The behavior of oil and water in tight rocks can change the distribution of oil or water in pores,which affects the production of crude oil.Nuclear Magnetic Resonance(NMR)method is an effective and nondestructive tool...The behavior of oil and water in tight rocks can change the distribution of oil or water in pores,which affects the production of crude oil.Nuclear Magnetic Resonance(NMR)method is an effective and nondestructive tool for evaluating rocks with comparison and analysis both quantitatively and qualitatively.In our study,20 MHz NMR Relaxometry is used as a key technique to study the changes of water and oil behaviors in Chinese lacustrine Qingshankou shales under different saturated states(imbibition and evaporation without pressure).The results show that variation in different proton populations(water,oil and organic)can be distinguished using 2D T_(1)-T_(2)maps.The comparison among T_(1)-T_(2)maps with different saturated states shows that different signal regions changed during oil and water migrations,which the 1D NMR Relaxometry may be not easy to approach.Combined with the pyrolysis analysis,T2 shift and differences of signal regions in T_(1)-T_(2)maps can reflect properties such as wettability and composition(organic matter,clay and magnetic minerals)to some extent.This study provides better insight into oil and water behaviors in lacustrine oil shales with further understanding of 20 MHz NMR 2D T_(1)-T_(2)maps both in qualitative and quantitative analysis.展开更多
Fuel accumulation, mainly as fatty acids, is one of the main characteristics of migratory, birds. Studying to what extent each population or species manages fuel load and how it varies along routes of migration or bet...Fuel accumulation, mainly as fatty acids, is one of the main characteristics of migratory, birds. Studying to what extent each population or species manages fuel load and how it varies along routes of migration or between seasons （autumn and spring migrations） is crucial to our understanding of bird migration strategies. Our aim here was to analyse whether migratory blackcaps Sylvia atrieapilla passing through northern Iberia differ in their mean fuel loads, rate of fuel accumulation and ＇ potential＇ flight ranges between migration seasons. Blackcaps were mist netted for 4 h-periods beginning at dawn from 16 September to 15 November 2003 - 2005, and from 1 March to 30 April 2004 - 2006 in a European Atlantic hedgerow at Loza, northern Iberia. Both fuel load and fuel deposition rate （this latter assessed with difference in body mass of within-season recaptured individuals） were higher in autumn than in spring. Possible hypotheses explaining these results could be seasonal-associated variations in food availability （likely lower during spring than during autumn）, the fact that a fraction of the migrants captured in spring could breed close to the study area and different selective pressures for breeding and wintering展开更多
Mass aggregations and migrations of millipedes despite numerous attempts to find causes for their occurrences are still an enigma. They have been reported from both southern and northern hemisphere countries, from hig...Mass aggregations and migrations of millipedes despite numerous attempts to find causes for their occurrences are still an enigma. They have been reported from both southern and northern hemisphere countries, from highlands and lowlands of both tropical and temperate regions and they can involve species belonging to the orders Julida and Spirobolida, Polydesmida and Glomerida. According to the main suggestions put forward in the past, mass occurrences in Diplopoda occur：（1） because of a lack of food and a population increase beyond sustainable levels;（2） for the purpose of reproduction and in order to locate suitable oviposition sites;（3） to find overwintering or aestivation sites;（4） because of habitat disruption and changes in the local environment;（5） as a consequence of weather conditions the year（or winter and spring） before. A recent outbreak（November 2014） of a mass migration of the polydesmid Chamberlinius hualienensis Wang 1956 on the Japanese Izu Island of Hachijojima 300 km to the south of Tokyo gave this author an opportunity to review the existing literature on millipede mass migrations and to carry out additional observations on the phenomenon in the field as well as the laboratory. Hitherto unreported heavy infestations with phoretic deutonymphs of the mite Histiostoma sp. as well as dense populations of internal rhabditid nematodes（Oscheius cf. necromena and an unidentified species of the genus Fictor）, suggest that infestations of this kind could be necromenic and either have been a contributing factor for the mass migration or been a consequence of so manyindividuals occurring together at close proximity. It is concluded that mass migrations and aggregations in millipedes do not have one common cause, but represent phenomena that often are seasonally recurring events and appear identical in their outcome, but which have evolved as responses to different causes in different millipede taxa and therefore need to be examined on a case-to-case basis.展开更多
IT infrastructures have been widely deployed in datacentres by cloud service providers for Infrastructure as a Service (IaaS) with Virtual Machines (VMs). With the rapid development of cloud-based tools and techniques...IT infrastructures have been widely deployed in datacentres by cloud service providers for Infrastructure as a Service (IaaS) with Virtual Machines (VMs). With the rapid development of cloud-based tools and techniques, IaaS is changing the current cloud infrastructure to meet the customer demand. In this paper, an efficient management model is presented and evaluated using our unique Trans-Atlantic high-speed optical fibre network connecting three datacentres located in Coleraine (Northern Ireland), Dublin (Ireland) and Halifax (Canada). Our work highlights the design and implementation of a management system that can dynamically create VMs upon request, process live migration and other services over the high-speed inter-networking Datacentres (DCs). The goal is to provide an efficient and intelligent on-demand management system for virtualization that can make decisions about the migration of VMs and get better utilisation of the network.展开更多
