Mitochondria are organelles that serve numerous critical cellular functions,including energy production,Ca2+home-ostasis,redox signaling,and metabolism.These functions are intimately linked to mitochondrial morphology...Mitochondria are organelles that serve numerous critical cellular functions,including energy production,Ca2+home-ostasis,redox signaling,and metabolism.These functions are intimately linked to mitochondrial morphology,which is highly dynamic and capable of rapid and transient changes to alter cellular functions in response to environmental cues and cellular demands.Mitochondrial morphology and activity are critical for various physiological processes,including wound healing.In mammals,wound healing is a complex process that requires coordinated function of multiple cell types and progresses in partially overlapping but distinct stages:hemostasis and inflammation,cell pro-liferation and migration,and tissue remodeling.The repair process at the single-cell level forms the basis for wound healing and regeneration in tissues.Recent findings reveal that mitochondria fulfill the intensive energy demand for wound repair and aid wound closure by cytoskeleton remodeling via morphological changes and mitochondrial reactive oxygen species(mtROS)signaling.In this review,we will mainly elucidate how wounding induces changes in mitochondrial morphology and activity and how these changes,in turn,contribute to cellular wound response and repair.展开更多
基金The work in the Xu lab is supported by the National Key R&D Program of China(2021YFA1300302,2021YFA1101002)the National Natural Science Foundation of China(91754111)the Zhejiang Province Natural Science Foundation(2-2060203-21-001)to S.X.
文摘Mitochondria are organelles that serve numerous critical cellular functions,including energy production,Ca2+home-ostasis,redox signaling,and metabolism.These functions are intimately linked to mitochondrial morphology,which is highly dynamic and capable of rapid and transient changes to alter cellular functions in response to environmental cues and cellular demands.Mitochondrial morphology and activity are critical for various physiological processes,including wound healing.In mammals,wound healing is a complex process that requires coordinated function of multiple cell types and progresses in partially overlapping but distinct stages:hemostasis and inflammation,cell pro-liferation and migration,and tissue remodeling.The repair process at the single-cell level forms the basis for wound healing and regeneration in tissues.Recent findings reveal that mitochondria fulfill the intensive energy demand for wound repair and aid wound closure by cytoskeleton remodeling via morphological changes and mitochondrial reactive oxygen species(mtROS)signaling.In this review,we will mainly elucidate how wounding induces changes in mitochondrial morphology and activity and how these changes,in turn,contribute to cellular wound response and repair.
