The emergence of Medical Large Language Models has significantly transformed healthcare.Medical Large Language Models(Med-LLMs)serve as transformative tools that enhance clinical practice through applications in decis...The emergence of Medical Large Language Models has significantly transformed healthcare.Medical Large Language Models(Med-LLMs)serve as transformative tools that enhance clinical practice through applications in decision support,documentation,and diagnostics.This evaluation examines the performance of leading Med-LLMs,including GPT-4Med,Med-PaLM,MEDITRON,PubMedGPT,and MedAlpaca,across diverse medical datasets.It provides graphical comparisons of their effectiveness in distinct healthcare domains.The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making,documentation,drug discovery,research,patient interaction,and public health.The paper addresses deployment challenges of Medical-LLMs,emphasizing trustworthiness and explainability as essential requirements for healthcare AI.It presents current evaluation techniques that improve model transparency in high-stakes medical contexts and analyzes regulatory frameworks using benchmarking datasets such asMedQA,MedMCQA,PubMedQA,and MIMIC.By identifying ongoing challenges in biasmitigation,reliability,and ethical compliance,thiswork serves as a resource for selecting appropriate Med-LLMs and outlines future directions in the field.This analysis offers a roadmap for developing Med-LLMs that balance technological innovation with the trust and transparency required for clinical integration,a perspective often overlooked in existing literature.展开更多
Generative Adversarial Networks(GANs)have become valuable tools in medical imaging,enabling realistic image synthesis for enhancement,augmentation,and restoration.However,their integration into clinical workflows rais...Generative Adversarial Networks(GANs)have become valuable tools in medical imaging,enabling realistic image synthesis for enhancement,augmentation,and restoration.However,their integration into clinical workflows raises concerns,particularly the risk of subtle distortions or hallucinations that may undermine diagnostic accuracy and weaken trust in AI-assisted decision-making.To address this challenge,we propose a hybrid deep learning framework designed to detect GAN-induced artifacts in medical images,thereby reinforcing the reliability of AI-driven diagnostics.The framework integrates low-level statistical descriptors,including high-frequency residuals and Gray-Level Co-occurrence Matrix(GLCM)texture features,with high-level semantic representations extracted from a pre-trained ResNet18.This dual-stream approach enables detection of both pixel-level anomalies and structural inconsistencies introduced by GAN-based manipulation.We validated the framework on a curated dataset of 10,000 medical images,evenly split between authentic and GAN-generated samples across four modalities:MRI,CT,X-ray,and fundus photography.To improve generalizability to real-world clinical settings,we incorporated domain adaptation strategies such as adversarial training and style transfer,reducing domain shift by 15%.Experimental results demonstrate robust performance,achieving 92.6%accuracy and an F1-score of 0.91 on synthetic test data,and maintaining strong performance on real-world GAN-modified images with 87.3%accuracy and an F1-score of 0.85.Additionally,the model attained an AUC of 0.96 and an average precision of 0.92,outperforming conventional GAN detection pipelines and baseline Convolutional Neural Network(CNN)architectures.These findings establish the proposed framework as an effective and reliable solution for detecting GAN-induced hallucinations in medical imaging,representing an important step toward building trustworthy and clinically deployable AI systems.展开更多
Over the years,Generative Adversarial Networks(GANs)have revolutionized the medical imaging industry for applications such as image synthesis,denoising,super resolution,data augmentation,and cross-modality translation...Over the years,Generative Adversarial Networks(GANs)have revolutionized the medical imaging industry for applications such as image synthesis,denoising,super resolution,data augmentation,and cross-modality translation.The objective of this review is to evaluate the advances,relevances,and limitations of GANs in medical imaging.An organised literature review was conducted following the guidelines of PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses).The literature considered included peer-reviewed papers published between 2020 and 2025 across databases including PubMed,IEEE Xplore,and Scopus.The studies related to applications of GAN architectures in medical imaging with reported experimental outcomes and published in English in reputable journals and conferences were considered for the review.Thesis,white papers,communication letters,and non-English articles were not included for the same.CLAIM based quality assessment criteria were applied to the included studies to assess the quality.The study classifies diverse GAN architectures,summarizing their clinical applications,technical performances,and their implementation hardships.Key findings reveal the increasing applications of GANs for enhancing diagnostic accuracy,reducing data scarcity through synthetic data generation,and supporting modality translation.However,concerns such as limited generalizability,lack of clinical validation,and regulatory constraints persist.This review provides a comprehensive study of the prevailing scenario of GANs in medical imaging and highlights crucial research gaps and future directions.Though GANs hold transformative capability for medical imaging,their integration into clinical use demands further validation,interpretability,and regulatory alignment.展开更多