Mobile agents are able to migrate among machines to achieve their tasks. This feature is attractive to design, implement, and maintain distributed systems because we can implement both client-side and server-side prog...Mobile agents are able to migrate among machines to achieve their tasks. This feature is attractive to design, implement, and maintain distributed systems because we can implement both client-side and server-side programming in one mobile agent. However, it involves the increase of data traffic for mobile agent migrations. In this paper, we propose program code caching to reduce the data traffic caused by mobile agent migrations. A mobile agent consists of many program codes that define a task executed in each machine they migrate; thus, the mobile agent migration involves the transfer of their program codes. Therefore, our method reduces the number of the transfer of program codes by using program code cache. We have implemented our method on a mobile agent framework called Maglog and conducted experiments on a meeting scheduling system.展开更多
During the 1950s the Hula wetlands and old lake were drained and the land converted utilization to agriculture and ecotourism. As a result of the drainage, the Peat Soil was exposed to atmospheric oxygen. The geochemi...During the 1950s the Hula wetlands and old lake were drained and the land converted utilization to agriculture and ecotourism. As a result of the drainage, the Peat Soil was exposed to atmospheric oxygen. The geochemical environment was modified from reductive to oxidative and the Nitrogen in it was converted from Ammonium to Nitrate. Intensive migration of Nitrate from the Hula Valley induced a national concern of water quality deterioration in the lake which was dissipated when Nitrogen deficiency was developed in Lake Kinneret. Forty years after drainage the ecosystem structure was renovated (Hula Project, HP) aimed at agricultural management and nutrient migration reduction. The paper examines through evaluation of the ecological data record (1993-2018) the impact of hydrological changes, attributed to the HP implementation on nutrient dynamics within surface waters in the Hula Valley. It is suggested that soil moisture elevation by irrigation in summer reduced Phosphorus and enhanced Nitrate concentrations.展开更多
Herein,we report a distinctive and marvelous dual-migration of alkynyl tetracoordinate borons activated by both hydrochloric acid(HCl)and N-chlorosuccinimide(NCS),which is significantly different from conventional mig...Herein,we report a distinctive and marvelous dual-migration of alkynyl tetracoordinate borons activated by both hydrochloric acid(HCl)and N-chlorosuccinimide(NCS),which is significantly different from conventional migration modes under basic conditions.In this protocol,HCl,as the first electrophile,activates the C≡C bond,triggering the first 1,2-aryl migration.Subsequently,NCS promotes a secondary metallate shift,enabling the construction of polysubstituted alkenes.Notably,this process can work well under mild conditions,exhibits high efficiency,and provides valuable products.This transformation reveals that Zweifel olefination is not just limited to traditional basic conditions,it can proceed smoothly under acidic conditions as well,which greatly expands the scope of this well-known olefination reaction.展开更多
Photocatalyzed alkylsulfonylation of unactivated alkenes using DABCO.(SO_(2))_(2) and thianthrenium salts via a distal heteroaryl migration process has been developed,which provides a new means of synthesizing a varie...Photocatalyzed alkylsulfonylation of unactivated alkenes using DABCO.(SO_(2))_(2) and thianthrenium salts via a distal heteroaryl migration process has been developed,which provides a new means of synthesizing a variety of valuable alkylsulfonyl-substituted compounds.These alkylsulfonyl radicals couple with unactivated alkenes to undergo efficient intermolecular reactions,followed by distal heteroaryl migration.This mild catalytic method is tolerant of functional groups and affords medicinally relevant alkylsulfonylated heterocycles.展开更多
Adult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents.While it is known transforming growth factor-βsignaling is important in embryonic neurogenesis,its role in postn...Adult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents.While it is known transforming growth factor-βsignaling is important in embryonic neurogenesis,its role in postnatal neurogenesis remains unclear.In this study,to define the precise role of transforming growth factor-βsignaling in postnatal neurogenesis at distinct stages of the neurogenic cascade both in vitro and in vivo,we developed two novel inducible and cell type-specific mouse models to specifically silence transforming growth factor-βsignaling in neural stem cells in(mGFAPcre-ALK5fl/fl-Ai9)or immature neuroblasts in(DCXcreERT2-ALK5fl/fl-Ai9).Our data showed that exogenous transforming growth factor-βtreatment led to inhibition of the proliferation of primary neural stem cells while stimulating their migration.These effects were abolished in activin-like kinase 5(ALK5)knockout primary neural stem cells.Consistent with this,inhibition of transforming growth factor-βsignaling with SB-431542 in wild-type neural stem cells stimulated proliferation while inhibited the migration of neural stem cells.Interestingly,deletion of transforming growth factor-βreceptor in neural stem cells in vivo inhibited the migration of postnatal born neurons in mGFAPcre-ALK5fl/fl-Ai9 mice,while abolishment of transforming growth factor-βsignaling in immature neuroblasts in DCXcreERT2-ALK5fl/fl-Ai9 mice did not affect the migration of these cells in the hippocampus.In summary,our data supports a dual role of transforming growth factor-βsignaling in the proliferation and migration of neural stem cells in vitro.Moreover,our data provides novel insights on cell type-specific-dependent requirements of transforming growth factor-βsignaling on neural stem cell proliferation and migration in vivo.展开更多
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplanta...Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells alone.Bone marrow mesenchymal stem cells regulate and interact with various cells in the retinal microenvironment by secreting neurotrophic factors and extracellular vesicles.Small extracellular vesicles derived from bone marrow mesenchymal stem cells,which offer low immunogenicity,minimal tumorigenic risk,and ease of transportation,have been utilized in the treatment of various neurological diseases.These vesicles exhibit various activities,including anti-inflammatory actions,promotion of tissue repair,and immune regulation.Therefore,novel strategies using human retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles may represent an innovation in stem cell therapy for retinal degeneration.In this study,we developed such an approach utilizing retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles to treat retinal degeneration in Royal College of Surgeons rats,a genetic model of retinal degeneration.Our findings revealed that the combination of bone marrow mesenchymal stem cell-derived small extracellular vesicles and retinal progenitor cells significantly improved visual function in these rats.The addition of bone marrow mesenchymal stem cell-derived small extracellular vesicles as adjuvants to stem cell transplantation with retinal progenitor cells enhanced the survival,migration,and differentiation of the exogenous retinal progenitor cells.Concurrently,these small extracellular vesicles inhibited the activation of regional microglia,promoted the migration of transplanted retinal progenitor cells to the inner nuclear layer of the retina,and facilitated their differentiation into photoreceptors and bipolar cells.These findings suggest that bone marrow mesenchymal stem cell-derived small extracellular vesicles potentiate the therapeutic efficacy of retinal progenitor cells in retinal degeneration by promoting their survival and differentiation.展开更多
