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MPEG1作为泛癌预后标志物及其与免疫浸润的相关性研究
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作者 魏瑜 孟平平 《农垦医学》 2026年第1期43-50,共8页
目的:研究MPEG1在泛癌中的作用。方法:采用TCGA、TCGA_GTEx和TCGA配对样本分析MPEG1表达情况;利用Cox回归评估TCGA泛癌患者中MPEG1表达和临床结果之间的关系;运用TIMER 2.0分析异常表达MPEG1与免疫浸润的相关性;以基因本体论(Gene Ontol... 目的:研究MPEG1在泛癌中的作用。方法:采用TCGA、TCGA_GTEx和TCGA配对样本分析MPEG1表达情况;利用Cox回归评估TCGA泛癌患者中MPEG1表达和临床结果之间的关系;运用TIMER 2.0分析异常表达MPEG1与免疫浸润的相关性;以基因本体论(Gene Ontology,GO)/京都基因与基因组百科全书(Kyoto Encyclopediaof Genesand Genomes,KEGG)进行MPEG1相关基因的功能富集分析。结果:TCGA、TCGA_GTEx和TCGA配对样本分析MPEG1在多种肿瘤中高表达;Cox回归分析表明MPEG1表达与多种肿瘤患者预后有关,且MPEG1表达与病理分期、T分期、M分期有关;异常表达MPEG1与免疫浸润显著相关,如B细胞、T细胞;基因富集分析表明,MPEG1主要和免疫反应通路相关。结论:MPEG1可能是预测泛癌预后和免疫治疗效果的有价值的分子生物标志物。 展开更多
关键词 mpeg1 免疫浸润 泛癌 生存分析 预后标志物 生物信息学分析
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A Review of Ice Deformation and Breaking Under Flexural–Gravity Waves Induced by Moving Loads 被引量:2
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作者 Baoyu Ni Hang Xiong +3 位作者 Duanfeng Han Lingdong Zeng Linhua Sun Hao Tan 《哈尔滨工程大学学报(英文版)》 2025年第1期35-52,共18页
Ice-breaking methods have become increasingly significant with the ongoing development of the polar regions.Among many ice-breaking methods,ice-breaking that utilizes a moving load is unique compared with the common c... Ice-breaking methods have become increasingly significant with the ongoing development of the polar regions.Among many ice-breaking methods,ice-breaking that utilizes a moving load is unique compared with the common collision or impact methods.A moving load can generate flexural-gravity waves(FGWs),under the influence of which the ice sheet undergoes deformation and may even experience structural damage.Moving loads can be divided into above-ice loads and underwater loads.For the above-ice loads,we discuss the characteristics of the FGWs generated by a moving load acting on a complete ice sheet,an ice sheet with a crack,and an ice sheet with a lead of open water.For underwater loads,we discuss the influence on the ice-breaking characteristics of FGWs of the mode of motion,the geometrical features,and the trajectory of motion of the load.In addition to discussing the status of current research and the technical challenges of ice-breaking by moving loads,this paper also looks ahead to future research prospects and presents some preliminary ideas for consideration. 展开更多
关键词 ICE-BREAKING moving load Flexural-gravity wave Ice sheet Above-ice load Underwater load
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基于mPEG-PCL修饰的多西他赛脂质体的制备及体外抗肿瘤活性评价
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作者 侯盼盼 杨春杰 +4 位作者 苏慧慧 钱慧琴 李柯儒 崔茜 郭新红 《药物评价研究》 北大核心 2025年第6期1546-1556,共11页
目的 制备单甲氧基聚乙二醇5000-聚己内酯10000(mPEG5000-PCL10000)修饰的多西他赛(DTX)脂质体(DTXPLip),并初步评价其体外抗肿瘤活性。方法 采用薄膜分散-水化法制备DTX-Plip。以粒径、包封率(EE)、载药量(LC)为评价指标,通过单因素及... 目的 制备单甲氧基聚乙二醇5000-聚己内酯10000(mPEG5000-PCL10000)修饰的多西他赛(DTX)脂质体(DTXPLip),并初步评价其体外抗肿瘤活性。方法 采用薄膜分散-水化法制备DTX-Plip。以粒径、包封率(EE)、载药量(LC)为评价指标,通过单因素及正交试验优选DTX-PLip的最佳处方工艺;研究DTX-PLip的透射电镜微观形态、粒径、ζ电位、EE及LC;考察其在4℃放置21 d内的稳定性;采用透析法对DTX-PLip的体外释放特性进行研究;采用MTT法评估DTXPLip对小鼠乳腺癌4T1细胞的增殖抑制效应;通过体外细胞摄取实验,结合荧光显微镜观察与流式细胞术定量分析4T1细胞对DTX-PLip的摄取效率。结果 DTX-PLip最佳处方为mPEG5000-PCL10000用量150 mg,DTX用量8 mg,药脂比为1∶20,胆脂比为1∶5。透射电子显微镜图片显示DTX-PLip具封闭囊泡结构,平均粒径为(82.13±3.33)nm,ζ电位为(-15.70±3.86)mV;EE为(89.34±1.07)%,LC为(2.04±0.02)%;体外释放结果表明,DTX-PLip 72 h体外累积释放率为58%,具有一定的缓释性,4℃放置21 d内储存稳定;细胞毒实验结果表明DTX-PLip对4T1细胞的半数抑制浓度(IC50)值为(0.13±0.01)μg·mL-1,均显著高于DTX溶液组和DTX脂质体(DTX-Lip)组(P<0.001),具有良好的抗肿瘤活性;荧光显微镜观察结果表明DTX-PLip在各个时间平均荧光强度均显著高于DTX-Lip(P<0.01),流式细胞术结果表明,与DTX-Lip相比,DTX-PLip细胞摄取量显著增加(P<0.001)。结论 DTX-PLip表现出明显的缓释作用,能增强DTX的抗肿瘤效果。 展开更多
关键词 多西他赛 单甲氧基-聚乙二醇(mpeg-PCL) 脂质体 处方工艺 抗肿瘤活性 乳腺癌
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Method to Determine the Propulsion Characteristics of a Ship Moving in Ice 被引量:1
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作者 Kirill Sazonov Grigorii Kanevskii +1 位作者 Alexandr Klubnichkin Aleksei Dobrodeev 《哈尔滨工程大学学报(英文版)》 2025年第3期532-541,共10页