In recent years,the rising incidence of gastrointestinal(GI)cancer has triggered an urgent need for effective early intervention strategies.Traditional endoscopic techniques often cause patient discomfort,and it is di...In recent years,the rising incidence of gastrointestinal(GI)cancer has triggered an urgent need for effective early intervention strategies.Traditional endoscopic techniques often cause patient discomfort,and it is difficult to navigate deep regions of complex organ structures.This work proposes a kind of bio-inspired magnetic soft robot(BMSR)to address these challenges.The design of the BMSRs is inspired by the rolling motion of the golden wheel spider.Two six-degree-of-freedom(6-DOF)robotic arms are used,where one arm is responsible for real-time manipulation of the BMSRs,and the other is dedicated to monitoring their status.Under the actuation of an external rotating magnetic field,the BMSRs can flexibly climb on inclined surfaces at any angle,involving the inverted surface.Through the powerful output force,the BMSRs can overcome the mobility barrier induced by different human organs,including mucus,folds,and height differences of up to 8 cm.Such an exceptional mobility enables the BMSRs to deliver drugs in the targeted complex GI environment.Moreover,in combination with an endoscope,it provides real-time visual feedback for precise navigation.In vitro animal experiments validate the feasibility of BMSRs,paving a way for their usage in minimally invasive GI treatment.This work advances the potential applications of magnetic soft robots in the biomedical field.展开更多
BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Resear...BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.展开更多
While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information,spatial omics technologies enable high-throughput...While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information,spatial omics technologies enable high-throughput molecular mapping across tissue microenvironments.These technologies are emerging as transformative tools in molecular diagnostics and medical research.By integrating histopathological morphology with spatial multi-omics profiling(genome,transcriptome,epigenome,and proteome),spatial omics technologies open an avenue for understanding disease progression,therapeutic resistance mechanisms,and precise diagnosis.It particularly enhances tumor microenvironment analysis by mapping immune cell distributions and functional states,which may greatly facilitate tumor molecular subtyping,prognostic assessment,and prediction of the radiotherapy and chemotherapy efficacy.Despite the substantial advancements in spatial omics,the translation of spatial omics into clinical applications remains challenging due to robustness,efficacy,clinical validation,and cost constraints.In this review,we summarize the current progress and prospects of spatial omics technologies,particularly in medical research and diagnostic applications.展开更多
Medical imaging is essential in modern health care,allowing accurate diagnosis and effective treatment planning.These images,however,often demonstrate low contrast,noise,and brightness distortion that reduce their dia...Medical imaging is essential in modern health care,allowing accurate diagnosis and effective treatment planning.These images,however,often demonstrate low contrast,noise,and brightness distortion that reduce their diagnostic reliability.This review presents a structured and comprehensive analysis of advanced histogram equalization(HE)-based techniques for medical image enhancement.Our review methodology encompasses:(1)classical HE approaches and related limitations in medical domains;(2)adaptive schemes like Adaptive Histogram Equalization(AHE)and Contrast Limited Adaptive Histogrma Equalization(CLAHE)and their advance variants;(3)brightnesspreserving schemes like BBHE and MMBEBHE and related algorithms;(4)dynamic and recursive histogram equalization methods incorporating DHE and RMSHE;(5)fuzzy logic-based enhancement methodologies addressing uncertainty and noise in medical images;and(6)hybrid optimization methodologies through the application of metaheuristic algorithms(World Cup Optimization,Particle Swarm Optimization,Genetic Algorithms,along with histogram-based methodologies.)There is also a comparative discussion given based on contrast improvement,image brightness preservation,noise management,and computational efficiency.Such advancements have better capabilities of improving image quality,which is more important for improved diagnosis and image analysis.展开更多
