Background:No standard monsplasty technique has existed until now.Although various monsplasty methods have been described,they exhibit high complication rates with sparse postoperative data.Studies that used pubic sus...Background:No standard monsplasty technique has existed until now.Although various monsplasty methods have been described,they exhibit high complication rates with sparse postoperative data.Studies that used pubic suspension techniques did not describe exact anatomical landmarks for the mons pexy.This study aimed to improve the aesthetic and functional appearance of the pubic region with long-term results for all grades of pubic ptosis or bulging with abdominoplasty and provide exact anatomical points to anchor the mons to the rectus sheath.Methods:This non-randomized prospective clinical trial included 30 patients with various degrees of abdominal wall laxity between December 2017 and September 2019.The surgical procedure was performed for female patients with pendulous abdomen,pubic ptosis or bulging,body mass index≤35 kg/m^(2),and age 18–60 years.All patients were followed for up to one year;patient satisfaction was assessed before and after surgery regarding aesthetic results and impact on outfits,hygiene,and sexual activity.Results:The marginal homogeneity test revealed a statistically significant patient satisfaction rate regarding outfits,sexual function,hygiene,and aesthetics.Regarding postoperative complications,seroma(one case)was managed by aspiration,and one case of wound dehiscence was managed conservatively with dressings.Conclusion:This study recommends a quick and reproducible monsplasty technique with a low complication rate,a technique that helps determine specific anatomical landmarks for anchoring the mons to the rectus sheath.Combining this technique with abdominal contouring is advisable for optimal aesthetic results and maintained lymphatic drainage in the pubic region.展开更多
Timing of uplift of the Tibetan Plateau is a fundamental work to understand global climatic change and mountain\|building mechanism. Because most of the evidence comes from the Himalaya\|South Tibet, the northern marg...Timing of uplift of the Tibetan Plateau is a fundamental work to understand global climatic change and mountain\|building mechanism. Because most of the evidence comes from the Himalaya\|South Tibet, the northern margin of the Plateau may hold the key to unravel a whole view of the Plateau uplift history, in which basin sediments are the most important part because they have continuously recorded the history of pure surface uplift in related mountains. In the whole foredeep bordered by the North Marginal Thrust (Kunlun—Altun—Qilian—Longmen Trusts) along the northern and eastern Tibetan Plateau, thick Cenozoic stratigraphy is widely distributed and records the whole history of the Plateau uplift process. It can be lithologically divided in three large units from top to bottom: light colored sediments, boulder conglomerate and red bed. The red bed is mostly fine sediments of lacustrine and/or fluviolacustrine origins and the boulder conglomerate has been long thought as evidence of rapid uplift of the Tibetan Plateau. The light colored sediments are mostly eolian and/or fluviolacustrine deposits or desert\|gobi sediments. Thus, to date the boulder conglomerate holds the key to unravel the Plateau uplift. We chose the Linxia Basin in the northeastern Tibetan Plateau and Jiuquan Basin in the northern Qilian Mountains as two pilot controlling sites to reconstruct the history of uplift process of the Tibetan Plate au and its accompanied climatic change and to see if a coupling process would ex ist between the uplift of the Plateau and Asian monsoon system.展开更多
