Rui Chena,b,Tangbing Cui a,b,∗a School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China b Guangdong Key Laboratory of Fermentation and Enzyme Engineering,South China Un...Rui Chena,b,Tangbing Cui a,b,∗a School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China b Guangdong Key Laboratory of Fermentation and Enzyme Engineering,South China University of Technology,Guangzhou 510006,China The authors regret that the published version of this article contained several errors and omissions,which are described and corrected below.1.Figs.3 and 4(figure order and legends).In the published article,Figs.3 and 4 were inadvertently published in reversed order.The figures should be swapped so that the figure content matches its caption.The correct figures and their legends are provided on the following page.2.Title correction.The compound name in the published title was incorrectly typeset as“benzo[a]pyrene”The correct spelling is“benzo[a]pyrene.”3.Text corrections in Section 2.4.Several typographical errors occurred in Section 2.4(“Up-regulation of acetoin,lactate,and kanosamine biosynthesis under sodium gluconate treatment”).展开更多
Vaccination is the preferred strategy for preventing infections such as influenza in elderly individuals;however,its efficacy is often suboptimal due in part to age-related declines in immune function.In this study,we...Vaccination is the preferred strategy for preventing infections such as influenza in elderly individuals;however,its efficacy is often suboptimal due in part to age-related declines in immune function.In this study,we discovered that the infusion of mesenchymal stromal cells(MSCs)restored defects in the splenic stromal cell network and lymphocyte architecture in aged mice while also increasing specific antibody levels following vaccine immunization.This significantly protected aging mice from influenza infection.Mechanistically,the delivered MSCs localized in the splenic marginal zones,where they positioned themselves near marginal reticular cells(MRCs)and stimulated MRC proliferation,partially through the action of vascular endothelial growth factor A(VEGFA).This MSC‒MRC interaction orchestrated the reconstruction of the stromal network,thereby restoring lymphocyte homeostasis and germinal center reactions.Importantly,the MSC-mediated enhancement of the vaccine response was further validated in aged cynomolgus monkeys.Collectively,our findings provide new insights into the application of MSCs in addressing age-related immune decline and highlight splenic MRCs as critical therapeutic targets.展开更多
Multipotent stromal cells,otherwise known as mesenchymal stem cells(MSCs),have been widely studied for their regenerative potential across multiple tissues,including the nervous system(Caplan,2017).Reports suggesting ...Multipotent stromal cells,otherwise known as mesenchymal stem cells(MSCs),have been widely studied for their regenerative potential across multiple tissues,including the nervous system(Caplan,2017).Reports suggesting that MSCs can differentiate into neurons and glia spurred optimism towards their future therapeutic application in nervous system disorders.Despite extensive research,however,the precise cellular mechanisms underlying their neural differentiation potential are unclear(George et al.,2019).展开更多
昆仑能源湖北黄冈液化天然气工厂是中国唯一的百万吨级天然气液化工厂,经过10年的平稳运行,证明我国自主开发的百万吨级天然气液化工艺技术和国产化装备可靠性较高。中国已实现百万吨级液化天然气工厂的自主建设和运营,但在工艺优化和...昆仑能源湖北黄冈液化天然气工厂是中国唯一的百万吨级天然气液化工厂,经过10年的平稳运行,证明我国自主开发的百万吨级天然气液化工艺技术和国产化装备可靠性较高。中国已实现百万吨级液化天然气工厂的自主建设和运营,但在工艺优化和降低能耗方面仍存在较大提升空间。为此,以昆仑能源湖北黄冈液化天然气工厂为例,重点对该工厂的工艺流程进行了介绍和模拟验证,并在此基础上对工艺参数进行了优化。研究结果表明:(1)采用工厂实际运行数据对多级单组分制冷天然气液化工艺(Multistage Single Component refrigeration natural gas liquefaction process,MSC)的计算模型进行了验证,并采用热力学分析方法对MSC工艺的换热系统进行了优化;(2)模拟计算结果和实际运行数据吻合度高,单位能耗数据相差2.40%,证实计算模型可信度高;(3)基于热力学分析,优化了对数平均温差,换热过程的总?损降低了15.67%,单位能耗为每千克LNG 0.318 k W·h,比验证计算模型下降2.15%。结论认为,研究成果可指导该工厂下一步的节能降耗,同时为开发单线规模800×10^(4) t/a的超大型天然气液化成套技术提供理论支撑,实践经验对指导中国超大型天然气液化工厂高质量发展具有重要的工程应用价值。展开更多
文摘Rui Chena,b,Tangbing Cui a,b,∗a School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China b Guangdong Key Laboratory of Fermentation and Enzyme Engineering,South China University of Technology,Guangzhou 510006,China The authors regret that the published version of this article contained several errors and omissions,which are described and corrected below.1.Figs.3 and 4(figure order and legends).In the published article,Figs.3 and 4 were inadvertently published in reversed order.The figures should be swapped so that the figure content matches its caption.The correct figures and their legends are provided on the following page.2.Title correction.The compound name in the published title was incorrectly typeset as“benzo[a]pyrene”The correct spelling is“benzo[a]pyrene.”3.Text corrections in Section 2.4.Several typographical errors occurred in Section 2.4(“Up-regulation of acetoin,lactate,and kanosamine biosynthesis under sodium gluconate treatment”).
