目的评估人工角膜移植术后患者的视觉相关生活质量及其影响因素。方法采用横断面研究方法收集2004-01/2019-12月在作者医院接受过单眼MICOF人工角膜或BostonⅠ型人工角膜植入术的127例双眼角膜盲患者人口学资料及临床资料,并采用中文版...目的评估人工角膜移植术后患者的视觉相关生活质量及其影响因素。方法采用横断面研究方法收集2004-01/2019-12月在作者医院接受过单眼MICOF人工角膜或BostonⅠ型人工角膜植入术的127例双眼角膜盲患者人口学资料及临床资料,并采用中文版国家眼科研究所视功能问卷-25项(Chinese national eye institute visual function questionnaire-25,CHI-NEI-VFQ-25)评估患者视觉相关生活质量。采用皮尔逊相关分析和斯皮尔曼相关分析术后手术眼BCVA与视觉相关生活质量的相关性。采用多元逐步线性回归分析视觉相关生活质量的影响因素。结果127例患者中,术后随访(4.31±3.16)年,CHI-NEI-VFQ-25综合得分为(44.18±18.40)分。手术至问卷调查时间间隔<2年的患者远距离活动、心理健康、依赖性、驾驶能力得分和综合评分较手术至问卷调查时间间隔≥2年者更低(P均<0.05);接受米赫(MICOF)人工角膜植入患者眼部疼痛、近距离活动、角色困难得分和综合评分较接受波士顿(Boston)Ⅰ型者更高(P均<0.05)。手术眼的术后最佳矫正视力(best corrected visual acuity,BCVA)与CHI-NEI-VFQ-25综合评分(r=-0.775,P<0.001)及除了眼部疼痛(r=0.139,P=0.120)以外的其他子量表得分均呈负相关(P均<0.05)。术后手术眼BCVA和手术至问卷调查时间间隔<2年对CHI-NEI-VFQ-25综合评分具有负向预测作用(β=-21.546,P<0.001;β=-5.698,P=0.029)。结论双眼角膜盲患者的视觉相关生活质量在接受单眼人工角膜手术后有所改善。术后视觉相关生活质量的主要影响因素是手术眼术后视力,但人工角膜植入手术至问卷调查时间间隔是否<2年也会影响视觉相关生活质量。展开更多
Two new nanosurface molecularly imprinted covalent organic framework nanoprobes(MICOF)with recognition and catalytic amplification di-functions for the detection of trace endocrine disruptor nonylphenol(NPN)in milk we...Two new nanosurface molecularly imprinted covalent organic framework nanoprobes(MICOF)with recognition and catalytic amplification di-functions for the detection of trace endocrine disruptor nonylphenol(NPN)in milk were synthesized,gold nanocluster(AuNC)/nanopolyvinylchloride(PVC)as substrates,NPN as the template molecule,benzidine and 2,4,6-triformylphloroglucinol as the functional monomers.The di-nanoprobes efficiently catalyzed a new indicator nanoreaction between HAuCl4 and triethanolamine to generate gold nanoparticles(AuNPs)with SERS effect.Surprisingly,under ultrasonic irradiation,the di-nanoprobes exhibited extremely strong catalysis,due to the triboelectric nanogenerator(TENG)constructed.The AuNC@COF was positive and the PVC@COF was negative,with an increase in catalytic activity of 680%.When NPN was added,it was selectively adsorbed in the nanoprobe imprinted sites,further enhancing catalysis.The working curve slope was increased by 2000%,with a linear range of 0.2–10 nmol/L and limit of detection(LOD)was 0.060 nmol/L NPN.The method was applied to the determination of milk with relative deviations(RSD)of 0.97–9.6%and recovery of 90.4–109.8%.In addition,this new SERS quantitative analysis method was also used to determine phenol,bisphenol A and 1-naphthol with LOD were 0.080,0.060 and 0.12 nmol/L respectively,which proved that it is of universality and high sensitivity.The ultrasonic driven MICOF di-probe TENG catalytic enhancement mechanism was constructed.展开更多