奥氏体耐热钢由于良好的高温性能因而在火电、核电、航空航天等领域有着重要的应用.细小的晶粒尺寸及基体中弥散分布的碳化物是奥氏体钢具有优异高温性能的关键.奥氏体钢在服役过程中受热循环的影响,其显微组织发生衰退.为探究热循环过...奥氏体耐热钢由于良好的高温性能因而在火电、核电、航空航天等领域有着重要的应用.细小的晶粒尺寸及基体中弥散分布的碳化物是奥氏体钢具有优异高温性能的关键.奥氏体钢在服役过程中受热循环的影响,其显微组织发生衰退.为探究热循环过程中组织演变对力学性能的影响,针对一种供货态的奥氏体耐热钢0Cr25Ni13Si2MoN开展了三组热循环实验.借助光镜(optical microscope,OM)、扫描电镜(scanning electron microscope,SEM)、透射电镜(transmission electron microscope,TEM)和冲击试验机等试验设备,对不同热循环次数后的试样分别进行了显微组织及力学性能分析.结果表明:热循环过程中的组织演变表现出一定的时间依赖性,一次热循环过程完成了回复与再结晶,晶界处析出网状分布的M 23 C 6,降低了材料的韧性.后两次的热循环过程退火孪晶密度增大,但晶界处碳化物数量增加并发生粗化,材料的韧性逐渐恶化.展开更多
Autophagy is a fundamental cellular process,conserved across species from yeast to mammals,that plays a crucial role in maintaining cellular homeostasis.The functionally conserved MON1-CCZ1(MC1)complex serves as a gua...Autophagy is a fundamental cellular process,conserved across species from yeast to mammals,that plays a crucial role in maintaining cellular homeostasis.The functionally conserved MON1-CCZ1(MC1)complex serves as a guanine nucleotide exchange factor(GEF)for the RAB GTPase RAB7A and is indispensable for directing RAB7A recruitment to autophagosome or lysosomal membranes.Despite its critical role,the precise molecular mechanism underlying the assembly of the human MON1A-CCZ1(HsMC1)complex and its specific GEF activity towards RAB7A has remained unclear.In this study,we report the high-resolution cryo-electron microscopy(cryo-EM)structure of the HsMC1 GEF domain in a complex with the nucleotide-free RAB7A^(N125I)at 2.85 A resolution.Our structural data demonstrate that engagement with the HsMC1 complex induces marked conformational shifts in the phosphate-binding loop(P-loop)and SwitchⅠ/Ⅱregions of RAB7A.A striking feature of this complex is the direct interaction between the P-loop of RAB7A and CCZ1,a structural detail not previously observed.Furthermore,biochemical assays targeting residues within InterfaceⅠorⅡof the HsMC1-RAB7A complex highlight their critical role in mediating the interaction and suggest a unique mechanism for nucleotide exchange facilitated by the HsMC1 complex.These findings provide novel molecular insights into the functional mechanisms of the HsMC1-RAB7A complex,offering a robust structural framework to inform future investigations into disease-related targets and therapeutic development.展开更多
Monsters in the Forbidden City,containing 18 books,is the frst set of fairy tales about the Palace Museum from a child's perspective.The story starts with a magical gem earring picked up by pupil Li Xiaoyu at the ...Monsters in the Forbidden City,containing 18 books,is the frst set of fairy tales about the Palace Museum from a child's perspective.The story starts with a magical gem earring picked up by pupil Li Xiaoyu at the Palace Museum.With the magic of the"Cave Light Gem,"Li Xiaoyu heard the talks of the monsters and fairies,who had lived in the Palace Museum for hundreds of years and experienced many breathtaking stories.展开更多
转基因玉米MON87411是孟山都远东有限公司研发的抗虫耐除草剂玉米转化体,该转化体已获得进口加工原料的农业转基因生物安全证书。以转基因玉米MON87411品系特异性序列为靶标设计引物和探针,经特异性测试、体系优化、灵敏度测试及检出限...转基因玉米MON87411是孟山都远东有限公司研发的抗虫耐除草剂玉米转化体,该转化体已获得进口加工原料的农业转基因生物安全证书。以转基因玉米MON87411品系特异性序列为靶标设计引物和探针,经特异性测试、体系优化、灵敏度测试及检出限测试,建立了转基因玉米MON87411的实时荧光PCR定性检测方法。结果表明,该方法能检测出转基因玉米MON87411的转化体成分,检出限(limit of detection,LOD)可达0.05%,具有稳定性好、特异性强、灵敏度高的特点。国内8家转基因生物安全检测机构对本方法进行了特异性测试、检出限测试和再现性测试,循环验证报告显示该方法符合国家标准方法的各项要求,可在检测行业推广应用。研究建立的方法可为我国对转基因玉米MON87411品系的安全监管提供有效的技术支撑。展开更多