A single-species population model with migrations and harvest between the protected patch and the unprotected patch is formulated and investigated in this paper. We study the local stability and the global stability o...A single-species population model with migrations and harvest between the protected patch and the unprotected patch is formulated and investigated in this paper. We study the local stability and the global stability of the equilibria. The research points out, under some suitable conditions, the singlespecies population model admits a unique positive equilibrium, which is globally asymptotically stable. We also derive that the trivial solution is globally asymptotically stable when the harvesting rate exceeds the threshold. Further, we discuss the practical effects of the protection zones and the harvest. The main results indicate that the protective zones indeed eliminate the extinction of the species under some cases, and the theoretical threshold of harvest to the practical management of the endangered species is provided as well. To end this contribution and to check the validity of the main results, numerical simulations are separately carried out to illustrate these results.展开更多
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu...Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.展开更多
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(...Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].展开更多
Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration vi...Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling;however,their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection,which are similar to the risks associated with other stem cell transplantations.The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells,which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.In vitro,small extracellular vesicles derived from hair follicle neural crest stem cells significantly enhanced the proliferation,migration,tube formation,and barrier function of perineurial cells,and subsequently upregulated the expression of tight junction proteins.Furthermore,in a rat model of sciatic nerve defects bridged with silicon tubes,treatment with small extracellular vesicles derived from hair follicle neural crest stem cells resulted in higher tight junction protein expression in perineurial cells,thus facilitating neural tissue regeneration.At 10 weeks post-surgery,rats treated with small extracellular vesicles derived from hair follicle neural crest stem cells exhibited improved nerve function recovery and reduced muscle atrophy.Transcriptomic and micro RNA analyses revealed that small extracellular vesicles derived from hair follicle neural crest stem cells deliver mi R-21-5p,which inhibits mothers against decapentaplegic homolog 7 expression,thereby activating the transforming growth factor-β/mothers against decapentaplegic homolog signaling pathway and upregulating hyaluronan synthase 2 expression,and further enhancing tight junction protein expression.Together,our findings indicate that small extracellular vesicles derived from hair follicle neural crest stem cells promote the proliferation,migration,and tight junction protein formation of perineurial cells.These results provide new insights into peripheral nerve regeneration from the perspective of perineurial cells,and present a novel approach for the clinical treatment of peripheral nerve defects.展开更多
Over one hundred artifacts, including shards, chopped wood, bronze and iron ware debris as well as footprints, have been discovered during archaeological investigations at and around the central Taklamakan Desert Yuan...Over one hundred artifacts, including shards, chopped wood, bronze and iron ware debris as well as footprints, have been discovered during archaeological investigations at and around the central Taklamakan Desert Yuansha Site (38°52′N, 81°35′E). Dating (14C and OSL) and landform study show that the present-day dry Keriya River once sustained an oasis human settle- ment in 2.6 ka BP, historically falling into the Spring and Autumn Period (716-475 BCE) of Chinese history. The chronology and archaeological interpretations also show that some 400 years later, the local Keriya River channel had shifted 40 km southeast to sustain a Western Han (206 BCE-25 CE) Wumi settlement at the Karadun site. In the meantime, river-channel migration had allowed reoccupation of a site west of Yuansha City around 1.9 ka BP (abandoned again by 1.6 ka BP). The remains' chronology shows that this site was affiliated to Wumi culture and Eastern Han (24-220 CE) dynasty rule. Palaeoclimatic records indicate that the migrations of the river and oasis settlers between 2.7 and 1.6 ka BP were coeval with Central Asian climate changes. Yuansha City was built just after the end of 2.8 ka BP glacier advances in western China, suggesting that release of more water during the subsequent glacier recession may have facilitated oasis development such that Iron Age European peoples could settle in the Tarim Basin. As shown from analysis of archeological remains, not only at Yuansha but also in other ancient cities in the Tarim such as Loulan and Jingjue (Niya), conditions around 1.6 ka BP were dry enough to cause oasis decline. Thus, the results reported here enhance our knowledge about environmental changes and their effects on human activities and cultural evolution in western China and will stimulate further interdisciplinary studies of landscape and oasis history in the Tarim Basin.展开更多
