AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glauc...AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glaucoma eyes undergoing ACP implantation,as a standalone procedure or in combination with cataract phacoemulsification.Intraocular pressure(IOP)was evaluated prior to surgery and 1wk,1,3,6mo and 1y postoperatively.In addition,the number of antiglaucoma drugs and intra and postoperative complications were assessed.RESULTS:A total of 30 eyes of 28 patients were included in the study.The patients were on average 72.8(13.4)years old and 53.6%were male.Totally 40%of the eyes had primary open angle glaucoma,16.7%had neovascular glaucoma,16.7%had pseudoexfoliative glaucoma,10%had glaucoma secondary to pars plana vitrectomy with silicone oil tamponade,6.7%had aphakic glaucoma,6.7%had primary congenital glaucoma and 3.3%had pigmentary glaucoma.Before surgery mean IOP was 26.1(10.8)mm Hg and mean glaucoma medication use was 3.7(0.5).At 1,3,6 and 12mo mean IOP was 16.1,11.7,11.8 and 11.5 mm Hg,respectively.Mean glaucoma medication use was 1.9,1.5,1.2 and 1.2,respectively.At 1y,complete surgical success was found in 46.7%patients(n=14)and qualified success in 53.3%(n=16).There were no intraoperative complications.Postoperative complications include choroidal effusion(n=5),transient hyphema(n=2),early hypotony with shallow anterior chamber(n=2)and late hemorrhagic choroidal detachment(n=1).CONCLUSION:The ACP appears to be an efficient surgical option for treating refractory glaucoma,achieving good IOP control and decreasing medication burden.The results obtained at 6mo are an important prognostic factor for long-term outcomes.展开更多
A detailed theoretical investigation on Co^3＋ hydration in aqueous solution has been carded out by means of molecular dynamics （MD） simulations based on the atom-bond electronegativity equalization method fused int...A detailed theoretical investigation on Co^3＋ hydration in aqueous solution has been carded out by means of molecular dynamics （MD） simulations based on the atom-bond electronegativity equalization method fused into molecular mechanics （ABEEM/MM）. The effective Co^3＋ ion-water potential has been constructed by fitting to ab initio structures and binding energies for ionic clusters. And then the ion-water interaction potential was applied in combination with the ABEEM-7P water model to molecular dynamics simulations of single Co^3＋（aq.） solution, managing to reproduce many experimental structural and dynamical properties of the solution. Here, not only the common properties （radial distribution function, angular distribution function and solvation energy） obtained for Co^3＋ in ABEEM-7P water solution were in good agreement with those from the experimental methods and other molecular dynamics simulations but also very interesting properties of charge distributions, geometries of water molecules, hydrogen bond, diffusion coefficients, vibrational spectra are investigated by ABEEM/MM model.展开更多
Compared with accurate diagnosis, the system’s selfdiagnosing capability can be greatly increased through the t/kdiagnosis strategy at most k vertexes to be mistakenly identified as faulty under the comparison model,...Compared with accurate diagnosis, the system’s selfdiagnosing capability can be greatly increased through the t/kdiagnosis strategy at most k vertexes to be mistakenly identified as faulty under the comparison model, where k is typically a small number. Based on the Preparata, Metze, and Chien(PMC)model, the n-dimensional hypercube network is proved to be t/kdiagnosable. In this paper, based on the Maeng and Malek(MM)*model, a novel t/k-fault diagnosis(1≤k≤4) algorithm of ndimensional hypercube, called t/k-MM*-DIAG, is proposed to isolate all faulty processors within the set of nodes, among which the number of fault-free nodes identified wrongly as faulty is at most k. The time complexity in our algorithm is only O(2~n n~2).展开更多
ABEEM/MM model has been applied to compute the various properties characterizing water clusters(H2O) n(n = 7-10) ,such as optimized geometries,the hydrogen bonds number,cluster interaction en-ergies,stabilities,ABEEM ...ABEEM/MM model has been applied to compute the various properties characterizing water clusters(H2O) n(n = 7-10) ,such as optimized geometries,the hydrogen bonds number,cluster interaction en-ergies,stabilities,ABEEM charge distributions,dipole moments,structural parameters,and so on,and to describe the transition reflected by the hexamer region from two-dimensional(from dimer to pen-tamer) to three-dimensional structures(for clusters larger than the hexamer) .展开更多
