For solving the dilemma of the short exothermic life-span of WO_(3)based metastable interstitial composites(MICs)with extensive application prospect,this paper has firstly designed the promising antiwetting Al/WO_(3)M...For solving the dilemma of the short exothermic life-span of WO_(3)based metastable interstitial composites(MICs)with extensive application prospect,this paper has firstly designed the promising antiwetting Al/WO_(3)MICs via electrophoresis assembly of nano-Al and WO_(3)particles fabricated by hydrothermal synthesis method,followed by the subsequent fluorination treatment.A combination of X ray diffraction(XRD),field emission scanning electron microscope(FESEM),energy dispersive X-ray spectroscopy(EDX),and Fourier transform infrared spectroscopy(FT-IR)techniques were utilized in order to characterize the crystal structure,microstructure,and elemental composition distribution of target films after different natural exposure tests.The product with uniform distribution and high purity possesses a high contact angle of~170°and a minute sliding angle of~1°,and displays the outstanding anti-wetting property using droplets with different surface tensions.It also shows great moisture stability in high relative-humidity circumstances after one year of the natural exposure experiment.Notably,the heat output of a fresh sample can reach up to 2.3 kJ/g and retain 96%after the whole exposure test,showing outstanding thermo-stability for at least one year.This work further proposed the mechanism of antiwetting Al/WO_(3)MICs considering the variation tendency of their DSC curve,providing a valuable theoretical reference for designing other self-protected MICs with a long exothermic life-span applied in wide fields of national defense,military industry,etc.展开更多
Low profile antenna in communication is a new methodology. Fractal geometry is a methodology through which size reduction is achieved. A Self-similar fractal antenna using multicantor technique is proposed and experim...Low profile antenna in communication is a new methodology. Fractal geometry is a methodology through which size reduction is achieved. A Self-similar fractal antenna using multicantor technique is proposed and experimentally studied. Space-filling cantors and self-similarity properties of fractal geometry have been adopted in the proposed antenna to miniaturize the size of antenna. The antenna is designed in such a way to operate at MICS band (Medical Implant communication Service) for wireless telemedicine application. The prototype antenna exhibits wideband characteristics and provides a good agreement of return loss (S11). Experimental return loss has been compared with that which is obtained using method of moments. The objective of using self-similar concept in antenna makes it flexible in terms of controlling the resonance and bandwidth. In this paper, the Self-similar property of fractal geometry is examined by maintaining return loss (S11) more than –30 dB approximately in all the iterations (n) and the prototype antenna has return loss greater than –10 dB and exhibits wideband characteristics.展开更多
A BFSK and OOK IF base-band circuit is provided to implement the low-IF RF receivers for a dualband MICS/BCC network controller. In order to transfer the massive vital data immediately, the IF circuit is comprised of ...A BFSK and OOK IF base-band circuit is provided to implement the low-IF RF receivers for a dualband MICS/BCC network controller. In order to transfer the massive vital data immediately, the IF circuit is comprised of the fast-settling feed-forward programmable gain amplifier（PGA）, a Gm-C complex filter, the fixed gain amplifier（FGA） and a 4-input ＂quadratic sum＂ demodulator. A novel auto-switched coarse gain-setting method is adopted in the PGA to enhance the reaction speed and narrow the output signal range. Also the PGA does not suffer the same stability constraint as open-loop topologies. The complex filter fulfills the function of image rejection,in which the center frequency and bandwidth can be adjusted individually. The FGA is used to ameliorate the linearity and the ＇quadratic sum＇ demodulator can reduce the overall power consumption. The designed IF circuit is fabricated with SMIC 0.18 μm CMOS process. The chip area is about 5.36 mm^2. Measurement results are given to verify the design goals.展开更多
Intestinal cancers are developed from intestinal epithelial stem cells(ISCs)in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes.ISCs play a key role ...Intestinal cancers are developed from intestinal epithelial stem cells(ISCs)in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes.ISCs play a key role in maintaining the homeostasis of gut epithelium.In 2009,Sato et al established a three-dimensional culture system,which mimicked the niche microenvironment by employing the niche factors,and successfully grew crypt ISCs into organoids or Mini-guts in vitro.Since then,the intestinal organoid technology has been used to delineate cellular signaling in ISC biology.However,the cultured organoids consist of heterogeneous cell populations,and it was technically challenging to introduce genomic changes into three-dimensional organoids.Thus,there was a technical necessity to develop a twodimensional ISC culture system for effective genomic manipulations.In this study,we established a conditionally immortalized mouse intestinal crypt(ciMIC)cell line by using a piggyBac transposon-based SV40 T antigen expression system.We showed that the ciMICs maintained long-term proliferative activity under two-dimensional niche factor-containing culture condition,retained the biological characteristics of intestinal epithelial stem cells,and could form intestinal organoids in three-dimensional culture.While in vivo cell implantation tests indicated that the ciMICs were non-tumorigenic,the ciMICs overexpressing oncogenic b-catenin and/or KRAS exhibited high proliferative activity and developed intestinal adenoma-like pathological features in vivo.Collectively,these findings strongly suggested that the engineered ciMICs should be used as a valuable tool cell line to dissect the genetic and/or epigenetic underpinnings of intestinal tumorigenesis.展开更多
基金funded by the financial support from National Natural Science Foundation of China(Grant No 21805014 and No82102635)Science and Technology Research Project of Chongqing Education Board(Grant No.KJQN201901428)。
文摘For solving the dilemma of the short exothermic life-span of WO_(3)based metastable interstitial composites(MICs)with extensive application prospect,this paper has firstly designed the promising antiwetting Al/WO_(3)MICs via electrophoresis assembly of nano-Al and WO_(3)particles fabricated by hydrothermal synthesis method,followed by the subsequent fluorination treatment.A combination of X ray diffraction(XRD),field emission scanning electron microscope(FESEM),energy dispersive X-ray spectroscopy(EDX),and Fourier transform infrared spectroscopy(FT-IR)techniques were utilized in order to characterize the crystal structure,microstructure,and elemental composition distribution of target films after different natural exposure tests.The product with uniform distribution and high purity possesses a high contact angle of~170°and a minute sliding angle of~1°,and displays the outstanding anti-wetting property using droplets with different surface tensions.It also shows great moisture stability in high relative-humidity circumstances after one year of the natural exposure experiment.Notably,the heat output of a fresh sample can reach up to 2.3 kJ/g and retain 96%after the whole exposure test,showing outstanding thermo-stability for at least one year.This work further proposed the mechanism of antiwetting Al/WO_(3)MICs considering the variation tendency of their DSC curve,providing a valuable theoretical reference for designing other self-protected MICs with a long exothermic life-span applied in wide fields of national defense,military industry,etc.