Over the last three decades, special purpose “entomological” radars have contributed much to the development of our understanding of insect migration, especially of the nocturnal migrations at altitudes of up to ～1...Over the last three decades, special purpose “entomological” radars have contributed much to the development of our understanding of insect migration, especially of the nocturnal migrations at altitudes of up to ～1 km that are regularly undertaken by many important pest species. One of the limitations of early radar studies, the difficulty of maintaining observations over long periods, has recently been overcome by the development of automated units that operate autonomously and transmit summaries of their observations to a base laboratory over the public telephone network. These relatively low cost Insect Monitoring Radars (IMRs) employ a novel “ZLC” configuration that allows high quality data on the migrants' flight parameters and identity to be acquired. Two IMRs are currently operating in the semi arid inland of eastern Australia, in a region where populations of migrant moths (Lepidoptera) and Australian plague locusts Chortoicetes terminifera (Orthoptera) commonly originate, and some examples of outputs from one of these units are presented. IMRs are able to provide the data needed to characterize a migration system, i.e. to estimate the probabilities of migration events occurring in particular directions at particular seasons and in response to particular environmental conditions and cues. They also appear capable of fulfilling a “sentinel” role for pest management organisations, alerting forecasters to major migration events and thus to the likely new locations of potential target populations. Finally, they may be suitable for a more general ecological monitoring role, perhaps especially for quantifying year to year variations in biological productivity.展开更多
The development of azide migration reactions is a formidable challenge due to potential competition from side processes driven by the release of molecular nitrogen. Here, we show a novel neighbouring carbonyl group-as...The development of azide migration reactions is a formidable challenge due to potential competition from side processes driven by the release of molecular nitrogen. Here, we show a novel neighbouring carbonyl group-assisted sequential 1,2-azide and 1,4-oxygen migration reaction of α-vinyl azides for the efficient preparation of a range of α-azido ketones. This represents the first transformation of α-vinyl azides into α-azido ketones. Notable features of this method are its high efficiency, broad substrate scope, excellent functional group compatibility, and high yields. The computational studies gave a key insights into the regioselective 1,2-azide and 1,4-oxygen migrations assisted by the neighbouring carbonyl group. Further conversions into a variety of nitrogen-containing compounds demonstrated the synthetic utility of the α-azido ketone products. Preliminary mechanistic studies disclosed a novel reaction mechanism involving neighbouring carbonyl group-assisted sequential 1,2-azide and1,4-oxygen migrations.展开更多
Internal migration motivated by access to higher education is a relatively unexplored topic in Colombia,leading to a lack of data on its dimensions,characteristics,and impacts on urban space and the emotional conditio...Internal migration motivated by access to higher education is a relatively unexplored topic in Colombia,leading to a lack of data on its dimensions,characteristics,and impacts on urban space and the emotional conditions of migrants.For this reason,an academic program of architecture in a public university was selected to comprehend the internal migrations of students,exploring their territorial experiences,living conditions,and social mobility capacity.An exploratory methodology was designed to recognize the phenomenon through a descriptive analysis,utilizing institutional data,surveys,and interviews.The research identifies the primary reasons,barriers,and impacts experienced by the migrant population in Ibagué,Colombia.The study concludes with recommendations pertaining to both institutional and urban planning to address these identified challenges.展开更多
The earliest written record of the term “Kaxabu” dates to the 1908 survey report by the Japanese scholar Ino Kanori. In his study of the Pazzehe tribe in central Taiwan, he wrote： “Kaxabu was the name given by the...The earliest written record of the term “Kaxabu” dates to the 1908 survey report by the Japanese scholar Ino Kanori. In his study of the Pazzehe tribe in central Taiwan, he wrote： “Kaxabu was the name given by the Pazzehe to Daiyao＇puru, a small division of its ethnic group.” During the Qing era, the Pazzehe was called the Anli group by Chinese speakers in Taiwan, while the Kaxabu were named Puzili she （the Puzili tribe）. Since the Kaxabu originated from the Pazzehe, thus in determining the time when the Kaxabu became distinct from the Pazzehe and in exploring the differences between them, we will also elucidate historical developments before the Japanese colonial era. Using Qing historical materials such as travelogues, expedition-records, newspapers, data from fieldwork, surveys, and interviews, this study traces the intervention of the Qing court into tribal relationships in central Taiwan, beginning with the Dajiaxi she Incident （1731-32）, it touches on the changing environment of the Kaxabu/ Puzili she in their migrations in order to shed light on the development of the two distinctive identities-the Kaxabu and Pazzehe/Anli group. The analysis also reveals the impact of uprisings and migrations upon the border area surrounding Qing Taiwan, as well as problems of ethnic identification and geography.展开更多
基金supported by the Opening Fund of Key Laboratory of Continental Shale Accumulation and Development(Northeast Petroleum University,China)the National Natural Science Foundation of China(Grant No.51605089,Grant No.41972156)
文摘The behavior of oil and water in tight rocks can change the distribution of oil or water in pores,which affects the production of crude oil.Nuclear Magnetic Resonance(NMR)method is an effective and nondestructive tool for evaluating rocks with comparison and analysis both quantitatively and qualitatively.In our study,20 MHz NMR Relaxometry is used as a key technique to study the changes of water and oil behaviors in Chinese lacustrine Qingshankou shales under different saturated states(imbibition and evaporation without pressure).The results show that variation in different proton populations(water,oil and organic)can be distinguished using 2D T_(1)-T_(2)maps.The comparison among T_(1)-T_(2)maps with different saturated states shows that different signal regions changed during oil and water migrations,which the 1D NMR Relaxometry may be not easy to approach.Combined with the pyrolysis analysis,T2 shift and differences of signal regions in T_(1)-T_(2)maps can reflect properties such as wettability and composition(organic matter,clay and magnetic minerals)to some extent.This study provides better insight into oil and water behaviors in lacustrine oil shales with further understanding of 20 MHz NMR 2D T_(1)-T_(2)maps both in qualitative and quantitative analysis.
