Malignant myoepitheliomas are rare malignant salivary gland neoplasms which usually occur in the parotid gland. Very little material on this topic has been published. This tumour represents a therapeutic challenge sin...Malignant myoepitheliomas are rare malignant salivary gland neoplasms which usually occur in the parotid gland. Very little material on this topic has been published. This tumour represents a therapeutic challenge since there are no specific recommendations or guidelines. We present a case of malignant myoepithelioma arising de novo in the parotid gland. We discuss our therapeutic approach and considerations on appropriate post-surgical treatment. Then we provide a review of international literature on this interesting and rare oncological entity.展开更多
Introduction Adenomyoepithelioma （AME） is uncommon characterized by biphasic proliferation of both epithelial and myoepithelial cells. More than half of the adenomyoepitheliomas （AME） are benign, but in rare insta...Introduction Adenomyoepithelioma （AME） is uncommon characterized by biphasic proliferation of both epithelial and myoepithelial cells. More than half of the adenomyoepitheliomas （AME） are benign, but in rare instances, it may become malignant. Malignant adenomyoepitheliomas almost always occur in the breast and salivary gland. They are unusual in vulva. We report this case and provide some information about symptoms, microstructure, treatment, and a discussion about this kind of disease.展开更多
Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. The histological appearance includes solid, m...Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. The histological appearance includes solid, myxoid and reticular growth patterns. Vimentin and S-100 protein are very sensitive but non-specific immunohistochemical markers of neoplastic myoepithelium. Conservative surgery is the treatment of choice. A case of myoepithelioma of the minor salivary gland of tongue is described, focusing on clinical behaviour, histopathological and immunohistochemical features.展开更多
目的:探讨外阴肌上皮瘤样肿瘤(myoepithelioma-like tumors of the vulvar region, MELTVR)的临床病理学特征、分子特征、诊断及鉴别诊断。方法:回顾性分析我院1例发生于左侧腹股沟MELTVR临床病理学资料,并进行相关文献复习。结果:患者...目的:探讨外阴肌上皮瘤样肿瘤(myoepithelioma-like tumors of the vulvar region, MELTVR)的临床病理学特征、分子特征、诊断及鉴别诊断。方法:回顾性分析我院1例发生于左侧腹股沟MELTVR临床病理学资料,并进行相关文献复习。结果:患者女,35岁,以“左侧腹股沟肿物2次手术后再发1个月”为主诉入院。镜检示:肿瘤呈弥漫实性分布,其内可见大小不等的滤泡样结构及片状坏死。肿瘤细胞呈上皮样或梭形,间质可见多量小血管增生,呈圆形或分枝状,部分区域可见肿瘤细胞围血管生长、呈“假菊形团”样结构。高倍镜下,胞质嗜酸、局灶胞质透亮,核染色质不均匀、略呈泡状,可见一到数个小核仁,核分裂象易见(>20/10 HPF)。肿瘤位于皮下脂肪组织,可见一层纤细的纤维组织与周围组织分隔,局灶可见脂肪组织浸润。免疫表型:ER、EMA和Vimentin弥漫阳性,INI1阴性。FISH结果显示:EWSR1基因无断裂。结论:MELTVR是一种罕见的发生于女性外阴区的间叶源性肿瘤。它具有多变的组织学模式。与以往文献不同的是该病例未见明确的黏液样区域,正确认识该疾病有助于避免误诊和漏诊。展开更多
