地基增强系统(Ground Based Augmentation System,GBAS)是支持飞行器精密进近着陆的有效手段,完好性监测算法的设计是保障飞行安全的关键点与系统设计的难点,多参考接收机一致性监测(MRCC)通过B值计算与故障监测流程可排除校正中产生很...地基增强系统(Ground Based Augmentation System,GBAS)是支持飞行器精密进近着陆的有效手段,完好性监测算法的设计是保障飞行安全的关键点与系统设计的难点,多参考接收机一致性监测(MRCC)通过B值计算与故障监测流程可排除校正中产生很大误差的接收机信道,保证GBAS地面站发送差分修正量的可靠性。分析了MRCC算法的原理与方法,发现MRCC故障监测流程无法有效处理伪距与载波相位B值均超过阈值,且最大值不为同一通道的问题,针对该问题提出了一种MRCC故障监测流程改进算法,并且对已有和改进的MRCC故障监测流程算法进行了实验对比。结果表明,改进算法故障监测流程针对伪距和载波相位引起的不一致性分层处理,可有效解决当前存在问题。展开更多
Objective To establish a SOI model of human renal carcinoma and a high metastatic cell subline. Methods A human renal cell line RCC-9863 has been established by inoculating a human renal tumor tissue into nude mice s....Objective To establish a SOI model of human renal carcinoma and a high metastatic cell subline. Methods A human renal cell line RCC-9863 has been established by inoculating a human renal tumor tissue into nude mice s. c.. When RCC-9863 passaged for 20 times, the tissue from the same xemotransplant tumor were used to construct SOI model. Cultured the metastatic tissue in vitro, the tumor cell suspension was then injected orthotopically, The metastatic tissue obtained underwent the same procedure again. At last, the metastatic tumor was cultured in vitro and cloned. Results 15 days later, a tumor mass sized 1. 7 cm × 0. 6 cm in the nude mouse’s renal parenchyma was grown which lobulated, rude, and with multiply blood vessels and 55 days later later the mouse became moribund and metastases in the lungs were formed. The transplanted renal tumor in the SOI model grew fast and invasively and metastasized to lungs, lymphatic node and liver. A subline, MRCC, with metastatic ability to the lung was selected.展开更多
Objective: To describe the epidemiological, clinical and therapeutic aspects of cervical compressive myeloradiculopathy seen in neurosurgery consultation at the Sino-Guinean Friendship Hospital (HASIGUI). Material and...Objective: To describe the epidemiological, clinical and therapeutic aspects of cervical compressive myeloradiculopathy seen in neurosurgery consultation at the Sino-Guinean Friendship Hospital (HASIGUI). Material and Methods: A prospective descriptive study was conducted at the Neurosurgery Department of the Sino-Guinean Friendship Hospital (Guinea, Conakry) over a 6-month period between May and November 2021. All patients seen in consultation, in whom the diagnosis of cervical compressive myeloradiculopathy (CRM) was established, were included. A survey form was used to collect epidemiological, clinical and therapeutic characteristics. Results: The hospital prevalence of cervical compressive myeloradiculopathy was 13.33%, or 42 cases among 315 neurosurgical pathologies. Men predominated (n = 34;81%) with a mean age of 52.8 ± 11.4 years and extremes of 38 and 81 years;the professional categories of administrators and professionals were affected in the same proportion (15 cases, or 35.7% of cases);chronic neck pain was found in 38 patients (88.4%) as a previous history. The most common reasons for consultation were: neck pain (100% of cases), paresthesia of the fingertips (92.9% of cases), cervicobrachial neuralgia (78.6% of cases), weakness of the upper limbs (64.3% of cases), cramps (61.9%), sphincter disorders (38.1% of cases). The most common cause found on the basis of neuroimaging was cervicarthrosis in 40.3% of the cases, with an improvement of medical treatment in 59.5% and surgical decompression in 19% of the cases. Conclusion: Cervical compressive myeloradiculopathy is increasingly diagnosed in our working environment. It is the prerogative of the elderly subject, who has male predominance. Neurological signs are in the foreground. CT and/or MRI is the imaging test of choice for diagnosis.展开更多
This article puts forth suggestion that the ship Inmarsat identification code be added to the data structure of A and B class ship equipment of AIS for the prompt and effective communication with ships in distress and...This article puts forth suggestion that the ship Inmarsat identification code be added to the data structure of A and B class ship equipment of AIS for the prompt and effective communication with ships in distress and those around via Inmarsat in the process of search and rescue through MRCC （Maritime Rescue Coordination Center）.展开更多
