"桑吉"轮溢油事故是世界航运史上首例载运凝析油油船被撞失火的船舶全损事故。从船员和管理的视角探究"桑吉"轮因碰撞导致溢油事故的主要致因和深层次原因,采用能量踪迹和屏障分析理论,对"桑吉"轮和"..."桑吉"轮溢油事故是世界航运史上首例载运凝析油油船被撞失火的船舶全损事故。从船员和管理的视角探究"桑吉"轮因碰撞导致溢油事故的主要致因和深层次原因,采用能量踪迹和屏障分析理论,对"桑吉"轮和"水晶"轮碰撞事故进行屏障分析,构建了基于管理疏忽与危险树(MORT,Management Oversight and Risk Tree)的"桑吉"轮因碰撞导致溢油事故的致因分析模型,并利用结构熵权法计算因子权重并排序。结果表明:事故的主要原因为船员违章操作、责任心不强、专业水平低,其中,船员违章操作对事故的影响最大;事故深层次的原因为航运公司对船员专业技能培训不到位、海事监管机构对海员选拔和资质认证把关不严、航运公司的安全教育和现场监督检查不到位。研究结论可为剖析由船舶碰撞引起的溢油事故的致因因素提供理论参考。展开更多
AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the al...AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/ FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.展开更多
Mort Aux Vaches乃Staalplaat旗下的一个特定声音系列和音乐计划.其出品皆源自由荷兰VPRO电台所邀请的全球各路先锋实验高手(以抽象派的电子居多)在该电台的现场表演/演奏录音实况记载.并且.该系列的所有CD均有着一个共同的唱片设... Mort Aux Vaches乃Staalplaat旗下的一个特定声音系列和音乐计划.其出品皆源自由荷兰VPRO电台所邀请的全球各路先锋实验高手(以抽象派的电子居多)在该电台的现场表演/演奏录音实况记载.并且.该系列的所有CD均有着一个共同的唱片设计概念,即在每张CD封套包装的中心部分.都死死地别着一枚分外醒目的钉子.很多乐迷都将这颗钉子戏称作"钉在Mort Aux Vaches中间位置的一颗棺钉".就目前而言,这样的外在装祯设计主义在全球范围内的唱片出版行业里,自然已是一个不出其右、无可厚非的独树先驱了.更令人吃惊的是,Mort Aux Vaches系列的所有出品均为极具收藏价值的限量版,其每张唱片的出版数量最多不超过1000张.而且.有相当一部分出品Staalplaat还坚持一律手写编号的特殊做法.这.就是Mort Aux Vaches的原则与风格.……展开更多
文摘"桑吉"轮溢油事故是世界航运史上首例载运凝析油油船被撞失火的船舶全损事故。从船员和管理的视角探究"桑吉"轮因碰撞导致溢油事故的主要致因和深层次原因,采用能量踪迹和屏障分析理论,对"桑吉"轮和"水晶"轮碰撞事故进行屏障分析,构建了基于管理疏忽与危险树(MORT,Management Oversight and Risk Tree)的"桑吉"轮因碰撞导致溢油事故的致因分析模型,并利用结构熵权法计算因子权重并排序。结果表明:事故的主要原因为船员违章操作、责任心不强、专业水平低,其中,船员违章操作对事故的影响最大;事故深层次的原因为航运公司对船员专业技能培训不到位、海事监管机构对海员选拔和资质认证把关不严、航运公司的安全教育和现场监督检查不到位。研究结论可为剖析由船舶碰撞引起的溢油事故的致因因素提供理论参考。
基金Supported by the Intramural grant (MAIFOR) to M.S.
文摘AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/ FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.
文摘 Mort Aux Vaches乃Staalplaat旗下的一个特定声音系列和音乐计划.其出品皆源自由荷兰VPRO电台所邀请的全球各路先锋实验高手(以抽象派的电子居多)在该电台的现场表演/演奏录音实况记载.并且.该系列的所有CD均有着一个共同的唱片设计概念,即在每张CD封套包装的中心部分.都死死地别着一枚分外醒目的钉子.很多乐迷都将这颗钉子戏称作"钉在Mort Aux Vaches中间位置的一颗棺钉".就目前而言,这样的外在装祯设计主义在全球范围内的唱片出版行业里,自然已是一个不出其右、无可厚非的独树先驱了.更令人吃惊的是,Mort Aux Vaches系列的所有出品均为极具收藏价值的限量版,其每张唱片的出版数量最多不超过1000张.而且.有相当一部分出品Staalplaat还坚持一律手写编号的特殊做法.这.就是Mort Aux Vaches的原则与风格.……
