Grant Nos.32102350,32130092)+1 种基金Liaoning Provincial Department of Education Project(Grant No.LJKZ0635)funded by Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Vegetables),Ministry of Agriculture and Rural Affairs.
文摘Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation.
基金the National Natural Science Foundation of China (Nos.52430001,52470091,52200108) for the financial support。
文摘Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of NF membranes is intrinsically constrained by the morphology and structure of the polyamide(PA) selective layer.This issue arises because NF membranes typically exhibit relatively smooth nodular structures,which theoretically impede efficient water transport.In this study,we enhanced the formation of nanobubbles by synergistically regulating with surfactant and low temperatures,resulting in the fabrication of PA NF membranes with a crumpled morphology.We observed that lower temperatures promote enhanced gas solubility in the aqueous phase,facilitating increased nanobubble formation through the foaming effect of surfactant sodium dodecylbenzene sulfonate(SDBS).Consequently,this resulted in the creation of PA NF membranes with more crumpled structures and superior performance,with pure water permeance reaching 36.25 ± 0.42 L m^(-2)h^(-1)bar^(-1),representing an improvement of 14.47 L m^(-2)h^(-1)bar^(-1)compared to the control group.Additionally,it maintains a high Na_(2)SO_(4) rejection rate of97.00 % ± 0.58 %.The PA NF membranes produced by eliminating nanobubbles and free interfaces exhibited a smooth structure,whereas introducing nanobubbles(through Na HCO_(3) addition,N_(2) pressurization,and ultrasonication) resulted in the formation of crumpled membranes.This emphasized that the large amount of nanobubbles generated by SDBS and low temperature in the interfacial process played a critical role in shaping crumpled PA NF membranes and enhancing membrane performance.This approach has the potential to provide valuable insights into customizing the structural design of TFC PA NF membranes,contributing to further advancements in this field.
基金supported by the National Key Research and Development Program of China(2022YFD1200400)the National Natural Science Foundation of China(32272111)+4 种基金Special fund for youth team of the Southwest Universities(SWU-XJPY202306)Chongqing Natural Science Foundation(CSTB2024NSCQLZX0012)Modern Agro-industry Technology Research System(CARS-12)Chongqing Modern Agricultural Industry Technology System(COMAITS202504)Biological Breeding-National Science and Technology Major Project(2022ZD04008).We sincerely appreciate the Plant Editors team for English language editing of the manuscript,which significantly improved its clarity and overall quality.
文摘Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptabillity of rapeseed(Brassica napus L.).Strategically advancing flowering time can reduce the risk of yield losses due to extreme climatic conditions and facilitate the cultivation of subsequent crops on the same land,thereby enhancing overall agricultural efficiency.In this review,we synthesize current information on flowering time regulation in rapeseed through an integrated analysis of its genetic,hormonal,and environmental dimensions,emphasizing their crosstalk and implications for yield.We consolidate multi-omics evidence from population genetics,functional genomics,and systems biology to create a haplotype-based framework that overcomes the trade-off between flowering time and yield,providing support for the precision breeding of early-maturing cultivars.The insights presented here could inform future research on flowering time regulation and guide strategies for increasing rapeseed productivity.
基金financially supported by The Excellent Youth Project of the Education Department of Hunan Province(No.24B0008)the National Natural Science Foundation of China(No.52377222)。
文摘Parasitic interface side reactions and uncontrollable Zn deposition seriously erode the cycling performance of aqueous zinc ion batteries,thus impeding the large-scale application.Herein,an organic acid molecule with a unique molecular structure,camphorsulfonic acid(CSA),is first proposed to remodel the interface microenvironment as an electrolyte additive.The proton provided by CSA can neutralize the hydroxide ions generated by side reactions and inhibit the accumulation of alkaline by-products.The sulfonic acid groups are firmly adsorbed on the Zn anode surface,thereby enabling the regulation of interfacial species.Specifically,oxygen-containing functional groups combined with hydrophobic rigid carbon rings achieve a water-poor interface environment and promote the transfer of Zn^(2+),providing a suitable environment for Zn deposition.As a result,Zn//Zn symmetrical battery can run for over 2800 h(2 mA cm^(-2)-2 mAh cm^(-2)),demonstrating 28-times lifespan compared to the battery without CSA.Furthermore,Zn//KVO full cell presents excellent performance of 800 cycles at 3 A g^(-1).Besides,the pouch cell with CSA can also operate a capacity of 153.8 mAh after 60 cycles at 0.5 A g^(-1) with96.5%capacity retention rate.This work provides an organism-inspired additive selection for stabilizing the interface chemistry of the Zn anode.
