To establish a simple and reliable animal model of skin photo-damage, 20 mice were treated with 8-MOP and exposed to UVA （UVA 320-400 nm） for 24 h. After irradiation, the structure of the epidermis and dermis, colla...To establish a simple and reliable animal model of skin photo-damage, 20 mice were treated with 8-MOP and exposed to UVA （UVA 320-400 nm） for 24 h. After irradiation, the structure of the epidermis and dermis, collagen fibers, elastic fibers were observed by using HE staining and Weigert technique and compared with the normal controls. The acanthosis and epidemis proliferation with accompanying hyperkeratosis and parakeratosis were observed. Inflammatory infiltration was noted in the dermis. The elastic fibers became coarse, irregularly arranged and clustered, with their number increased. The collagen fibers showed obvious degeneration and some amorphous materials could also be observed. The blood vessels were irregularly dilated and vascular walls were thickened, with infiltration of inflammatory cells. It is concluded that murine photodamage model can be quickly, conveniently and reliably established by means of 8-MOP/UVA.展开更多
调整优化城市土地利用结构与布局,实现社会经济发展和生态保护的协同优化是城市土地利用规划管理和决策的关键。该研究使用多目标规划(multiple objective planning,MOP)模型和未来土地利用模拟(future land use simulation model,FLUS...调整优化城市土地利用结构与布局,实现社会经济发展和生态保护的协同优化是城市土地利用规划管理和决策的关键。该研究使用多目标规划(multiple objective planning,MOP)模型和未来土地利用模拟(future land use simulation model,FLUS)模型相结合的方法,运用权衡分析制定多目标权衡下的土地利用优化配置情景方案,以期为杭州市土地利用优化配置规划和管理提供科学参考。结果表明:1)通过耦合MOP模型和FLUS模型,从土地利用生态-经济转化效率视角可以有效实现土地利用结构和布局的优化配置情景模拟。2)通过比较单位经济效益的减少比例可产生的生态效益增加比例,确定土地利用经济与生态效益权重比例为4:6的发展情景是权衡土地利用社会、经济和生态效益下的杭州市土地利用结构最优方案。3)最优土地利用结构方案的建设用地扩张规模介于经济发展优化和生态保护优先情景方案间,耕地规模较其他情景方案减少幅度放缓,在空间上减少对生态用地的侵占,土地利用景观格局破碎度和复杂性降低。该研究的方法和结果可为区域土地利用规划决策和可持续发展提供理论与应用参考。展开更多
基金a grant from Hubei Province Natural Science Foundation (No.302131041).
文摘To establish a simple and reliable animal model of skin photo-damage, 20 mice were treated with 8-MOP and exposed to UVA （UVA 320-400 nm） for 24 h. After irradiation, the structure of the epidermis and dermis, collagen fibers, elastic fibers were observed by using HE staining and Weigert technique and compared with the normal controls. The acanthosis and epidemis proliferation with accompanying hyperkeratosis and parakeratosis were observed. Inflammatory infiltration was noted in the dermis. The elastic fibers became coarse, irregularly arranged and clustered, with their number increased. The collagen fibers showed obvious degeneration and some amorphous materials could also be observed. The blood vessels were irregularly dilated and vascular walls were thickened, with infiltration of inflammatory cells. It is concluded that murine photodamage model can be quickly, conveniently and reliably established by means of 8-MOP/UVA.
文摘调整优化城市土地利用结构与布局,实现社会经济发展和生态保护的协同优化是城市土地利用规划管理和决策的关键。该研究使用多目标规划(multiple objective planning,MOP)模型和未来土地利用模拟(future land use simulation model,FLUS)模型相结合的方法,运用权衡分析制定多目标权衡下的土地利用优化配置情景方案,以期为杭州市土地利用优化配置规划和管理提供科学参考。结果表明:1)通过耦合MOP模型和FLUS模型,从土地利用生态-经济转化效率视角可以有效实现土地利用结构和布局的优化配置情景模拟。2)通过比较单位经济效益的减少比例可产生的生态效益增加比例,确定土地利用经济与生态效益权重比例为4:6的发展情景是权衡土地利用社会、经济和生态效益下的杭州市土地利用结构最优方案。3)最优土地利用结构方案的建设用地扩张规模介于经济发展优化和生态保护优先情景方案间,耕地规模较其他情景方案减少幅度放缓,在空间上减少对生态用地的侵占,土地利用景观格局破碎度和复杂性降低。该研究的方法和结果可为区域土地利用规划决策和可持续发展提供理论与应用参考。
