BACKGROUND Mammary-type myofibroblastoma(MTMF)is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation.Although 160 cases of MTMF have been reported in the literature since 2001,no cases of...BACKGROUND Mammary-type myofibroblastoma(MTMF)is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation.Although 160 cases of MTMF have been reported in the literature since 2001,no cases of infarction or atypical mitosis have been reported so far.Herein,we report an unusual case of MTMF in the pelvic cavity,which mimicked some malignant features,including infarction,atypical mitosis,infiltrative growth,and prominent cytologic atypia,making it difficult to ascertain whether the tumor was benign.CASE SUMMARY A 49-year-old man complained of pain and discomfort in the right buttock for more than 4 mo and did not receive any treatment.Nuclear magnetic resonance imaging(MRI)showed a 13-cm-sized mass in his right pelvic cavity.Histologically significant differences were atypical mitosis figures and multiple necrotic foci in the tumor.In addition,smooth muscle and skeletal muscle were invaded within and at the edge of the tumor.These morphologic features are often reminiscent of malignant tumors and therefore pose a diagnostic challenge to pathologists.The tumor cells were strongly positive for both cluster of differentiation 34 and desmin,and the loss of retinoblastoma 1 shown by immunohistochemical and fluorescence in situ hybridization results confirmed the pathological diagnosis of MTMF.Currently,the patient is alive and in good condition without tumor recurrence or metastasis after 2.5 years of follow-up by telephone and MRI.CONCLUSION The two pseudo-malignant characteristics of infarction and atypical mitosis broaden the morphological lineage of MTMF,a rare mesenchymal tumor.展开更多
In July 2006, a 32-year old female patient was found to have a 3 ×3 cm^2 neoplasm in the left lateral wall of her bladder. There was superficial necrosis and bleeding. Previously she had received a cystoscopy in ...In July 2006, a 32-year old female patient was found to have a 3 ×3 cm^2 neoplasm in the left lateral wall of her bladder. There was superficial necrosis and bleeding. Previously she had received a cystoscopy in another hospital because of painless gross hematuria and anemia. A partial resection of the bladder was conducted because attempts of medical hemostasis were unsatisfactory. Pathological examination indicated that the lesion was a spindle cell tumor of the bladder （Fig. 1）. Since the tumor cells had encroached into the smooth muscle, there was extensive cellular proliferation in the muscle layer and pathologic karyokinesis could be seen, suggestive of a malignant myofibroblastoma. The lateral and basilar cutting edges were oositive.展开更多
Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-o...Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic consultation was performed. Clinical examination revealed a firm 25 mm mass on the medial part of the left breast with skin involvement. A biopsy was performed and analysis result came back in favor of a cellular type myofibroblastoma showing a fibrous component consisting of spindle cells with a herringbone arrangement. Anatomopathological results concluded to a dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor population strongly positive for CD34 expression. The search for a rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of the lesions with margins greater than 2 cm, on which the prognosis mainly depends. Micrographic surgery and oncoplastic breast surgery are of major interest in this location.展开更多
Myofibroblastoma of the breast(MFB)is a rare benign mesenchymal tumor of the breast.A case of giant breast myofibroblastic tumor,which is rarely reported in literature,was recently diagnosed in our department.We also ...Myofibroblastoma of the breast(MFB)is a rare benign mesenchymal tumor of the breast.A case of giant breast myofibroblastic tumor,which is rarely reported in literature,was recently diagnosed in our department.We also analyzed the clinicopathological features of MFB to improve the understanding of the tumor and avoid misdiagnosis.展开更多
In 2001, Laskin et al firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They propo...In 2001, Laskin et al firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They proposed the term ＂superficial cervicovaginal myofibroblastoma （SCVM）＂ to highlight the unique features of this tumor： the superficial subepithelial location and myofibroblastic differentiation of the minor cells. SCVM appears less well recognized with only three additional reports have been documented in the English literatures.24 In this study, we described four new cases of SCVM to further characterize the clinical and pathological features of this rare entity.展开更多
文摘BACKGROUND Mammary-type myofibroblastoma(MTMF)is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation.Although 160 cases of MTMF have been reported in the literature since 2001,no cases of infarction or atypical mitosis have been reported so far.Herein,we report an unusual case of MTMF in the pelvic cavity,which mimicked some malignant features,including infarction,atypical mitosis,infiltrative growth,and prominent cytologic atypia,making it difficult to ascertain whether the tumor was benign.CASE SUMMARY A 49-year-old man complained of pain and discomfort in the right buttock for more than 4 mo and did not receive any treatment.Nuclear magnetic resonance imaging(MRI)showed a 13-cm-sized mass in his right pelvic cavity.Histologically significant differences were atypical mitosis figures and multiple necrotic foci in the tumor.In addition,smooth muscle and skeletal muscle were invaded within and at the edge of the tumor.These morphologic features are often reminiscent of malignant tumors and therefore pose a diagnostic challenge to pathologists.The tumor cells were strongly positive for both cluster of differentiation 34 and desmin,and the loss of retinoblastoma 1 shown by immunohistochemical and fluorescence in situ hybridization results confirmed the pathological diagnosis of MTMF.Currently,the patient is alive and in good condition without tumor recurrence or metastasis after 2.5 years of follow-up by telephone and MRI.CONCLUSION The two pseudo-malignant characteristics of infarction and atypical mitosis broaden the morphological lineage of MTMF,a rare mesenchymal tumor.
文摘In July 2006, a 32-year old female patient was found to have a 3 ×3 cm^2 neoplasm in the left lateral wall of her bladder. There was superficial necrosis and bleeding. Previously she had received a cystoscopy in another hospital because of painless gross hematuria and anemia. A partial resection of the bladder was conducted because attempts of medical hemostasis were unsatisfactory. Pathological examination indicated that the lesion was a spindle cell tumor of the bladder （Fig. 1）. Since the tumor cells had encroached into the smooth muscle, there was extensive cellular proliferation in the muscle layer and pathologic karyokinesis could be seen, suggestive of a malignant myofibroblastoma. The lateral and basilar cutting edges were oositive.
文摘Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic consultation was performed. Clinical examination revealed a firm 25 mm mass on the medial part of the left breast with skin involvement. A biopsy was performed and analysis result came back in favor of a cellular type myofibroblastoma showing a fibrous component consisting of spindle cells with a herringbone arrangement. Anatomopathological results concluded to a dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor population strongly positive for CD34 expression. The search for a rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of the lesions with margins greater than 2 cm, on which the prognosis mainly depends. Micrographic surgery and oncoplastic breast surgery are of major interest in this location.
基金The Beijing-Tianjin-Hebei Basic Research Cooperation Special Project(2019):"Visualized Stem Cell Targeted Tumor Therapy Techniques for Precise Diagnosis and Treatment of Tumors"Project Number:19JCZDJC65800(Z).
文摘Myofibroblastoma of the breast(MFB)is a rare benign mesenchymal tumor of the breast.A case of giant breast myofibroblastic tumor,which is rarely reported in literature,was recently diagnosed in our department.We also analyzed the clinicopathological features of MFB to improve the understanding of the tumor and avoid misdiagnosis.
文摘In 2001, Laskin et al firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They proposed the term ＂superficial cervicovaginal myofibroblastoma （SCVM）＂ to highlight the unique features of this tumor： the superficial subepithelial location and myofibroblastic differentiation of the minor cells. SCVM appears less well recognized with only three additional reports have been documented in the English literatures.24 In this study, we described four new cases of SCVM to further characterize the clinical and pathological features of this rare entity.