In designing modern vessels, calculating the propulsion performance of ships in ice is important, including propeller effective thrust, number of revolutions, consumed power, and ship speed. Such calculations allow fo... In designing modern vessels, calculating the propulsion performance of ships in ice is important, including propeller effective thrust, number of revolutions, consumed power, and ship speed. Such calculations allow for more accurate prediction of the ice performance of a designed ship and provide inputs for designers of ship power and automation systems. Preliminary calculations of ship propulsion and thrust characteristics in ice can enable predictions of full-scale ice resistance without measuring the propeller thrust during sea trials. Measuring propeller revolutions,ship speed, and the power delivered to propellers could be sufficient to determine the propeller thrust of the vessel. At present, significant difficulties arise in determining the thrust of icebreakers and ice-class ships in ice conditions. These challenges are related to the fact that the traditional system of propeller/hull interaction coefficients does not function correctly in ice conditions. The wake fraction becomes negative and tends to minus infinity starting from a certain value of the propeller advance coefficient. This issue prevents accurate determination of the performance characteristics, thrust, and rotational speed of the propulsors. In this study, an alternative system of propeller/hull interaction coefficients for ice is proposed. It enables the calculation of all propulsion parameters in ice based on standard hydrodynamic tests with selfpropulsion models. An experimental method is developed to determine alternative propeller/hull interaction coefficients. A prediction method is suggested to determine propulsion performance in ice based on the alternative interaction coefficient system. A case study applying the propulsion prediction method for ice conditions is provided. This study also discusses the following issues of ship operation in ice: the scale effect of icebreaker propellers and the prospects for introducing an ice interaction coefficient. 展开更多
关键词 ICEBREAKER Model experiment Interaction coefficients Propeller Calculation Off-design mode Propulsion characteristics Ship moving in ice
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A review of current studies on the unmanned aerial vehicle-based moving target tracking methods 被引量:1
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作者 Binbin Yan Yuxin Wei +3 位作者 Shuangxi Liu Wei Huang Ruizhe Feng Xiaoqian Chen 《Defence Technology(防务技术)》 2025年第9期201-219,共19页
Unmanned aerial vehicles(UAVs)have become crucial tools in moving target tracking due to their agility and ability to operate in complex,dynamic environments.UAVs must meet several requirements to achieve stable track... Unmanned aerial vehicles(UAVs)have become crucial tools in moving target tracking due to their agility and ability to operate in complex,dynamic environments.UAVs must meet several requirements to achieve stable tracking,including maintaining continuous target visibility amidst occlusions,ensuring flight safety,and achieving smooth trajectory planning.This paper reviews the latest advancements in UAV-based target tracking,highlighting information prediction,tracking strategies,and swarm cooperation.To address challenges including target visibility and occlusion,real-time prediction and tracking in dynamic environments,flight safety and coordination,resource management and energy efficiency,the paper identifies future research directions aimed at improving the performance,reliability,and scalability of UAV tracking system. 展开更多
关键词 Unmanned aerial vehicle(UAV) Tracking methods moving targets Information prediction Tracking strategies Swarm cooperation
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Swedish automation keeps filter products moving
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《China Textile》 2025年第1期46-47,共2页
Members of TMAS-the Swedish textile machinery association-are providing crucial manufacturing and automation services to the filtration sector which is an often invisible but very significant part of the global textil... Members of TMAS-the Swedish textile machinery association-are providing crucial manufacturing and automation services to the filtration sector which is an often invisible but very significant part of the global textile industry.Technical woven and nonwoven fabrics are used in a wide variety of products in filtration systems for air,gas and liquid filtration,touching on almost every facet of life in the 21st Century. 展开更多
关键词 NONWOVEN moving AUTOMATION
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Safety Evaluation of Bridge underMoving Abnormal Indivisible Load Based on Fusing Bridge Inspection Data and Load Test Data