文摘Low profile antenna in communication is a new methodology. Fractal geometry is a methodology through which size reduction is achieved. A Self-similar fractal antenna using multicantor technique is proposed and experimentally studied. Space-filling cantors and self-similarity properties of fractal geometry have been adopted in the proposed antenna to miniaturize the size of antenna. The antenna is designed in such a way to operate at MICS band (Medical Implant communication Service) for wireless telemedicine application. The prototype antenna exhibits wideband characteristics and provides a good agreement of return loss (S11). Experimental return loss has been compared with that which is obtained using method of moments. The objective of using self-similar concept in antenna makes it flexible in terms of controlling the resonance and bandwidth. In this paper, the Self-similar property of fractal geometry is examined by maintaining return loss (S11) more than –30 dB approximately in all the iterations (n) and the prototype antenna has return loss greater than –10 dB and exhibits wideband characteristics.
文摘A BFSK and OOK IF base-band circuit is provided to implement the low-IF RF receivers for a dualband MICS/BCC network controller. In order to transfer the massive vital data immediately, the IF circuit is comprised of the fast-settling feed-forward programmable gain amplifier（PGA）, a Gm-C complex filter, the fixed gain amplifier（FGA） and a 4-input ＂quadratic sum＂ demodulator. A novel auto-switched coarse gain-setting method is adopted in the PGA to enhance the reaction speed and narrow the output signal range. Also the PGA does not suffer the same stability constraint as open-loop topologies. The complex filter fulfills the function of image rejection,in which the center frequency and bandwidth can be adjusted individually. The FGA is used to ameliorate the linearity and the ＇quadratic sum＇ demodulator can reduce the overall power consumption. The designed IF circuit is fabricated with SMIC 0.18 μm CMOS process. The chip area is about 5.36 mm^2. Measurement results are given to verify the design goals.
文摘随着建筑工业化进程的不断推进,模块化集成建筑(Modular Integrated Construction,MIC)凭借其高效、环保与可控性强等优势,已在建筑工程中得到广泛应用。然而,MIC项目中装配式构件种类繁多、节点构造复杂,且工厂预制与现场安装环节高度耦合,致使施工协调难度加剧、进度管理日趋复杂。文章基于建筑信息模型(Building Information Modeling,BIM)技术,探讨其在MIC装配式建筑施工协调与进度管理中的应用策略,通过构建BIM三维模型和建立统一信息平台,实现构件从设计、预制至安装全过程的可视化管理,并借助4D建模优化施工排程,增强进度计划的可控性与动态调整能力。研究表明,BIM技术可有效提升MIC项目的施工管理水平,助力建筑产业现代化发展。
文摘Intestinal cancers are developed from intestinal epithelial stem cells(ISCs)in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes.ISCs play a key role in maintaining the homeostasis of gut epithelium.In 2009,Sato et al established a three-dimensional culture system,which mimicked the niche microenvironment by employing the niche factors,and successfully grew crypt ISCs into organoids or Mini-guts in vitro.Since then,the intestinal organoid technology has been used to delineate cellular signaling in ISC biology.However,the cultured organoids consist of heterogeneous cell populations,and it was technically challenging to introduce genomic changes into three-dimensional organoids.Thus,there was a technical necessity to develop a twodimensional ISC culture system for effective genomic manipulations.In this study,we established a conditionally immortalized mouse intestinal crypt(ciMIC)cell line by using a piggyBac transposon-based SV40 T antigen expression system.We showed that the ciMICs maintained long-term proliferative activity under two-dimensional niche factor-containing culture condition,retained the biological characteristics of intestinal epithelial stem cells,and could form intestinal organoids in three-dimensional culture.While in vivo cell implantation tests indicated that the ciMICs were non-tumorigenic,the ciMICs overexpressing oncogenic b-catenin and/or KRAS exhibited high proliferative activity and developed intestinal adenoma-like pathological features in vivo.Collectively,these findings strongly suggested that the engineered ciMICs should be used as a valuable tool cell line to dissect the genetic and/or epigenetic underpinnings of intestinal tumorigenesis.
