Objective:To study the correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodeling in patients with left heart failure.Methods:A total of 104 patients with chronic heart failure ...Objective:To study the correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodeling in patients with left heart failure.Methods:A total of 104 patients with chronic heart failure treated in our hospital between May 2013 and May 2016 were selected as the heart failure group of the research and 95 healthy volunteers receiving physical examination in our hospital over the same period were selected as the control group of the research. Serum was collected to detect the content of MR-ProANP, NT-ProBNP as well as ventricular remodeling-related molecules, and cardiac color Doppler ultrasonography was conducted to determine the heart pump function- and myocardial remodeling-related parameters.Results:Serum MR-ProANP, NT-ProBNP, MMP2, MMP9, MMP10, PICP and PIIINP content as well as ultrasound parameters IVSd, PWT, LVMI, MWS levels of heart failure group were significantly higher than those of control group, ultrasound parameters LAEF, LAPEF and LAAEF levels were significantly lower than those of control group;serum MR-ProANP and NT-ProBNP content were positively correlated with ultrasound parameters IVSd, PWT, LVMI, MWS as well as serum MMP2, MMP9, MMP10, PICP and PIIINP content, negatively correlated with ultrasound parameters LAEF, LAPEF and LAAEF, and the correlation coefficients of MR-ProANP with these indexes were all higher than those of NT-ProBNP.Conclusion:Serum MR-ProANP and NT-ProBNP content in patients with left heart failure are closely related to the pump function and ventricular remodeling, and MR-ProANP is more valuable for evaluating pump function decrease and ventricular remodeling increase.展开更多
急性心力衰竭(AHF)是慢性阻塞性肺疾病急性加重(AECOPD)患者最重要的合并症之一,与无AHF的患者相比,住院率和死亡率更高。AECOPD时其他急性事件(如AHF)的风险增加,需要优先对AECOPD并发AHF患者进行全面病情评估,因此对于AECOPD患者并发...急性心力衰竭(AHF)是慢性阻塞性肺疾病急性加重(AECOPD)患者最重要的合并症之一,与无AHF的患者相比,住院率和死亡率更高。AECOPD时其他急性事件(如AHF)的风险增加,需要优先对AECOPD并发AHF患者进行全面病情评估,因此对于AECOPD患者并发AHF的诊断尤为重要。由于AECOPD和AHF的症状和体征可出现部分重叠,AECOPD时是否伴有AHF的诊断具有较大难度。本综述将探究MR-proANP、BNP及NT-proBNP对AECOPD患者并发AHF的诊断价值的研究进展。Acute heart failure (AHF) is one of the most important comorbidities in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with higher rates of hospitalization and mortality compared to patients without AHF. The increased risk of other acute events (e.g., AHF) in the presence of AECOPD necessitates prioritization of patients with AECOPD complicated by AHF for a thorough evaluation of their condition. Therefore, it is particularly important for the diagnosis of AHF in patients with AECOPD. Since the signs and symptoms of AECOPD and AHF may partially overlap, the diagnosis of AHF in AECOPD can be difficult. In this review, we will investigate the progress of MR-proANP, BNP and NT-proBNP in the diagnosis of AHF in patients with AECOPD.展开更多
文摘Objective:To study the correlation of serum MR-ProANP and NT-ProBNP content with pump function and ventricular remodeling in patients with left heart failure.Methods:A total of 104 patients with chronic heart failure treated in our hospital between May 2013 and May 2016 were selected as the heart failure group of the research and 95 healthy volunteers receiving physical examination in our hospital over the same period were selected as the control group of the research. Serum was collected to detect the content of MR-ProANP, NT-ProBNP as well as ventricular remodeling-related molecules, and cardiac color Doppler ultrasonography was conducted to determine the heart pump function- and myocardial remodeling-related parameters.Results:Serum MR-ProANP, NT-ProBNP, MMP2, MMP9, MMP10, PICP and PIIINP content as well as ultrasound parameters IVSd, PWT, LVMI, MWS levels of heart failure group were significantly higher than those of control group, ultrasound parameters LAEF, LAPEF and LAAEF levels were significantly lower than those of control group;serum MR-ProANP and NT-ProBNP content were positively correlated with ultrasound parameters IVSd, PWT, LVMI, MWS as well as serum MMP2, MMP9, MMP10, PICP and PIIINP content, negatively correlated with ultrasound parameters LAEF, LAPEF and LAAEF, and the correlation coefficients of MR-ProANP with these indexes were all higher than those of NT-ProBNP.Conclusion:Serum MR-ProANP and NT-ProBNP content in patients with left heart failure are closely related to the pump function and ventricular remodeling, and MR-ProANP is more valuable for evaluating pump function decrease and ventricular remodeling increase.
文摘急性心力衰竭(AHF)是慢性阻塞性肺疾病急性加重(AECOPD)患者最重要的合并症之一,与无AHF的患者相比,住院率和死亡率更高。AECOPD时其他急性事件(如AHF)的风险增加,需要优先对AECOPD并发AHF患者进行全面病情评估,因此对于AECOPD患者并发AHF的诊断尤为重要。由于AECOPD和AHF的症状和体征可出现部分重叠,AECOPD时是否伴有AHF的诊断具有较大难度。本综述将探究MR-proANP、BNP及NT-proBNP对AECOPD患者并发AHF的诊断价值的研究进展。Acute heart failure (AHF) is one of the most important comorbidities in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with higher rates of hospitalization and mortality compared to patients without AHF. The increased risk of other acute events (e.g., AHF) in the presence of AECOPD necessitates prioritization of patients with AECOPD complicated by AHF for a thorough evaluation of their condition. Therefore, it is particularly important for the diagnosis of AHF in patients with AECOPD. Since the signs and symptoms of AECOPD and AHF may partially overlap, the diagnosis of AHF in AECOPD can be difficult. In this review, we will investigate the progress of MR-proANP, BNP and NT-proBNP in the diagnosis of AHF in patients with AECOPD.