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作者 He Zhang He-Qing Mu +2 位作者 Xiao Zhang He Zhang Yuedong Yang 《Structural Durability & Health Monitoring》 2025年第3期499-530,共32页
Safety evaluation of a bridge under Moving Abnormal Indivisible Loads(MAILs)directly relates to whether an oversized and/or overweight Large-Cargo Transportation(LCT)vehicle is permitted to pass the bridge.Safety eval... Safety evaluation of a bridge under Moving Abnormal Indivisible Loads(MAILs)directly relates to whether an oversized and/or overweight Large-Cargo Transportation(LCT)vehicle is permitted to pass the bridge.Safety evaluation can be updated by fusing bridge inspection data and load test data,but there are two fundamental difficulties in updating.The first difficulty is to develop an updating scheme to utilize the unstructured inspection data.The second difficulty is to develop a successive updating scheme using load test data based on the previous updating results of the inspection data.This paper proposed a framework,consisting of three modules,to tackle these two fundamental difficulties of updating.Module one is the updating of Finite Element Model(FEM)and resistance of the bridge based on fusing bridge inspection data and load test data.The first difficulty in utilizing the unstructured inspection data is tackled by introducing updating guidelines using the unstructured inspection data.The second difficulty in conducting a successively updating scheme using load test data based on previous updating results is tackled by Bayesian updating.Module two is the simulation of a bridge under a MAIL,updating the ProbabilityDensity Functions(PDFs)of Load Effects(LEs)of critical sections of critical components based on the updated FEM and the givenMAIL.Module three is the safety evaluation of the bridge based on the load-bearing capacity index and reliability index,updating indices based on the updated resistance and LE.Theillustrative examples consist of a simulated example and an engineering example,demonstrating the effectiveness of the proposed framework.The simulated example is the safety evaluation of a bridge under a MAIL,and the engineering example is the safety evaluation of the Anning River Bridge of the Yazhong-Jiangxi Ultra-High-Voltage Direct Current(UHVDC)MAIL project.The results show that it is crucial to fuse bridge inspection data and load test data for updating the safety evaluation of bridges under MAILs. 展开更多
关键词 moving loads moving abnormal indivisible load large-cargo transportation vehicle load-bearing capacity bridge reliability bridge safety evaluation reliability updating
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Distributed Feedback Quadratic Filter for Estimating Moving Target in Time-Varying Non-Gaussian Systems with Limited Sensing Range
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作者 SUO Jinghui ZHU Xuefeng 《Journal of Donghua University(English Edition)》 2025年第6期661-672,共12页
This research considers the tracking problem of a moving target in distributed sensor networks with a limited sensing range(LSR)affected by non-Gaussian noise.In such sensor networks,observation loss due to LSR is a p... This research considers the tracking problem of a moving target in distributed sensor networks with a limited sensing range(LSR)affected by non-Gaussian noise.In such sensor networks,observation loss due to LSR is a prevalent issue that has received insufficient attention.We introduce a time-varying random variable to describe whether the sensor observes a moving target at each moment.When a single sensor node is unable to receive information from other nodes,it cannot update its state estimation of the moving target once the target moves beyond this node’s observation range.We propose an information flow topology within distributed sensor networks to facilitate the reception of prior state estimation data transmitted by neighboring nodes.Based on this information,a quadratic distributed estimator is designed for each sensor,and an output injection term is introduced to handle unstable systems.Finally,a numerical example is provided to illustrate the effectiveness of the proposed control scheme. 展开更多
关键词 non-Gaussian system quadratic estimation moving target TIME-VARYING
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Improved Meshfree Moving-Kriging Formulation for Free Vibration Analysis of FGM-FGCNTRC Sandwich Shells
