Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and functional homeostasis of nervous tissue.Albeit with certain si...Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and functional homeostasis of nervous tissue.Albeit with certain similarities,the regulation of CNS and PNS myelination is executed differently.Recent advances highlight the coordinated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways.In this review,we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination,with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling pathways.We also discuss recent progress on the metabolic regulation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease.展开更多
基金supported by Grants from the Shenzhen Innovation Committee of Science and Technology(ZDSYS20200811144002008 to Shenzhen Key Laboratory of Gene Regulation and Systems Biology,2019193984)the National Natural Science Foundation of China(31970773 and 31530042)the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2021SHIBS0002).
文摘Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and functional homeostasis of nervous tissue.Albeit with certain similarities,the regulation of CNS and PNS myelination is executed differently.Recent advances highlight the coordinated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways.In this review,we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination,with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling pathways.We also discuss recent progress on the metabolic regulation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease.