基金Supported by National Natural Science Foundation of China(Grant No.51875031)Beijing Municipal Natural Science Foundation of China(Grant No.3212010).
文摘Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-line self-recovery of unbalanced vibration faults in a rotor system,a self-recovery regulation method based on the grey wolf optimization-adaptive linear quadratic regulator(GWO-ALQR)is proposed.First,a self-recovery regulation system for unbalanced vibrations was constructed,with the state-space equation of the control system obtained and discretized based on the dynamic equation of the rotor-bearing system.Subsequently,a self-recovery regulation method for unbalanced vi-brations based on GWO-ALQR was designed based on the state-space equation.In this method,the parameters of the control system are optimized using grey wolf optimization(GwO),with the working conditions identified on-line.The optimization parameters were selected independently,while the control commands were generated through a linear quadratic regulator(LQR)to control the action of the actuator to achieve self-recovery of the unbalanced vibration.The experimental results indicate that the unbalanced vibration of the rotor system can be restrained below the expected vibration threshold by the self-recovery regulation system based on GWO-ALQR and the final vibration suppression effect can exceed 70%.
基金supported by the National Natural Science Foundation of China(22269020,U23A20582,42167068)the Gansu Province Higher Education Industry Support Plan Project(2023CYZC-17)+1 种基金2024 Major Cultivation Project for University Research and Innovation Platforms(2024CXPT-10)the Key Project of the Natural Science Foundation of Gansu Province(25JRRA004).
文摘Hard carbon(HC)remains a leading anode candidate for sodium-ion storage,yet its application is hindered by low initial Coulombic efficiency(ICE)and limited plateau capacity due to uncontrolled defect density and open porosity.Here,we propose a scalable dual-regulation strategy that simultaneously tunes pore mouth size and defect chemistry to enhance sodium storage performance.Using phenol-formaldehyde resin as the carbon precursor and phosphorus pentoxide(P_(2)O_(5))as a bifunctional sacrificial template and dopant source,we synthesize phosphorus-functionalized hard carbon(PF-PHC)featuring a high density of closed pores with well-confined sub-nanometer pore entrances.The in-situ sublimation of P_(2)O_(5) during pyrolysis promotes the formation of closed-pore architectures,while residual phosphorus atoms effectively passivate vacancy-type defects,thereby reducing irreversible Na+adsorption and mitigating excessive solid electrolyte interphase(SEI)formation.As a result,PF-PHC achieves an ICE of 89.3%and a plateau capacity of 289 mAh g^(−1).In-situ characterizations reveal that regulating pore mouth dimensions decouples Na+and solvent access,enabling highly selective ion transport and stable interfacial chemistry.Sodium-ion hybrid capacitors(SIHCs)assembled based on PF-PHC deliver exceptional rate performance and outstanding long-term cycling stability,retaining 98.2%after 10,000 cycles at 2 A g^(−1).This study establishes pore mouth engineering as a robust and scalable design principle for advancing next-generation HC-based sodium storage materials.
基金supported by the Heilongjiang Province“Double First Class”Discipline Collaborative Innovation Project(LJGXCG2023-061)。
文摘Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the adsorption layer and the ambiguous mechanisms of action.In this study,a highly stable Vani molecular brush additive was designed.The additive effectively inhibits H_(2) generation by targeting and anchoring H+in the inner Helmholtz layer,and reduces the water activity by constructing an enhanced hydrogen bonding network through the interaction with water molecules,thus inhibiting the parasitic side reactions on the zinc anode.In addition,the dynamic interfacial molecular layer can regulate and buffer the interfacial Zn^(2+)for highly reversible plating/stripping.Experiments show that the symmetric cell cycle life is as long as 3760 h at a Vani content of only 2×10^(-3) g L^(-1) with a current density of5 mA cm^(-2).The cycle life of the Zn‖MnO_(2) and Zn‖Zn_(0.58)V_(2)O_(5) H_(2)O full battery is significantly improved.This study deepens the understanding of the working mechanism of the zinc electrode interface and provides new ideas for non-sacrififcial trace additive design.