目的探讨外阴肌上皮瘤样肿瘤(myoepithelioma-like tumour of the vulvar region,MELTVR)临床特征、形态特点、免疫表型、鉴别诊断及预后。方法收集5例MELTVR,对其临床资料、病理形态进行分析,总结其临床病理及免疫表型特征,并复习相关...目的探讨外阴肌上皮瘤样肿瘤(myoepithelioma-like tumour of the vulvar region,MELTVR)临床特征、形态特点、免疫表型、鉴别诊断及预后。方法收集5例MELTVR,对其临床资料、病理形态进行分析,总结其临床病理及免疫表型特征,并复习相关文献。结果5例患者均为女性,中位年龄45岁,病变均位于外阴皮下。肿瘤界限较清,局部见薄纤维包膜分割呈分叶状,有不等比例的黏液区域。肿瘤细胞由上皮样或梭形细胞样成分混合组成,胞质嗜双色或嗜伊红性,细胞核伴轻中度异型性,可见核分裂象和核仁。间质包括黏液样区和实性区,黏液样区瘤细胞稀疏散在分布呈条索状,实性区瘤细胞弥漫成片或席纹状。免疫表型:肿瘤细胞均表达EMA、ER、vimentin;部分病例可不同程度表达Calponin、PR、SMA、CK(AE1/AE3)、CD56,个别灶性表达Syn、STAT6;均不表达S-100、desmin、WT-1、CD10、MyoD1、Myogein、CD34、GFAP、Melan A;Ki67增殖指数10%~20%,SMARCB1/INI-1均表达缺失。5例患者均通过手术切除,未行放、化疗,均未见远处转移。结论MELTVR是一种罕见的低级别或具有低度恶性潜能的间叶源性肿瘤,与多种软组织肿瘤的形态学相似,需要通过临床病史、形态学、免疫组化和分子检测进行整合诊断。展开更多
目的探讨软组织肌上皮瘤／混合瘤（myoepithelioma/mixed tumour of soft tissue，MMT）的临床病理学特征、免疫表型、鉴别诊断及预后。方法采用免疫组化EnVision两步法对6例MMT进行免疫组化染色，并复习相关文献。结果6例MMT中男性3例...目的探讨软组织肌上皮瘤／混合瘤（myoepithelioma/mixed tumour of soft tissue，MMT）的临床病理学特征、免疫表型、鉴别诊断及预后。方法采用免疫组化EnVision两步法对6例MMT进行免疫组化染色，并复习相关文献。结果6例MMT中男性3例，女性3例，年龄11～63岁，平均44岁。肿瘤直径2—17．5cm，平均6．5cm。免疫表型：75％（3／4）表达CK，100％（4／4）表达vimentin，66．7％（2／3）表达S-100，50％（2／4）表达GFAP，100％（3／3）表达EMA，（0／4）不表达SMA。6例MMT随访时间5—10年，3例局部复发，1例复发且发生肺转移，所有患者均存活。结论临床上，MMT通常表现为无痛性肿块，持续数周至数年，偶有局部疼痛。多发生于成人，男女比例大致相同。肿瘤境界清楚，绝大多数肿瘤位于四肢皮下或深部的筋膜下软组织。组织学上，MMT类似于涎腺的多形性腺瘤，含有不同比例的上皮和（或）肌上皮成分，间质玻璃样变或为软骨黏液样。大部分MMT为良性行为，但少数可局部复发和转移，导致死亡。展开更多
文摘Malignant myoepitheliomas are rare malignant salivary gland neoplasms which usually occur in the parotid gland. Very little material on this topic has been published. This tumour represents a therapeutic challenge since there are no specific recommendations or guidelines. We present a case of malignant myoepithelioma arising de novo in the parotid gland. We discuss our therapeutic approach and considerations on appropriate post-surgical treatment. Then we provide a review of international literature on this interesting and rare oncological entity.
文摘Introduction Adenomyoepithelioma （AME） is uncommon characterized by biphasic proliferation of both epithelial and myoepithelial cells. More than half of the adenomyoepitheliomas （AME） are benign, but in rare instances, it may become malignant. Malignant adenomyoepitheliomas almost always occur in the breast and salivary gland. They are unusual in vulva. We report this case and provide some information about symptoms, microstructure, treatment, and a discussion about this kind of disease.
文摘Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. The histological appearance includes solid, myxoid and reticular growth patterns. Vimentin and S-100 protein are very sensitive but non-specific immunohistochemical markers of neoplastic myoepithelium. Conservative surgery is the treatment of choice. A case of myoepithelioma of the minor salivary gland of tongue is described, focusing on clinical behaviour, histopathological and immunohistochemical features.