基金supported by a postgraduate fellowship from the Basque Governmentsupported by project CGL2007-61395(Ministry of Education and Science,Government of Spain)
文摘Fuel accumulation, mainly as fatty acids, is one of the main characteristics of migratory, birds. Studying to what extent each population or species manages fuel load and how it varies along routes of migration or between seasons （autumn and spring migrations） is crucial to our understanding of bird migration strategies. Our aim here was to analyse whether migratory blackcaps Sylvia atrieapilla passing through northern Iberia differ in their mean fuel loads, rate of fuel accumulation and ＇ potential＇ flight ranges between migration seasons. Blackcaps were mist netted for 4 h-periods beginning at dawn from 16 September to 15 November 2003 - 2005, and from 1 March to 30 April 2004 - 2006 in a European Atlantic hedgerow at Loza, northern Iberia. Both fuel load and fuel deposition rate （this latter assessed with difference in body mass of within-season recaptured individuals） were higher in autumn than in spring. Possible hypotheses explaining these results could be seasonal-associated variations in food availability （likely lower during spring than during autumn）, the fact that a fraction of the migrants captured in spring could breed close to the study area and different selective pressures for breeding and wintering
文摘Mass aggregations and migrations of millipedes despite numerous attempts to find causes for their occurrences are still an enigma. They have been reported from both southern and northern hemisphere countries, from highlands and lowlands of both tropical and temperate regions and they can involve species belonging to the orders Julida and Spirobolida, Polydesmida and Glomerida. According to the main suggestions put forward in the past, mass occurrences in Diplopoda occur：（1） because of a lack of food and a population increase beyond sustainable levels;（2） for the purpose of reproduction and in order to locate suitable oviposition sites;（3） to find overwintering or aestivation sites;（4） because of habitat disruption and changes in the local environment;（5） as a consequence of weather conditions the year（or winter and spring） before. A recent outbreak（November 2014） of a mass migration of the polydesmid Chamberlinius hualienensis Wang 1956 on the Japanese Izu Island of Hachijojima 300 km to the south of Tokyo gave this author an opportunity to review the existing literature on millipede mass migrations and to carry out additional observations on the phenomenon in the field as well as the laboratory. Hitherto unreported heavy infestations with phoretic deutonymphs of the mite Histiostoma sp. as well as dense populations of internal rhabditid nematodes（Oscheius cf. necromena and an unidentified species of the genus Fictor）, suggest that infestations of this kind could be necromenic and either have been a contributing factor for the mass migration or been a consequence of so manyindividuals occurring together at close proximity. It is concluded that mass migrations and aggregations in millipedes do not have one common cause, but represent phenomena that often are seasonally recurring events and appear identical in their outcome, but which have evolved as responses to different causes in different millipede taxa and therefore need to be examined on a case-to-case basis.
文摘IT infrastructures have been widely deployed in datacentres by cloud service providers for Infrastructure as a Service (IaaS) with Virtual Machines (VMs). With the rapid development of cloud-based tools and techniques, IaaS is changing the current cloud infrastructure to meet the customer demand. In this paper, an efficient management model is presented and evaluated using our unique Trans-Atlantic high-speed optical fibre network connecting three datacentres located in Coleraine (Northern Ireland), Dublin (Ireland) and Halifax (Canada). Our work highlights the design and implementation of a management system that can dynamically create VMs upon request, process live migration and other services over the high-speed inter-networking Datacentres (DCs). The goal is to provide an efficient and intelligent on-demand management system for virtualization that can make decisions about the migration of VMs and get better utilisation of the network.
文摘Mobile agents are able to migrate among machines to achieve their tasks. This feature is attractive to design, implement, and maintain distributed systems because we can implement both client-side and server-side programming in one mobile agent. However, it involves the increase of data traffic for mobile agent migrations. In this paper, we propose program code caching to reduce the data traffic caused by mobile agent migrations. A mobile agent consists of many program codes that define a task executed in each machine they migrate; thus, the mobile agent migration involves the transfer of their program codes. Therefore, our method reduces the number of the transfer of program codes by using program code cache. We have implemented our method on a mobile agent framework called Maglog and conducted experiments on a meeting scheduling system.