目的:旨在评估肿瘤浸润性程序性死亡受体-1(programmed cell death protein-1,PD-1)阳性淋巴细胞及调节性T细胞(regu-latory T cell,Treg)对转移性肾癌(metastatic renal cell carcinoma,mRCC)预后的预测价值。探讨PD-1和Treg在mRCC中...目的:旨在评估肿瘤浸润性程序性死亡受体-1(programmed cell death protein-1,PD-1)阳性淋巴细胞及调节性T细胞(regu-latory T cell,Treg)对转移性肾癌(metastatic renal cell carcinoma,mRCC)预后的预测价值。探讨PD-1和Treg在mRCC中的表达及其与患者临床病理参数、预后的相关性。方法:收集2007年6月至2017年6月269例复旦大学附属中山医院mRCC患者的临床病理资料,应用免疫组织化学法检测mRCC患者组织中PD-1和Treg的表达,分析其与各项临床指标及预后的关系。结果:mRCC患者组织中PD-1表达的阳性率为31.60%(85/269),表达水平与肿瘤Fuhrman分级呈正相关,与预后呈负相关;Treg表达的阳性率为36.80%(99/269),表达水平亦与肿瘤Fuhrman分级呈正相关,与预后呈负相关。单因素分析显示,PD-1阳性和高Treg浸润数量与总生存(overall survival,OS)率及无进展生存(progression free survival,PFS)率呈负相关。PD-1阳性和高Treg浸润数量为OS和PFS的独立预后指标,二者联合可起到较好的预测效果。结论:PD-1阳性或高Treg浸润数量可作为mRCC的预后指标,二者联合预测效果更佳。mRCC患者组织中PD-1阳性淋巴细胞或Treg浸润数量的评估可为临床预后判断提供依据。展开更多
Renal cell carcinoma(RCC)is responsible for an estimated 434,419 new cases and 155,702 deaths,which amounts to 2.2%of all new cancer globally[1].Despite the advent of new combination therapies,the 3-year overall survi...Renal cell carcinoma(RCC)is responsible for an estimated 434,419 new cases and 155,702 deaths,which amounts to 2.2%of all new cancer globally[1].Despite the advent of new combination therapies,the 3-year overall survival(OS)in metastatic RCC(mRCC)remains around 60%[2-4].展开更多
文摘地基增强系统(Ground Based Augmentation System,GBAS)是支持飞行器精密进近着陆的有效手段,完好性监测算法的设计是保障飞行安全的关键点与系统设计的难点,多参考接收机一致性监测(MRCC)通过B值计算与故障监测流程可排除校正中产生很大误差的接收机信道,保证GBAS地面站发送差分修正量的可靠性。分析了MRCC算法的原理与方法,发现MRCC故障监测流程无法有效处理伪距与载波相位B值均超过阈值,且最大值不为同一通道的问题,针对该问题提出了一种MRCC故障监测流程改进算法,并且对已有和改进的MRCC故障监测流程算法进行了实验对比。结果表明,改进算法故障监测流程针对伪距和载波相位引起的不一致性分层处理,可有效解决当前存在问题。
文摘Objective To establish a SOI model of human renal carcinoma and a high metastatic cell subline. Methods A human renal cell line RCC-9863 has been established by inoculating a human renal tumor tissue into nude mice s. c.. When RCC-9863 passaged for 20 times, the tissue from the same xemotransplant tumor were used to construct SOI model. Cultured the metastatic tissue in vitro, the tumor cell suspension was then injected orthotopically, The metastatic tissue obtained underwent the same procedure again. At last, the metastatic tumor was cultured in vitro and cloned. Results 15 days later, a tumor mass sized 1. 7 cm × 0. 6 cm in the nude mouse’s renal parenchyma was grown which lobulated, rude, and with multiply blood vessels and 55 days later later the mouse became moribund and metastases in the lungs were formed. The transplanted renal tumor in the SOI model grew fast and invasively and metastasized to lungs, lymphatic node and liver. A subline, MRCC, with metastatic ability to the lung was selected.
文摘Objective: To describe the epidemiological, clinical and therapeutic aspects of cervical compressive myeloradiculopathy seen in neurosurgery consultation at the Sino-Guinean Friendship Hospital (HASIGUI). Material and Methods: A prospective descriptive study was conducted at the Neurosurgery Department of the Sino-Guinean Friendship Hospital (Guinea, Conakry) over a 6-month period between May and November 2021. All patients seen in consultation, in whom the diagnosis of cervical compressive myeloradiculopathy (CRM) was established, were included. A survey form was used to collect epidemiological, clinical and therapeutic characteristics. Results: The hospital prevalence of cervical compressive myeloradiculopathy was 13.33%, or 42 cases among 315 neurosurgical pathologies. Men predominated (n = 34;81%) with a mean age of 52.8 ± 11.4 years and extremes of 38 and 81 years;the professional categories of administrators and professionals were affected in the same proportion (15 cases, or 35.7% of cases);chronic neck pain was found in 38 patients (88.4%) as a previous history. The most common reasons for consultation were: neck pain (100% of cases), paresthesia of the fingertips (92.9% of cases), cervicobrachial neuralgia (78.6% of cases), weakness of the upper limbs (64.3% of cases), cramps (61.9%), sphincter disorders (38.1% of cases). The most common cause found on the basis of neuroimaging was cervicarthrosis in 40.3% of the cases, with an improvement of medical treatment in 59.5% and surgical decompression in 19% of the cases. Conclusion: Cervical compressive myeloradiculopathy is increasingly diagnosed in our working environment. It is the prerogative of the elderly subject, who has male predominance. Neurological signs are in the foreground. CT and/or MRI is the imaging test of choice for diagnosis.
文摘This article puts forth suggestion that the ship Inmarsat identification code be added to the data structure of A and B class ship equipment of AIS for the prompt and effective communication with ships in distress and those around via Inmarsat in the process of search and rescue through MRCC （Maritime Rescue Coordination Center）.
文摘Renal cell carcinoma(RCC)is responsible for an estimated 434,419 new cases and 155,702 deaths,which amounts to 2.2%of all new cancer globally[1].Despite the advent of new combination therapies,the 3-year overall survival(OS)in metastatic RCC(mRCC)remains around 60%[2-4].