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作者 Suppakit Eiadtrong Tan N.Nguyen +1 位作者 Mohamed-Ouejdi Belarbi Nuttawit Wattanasakulpong 《Computer Modeling in Engineering & Sciences》 2025年第9期2819-2848,共30页
An improved meshfree moving-Kriging(MK)formulation for free vibration analysis of functionally graded material-functionally graded carbon nanotube-reinforced composite(FGM-FGCNTRC)sandwich shells is first proposed in ... An improved meshfree moving-Kriging(MK)formulation for free vibration analysis of functionally graded material-functionally graded carbon nanotube-reinforced composite(FGM-FGCNTRC)sandwich shells is first proposed in this article.The proposed sandwich structure consists of skins of FGM layers and an FGCNTRC core.This structure possesses all the advantages of FGM and FGCNTRC,including high electrical or thermal insulating properties,high fatigue resistance,good corrosion resistance,high stiffness,low density,high strength,and high aspect ratios.Such sandwich structures can be used to replace conventional FGM structures.The present formulation has been established by using an improved meshfree MK method and the first-order shear deformation shell theory(FSDT).The effective material characteristics of the FGM-skin layers and the FGCNTRC core were calculated using the rule of mixture.Key parameters and factors such as the thickness-to-radius ratio,the length-to-radius ratio,layer-thickness ratios,CNT distributions,the volume fraction of CNTs,the power-law index,and various boundary conditions were rigorously investigated.A nonlinear CNT distribution that we term FG-nX is first proposed in this work,and many new results of FGM-FGCNTRC sandwich shells have been provided. 展开更多
关键词 moving kriging meshfree method sandwich shells FGM FGCNTRC
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Hypergraph-Based Asynchronous Event Processing for Moving Object Classification
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作者 YU Nannan WANG Chaoyi +4 位作者 QIAO Yu WANG Yuxin ZHENG Chenglin ZHANG Qiang YANG Xin 《Journal of Shanghai Jiaotong university(Science)》 2025年第5期952-961,共10页
Unlike traditional video cameras,event cameras capture asynchronous event streams in which each event encodes pixel location,triggers’timestamps,and the polarity of brightness changes.In this paper,we introduce a nov... Unlike traditional video cameras,event cameras capture asynchronous event streams in which each event encodes pixel location,triggers’timestamps,and the polarity of brightness changes.In this paper,we introduce a novel hypergraph-based framework for moving object classification.Specifically,we capture moving objects with an event camera,to perceive and collect asynchronous event streams in a high temporal resolution.Unlike stacked event frames,we encode asynchronous event data into a hypergraph,fully mining the high-order correlation of event data,and designing a mixed convolutional hypergraph neural network for training to achieve a more efficient and accurate motion target recognition.The experimental results show that our method has a good performance in moving object classification(e.g.,gait identification). 展开更多
关键词 hypergraph learning event stream moving object classification
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High-Quality Sound Recovery of Moving Sound Source Using Millimeter-Wave Radio
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作者 Yuyong Xiong Zhaoyu Liu +2 位作者 Xiangyi Tang Haibin Meng Zhike Peng 《Journal of Dynamics, Monitoring and Diagnostics》 2025年第1期22-30,共9页
The emerging millimeter-wave microphones have garnered considerable attention in recent years due to their potential for sound detection in various applications,particularly in situations where traditional microphones... The emerging millimeter-wave microphones have garnered considerable attention in recent years due to their potential for sound detection in various applications,particularly in situations where traditional microphones may be impractical.However,despite their promise,there is a notable lack of evidence demonstrating high-quality sound recovery of moving sources,which remains a significant challenge in thefield.This paper addresses this critical gap by proposing a novel method for displacement alignment that improves the detection and recovery of sound signals from moving sources.The proposed method works byfirst aligning the displacement of the sound