文摘During the 1950s the Hula wetlands and old lake were drained and the land converted utilization to agriculture and ecotourism. As a result of the drainage, the Peat Soil was exposed to atmospheric oxygen. The geochemical environment was modified from reductive to oxidative and the Nitrogen in it was converted from Ammonium to Nitrate. Intensive migration of Nitrate from the Hula Valley induced a national concern of water quality deterioration in the lake which was dissipated when Nitrogen deficiency was developed in Lake Kinneret. Forty years after drainage the ecosystem structure was renovated (Hula Project, HP) aimed at agricultural management and nutrient migration reduction. The paper examines through evaluation of the ecological data record (1993-2018) the impact of hydrological changes, attributed to the HP implementation on nutrient dynamics within surface waters in the Hula Valley. It is suggested that soil moisture elevation by irrigation in summer reduced Phosphorus and enhanced Nitrate concentrations.
基金the financial support from the National Key Research&Development Program of China(2023YFF0723900)the National Natural Science Foundation of China(22271105)+3 种基金the Natural Science Foundation of Fujian Province(2022J02009)the Open Research Fund of State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical Engineering,Nanjing Universitythe Hubei Key Laboratory of Pollutant Analysis&Reuse Technology Open Foundation(PA240102)。
文摘Herein,we report a distinctive and marvelous dual-migration of alkynyl tetracoordinate borons activated by both hydrochloric acid(HCl)and N-chlorosuccinimide(NCS),which is significantly different from conventional migration modes under basic conditions.In this protocol,HCl,as the first electrophile,activates the C≡C bond,triggering the first 1,2-aryl migration.Subsequently,NCS promotes a secondary metallate shift,enabling the construction of polysubstituted alkenes.Notably,this process can work well under mild conditions,exhibits high efficiency,and provides valuable products.This transformation reveals that Zweifel olefination is not just limited to traditional basic conditions,it can proceed smoothly under acidic conditions as well,which greatly expands the scope of this well-known olefination reaction.
基金the National Natural Science Foundation of China(Nos.21702103 and 21522604)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(No.XTD2203)+1 种基金the Natural Science Research Projects of Jiangsu Higher Education(No.19KJB150027)Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB389).
文摘Photocatalyzed alkylsulfonylation of unactivated alkenes using DABCO.(SO_(2))_(2) and thianthrenium salts via a distal heteroaryl migration process has been developed,which provides a new means of synthesizing a variety of valuable alkylsulfonyl-substituted compounds.These alkylsulfonyl radicals couple with unactivated alkenes to undergo efficient intermolecular reactions,followed by distal heteroaryl migration.This mild catalytic method is tolerant of functional groups and affords medicinally relevant alkylsulfonylated heterocycles.
基金supported by NIH grants,Nos.R01NS125074,R01AG083164,R01NS107365,and R21NS127177(to YL),1F31NS129204-01A1(to KW)and Albert Ryan Fellowship(to KW).
文摘Adult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents.While it is known transforming growth factor-βsignaling is important in embryonic neurogenesis,its role in postnatal neurogenesis remains unclear.In this study,to define the precise role of transforming growth factor-βsignaling in postnatal neurogenesis at distinct stages of the neurogenic cascade both in vitro and in vivo,we developed two novel inducible and cell type-specific mouse models to specifically silence transforming growth factor-βsignaling in neural stem cells in(mGFAPcre-ALK5fl/fl-Ai9)or immature neuroblasts in(DCXcreERT2-ALK5fl/fl-Ai9).Our data showed that exogenous transforming growth factor-βtreatment led to inhibition of the proliferation of primary neural stem cells while stimulating their migration.These effects were abolished in activin-like kinase 5(ALK5)knockout primary neural stem cells.Consistent with this,inhibition of transforming growth factor-βsignaling with SB-431542 in wild-type neural stem cells stimulated proliferation while inhibited the migration of neural stem cells.Interestingly,deletion of transforming growth factor-βreceptor in neural stem cells in vivo inhibited the migration of postnatal born neurons in mGFAPcre-ALK5fl/fl-Ai9 mice,while abolishment of transforming growth factor-βsignaling in immature neuroblasts in DCXcreERT2-ALK5fl/fl-Ai9 mice did not affect the migration of these cells in the hippocampus.In summary,our data supports a dual role of transforming growth factor-βsignaling in the proliferation and migration of neural stem cells in vitro.Moreover,our data provides novel insights on cell type-specific-dependent requirements of transforming growth factor-βsignaling on neural stem cell proliferation and migration in vivo.
基金supported by the National Natural Science Foundation of China,Nos.82271132(to YL),82101167(to BB)the Natural Science Foundation of Chongqing,Nos.CSTB2022NSCQ-MSX0020(to BB),cstc2019jcyj-msxmX0473(to FC).