基金supported by grants from the National Key Research and Development Program of China,Stem Cell and Translational Research(2022YFA1104100,2022YFA1105000,2018YFA0801404)the National Natural Science Foundation of China(82570270,82270230,32130046,82171617,82471689,82170540,82471462,82270566)+8 种基金the Guangdong Basic and Applied Basic Research Foundation(2023B1515020119)the Key Research and Development Program of Guangdong Province(2023B1111050006)the Key Scientific and Technological Program of Guangzhou City(2023B01J1002,202206080002)the Pioneering Talents Project of the Guangzhou Development Zone(2021-L029)the Guangdong Special Support Program(2019BT02Y276)the Shenzhen Science and Technology Program(KJZD20230923114504008)the Sanming Project of Medicine in Shenzhen Nanshan(SZSM2021034008)the Science and Technology Planning Project of Gaozhou(20240619111622)the Special Funds for the Cultivation of Guangdong College Students'Scientific and Technological Innovation(pdjh2025ak003).
文摘Vaccination is the preferred strategy for preventing infections such as influenza in elderly individuals;however,its efficacy is often suboptimal due in part to age-related declines in immune function.In this study,we discovered that the infusion of mesenchymal stromal cells(MSCs)restored defects in the splenic stromal cell network and lymphocyte architecture in aged mice while also increasing specific antibody levels following vaccine immunization.This significantly protected aging mice from influenza infection.Mechanistically,the delivered MSCs localized in the splenic marginal zones,where they positioned themselves near marginal reticular cells(MRCs)and stimulated MRC proliferation,partially through the action of vascular endothelial growth factor A(VEGFA).This MSC‒MRC interaction orchestrated the reconstruction of the stromal network,thereby restoring lymphocyte homeostasis and germinal center reactions.Importantly,the MSC-mediated enhancement of the vaccine response was further validated in aged cynomolgus monkeys.Collectively,our findings provide new insights into the application of MSCs in addressing age-related immune decline and highlight splenic MRCs as critical therapeutic targets.
文摘Multipotent stromal cells,otherwise known as mesenchymal stem cells(MSCs),have been widely studied for their regenerative potential across multiple tissues,including the nervous system(Caplan,2017).Reports suggesting that MSCs can differentiate into neurons and glia spurred optimism towards their future therapeutic application in nervous system disorders.Despite extensive research,however,the precise cellular mechanisms underlying their neural differentiation potential are unclear(George et al.,2019).
文摘昆仑能源湖北黄冈液化天然气工厂是中国唯一的百万吨级天然气液化工厂,经过10年的平稳运行,证明我国自主开发的百万吨级天然气液化工艺技术和国产化装备可靠性较高。中国已实现百万吨级液化天然气工厂的自主建设和运营,但在工艺优化和降低能耗方面仍存在较大提升空间。为此,以昆仑能源湖北黄冈液化天然气工厂为例,重点对该工厂的工艺流程进行了介绍和模拟验证,并在此基础上对工艺参数进行了优化。研究结果表明:(1)采用工厂实际运行数据对多级单组分制冷天然气液化工艺(Multistage Single Component refrigeration natural gas liquefaction process,MSC)的计算模型进行了验证,并采用热力学分析方法对MSC工艺的换热系统进行了优化;(2)模拟计算结果和实际运行数据吻合度高,单位能耗数据相差2.40%,证实计算模型可信度高;(3)基于热力学分析,优化了对数平均温差,换热过程的总?损降低了15.67%,单位能耗为每千克LNG 0.318 k W·h,比验证计算模型下降2.15%。结论认为,研究成果可指导该工厂下一步的节能降耗,同时为开发单线规模800×10^(4) t/a的超大型天然气液化成套技术提供理论支撑,实践经验对指导中国超大型天然气液化工厂高质量发展具有重要的工程应用价值。