文摘目的:探讨外阴肌上皮瘤样肿瘤(myoepithelioma-like tumors of the vulvar region, MELTVR)的临床病理学特征、分子特征、诊断及鉴别诊断。方法:回顾性分析我院1例发生于左侧腹股沟MELTVR临床病理学资料,并进行相关文献复习。结果:患者女,35岁,以“左侧腹股沟肿物2次手术后再发1个月”为主诉入院。镜检示:肿瘤呈弥漫实性分布,其内可见大小不等的滤泡样结构及片状坏死。肿瘤细胞呈上皮样或梭形,间质可见多量小血管增生,呈圆形或分枝状,部分区域可见肿瘤细胞围血管生长、呈“假菊形团”样结构。高倍镜下,胞质嗜酸、局灶胞质透亮,核染色质不均匀、略呈泡状,可见一到数个小核仁,核分裂象易见(>20/10 HPF)。肿瘤位于皮下脂肪组织,可见一层纤细的纤维组织与周围组织分隔,局灶可见脂肪组织浸润。免疫表型:ER、EMA和Vimentin弥漫阳性,INI1阴性。FISH结果显示:EWSR1基因无断裂。结论:MELTVR是一种罕见的发生于女性外阴区的间叶源性肿瘤。它具有多变的组织学模式。与以往文献不同的是该病例未见明确的黏液样区域,正确认识该疾病有助于避免误诊和漏诊。
文摘目的探讨外阴肌上皮瘤样肿瘤(myoepithelioma-like tumour of the vulvar region,MELTVR)临床特征、形态特点、免疫表型、鉴别诊断及预后。方法收集5例MELTVR,对其临床资料、病理形态进行分析,总结其临床病理及免疫表型特征,并复习相关文献。结果5例患者均为女性,中位年龄45岁,病变均位于外阴皮下。肿瘤界限较清,局部见薄纤维包膜分割呈分叶状,有不等比例的黏液区域。肿瘤细胞由上皮样或梭形细胞样成分混合组成,胞质嗜双色或嗜伊红性,细胞核伴轻中度异型性,可见核分裂象和核仁。间质包括黏液样区和实性区,黏液样区瘤细胞稀疏散在分布呈条索状,实性区瘤细胞弥漫成片或席纹状。免疫表型:肿瘤细胞均表达EMA、ER、vimentin;部分病例可不同程度表达Calponin、PR、SMA、CK(AE1/AE3)、CD56,个别灶性表达Syn、STAT6;均不表达S-100、desmin、WT-1、CD10、MyoD1、Myogein、CD34、GFAP、Melan A;Ki67增殖指数10%~20%,SMARCB1/INI-1均表达缺失。5例患者均通过手术切除,未行放、化疗,均未见远处转移。结论MELTVR是一种罕见的低级别或具有低度恶性潜能的间叶源性肿瘤,与多种软组织肿瘤的形态学相似,需要通过临床病史、形态学、免疫组化和分子检测进行整合诊断。
文摘目的探讨软组织肌上皮瘤／混合瘤（myoepithelioma/mixed tumour of soft tissue，MMT）的临床病理学特征、免疫表型、鉴别诊断及预后。方法采用免疫组化EnVision两步法对6例MMT进行免疫组化染色，并复习相关文献。结果6例MMT中男性3例，女性3例，年龄11～63岁，平均44岁。肿瘤直径2—17．5cm，平均6．5cm。免疫表型：75％（3／4）表达CK，100％（4／4）表达vimentin，66．7％（2／3）表达S-100，50％（2／4）表达GFAP，100％（3／3）表达EMA，（0／4）不表达SMA。6例MMT随访时间5—10年，3例局部复发，1例复发且发生肺转移，所有患者均存活。结论临床上，MMT通常表现为无痛性肿块，持续数周至数年，偶有局部疼痛。多发生于成人，男女比例大致相同。肿瘤境界清楚，绝大多数肿瘤位于四肢皮下或深部的筋膜下软组织。组织学上，MMT类似于涎腺的多形性腺瘤，含有不同比例的上皮和（或）肌上皮成分，间质玻璃样变或为软骨黏液样。大部分MMT为良性行为，但少数可局部复发和转移，导致死亡。