文摘Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells alone.Bone marrow mesenchymal stem cells regulate and interact with various cells in the retinal microenvironment by secreting neurotrophic factors and extracellular vesicles.Small extracellular vesicles derived from bone marrow mesenchymal stem cells,which offer low immunogenicity,minimal tumorigenic risk,and ease of transportation,have been utilized in the treatment of various neurological diseases.These vesicles exhibit various activities,including anti-inflammatory actions,promotion of tissue repair,and immune regulation.Therefore,novel strategies using human retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles may represent an innovation in stem cell therapy for retinal degeneration.In this study,we developed such an approach utilizing retinal progenitor cells combined with bone marrow mesenchymal stem cell-derived small extracellular vesicles to treat retinal degeneration in Royal College of Surgeons rats,a genetic model of retinal degeneration.Our findings revealed that the combination of bone marrow mesenchymal stem cell-derived small extracellular vesicles and retinal progenitor cells significantly improved visual function in these rats.The addition of bone marrow mesenchymal stem cell-derived small extracellular vesicles as adjuvants to stem cell transplantation with retinal progenitor cells enhanced the survival,migration,and differentiation of the exogenous retinal progenitor cells.Concurrently,these small extracellular vesicles inhibited the activation of regional microglia,promoted the migration of transplanted retinal progenitor cells to the inner nuclear layer of the retina,and facilitated their differentiation into photoreceptors and bipolar cells.These findings suggest that bone marrow mesenchymal stem cell-derived small extracellular vesicles potentiate the therapeutic efficacy of retinal progenitor cells in retinal degeneration by promoting their survival and differentiation.
基金supported by the National Natural Science Foundation of China(Grant Nos.11201075,11601085 and 61773122)Natural Science Foundation of Fujian Province(Grant No.2016J01015)
文摘A single-species population model with migrations and harvest between the protected patch and the unprotected patch is formulated and investigated in this paper. We study the local stability and the global stability of the equilibria. The research points out, under some suitable conditions, the singlespecies population model admits a unique positive equilibrium, which is globally asymptotically stable. We also derive that the trivial solution is globally asymptotically stable when the harvesting rate exceeds the threshold. Further, we discuss the practical effects of the protection zones and the harvest. The main results indicate that the protective zones indeed eliminate the extinction of the species under some cases, and the theoretical threshold of harvest to the practical management of the endangered species is provided as well. To end this contribution and to check the validity of the main results, numerical simulations are separately carried out to illustrate these results.
基金supported by the National Key R&D Program of China,Nos.2017YFA0104302(to NG and XM)and 2017YFA0104304(to BW and ZZ)
文摘Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
文摘Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].
基金supported by the National Natural Science Foundation of China,No.81571211(to FL)the Natural Science Foundation of Shanghai,No.22ZR1476800(to CH)。
文摘Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling;however,their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection,which are similar to the risks associated with other stem cell transplantations.The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells,which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.In vitro,small extracellular vesicles derived from hair follicle neural crest stem cells significantly enhanced the proliferation,migration,tube formation,and barrier function of perineurial cells,and subsequently upregulated the expression of tight junction proteins.Furthermore,in a rat model of sciatic nerve defects bridged with silicon tubes,treatment with small extracellular vesicles derived from hair follicle neural crest stem cells resulted in higher tight junction protein expression in perineurial cells,thus facilitating neural tissue regeneration.At 10 weeks post-surgery,rats treated with small extracellular vesicles derived from hair follicle neural crest stem cells exhibited improved nerve function recovery and reduced muscle atrophy.Transcriptomic and micro RNA analyses revealed that small extracellular vesicles derived from hair follicle neural crest stem cells deliver mi R-21-5p,which inhibits mothers against decapentaplegic homolog 7 expression,thereby activating the transforming growth factor-β/mothers against decapentaplegic homolog signaling pathway and upregulating hyaluronan synthase 2 expression,and further enhancing tight junction protein expression.Together,our findings indicate that small extracellular vesicles derived from hair follicle neural crest stem cells promote the proliferation,migration,and tight junction protein formation of perineurial cells.These results provide new insights into peripheral nerve regeneration from the perspective of perineurial cells,and present a novel approach for the clinical treatment of peripheral nerve defects.
基金supported by the National Basic Research Program of China (Grant No. 2009CB421308)the National Natural Science Foundation of China (Grant Nos. 40701188 and 40971020)+2 种基金the Natural Science Foundation of Xinjiang Uygur Autonomous Region (Grant No. 2010211A12)the Natural Science Foundation of Xinjiang University (Grant No. BS060112)the Project of Oasis Ecological Key Lab of Education Ministry Xinjiang University (Grant No. XJDX0206-2007-08)
文摘Over one hundred artifacts, including shards, chopped wood, bronze and iron ware debris as well as footprints, have been discovered during archaeological investigations at and around the central Taklamakan Desert Yuansha Site (38°52′N, 81°35′E). Dating (14C and OSL) and landform study show that the present-day dry Keriya River once sustained an oasis human settle- ment in 2.6 ka BP, historically falling into the Spring and Autumn Period (716-475 BCE) of Chinese history. The chronology and archaeological interpretations also show that some 400 years later, the local Keriya River channel had shifted 40 km southeast to sustain a Western Han (206 BCE-25 CE) Wumi settlement at the Karadun site. In the meantime, river-channel migration had allowed reoccupation of a site west of Yuansha City around 1.9 ka BP (abandoned again by 1.6 ka BP). The remains' chronology shows that this site was affiliated to Wumi culture and Eastern Han (24-220 CE) dynasty rule. Palaeoclimatic records indicate that the migrations of the river and oasis settlers between 2.7 and 1.6 ka BP were coeval with Central Asian climate changes. Yuansha City was built just after the end of 2.8 ka BP glacier advances in western China, suggesting that release of more water during the subsequent glacier recession may have facilitated oasis development such that Iron Age European peoples could settle in the Tarim Basin. As shown from analysis of archeological remains, not only at Yuansha but also in other ancient cities in the Tarim such as Loulan and Jingjue (Niya), conditions around 1.6 ka BP were dry enough to cause oasis decline. Thus, the results reported here enhance our knowledge about environmental changes and their effects on human activities and cultural evolution in western China and will stimulate further interdisciplinary studies of landscape and oasis history in the Tarim Basin.