Monforts,which is celebrating its 140th anniversary this year,exhibited a Montex stenter chamber with an integrated overhead heat recovery unit at ITM textile machinery exhibition in Istanbul from June 4-8.The heat re...Monforts,which is celebrating its 140th anniversary this year,exhibited a Montex stenter chamber with an integrated overhead heat recovery unit at ITM textile machinery exhibition in Istanbul from June 4-8.The heat recovery unit on display at the stand of Monforts partner Neotek was just one of a range of energy saving options the company is now providing for both new and existing line installations.展开更多
文摘Background:No standard monsplasty technique has existed until now.Although various monsplasty methods have been described,they exhibit high complication rates with sparse postoperative data.Studies that used pubic suspension techniques did not describe exact anatomical landmarks for the mons pexy.This study aimed to improve the aesthetic and functional appearance of the pubic region with long-term results for all grades of pubic ptosis or bulging with abdominoplasty and provide exact anatomical points to anchor the mons to the rectus sheath.Methods:This non-randomized prospective clinical trial included 30 patients with various degrees of abdominal wall laxity between December 2017 and September 2019.The surgical procedure was performed for female patients with pendulous abdomen,pubic ptosis or bulging,body mass index≤35 kg/m^(2),and age 18–60 years.All patients were followed for up to one year;patient satisfaction was assessed before and after surgery regarding aesthetic results and impact on outfits,hygiene,and sexual activity.Results:The marginal homogeneity test revealed a statistically significant patient satisfaction rate regarding outfits,sexual function,hygiene,and aesthetics.Regarding postoperative complications,seroma(one case)was managed by aspiration,and one case of wound dehiscence was managed conservatively with dressings.Conclusion:This study recommends a quick and reproducible monsplasty technique with a low complication rate,a technique that helps determine specific anatomical landmarks for anchoring the mons to the rectus sheath.Combining this technique with abdominal contouring is advisable for optimal aesthetic results and maintained lymphatic drainage in the pubic region.
文摘Timing of uplift of the Tibetan Plateau is a fundamental work to understand global climatic change and mountain\|building mechanism. Because most of the evidence comes from the Himalaya\|South Tibet, the northern margin of the Plateau may hold the key to unravel a whole view of the Plateau uplift history, in which basin sediments are the most important part because they have continuously recorded the history of pure surface uplift in related mountains. In the whole foredeep bordered by the North Marginal Thrust (Kunlun—Altun—Qilian—Longmen Trusts) along the northern and eastern Tibetan Plateau, thick Cenozoic stratigraphy is widely distributed and records the whole history of the Plateau uplift process. It can be lithologically divided in three large units from top to bottom: light colored sediments, boulder conglomerate and red bed. The red bed is mostly fine sediments of lacustrine and/or fluviolacustrine origins and the boulder conglomerate has been long thought as evidence of rapid uplift of the Tibetan Plateau. The light colored sediments are mostly eolian and/or fluviolacustrine deposits or desert\|gobi sediments. Thus, to date the boulder conglomerate holds the key to unravel the Plateau uplift. We chose the Linxia Basin in the northeastern Tibetan Plateau and Jiuquan Basin in the northern Qilian Mountains as two pilot controlling sites to reconstruct the history of uplift process of the Tibetan Plate au and its accompanied climatic change and to see if a coupling process would ex ist between the uplift of the Plateau and Asian monsoon system.