文摘This article utilizes Katherine Mansfield’s short story The Garden Party as the research object to explore the narrative generation conditions of ethical experience in the text. Through a close analysis of the novel’s narrative structure and key scenes, the article argues that ethical discomfort does not evolve into enduring moral judgments within the text;rather, it is continually managed and deferred through the interplay of aesthetic order, familial discourse, and the distribution of social roles. The novel eschews a linear trajectory of ethical awakening, instead crafting a narrative mechanism that keeps ethical experience palpable yet inarticulable. The female subject is given the role of sensing ethical incongruity, but lacks the narrative position from which to articulate it as judgment. Consequently, ethics remains confined to the level of personalization and unimplementability. Far from a narrative of moral growth or awakening, The Garden Party exposes why ethical judgment has become structurally unrealizable in modern narratives.
基金supported by the Key Laboratory of Sichuan Province for Lithium Resources Comprehensive Utilization and New Lithium Based Materials for Advanced Battery Technology(LRMKF202405)the National Natural Science Foundation of China(52402226)the Sichuan Provincial Natural Science Foundation (2024NSFSC1016)
文摘Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li^(+)solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li_(3)N-Li_(2)S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO_(2)//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering.
基金funded by China Law Society 2025 Annual Legal Research,Project grant number:CLS(2025)Y04.
文摘Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.
基金supported by National Natural Science Foundation of China(U22A20193)National Key Research and Development Program of China(2024YFB3409000)+1 种基金TCL science and technology innovation fund(20231751)Fundamental Research Funds for the Central Universities(No.2024ZYGXZR066)。
文摘The development of robust anode-electrolyte interfaces(AEI)with enhanced compatibility and mechanical strength is critical for regulating zinc-ion nucleation kinetics,suppressing dendrite formation,and advancing zinc-ion battery commercialization.To address persistent interface degradation during battery cycling,we propose a novel manufacturing strategy utilizing digital-light-processing(DLP)3D printing.This approach enables programmable regulation of gel-polymer electrolyte(GPE)structures through layer-by-layer photopolymerization,achieving precision regulation of macro-microstructures and interfacial stresses.The DLP-manufactured GPEs feature cross-scale structures combining dense porous networks with smooth surface topography,providing abundant electrochemical active sites and stable interfacial contact.Multiphase-field simulations integrated with in-situ/ex-situ characterizations reveal stress-enhanced zinc deposition mechanisms,where optimized interfacial stress eliminates AEI contact instability,ensuring rapid mass transfer between electrode and electrolyte.Under regulated interface stress,the symmetrical cell demonstrates stability exceeding 2000 hours,and the full cell retains 91.72%capacity after 8000 ultralong cycles,with reliable operation under extreme temperature conditions(-10℃/60℃).The precise regulation of interfacial stresses establishes stable AEI configurations,demonstrating a transformative approach to durable zinc-ion battery design.
文摘Background:Maternal mental health literacy is a cognitive resource that may support preschoolers’emotional development,yet its influence on emotional regulation and the related mechanisms remains unclear.This study examined whether maternal depressive mood and democratic parenting form a chain pathway linking maternal mental health literacy to preschoolers’emotional regulation ability.Methods:Mothers of 544 preschoolers in China’s Mainland completed an online questionnaire that assessed maternal mental health literacy,depressive mood,democratic parenting,and child emotional regulation.Structural path analysis was conducted with child age and gender controlled.Indirect effects were tested using 5000 bootstrap samples.Results:Maternal mental health literacy did not directly predict preschoolers’emotional regulation.Three indirect effects were significant.The pathway through depressive mood had an effect of 0.005,the pathway through democratic parenting had an effect of 0.004,and the chain pathway through depressive mood and democratic parenting had an effect of 0.002.All confidence intervals excluded 0.Conclusion:Maternal mental health literacy influences preschoolers’emotional regulation only through maternal depressive mood and democratic parenting,indicating that cognitive resources affect child emotional outcomes through emotional and behavioral processes rather than a direct pathway.
