Background:Fufang Muji Granules is a traditional Chinese medicine of the Manchu ethnic group and is thought to treat hepatitis and liver injury by inhibiting the elevation of alpha-fetoprotein.Methods:In this investig...Background:Fufang Muji Granules is a traditional Chinese medicine of the Manchu ethnic group and is thought to treat hepatitis and liver injury by inhibiting the elevation of alpha-fetoprotein.Methods:In this investigation,tandem mass tag(TMT)-based quantitative proteomics was performed to figure out the therapeutic mechanisms of Fufang Muji Granules on liver injury caused by carbon tetrachloride(CCl_(4))in rats.Results:Biochemical analyses(alanine aminotransferase;glutamate aminotransferase;aspartate aminotransferase)and histologic analyses(hematoxylin-eosin)demonstrated that FMG was effective in ameliorating liver injury.A sum of 6,208 proteins were identified and 2,475 proteins were determined as differential abundance proteins(DAPs)in rat liver treated with Fufang Muji Granules which compared to the model group.Bioinformatics analysis indicated that the DAPs are primarily enriched in multiple pathways such as rno00280(valine,leucine,and isoleucine degradation),rno00640(Propanoate metabolism),and rno00380(Tryptophan metabolism).Western blot was employed to validate the findings from the proteomic analysis.Conclusion:This study not only provides useful information on the mechanism of Fufang Muji Granules in the treatment of liver injury but also serves as a basis for further study of Fufang Muji Granules in vivo.展开更多
This article is a report of analysis of Muji's business strategy.First,the vision and mission are introduced.Second,the current strategy is identified.Then the industry analysis,industry driving forces,key success...This article is a report of analysis of Muji's business strategy.First,the vision and mission are introduced.Second,the current strategy is identified.Then the industry analysis,industry driving forces,key success factors,value chain analysis,competitive advantage,competitive power of the competitive advantage were analyzed.At last,on the basis of the former analysis the SWOT analysis was worked out.展开更多
无印良品（MUJ1）—直已超凡脱俗的设计被业界称赞,相应的MUJI AWARD设计大赛也被奉为经典。第一届MUJI AWARD是在2（X）6年举办的,这是一个国际性质的设计赛事。本届MUJI AWARD 04大赛作品审查、发表、颁奖和展览都是在上海举行的,无...无印良品（MUJ1）—直已超凡脱俗的设计被业界称赞,相应的MUJI AWARD设计大赛也被奉为经典。第一届MUJI AWARD是在2（X）6年举办的,这是一个国际性质的设计赛事。本届MUJI AWARD 04大赛作品审查、发表、颁奖和展览都是在上海举行的,无印良品（上海）商业有限公司主办了此次大赛。展开更多
基金National Natural Science Foundation of China(82104532 and 82173913)Joint Program(Applied Basic Research Project)of Liaoning Provincial Science and Technology Program(2023JH2/101700074)+1 种基金High-level Talent Innovation Support Program of Dalian(2021RD10)Fundamental Research Funds for the Central Universities(2023-SWGC-0101)。
文摘Background:Fufang Muji Granules is a traditional Chinese medicine of the Manchu ethnic group and is thought to treat hepatitis and liver injury by inhibiting the elevation of alpha-fetoprotein.Methods:In this investigation,tandem mass tag(TMT)-based quantitative proteomics was performed to figure out the therapeutic mechanisms of Fufang Muji Granules on liver injury caused by carbon tetrachloride(CCl_(4))in rats.Results:Biochemical analyses(alanine aminotransferase;glutamate aminotransferase;aspartate aminotransferase)and histologic analyses(hematoxylin-eosin)demonstrated that FMG was effective in ameliorating liver injury.A sum of 6,208 proteins were identified and 2,475 proteins were determined as differential abundance proteins(DAPs)in rat liver treated with Fufang Muji Granules which compared to the model group.Bioinformatics analysis indicated that the DAPs are primarily enriched in multiple pathways such as rno00280(valine,leucine,and isoleucine degradation),rno00640(Propanoate metabolism),and rno00380(Tryptophan metabolism).Western blot was employed to validate the findings from the proteomic analysis.Conclusion:This study not only provides useful information on the mechanism of Fufang Muji Granules in the treatment of liver injury but also serves as a basis for further study of Fufang Muji Granules in vivo.
文摘This article is a report of analysis of Muji's business strategy.First,the vision and mission are introduced.Second,the current strategy is identified.Then the industry analysis,industry driving forces,key success factors,value chain analysis,competitive advantage,competitive power of the competitive advantage were analyzed.At last,on the basis of the former analysis the SWOT analysis was worked out.
文摘无印良品（MUJ1）—直已超凡脱俗的设计被业界称赞,相应的MUJI AWARD设计大赛也被奉为经典。第一届MUJI AWARD是在2（X）6年举办的,这是一个国际性质的设计赛事。本届MUJI AWARD 04大赛作品审查、发表、颁奖和展览都是在上海举行的,无印良品（上海）商业有限公司主办了此次大赛。
