Objective:To evaluate the efficacy and safety of sodium fusidate ointment and mupirocin ointment in the treatment of bacteria-infected skin disease.Methods:The search terms“sodium fusidate ointment”,“mupirocin oint...Objective:To evaluate the efficacy and safety of sodium fusidate ointment and mupirocin ointment in the treatment of bacteria-infected skin disease.Methods:The search terms“sodium fusidate ointment”,“mupirocin ointment”,“bacterial infection”,etc.were searched in the database of PubMed,EMbase,Cochrane,Web of Science,Wanfang,VIP,and CNKI.The search time was from inception to November 2019.Randomized controlled trials of sodium fusidate ointment and mupirocin ointment for the treatment of bacteria-infected skin disease were collected.Two studies independently performed literature screening,data extraction,and literature quality evaluation.Meta analysis was performed using RevMan 5.3 software.Results:A total of 14 literature were included,involving 1,825 patients,916 in the experimental group,and 909 in the control group.Meta analysis results showed that the total clinical effective rate of the experimental group(RR=1.12,95%CI(1.06,1.19),P<0.0001),degree of improvement in pruritus score(MD=−1.21,95%CI(−1.78,−0.64),P<0.0001),degree of improvement of eczema area and severity index score(MD=−2.47,95%CI(−3.92,−1.02),P=0.0008),and sensitivity rate of drug sensitivity test(RR=1.35,95%CI(1.24,1.46),P<0.00001)were better than those of control group.The incidence of adverse reactions(RR=0.18,95%CI(0.09,0.39),P<0.00001)was significantly smaller than that of control group.But the bacterial clearance rate(RR=1.22,95%CI(0.98,1.52),P=0.08)compared with the control group,the difference was not statistically significant.Conclusion:Sodium fusidate ointment is better than mupirocin ointment in the treatment of bacteria-infected skin disease,and it helps to improve the severity of disease and itching,and has good safety,which is worthy of clinical promotion.展开更多
目的观察银离子抗菌敷料治疗外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)置管穿刺点感染的效果。方法将68例PICC穿刺点感染患者根据就诊时间分为对照组(29例)和观察组(39例)。对照组使用莫匹罗星软膏,观察...目的观察银离子抗菌敷料治疗外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)置管穿刺点感染的效果。方法将68例PICC穿刺点感染患者根据就诊时间分为对照组(29例)和观察组(39例)。对照组使用莫匹罗星软膏,观察组使用银离子抗菌敷料,观察两组的治疗效果及治愈时间。结果观察组换药次数少于对照组,治愈时间短于对照组(均P<0.01);两组治疗效果比较,差异无统计学意义(P>0.05)。结论使用银离子抗菌敷料治疗PICC穿刺点感染可以减少换药次数、缩短治疗时间,值得临床推广应用。展开更多
文摘Objective:To evaluate the efficacy and safety of sodium fusidate ointment and mupirocin ointment in the treatment of bacteria-infected skin disease.Methods:The search terms“sodium fusidate ointment”,“mupirocin ointment”,“bacterial infection”,etc.were searched in the database of PubMed,EMbase,Cochrane,Web of Science,Wanfang,VIP,and CNKI.The search time was from inception to November 2019.Randomized controlled trials of sodium fusidate ointment and mupirocin ointment for the treatment of bacteria-infected skin disease were collected.Two studies independently performed literature screening,data extraction,and literature quality evaluation.Meta analysis was performed using RevMan 5.3 software.Results:A total of 14 literature were included,involving 1,825 patients,916 in the experimental group,and 909 in the control group.Meta analysis results showed that the total clinical effective rate of the experimental group(RR=1.12,95%CI(1.06,1.19),P<0.0001),degree of improvement in pruritus score(MD=−1.21,95%CI(−1.78,−0.64),P<0.0001),degree of improvement of eczema area and severity index score(MD=−2.47,95%CI(−3.92,−1.02),P=0.0008),and sensitivity rate of drug sensitivity test(RR=1.35,95%CI(1.24,1.46),P<0.00001)were better than those of control group.The incidence of adverse reactions(RR=0.18,95%CI(0.09,0.39),P<0.00001)was significantly smaller than that of control group.But the bacterial clearance rate(RR=1.22,95%CI(0.98,1.52),P=0.08)compared with the control group,the difference was not statistically significant.Conclusion:Sodium fusidate ointment is better than mupirocin ointment in the treatment of bacteria-infected skin disease,and it helps to improve the severity of disease and itching,and has good safety,which is worthy of clinical promotion.
文摘目的观察银离子抗菌敷料治疗外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)置管穿刺点感染的效果。方法将68例PICC穿刺点感染患者根据就诊时间分为对照组(29例)和观察组(39例)。对照组使用莫匹罗星软膏,观察组使用银离子抗菌敷料,观察两组的治疗效果及治愈时间。结果观察组换药次数少于对照组,治愈时间短于对照组(均P<0.01);两组治疗效果比较,差异无统计学意义(P>0.05)。结论使用银离子抗菌敷料治疗PICC穿刺点感染可以减少换药次数、缩短治疗时间,值得临床推广应用。