source over time,which ensures that the signals are synchronized and avoids interference from movement of sources.Subsequently,precise surface vibrations are extracted from the aligned signals,providing data for sound recovery.Afinite impulse response(FIR)filter is applied to remove low-frequency motion,which often interferes with the clarity of the detected sound.Experimental results demonstrate the method’s effectiveness in recovering high-quality sound from moving sources,offering a promising solution for advancing the emerging millimeter-wave microphone technology in real-world applications.This work could pave the way for more accurate and reliable sound detection systems,particularly in dynamic environments. 展开更多
关键词 displacement alignment millimeter-wave microphone moving sound source sound recovery
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Random Coefficient-Moving Product Based Wireless Key Generation
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作者 Lu Xinjin Lei Jing Li Wei 《China Communications》 2025年第2期199-212,共14页
The physical layer key generation technique provides an efficient method,which utilizes the natural dynamics of wireless channel.However,there are some extremely challenging security scenarios such as static or quasi-... The physical layer key generation technique provides an efficient method,which utilizes the natural dynamics of wireless channel.However,there are some extremely challenging security scenarios such as static or quasi-static environment,which lead to the low randomness of generated keys.Meanwhile,the coefficients of the static channel may be dropped into the guard space and discarded by the quantization approach,which causes low key generation rate.To tackle these issues,we propose a random coefficient-moving product based wireless key generation scheme(RCMP-WKG),where new random resources with remarkable fluctuations can be obtained by applying random coefficient and by moving product on the legitimate nodes.Furthermore,appropriate quantization approaches are used to increase the key generation rate.Moreover,the security of our proposed scheme is evaluated by analyzing different attacks and the eavesdropper’s mean square error(MSE).The simulation results reveal that the proposed scheme can achieve better performances in key capacity,key inconsistency rate(KIR)and key generation rate(KGR)compared with the prior works in static environment.Besides,the proposed scheme can deteriorate the MSE performance of the eavesdropper and improve the key generation performance of legitimate nodes by controlling the length of the moving product. 展开更多
关键词 moving product random coefficient static environment wireless key generation
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Recent Advances in Intracortical Neural Interfaces for Freely Moving Animals:Technologies and Applications
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作者 Xinxia Cai Zhaojie Xu +2 位作者 Jingquan Liu Robert Wang Yirong Wu 《Engineering》 2025年第1期73-86,共14页
Intracortical neural interfaces directly connect brain neurons with external devices to achieve high temporal resolution and spatially precise sampling of neural activity.When applied to freely moving animals,this tec... Intracortical neural interfaces directly connect brain neurons with external devices to achieve high temporal resolution and spatially precise sampling of neural activity.When applied to freely moving animals,this technology provides in-depth insight into the underlying neural mechanisms for their movement and cognition in real-world scenarios.However,the application of implanted devices in freely moving animals is limited by restrictions on their behavioral freedom and physiologic impact.In this paper,four technological directions for ideal implantable neural interface devices are analyzed:higher spatial density,improved biocompatibility,enhanced multimodal detection of electrical/neurotransmitter signals,and more effective neural modulation.Finally,we discuss how these technological developments have been applied to freely moving animals to provide better insight into neuroscience and clinical medicine. 展开更多
关键词 Intracortical neural interfaces Freely moving animals Microelectrode array NEUROTRANSMITTER
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Vibration suppression of Timoshenko beams subjected to moving loads using an inertial nonlinear energy sink