Evaporation duct is an abnormal refractive phenomenon in the marine atmosphere boundary layer. It has been generally accepted that the evaporation duct prominently affects the performance of the electronic equipment o...Evaporation duct is an abnormal refractive phenomenon in the marine atmosphere boundary layer. It has been generally accepted that the evaporation duct prominently affects the performance of the electronic equipment over the sea because of its wide distribution and frequent occurrence. It has become a research focus of the navies all over the world. At present, the diagnostic models of the evaporation duct are all based on the Monin-Obukhov similarity theory, with only differences in the flux and character scale calculations in the surface layer. These models are applicable to the stationary and uniform open sea areas without considering the alongshore effect. This paper introduces the nonlinear factor a and the gust wind item wg into the Babin model, and thus extends the evaporation duct diagnostic model to the offshore area under extremely low wind speed. In addition, an evaporation duct prediction model is designed and coupled with the fifth generation mesoscale model （MMS）. The tower observational data and radar data at the Pingtan island of Fujian Province on May 25-26, 2002 were used to validate the forecast results. The outputs of the prediction model agree with the observations from 0 to 48 h. The relative error of the predicted evaporation duct height is 19.3% and the prediction results are consistent with the radar detection.展开更多
There is distinct difference in the tangential wind profile between different typhoons in the western North Pacific. At present, only two parameters, maximum wind and radius of maximum wind, are used in NCAR-AFWA bogu...There is distinct difference in the tangential wind profile between different typhoons in the western North Pacific. At present, only two parameters, maximum wind and radius of maximum wind, are used in NCAR-AFWA bogus for MM5 mesoscale numerical model. As a result, sometimes the outer structure of typhoon cannot be described accurately. The tangential wind profile of NCAR-AFWA bogus is improved by introducing radii of 25.7 m/s and 15.4 m/s, and then the track and intensity of Typhoon Nockten (No.0425) are simulated. The results show that the simulations of track and intensity of typhoon both have been improved by simultaneously introducing the radii in the tangential wind profile of typhoon bogus. At the same time, there is improvement in the gale wind range of the typhoon simulated.展开更多
Cobalt-protein complexes play an important role in biochemical processes.The structure of the model molecule,Co(H_2O)_3SO_4(phen) has been studied by molecular mechanics.The molecular force field (MM2) parameters have...Cobalt-protein complexes play an important role in biochemical processes.The structure of the model molecule,Co(H_2O)_3SO_4(phen) has been studied by molecular mechanics.The molecular force field (MM2) parameters have been developed for the particular class of the complexes.展开更多
文摘AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glaucoma eyes undergoing ACP implantation,as a standalone procedure or in combination with cataract phacoemulsification.Intraocular pressure(IOP)was evaluated prior to surgery and 1wk,1,3,6mo and 1y postoperatively.In addition,the number of antiglaucoma drugs and intra and postoperative complications were assessed.RESULTS:A total of 30 eyes of 28 patients were included in the study.The patients were on average 72.8(13.4)years old and 53.6%were male.Totally 40%of the eyes had primary open angle glaucoma,16.7%had neovascular glaucoma,16.7%had pseudoexfoliative glaucoma,10%had glaucoma secondary to pars plana vitrectomy with silicone oil tamponade,6.7%had aphakic glaucoma,6.7%had primary congenital glaucoma and 3.3%had pigmentary glaucoma.Before surgery mean IOP was 26.1(10.8)mm Hg and mean glaucoma medication use was 3.7(0.5).At 1,3,6 and 12mo mean IOP was 16.1,11.7,11.8 and 11.5 mm Hg,respectively.Mean glaucoma medication use was 1.9,1.5,1.2 and 1.2,respectively.At 1y,complete surgical success was found in 46.7%patients(n=14)and qualified success in 53.3%(n=16).There were no intraoperative complications.Postoperative complications include choroidal effusion(n=5),transient hyphema(n=2),early hypotony with shallow anterior chamber(n=2)and late hemorrhagic choroidal detachment(n=1).CONCLUSION:The ACP appears to be an efficient surgical option for treating refractory glaucoma,achieving good IOP control and decreasing medication burden.The results obtained at 6mo are an important prognostic factor for long-term outcomes.
基金Project supported by the National Natural Science Foundation （Nos. 20373021, 20633050） of China. Acknowledgements The authors greatly thank Professor Jay William Ponder for providing the Tinker programs.