文摘目的评估人工角膜移植术后患者的视觉相关生活质量及其影响因素。方法采用横断面研究方法收集2004-01/2019-12月在作者医院接受过单眼MICOF人工角膜或BostonⅠ型人工角膜植入术的127例双眼角膜盲患者人口学资料及临床资料,并采用中文版国家眼科研究所视功能问卷-25项(Chinese national eye institute visual function questionnaire-25,CHI-NEI-VFQ-25)评估患者视觉相关生活质量。采用皮尔逊相关分析和斯皮尔曼相关分析术后手术眼BCVA与视觉相关生活质量的相关性。采用多元逐步线性回归分析视觉相关生活质量的影响因素。结果127例患者中,术后随访(4.31±3.16)年,CHI-NEI-VFQ-25综合得分为(44.18±18.40)分。手术至问卷调查时间间隔<2年的患者远距离活动、心理健康、依赖性、驾驶能力得分和综合评分较手术至问卷调查时间间隔≥2年者更低(P均<0.05);接受米赫(MICOF)人工角膜植入患者眼部疼痛、近距离活动、角色困难得分和综合评分较接受波士顿(Boston)Ⅰ型者更高(P均<0.05)。手术眼的术后最佳矫正视力(best corrected visual acuity,BCVA)与CHI-NEI-VFQ-25综合评分(r=-0.775,P<0.001)及除了眼部疼痛(r=0.139,P=0.120)以外的其他子量表得分均呈负相关(P均<0.05)。术后手术眼BCVA和手术至问卷调查时间间隔<2年对CHI-NEI-VFQ-25综合评分具有负向预测作用(β=-21.546,P<0.001;β=-5.698,P=0.029)。结论双眼角膜盲患者的视觉相关生活质量在接受单眼人工角膜手术后有所改善。术后视觉相关生活质量的主要影响因素是手术眼术后视力,但人工角膜植入手术至问卷调查时间间隔是否<2年也会影响视觉相关生活质量。
基金supported by the Guangxi Science and Technology Program(Guike AD25069074)the National Natural Science Foundation of China(No.22264005)+1 种基金the Natural Science Foundation of Guangxi Province(No.2022GXNSFDA035073)the Innovation Project of Guangxi Graduate Education(No.YCSW2024176).
文摘Two new nanosurface molecularly imprinted covalent organic framework nanoprobes(MICOF)with recognition and catalytic amplification di-functions for the detection of trace endocrine disruptor nonylphenol(NPN)in milk were synthesized,gold nanocluster(AuNC)/nanopolyvinylchloride(PVC)as substrates,NPN as the template molecule,benzidine and 2,4,6-triformylphloroglucinol as the functional monomers.The di-nanoprobes efficiently catalyzed a new indicator nanoreaction between HAuCl4 and triethanolamine to generate gold nanoparticles(AuNPs)with SERS effect.Surprisingly,under ultrasonic irradiation,the di-nanoprobes exhibited extremely strong catalysis,due to the triboelectric nanogenerator(TENG)constructed.The AuNC@COF was positive and the PVC@COF was negative,with an increase in catalytic activity of 680%.When NPN was added,it was selectively adsorbed in the nanoprobe imprinted sites,further enhancing catalysis.The working curve slope was increased by 2000%,with a linear range of 0.2–10 nmol/L and limit of detection(LOD)was 0.060 nmol/L NPN.The method was applied to the determination of milk with relative deviations(RSD)of 0.97–9.6%and recovery of 90.4–109.8%.In addition,this new SERS quantitative analysis method was also used to determine phenol,bisphenol A and 1-naphthol with LOD were 0.080,0.060 and 0.12 nmol/L respectively,which proved that it is of universality and high sensitivity.The ultrasonic driven MICOF di-probe TENG catalytic enhancement mechanism was constructed.