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作者 Hao Sun Jie Chen +1 位作者 Wei Zhang Dekun Liu 《Acta Mechanica Sinica》 2025年第10期187-198,共12页
The dynamics of beams subjected to moving loads are of practical importance since the responses caused by these loads can be greater than those under equivalent static loads in some cases.In this work,a novel inertial... The dynamics of beams subjected to moving loads are of practical importance since the responses caused by these loads can be greater than those under equivalent static loads in some cases.In this work,a novel inertial nonlinear energy sink(NES)is applied for the first time to achieve vibration suppression in beams under moving loads.Based on the Timoshenko beam theory,the nonlinear motion equations of a beam with an inertial NES are derived using the energy method and Lagrange equations.The Newmark-βmethod combined with the Heaviside step function is adopted to calculate the responses of the beam under moving loads of constant amplitude and harmonic excitation.The accuracy of the modelling derivation and solution methodology are validated through comparisons with results from other studies.The results demonstrate that the velocity and excitation frequency of the moving load significantly affect the response of the beam as well as the performance of the inertial NES.To enhance its effectiveness under various moving load conditions,parametric optimization is numerically performed.The optimized inertial NES can achieve good performance by efficiently reducing the maximum deflection of the beam.The findings of this study contribute to advancing the understanding and application of NESs in mitigating structural vibrations caused by moving loads. 展开更多
关键词 Nonlinear energy sink moving loads Vibration control Timoshenko beam Inerter
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Reduction of moving-load induced vibrations of graphene-reinforced composite beams with general boundary conditions via a nonlinear energy sink
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作者 Hongli LIU Shangchuan XIE +2 位作者 Jie CHEN Fengming LI Wei ZHOU 《Applied Mathematics and Mechanics(English Edition)》 2025年第11期2075-2094,共20页
Moving-load induced vibrations can,in certain instances,exceed those caused by equivalent static loads,especially at the critical velocity of moving loads.Suppressing these vibrations is of critical practical importan... Moving-load induced vibrations can,in certain instances,exceed those caused by equivalent static loads,especially at the critical velocity of moving loads.Suppressing these vibrations is of critical practical importance in various engineering fields,including the design of precision robotics and advanced aerospace structures where components are subject to moving loads.In this paper,an inertial nonlinear energy sink(NES)is used for the first time to reduce the vibration response of graphene platelet(GPL)-reinforced nanocomposite beams with elastic boundaries under moving loads.Based on the von Kármán nonlinear theory,the governing equations of the beam-NES system are derived using the Lagrange equation.The Newmark-Newton method,in conjunction with the Heaviside step function,is used to obtain the nonlinear responses of the beam under moving loads.The effects of the boundary spring stiffness,the GPL parameters,as well as the velocity and frequency of the moving loads on the beam response and the performance of the NES are thoroughly studied.The results of this work provide insights into applying NESs to suppress the nonlinear vibrations induced by moving loads in composite structures with elastic boundaries. 展开更多
关键词 nonlinear energy sink(NES) moving load vibration control graphene nanoplatelet elastic boundary condition
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Novel hybrid aeroelastic control scheme for flexible wings using internal moving mass
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作者 Zongyu ZHANG Xiaoming WANG +1 位作者 Xinhan HU Wenya ZHOU 《Chinese Journal of Aeronautics》 2025年第7期262-272,共11页
