1.Introduction Adherence to 24-hour movement guidelines—which encompass regular physical activity,adequate sleep,and limited sedentary time1—significantly influences long-term health outcomes during adolescence and ...1.Introduction Adherence to 24-hour movement guidelines—which encompass regular physical activity,adequate sleep,and limited sedentary time1—significantly influences long-term health outcomes during adolescence and contributes holistically to overall health.2 However,its prospective relationship with midlife mortality remains unknown to date.Our aim was to determine the association between adherence to 24-hour movement guidelines during adolescence and premature mortality 26-27 years later.This aim was based on existing evidence3 suggesting a potential link between meeting these guidelines and reduced mortality risk among adults in an 11-year follow-up.展开更多
Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose tissue.We investigated the relationship between change in central adiposity and ch...Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose tissue.We investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the midlife.Serum concentrations of 34 PCBs and 19 OCPs were measured at four time points(1999/2000,2002/03,2005/06,2009/11)in a cohort of midlife women,the Study of Women’s Health Across the Nation.Linear mixed models were used to test the association between a change in waist circumference and a change in serum POP concentrations.Sixty-five women contributed 181 PCB observations.Fifty-nine women contributed 151 OCP observations.After adjustment for covariates(study site,race and ethnicity,age at baseline,parity),a one-inch(2.54 cm)increase in the change in waist circumference between visits was associated with a 4.9%decrease in the change in serum concentration of PCB 194(95%CI:−8.0%,−1.6%).No associations were observed for other PCB congeners or the presence of OCPs.An increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194,possibly due to the high lipophilicity.展开更多
During menopause,women undergo various physical and psychological changes that often create a significant challenge for most women to function in their daily activities.The present study explores the different literat...During menopause,women undergo various physical and psychological changes that often create a significant challenge for most women to function in their daily activities.The present study explores the different literature findings on challenges women face during their menopausal stage,primarily cognitive and biological.The present study selected around seventy research papers under the timeline of 2000 to 2021 and collected from various medical journals such as Lancet and Menopause.Women during menopause often face cognitive challenges such as primary memory functioning,attention,and perception,which significantly lead to forgetfulness or dementia.Biologically,women in their menopause could develop hypertension,hair fall,skin loosening,coronary disease,and many more,which could cause significant damage to their daily functioning.The study further explored the condition of Indian women with their menopausal symptoms.Indian women tend to develop more challenges than many other countries due to a lack of medical facilities and poor personal relationships.Due to a lack of awareness and poor public policies,fewer provisions are in force for menopausal women.Moreover,working women tend to experience low self-esteem and poor confidence due to a lack of support and no specific policy for menopause.Necessary interventions such as yoga,psychological interventions,physical support,and awareness programs in general and at the workplace and other public spaces will help ensure a supportive environment for women during menopause.展开更多
文摘1.Introduction Adherence to 24-hour movement guidelines—which encompass regular physical activity,adequate sleep,and limited sedentary time1—significantly influences long-term health outcomes during adolescence and contributes holistically to overall health.2 However,its prospective relationship with midlife mortality remains unknown to date.Our aim was to determine the association between adherence to 24-hour movement guidelines during adolescence and premature mortality 26-27 years later.This aim was based on existing evidence3 suggesting a potential link between meeting these guidelines and reduced mortality risk among adults in an 11-year follow-up.
基金The Study of Women’s Health Across the Nation(SWAN)has grant support from the National Institutes of Health(NIH),DHHS,through the National Institute on Aging(NIA),the National Institute of Nursing Research(NINR),and the NIH Office of Research on Women’s Health(ORWH)(Grants U01NR004061,U01AG012505,U01AG012535,U01AG012531,U01AG012539,U01AG012546,U01AG012553,U01AG012554,U01AG012495,and U19AG063720)supported by the SWAN Repository(U01AG017719)+3 种基金the National Center for Research Resources and the National Center for Advancing Translational Sciences,National Institutes of Health,through UCSFCTSI Grant Number UL1 RR024131supported by grants from the National Institute of Environmental Health Sciences(NIEHS)R01-ES026578,R01-ES026964,and P30-ES017885the Center for Disease Control and Prevention(CDC)/National Institute for Occupational Safety and Health(NIOSH)Grant T42-OH008455supported by the Environmental Toxicology and Epidemiology(ETEP)training grant from NIEHS(T32 ES007062).
文摘Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose tissue.We investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the midlife.Serum concentrations of 34 PCBs and 19 OCPs were measured at four time points(1999/2000,2002/03,2005/06,2009/11)in a cohort of midlife women,the Study of Women’s Health Across the Nation.Linear mixed models were used to test the association between a change in waist circumference and a change in serum POP concentrations.Sixty-five women contributed 181 PCB observations.Fifty-nine women contributed 151 OCP observations.After adjustment for covariates(study site,race and ethnicity,age at baseline,parity),a one-inch(2.54 cm)increase in the change in waist circumference between visits was associated with a 4.9%decrease in the change in serum concentration of PCB 194(95%CI:−8.0%,−1.6%).No associations were observed for other PCB congeners or the presence of OCPs.An increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194,possibly due to the high lipophilicity.
文摘During menopause,women undergo various physical and psychological changes that often create a significant challenge for most women to function in their daily activities.The present study explores the different literature findings on challenges women face during their menopausal stage,primarily cognitive and biological.The present study selected around seventy research papers under the timeline of 2000 to 2021 and collected from various medical journals such as Lancet and Menopause.Women during menopause often face cognitive challenges such as primary memory functioning,attention,and perception,which significantly lead to forgetfulness or dementia.Biologically,women in their menopause could develop hypertension,hair fall,skin loosening,coronary disease,and many more,which could cause significant damage to their daily functioning.The study further explored the condition of Indian women with their menopausal symptoms.Indian women tend to develop more challenges than many other countries due to a lack of medical facilities and poor personal relationships.Due to a lack of awareness and poor public policies,fewer provisions are in force for menopausal women.Moreover,working women tend to experience low self-esteem and poor confidence due to a lack of support and no specific policy for menopause.Necessary interventions such as yoga,psychological interventions,physical support,and awareness programs in general and at the workplace and other public spaces will help ensure a supportive environment for women during menopause.