文摘奥氏体耐热钢由于良好的高温性能因而在火电、核电、航空航天等领域有着重要的应用.细小的晶粒尺寸及基体中弥散分布的碳化物是奥氏体钢具有优异高温性能的关键.奥氏体钢在服役过程中受热循环的影响,其显微组织发生衰退.为探究热循环过程中组织演变对力学性能的影响,针对一种供货态的奥氏体耐热钢0Cr25Ni13Si2MoN开展了三组热循环实验.借助光镜(optical microscope,OM)、扫描电镜(scanning electron microscope,SEM)、透射电镜(transmission electron microscope,TEM)和冲击试验机等试验设备,对不同热循环次数后的试样分别进行了显微组织及力学性能分析.结果表明:热循环过程中的组织演变表现出一定的时间依赖性,一次热循环过程完成了回复与再结晶,晶界处析出网状分布的M 23 C 6,降低了材料的韧性.后两次的热循环过程退火孪晶密度增大,但晶界处碳化物数量增加并发生粗化,材料的韧性逐渐恶化.
基金supported by the grants from the National Natural Science Foundation of China(32201025 to D.T.,32071214 to S.Q.,32470738 to S.Q.,and 32471311 to D.T.)。
文摘Autophagy is a fundamental cellular process,conserved across species from yeast to mammals,that plays a crucial role in maintaining cellular homeostasis.The functionally conserved MON1-CCZ1(MC1)complex serves as a guanine nucleotide exchange factor(GEF)for the RAB GTPase RAB7A and is indispensable for directing RAB7A recruitment to autophagosome or lysosomal membranes.Despite its critical role,the precise molecular mechanism underlying the assembly of the human MON1A-CCZ1(HsMC1)complex and its specific GEF activity towards RAB7A has remained unclear.In this study,we report the high-resolution cryo-electron microscopy(cryo-EM)structure of the HsMC1 GEF domain in a complex with the nucleotide-free RAB7A^(N125I)at 2.85 A resolution.Our structural data demonstrate that engagement with the HsMC1 complex induces marked conformational shifts in the phosphate-binding loop(P-loop)and SwitchⅠ/Ⅱregions of RAB7A.A striking feature of this complex is the direct interaction between the P-loop of RAB7A and CCZ1,a structural detail not previously observed.Furthermore,biochemical assays targeting residues within InterfaceⅠorⅡof the HsMC1-RAB7A complex highlight their critical role in mediating the interaction and suggest a unique mechanism for nucleotide exchange facilitated by the HsMC1 complex.These findings provide novel molecular insights into the functional mechanisms of the HsMC1-RAB7A complex,offering a robust structural framework to inform future investigations into disease-related targets and therapeutic development.
文摘Monsters in the Forbidden City,containing 18 books,is the frst set of fairy tales about the Palace Museum from a child's perspective.The story starts with a magical gem earring picked up by pupil Li Xiaoyu at the Palace Museum.With the magic of the"Cave Light Gem,"Li Xiaoyu heard the talks of the monsters and fairies,who had lived in the Palace Museum for hundreds of years and experienced many breathtaking stories.
文摘转基因玉米MON87411是孟山都远东有限公司研发的抗虫耐除草剂玉米转化体,该转化体已获得进口加工原料的农业转基因生物安全证书。以转基因玉米MON87411品系特异性序列为靶标设计引物和探针,经特异性测试、体系优化、灵敏度测试及检出限测试,建立了转基因玉米MON87411的实时荧光PCR定性检测方法。结果表明,该方法能检测出转基因玉米MON87411的转化体成分,检出限(limit of detection,LOD)可达0.05%,具有稳定性好、特异性强、灵敏度高的特点。国内8家转基因生物安全检测机构对本方法进行了特异性测试、检出限测试和再现性测试,循环验证报告显示该方法符合国家标准方法的各项要求,可在检测行业推广应用。研究建立的方法可为我国对转基因玉米MON87411品系的安全监管提供有效的技术支撑。
文摘Monforts,which is celebrating its 140th anniversary this year,exhibited a Montex stenter chamber with an integrated overhead heat recovery unit at ITM textile machinery exhibition in Istanbul from June 4-8.The heat recovery unit on display at the stand of Monforts partner Neotek was just one of a range of energy saving options the company is now providing for both new and existing line installations.