基金the financial support from the Central South University Fundamental Research Funds (Grant No.2025ZZTS0444)the Innovation-Driven Research Program(Grant No. 2023 CXQD053)+3 种基金the National Natural Science Foundation of China (Grant No. 52274310)the financial support (Project No.H202111040350002)the provision of the hydroxide precursors from Ningbo Ronbay New Energy Technology Co.,Ltdsupported in part by the High-Performance Computing Center of Central South University
文摘Cation disordering is a common issue in Ni-rich cathodes that significantly degrades cycle life and compromises safety.The cubic rock-salt phase formation and the slow oxidation kinetics of Ni^(2+)during solid-state sintering are widely recognized as the principal causes of these structural defects.To solve this issue,a topotactic soft-chemical precursor engineering strategy is proposed for use in aqueous solution.By utilizing the layered structure of the precursor,this method allows for selective proton extraction and efficient Ni^(2+)oxidation,along with rapid Li+intercalation to form a layered lithiated intermediate.This intermediate crystallizes without further phase transitions during subsequent heat treatment,preventing structural defects caused by complex phase evolution and slow ion diffusion.The resulting cathode exhibits a long-range ordered layered structure and a uniform phase distribution,enabling efficient Li+insertion and extraction.Electrochemical tests reveal a high discharge capacity of 229.6 mAh g^(−1)and an initial coulombic efficiency of 95.77%at 0.1 C,greatly exceeding the performance of a conventionally synthesized cathode(210.3 mAh g^(−1),88.93%).Improved Li^(+)transport kinetics reduces phase-transition hysteresis and alleviates stress concentration,resulting in better cycling stability with a capacity retention of 85.3%after 300 cycles,compared to 61.5%for the conventional sample.This work presents a scalable and effective synthesis route for Ni-rich cathodes with reduced structural disorder and extended lifespan,providing valuable insights into how the regulation of intermediate phases influences electrochemical performance in high-performance Ni-rich cathodes.
基金supported by the National Natural Science Foundation of China(22471218)Shaanxi Fundamental Science Research Project for Chemistry&Biology(22JHQ002)+3 种基金Program for Young Talents of Shaanxi Province(5113190023)the Natural Science Foundation of Shaanxi Province(2025JC-YBMS-147 and2024JC-ZDXM-08)the Natural Science Foundation of Zhejiang Province(LY24B010002)the Natural Science Foundation of Guangdong Province(2025A1515012305)。
文摘Molecular engineering has demonstrated significant potential in modulating the crystallization and interfacial defect passivation of perovskite films.However,the deprotonation of conventional organic ammonium under light or thermal stress compromises the long-term operational stability of perovskite solar cells(PSCs).Here,we designed two multifunctional deprotonation-resistant cycloalkyl amidines with different heteroatoms,tetrahydro-2H-pyran-4-carboximidamide hydroiodide(TPCAI)and tetrahydro-2H-t hiopyran-4-carboximidamide hydroiodide(TTCAI),which were used to precisely regulate the crystallization process and interfacial properties of perovskite films.The larger dipole moment and enhanced electronic properties of sulfur-substituted TTCAI than TPCAI strengthen its interaction with the perovskite lattice.This interaction markedly slows down the crystallization rate,promotes preferential growth along the(100)crystal plane,reduces defect density,and effectively suppresses non-radiative recombination.TTCAI meanwhile construction of passivation layers on the surface and grain boundaries of the perovskite film through multiple hydrogen-bond interactions,passivates grain boundary defects,which significantly improves the film's environmental stability.Consequently,the TTCAI-modified device achieved a high efficiency of 25.58%,and the unencapsulated device retained 92%of its initial efficiency after 1200 h of storage at 65℃ under air(RH 30–65%).This study provides new insights into the rational design of multifunctional amidine ligands toward achieving efficient and stable PSCs.
文摘BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.
