目的:探讨PCSK9和MIF在乳腺癌中的水平及其临床意义。方法:选取从2021年1月至2022年12月在我院就诊的139例乳腺癌患者和125健康体检人员。测定血清及组织PCSK9和MIF水平,分析在乳腺癌中的相关性。结果:乳腺癌患者的血清PCSK9和MIF水平...目的:探讨PCSK9和MIF在乳腺癌中的水平及其临床意义。方法:选取从2021年1月至2022年12月在我院就诊的139例乳腺癌患者和125健康体检人员。测定血清及组织PCSK9和MIF水平,分析在乳腺癌中的相关性。结果:乳腺癌患者的血清PCSK9和MIF水平明显高于对照组(P Objective: To investigate the relationship between the level of PCSK9 and MIF and breast cancer. Methods: From January 2021 to December 2022, 139 breast cancer patients after surgery and 125 health people as control group were elected. The levels of propotein convertase subtilisin/kexin 9 (PCSK9) and macrophage migration inhibitory factors (MIF) were measured, and analyzed the relationship in breast cancer. Results: The serum levels of PCSK9 and MIF in breast cancer patients was significantly higher than the control group (P < 0.05). The tissue levels of PCSK9 and MIF in breast cancer patients was significantly higher than breast fibroma patients, but the difference was not statistically significant. PCSK9 levels correlated positively with MIF levels in breast cancer tissue. Conclusion: The levels of PCSK9 and MIF were related to breast cancer, and PCSK9 levels correlated positively with serum MIF levels. Through monitoring the levels of PCSK9 and MIF, the methods should provide a new theoretical basis for early diagnosis and screening of breast cancer and accurate treatment.展开更多
文摘目的:探讨PCSK9和MIF在乳腺癌中的水平及其临床意义。方法:选取从2021年1月至2022年12月在我院就诊的139例乳腺癌患者和125健康体检人员。测定血清及组织PCSK9和MIF水平,分析在乳腺癌中的相关性。结果:乳腺癌患者的血清PCSK9和MIF水平明显高于对照组(P Objective: To investigate the relationship between the level of PCSK9 and MIF and breast cancer. Methods: From January 2021 to December 2022, 139 breast cancer patients after surgery and 125 health people as control group were elected. The levels of propotein convertase subtilisin/kexin 9 (PCSK9) and macrophage migration inhibitory factors (MIF) were measured, and analyzed the relationship in breast cancer. Results: The serum levels of PCSK9 and MIF in breast cancer patients was significantly higher than the control group (P < 0.05). The tissue levels of PCSK9 and MIF in breast cancer patients was significantly higher than breast fibroma patients, but the difference was not statistically significant. PCSK9 levels correlated positively with MIF levels in breast cancer tissue. Conclusion: The levels of PCSK9 and MIF were related to breast cancer, and PCSK9 levels correlated positively with serum MIF levels. Through monitoring the levels of PCSK9 and MIF, the methods should provide a new theoretical basis for early diagnosis and screening of breast cancer and accurate treatment.