文摘Over the last three decades, special purpose “entomological” radars have contributed much to the development of our understanding of insect migration, especially of the nocturnal migrations at altitudes of up to ～1 km that are regularly undertaken by many important pest species. One of the limitations of early radar studies, the difficulty of maintaining observations over long periods, has recently been overcome by the development of automated units that operate autonomously and transmit summaries of their observations to a base laboratory over the public telephone network. These relatively low cost Insect Monitoring Radars (IMRs) employ a novel “ZLC” configuration that allows high quality data on the migrants' flight parameters and identity to be acquired. Two IMRs are currently operating in the semi arid inland of eastern Australia, in a region where populations of migrant moths (Lepidoptera) and Australian plague locusts Chortoicetes terminifera (Orthoptera) commonly originate, and some examples of outputs from one of these units are presented. IMRs are able to provide the data needed to characterize a migration system, i.e. to estimate the probabilities of migration events occurring in particular directions at particular seasons and in response to particular environmental conditions and cues. They also appear capable of fulfilling a “sentinel” role for pest management organisations, alerting forecasters to major migration events and thus to the likely new locations of potential target populations. Finally, they may be suitable for a more general ecological monitoring role, perhaps especially for quantifying year to year variations in biological productivity.
基金the National Natural Science Foundation of China(21871043)the Department of Science and Technology of Jilin Province(20180101185JC,20190701012GH)the Fundamental Research Funds for the Central Universities(2412019ZD001).
文摘The development of azide migration reactions is a formidable challenge due to potential competition from side processes driven by the release of molecular nitrogen. Here, we show a novel neighbouring carbonyl group-assisted sequential 1,2-azide and 1,4-oxygen migration reaction of α-vinyl azides for the efficient preparation of a range of α-azido ketones. This represents the first transformation of α-vinyl azides into α-azido ketones. Notable features of this method are its high efficiency, broad substrate scope, excellent functional group compatibility, and high yields. The computational studies gave a key insights into the regioselective 1,2-azide and 1,4-oxygen migrations assisted by the neighbouring carbonyl group. Further conversions into a variety of nitrogen-containing compounds demonstrated the synthetic utility of the α-azido ketone products. Preliminary mechanistic studies disclosed a novel reaction mechanism involving neighbouring carbonyl group-assisted sequential 1,2-azide and1,4-oxygen migrations.
文摘Internal migration motivated by access to higher education is a relatively unexplored topic in Colombia,leading to a lack of data on its dimensions,characteristics,and impacts on urban space and the emotional conditions of migrants.For this reason,an academic program of architecture in a public university was selected to comprehend the internal migrations of students,exploring their territorial experiences,living conditions,and social mobility capacity.An exploratory methodology was designed to recognize the phenomenon through a descriptive analysis,utilizing institutional data,surveys,and interviews.The research identifies the primary reasons,barriers,and impacts experienced by the migrant population in Ibagué,Colombia.The study concludes with recommendations pertaining to both institutional and urban planning to address these identified challenges.
文摘The earliest written record of the term “Kaxabu” dates to the 1908 survey report by the Japanese scholar Ino Kanori. In his study of the Pazzehe tribe in central Taiwan, he wrote： “Kaxabu was the name given by the Pazzehe to Daiyao＇puru, a small division of its ethnic group.” During the Qing era, the Pazzehe was called the Anli group by Chinese speakers in Taiwan, while the Kaxabu were named Puzili she （the Puzili tribe）. Since the Kaxabu originated from the Pazzehe, thus in determining the time when the Kaxabu became distinct from the Pazzehe and in exploring the differences between them, we will also elucidate historical developments before the Japanese colonial era. Using Qing historical materials such as travelogues, expedition-records, newspapers, data from fieldwork, surveys, and interviews, this study traces the intervention of the Qing court into tribal relationships in central Taiwan, beginning with the Dajiaxi she Incident （1731-32）, it touches on the changing environment of the Kaxabu/ Puzili she in their migrations in order to shed light on the development of the two distinctive identities-the Kaxabu and Pazzehe/Anli group. The analysis also reveals the impact of uprisings and migrations upon the border area surrounding Qing Taiwan, as well as problems of ethnic identification and geography.