Aeroelastic control is a critical technique for high-aspect-ratio flexible wings.A novel aeroelastic control method is introduced,utilizing the internal Moving Mass Control(MMC)technique,which demonstrates the potenti... Aeroelastic control is a critical technique for high-aspect-ratio flexible wings.A novel aeroelastic control method is introduced,utilizing the internal Moving Mass Control(MMC)technique,which demonstrates the potential to fulfill hybrid control demands without incurring a drag penalty.Dynamic equations for a flexible wing equipped with a spanwise moving mass under unsteady aerodynamic loading are derived using mass position as the input variable.Controloriented analyses indicate that intrinsic structural frequencies,flutter characteristics,and gust response can be actively modified by varying the spanwise and chordwise positions of the mass element.Among these,the chordwise position exerts a more significant impact on the structural modes and flutter speed of the wing.A hybrid aeroelastic control system,incorporating motion planning and control law,is proposed to evaluate real-time performance in Active Flutter Suppression(AFS)and Gust Load Alleviation(GLA).Control outcomes suggest that,with a mass ratio of 1/16 and a half-chord installation area for the guide rail,flutter speed increases by about 10%.Additionally,excitation amplitudes across different gust frequencies are substantially mitigated,achieving a maximum reduction of vibration amplitude by about 73%.These findings offer a comprehensive understanding of the MMC technique and its application to flexible aircraft. 展开更多
关键词 Aeroelastic control Flexible wings Flutter suppression Gust load alleviation moving mass
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Multi-Agent Reinforcement Learning for Moving Target Defense Temporal Decision-Making Approach Based on Stackelberg-FlipIt Games
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作者 Rongbo Sun Jinlong Fei +1 位作者 Yuefei Zhu Zhongyu Guo 《Computers, Materials & Continua》 2025年第8期3765-3786,共22页
Moving Target Defense(MTD)necessitates scientifically effective decision-making methodologies for defensive technology implementation.While most MTD decision studies focus on accurately identifying optimal strategies,... Moving Target Defense(MTD)necessitates scientifically effective decision-making methodologies for defensive technology implementation.While most MTD decision studies focus on accurately identifying optimal strategies,the issue of optimal defense timing remains underexplored.Current default approaches—periodic or overly frequent MTD triggers—lead to suboptimal trade-offs among system security,performance,and cost.The timing of MTD strategy activation critically impacts both defensive efficacy and operational overhead,yet existing frameworks inadequately address this temporal dimension.To bridge this gap,this paper proposes a Stackelberg-FlipIt game model that formalizes asymmetric cyber conflicts as alternating control over attack surfaces,thereby capturing the dynamic security state evolution of MTD systems.We introduce a belief factor to quantify information asymmetry during adversarial interactions,enhancing the precision of MTD trigger timing.Leveraging this game-theoretic foundation,we employMulti-Agent Reinforcement Learning(MARL)to derive adaptive temporal strategies,optimized via a novel four-dimensional reward function that holistically balances security,performance,cost,and timing.Experimental validation using IP addressmutation against scanning attacks demonstrates stable strategy convergence and accelerated defense response,significantly improving cybersecurity affordability and effectiveness. 展开更多
关键词 Cyber security moving target defense multi-agent reinforcement learning security metrics game theory
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Complete q-Order Moment Convergence of Moving Average Processes Generated by Negatively Dependent Random Variables under Sub-Linear Expectations
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作者 Mingzhou XU 《Journal of Mathematical Research with Applications》 2025年第3期395-410,共16页
Assume that{a_(i),−∞<i<∞}is an absolutely summable sequence of real numbers.We establish the complete q-order moment convergence for the partial sums of moving average processes{X_(n)=Σ_(i=−∞)^(∞)a_(i)Y_(i+... Assume that{a_(i),−∞<i<∞}is an absolutely summable sequence of real numbers.We establish the complete q-order moment convergence for the partial sums of moving average processes{X_(n)=Σ_(i=−∞)^(∞)a_(i)Y_(i+n),n≥1}under some proper conditions,where{Yi,-∞<i<∞}is a doubly infinite sequence of negatively dependent random variables under sub-linear expectations.These results extend and complement the relevant results in probability space. 展开更多