文摘A detailed theoretical investigation on Co^3＋ hydration in aqueous solution has been carded out by means of molecular dynamics （MD） simulations based on the atom-bond electronegativity equalization method fused into molecular mechanics （ABEEM/MM）. The effective Co^3＋ ion-water potential has been constructed by fitting to ab initio structures and binding energies for ionic clusters. And then the ion-water interaction potential was applied in combination with the ABEEM-7P water model to molecular dynamics simulations of single Co^3＋（aq.） solution, managing to reproduce many experimental structural and dynamical properties of the solution. Here, not only the common properties （radial distribution function, angular distribution function and solvation energy） obtained for Co^3＋ in ABEEM-7P water solution were in good agreement with those from the experimental methods and other molecular dynamics simulations but also very interesting properties of charge distributions, geometries of water molecules, hydrogen bond, diffusion coefficients, vibrational spectra are investigated by ABEEM/MM model.
基金supported by the National Natural Science Foundation of China(61363002)
文摘Compared with accurate diagnosis, the system’s selfdiagnosing capability can be greatly increased through the t/kdiagnosis strategy at most k vertexes to be mistakenly identified as faulty under the comparison model, where k is typically a small number. Based on the Preparata, Metze, and Chien(PMC)model, the n-dimensional hypercube network is proved to be t/kdiagnosable. In this paper, based on the Maeng and Malek(MM)*model, a novel t/k-fault diagnosis(1≤k≤4) algorithm of ndimensional hypercube, called t/k-MM*-DIAG, is proposed to isolate all faulty processors within the set of nodes, among which the number of fault-free nodes identified wrongly as faulty is at most k. The time complexity in our algorithm is only O(2~n n~2).
基金Supported by the National Natural Science Foundation of China (Grant No. 20373021)
文摘ABEEM/MM model has been applied to compute the various properties characterizing water clusters(H2O) n(n = 7-10) ,such as optimized geometries,the hydrogen bonds number,cluster interaction en-ergies,stabilities,ABEEM charge distributions,dipole moments,structural parameters,and so on,and to describe the transition reflected by the hexamer region from two-dimensional(from dimer to pen-tamer) to three-dimensional structures(for clusters larger than the hexamer) .
文摘Evaporation duct is an abnormal refractive phenomenon in the marine atmosphere boundary layer. It has been generally accepted that the evaporation duct prominently affects the performance of the electronic equipment over the sea because of its wide distribution and frequent occurrence. It has become a research focus of the navies all over the world. At present, the diagnostic models of the evaporation duct are all based on the Monin-Obukhov similarity theory, with only differences in the flux and character scale calculations in the surface layer. These models are applicable to the stationary and uniform open sea areas without considering the alongshore effect. This paper introduces the nonlinear factor a and the gust wind item wg into the Babin model, and thus extends the evaporation duct diagnostic model to the offshore area under extremely low wind speed. In addition, an evaporation duct prediction model is designed and coupled with the fifth generation mesoscale model （MMS）. The tower observational data and radar data at the Pingtan island of Fujian Province on May 25-26, 2002 were used to validate the forecast results. The outputs of the prediction model agree with the observations from 0 to 48 h. The relative error of the predicted evaporation duct height is 19.3% and the prediction results are consistent with the radar detection.
基金Experiments on coupling typhoons, waves and storm surges in the South China Sea andpreviews of typhoon-inflicted disasters, a project from the research foundation for the science of tropical andmarine meteorology
文摘There is distinct difference in the tangential wind profile between different typhoons in the western North Pacific. At present, only two parameters, maximum wind and radius of maximum wind, are used in NCAR-AFWA bogus for MM5 mesoscale numerical model. As a result, sometimes the outer structure of typhoon cannot be described accurately. The tangential wind profile of NCAR-AFWA bogus is improved by introducing radii of 25.7 m/s and 15.4 m/s, and then the track and intensity of Typhoon Nockten (No.0425) are simulated. The results show that the simulations of track and intensity of typhoon both have been improved by simultaneously introducing the radii in the tangential wind profile of typhoon bogus. At the same time, there is improvement in the gale wind range of the typhoon simulated.
基金Project supported by the National Natural Science Foundation of China.
文摘Cobalt-protein complexes play an important role in biochemical processes.The structure of the model molecule,Co(H_2O)_3SO_4(phen) has been studied by molecular mechanics.The molecular force field (MM2) parameters have been developed for the particular class of the complexes.