关键词 moving average processes negatively dependent random variables complete moment convergence sub-linear expectations
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Sensitivity-based state and parameter moving horizon estimation method for liquid propellant rocket engine
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作者 Zizhao WANG Dan WANG +2 位作者 Hongyu CHEN Zhijiang SHAO Zhengyu SONG 《Chinese Journal of Aeronautics》 2025年第7期46-60,共15页
The reuse of liquid propellant rocket engines has increased the difficulty of their control and estimation.State and parameter Moving Horizon Estimation(MHE)is an optimization-based strategy that provides the necessar... The reuse of liquid propellant rocket engines has increased the difficulty of their control and estimation.State and parameter Moving Horizon Estimation(MHE)is an optimization-based strategy that provides the necessary information for model predictive control.Despite the many advantages of MHE,long computation time has limited its applications for system-level models of liquid propellant rocket engines.To address this issue,we propose an asynchronous MHE method called advanced-multi-step MHE with Noise Covariance Estimation(amsMHE-NCE).This method computes the MHE problem asynchronously to obtain the states and parameters and can be applied to multi-threaded computations.In the background,the state and covariance estimation optimization problems are computed using multiple sampling times.In real-time,sensitivity is used to quickly approximate state and parameter estimates.A covariance estimation method is developed using sensitivity to avoid redundant MHE problem calculations in case of sensor degradation during engine reuse.The amsMHE-NCE is validated through three cases based on the space shuttle main engine system-level model,and we demonstrate that it can provide more accurate real-time estimates of states and parameters compared to other commonly used estimation methods. 展开更多
关键词 Sensitivity moving horizon estimation Noise covariance estimation Parameter estimation Liquid propellant rocket engine
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Experimental and numerical study of the interaction between a shaped charge jet and a single ERA moving plate
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作者 Nicolas Reboul Ashwin Chinnayya +5 位作者 Frédéric Paintendre Simon Dalle Piagge Vincent Jaulin Jérôme Limido Anthony Collé Fabien Rondot 《Defence Technology(防务技术)》 2025年第8期126-140,共15页
An analysis of the interaction mechanisms between a Shaped Charge Jet(SCJ) and a single Moving Plate(MP) is proposed in this article using both experimental and numerical approaches. First, an experimental set-up is p... An analysis of the interaction mechanisms between a Shaped Charge Jet(SCJ) and a single Moving Plate(MP) is proposed in this article using both experimental and numerical approaches. First, an experimental set-up is presented. Four collision tests have been performed: two tests in Backward Moving Plate(BMP) configuration, where the plate moves in opposition to jet, and two tests in Forward Moving Plate(FMP) configuration, where the plate moves alongside the jet. Based on the virtual origin approximation,a methodology(the Virtual Origin Method, VOM) is developed to extract quantities from the X-ray images, which serve as comparative data. γSPH simulations are carried out to complete the analysis, as they well capture the disturbance dynamics observed in the experiments. Based on these complementary experimental and numerical results, a new physical description is proposed through a detailed analysis of the interaction. It is shown that the SCJ/MP interaction is driven at first order by the contact geometry. Thus, BMP and FMP configurations do not generate the same disturbances because their local flow geometries are different. In the collision point frame of reference, the BMP flows in the same direction as the jet, causing its overall deflection. On the contrary, the FMP flow opposes that of the jet leading to an alternative creation of fragments and ligaments. An in-depth study, using the VOM shows that deflection angles, fragment-ligament creation frequencies, and deflection velocities evolve as the interaction progresses through slower jet elements. 展开更多
关键词 Shaped charge jet disturbance Single moving plate Virtual origin method gSPH simulations
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