Background:Artificial intelligence(AI)is transforming healthcare,demanding reevaluation of medical education.China's“New Medical Education”initiative urgently requires a standardized AI literacy framework for me...Background:Artificial intelligence(AI)is transforming healthcare,demanding reevaluation of medical education.China's“New Medical Education”initiative urgently requires a standardized AI literacy framework for medical students to address fragmented standards,rapid technological evolution,and insufficient localized ethical norms.Objective:To establish a Chinese expert consensus defining core AI competencies and a multi-modal assessment framework for medical students.Methods:A multidisciplinary(including medical education,clinical medicine,medical AI,public health,and medical ethics)expert group(n=32)developed an initial competency list based on the“Knowledge-Skills-Attitude”Medical Competency Model.Two Delphi rounds(100%response rate;consensus threshold:mean≥4.0,CV≤0.25)refined the framework.Core competencies were prioritized via Analytic Hierarchy Process(AHP).The final consensus document was established after multiple expert group meetings.Results:The consensus defines AI literacy for medical students as a comprehensive attribute for integrating AI into profes-sional knowledge,clinical practice,research,and health management.It comprises a 21-item Competencies of AI Proficiency(CAIP)list across knowledge(eight indicators),skills(seven indicators),and attitude(six indicators)dimensions.Key com-petencies prioritized include understanding AI's role in multidisciplinary knowledge integration(CAIP3),identifying AI output biases(CAIP4),understanding health data governance(CAIP2),maintaining physician-led AI-assisted diagnosis(CAIP16),and identifying AI diagnostic biases(CAIP12).A multi-modal assessment framework is recommended,including paper-based/computerized tests for knowledge,situational judgment tests(SJTs)for attitudes,and objective structured clinical examinations(OSCEs)with a specific“AI Clinical Decision Conflict Scoring Scale”for skills.A multi-stage dynamic assessment system(“Pre-enrollment-Pre-clinical-Post-clinical”)is proposed for longitudinal tracking.Educational integration pathways emphasize embedding AI literacy modularly from early undergraduate years,constructing an integrated curriculum covering fundamental principles,advanced large model applications(e.g.,prompt engineering,agent development),and ethical considerations,supported by a"digital twin hospital platform."Conclusion:This consensus provides authoritative,China-specific guidance for defining and assessing medical students'AI literacy,adhering to national policies and regulations.It offers a core action framework for optimizing AI integration into medical education,fostering future healthcare professionals proficient in both AI technology and medical humanism,with a commitment to dynamic updating to adapt to evolving AI advancements.展开更多
Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstructio...Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstruction methods either compromise on accuracy with iterative algorithms or suffer from limited generalizability with task-specific deep learning approaches.Methods:We present LDM-PIR,a lightweight physics-conditioned diffusion multi-model for medical image reconstruction that addresses key challenges in magnetic resonance imaging(MRI),CT,and low-photon imaging.Unlike traditional iterative methods,which are computationally expensive,or task-specific deep learning approaches lacking generalizability,integrates three innovations.A physics-conditioned diffusion framework that embeds acquisition operators(Fourier/Radon transforms)and noise models directly into the reconstruction process.A multi-model architecture that unifies denoising,inpainting,and super-resolution via shared weight conditioning.A lightweight design(2.1M parameters)enabling rapid inference(0.8s/image on GPU).Through self-supervised fine-tuning with measurement consistency losses adapts to new imaging modalities using fewer annotated samples.Results:Achieves state-of-the-art performance on fastMRI(peak signal-to-noise ratio(PSNR):34.04 for single-coil/31.50 for multi-coil)and Lung Image Database Consortium and Image Database Resource Initiative(28.83 PSNR under Poisson noise).Clinical evaluations demonstrate superior preservation of anatomical structures,with SSIM improvements of 8.8%for single-coil and 4.36%for multi-coil MRI over uDPIR.Conclusion:It offers a flexible,efficient,and scalable solution for medical image reconstruction,addressing the challenges of noise,undersampling,and modality generalization.The model’s lightweight design allows for rapid inference,while its self-supervised fine-tuning capability minimizes reliance on large annotated datasets,making it suitable for real-world clinical applications.展开更多
Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(Me...Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(MedSAM),have demonstrated strong performance but face challenges inmanymedical applications due to anatomical complexity and a limited domain-specific prompt.Thiswork introduces amethodology that enhances segmentation robustness and precision by automatically generating multiple informative point prompts,rather than relying on single inputs.The proposed approach randomly samples sets of spatially distributed point prompts based on image features,enabling MedSAM to better capture fine-grained anatomical structures and boundaries.During inference,probability maps are aggregated to reduce local misclassifications without additional model training.Extensive experiments on various computed tomography(CT)and magnetic resonance imaging(MRI)datasets demonstrate improvements in Dice Similarity Coefficient(DSC)and Normalized Surface Dice(NSD)metrics compared to baseline SAM and Scribble Prompt models.A semi-automatic point sampling version based on the ground truth segmentations yielded enhanced results,achieving up to 92.1%DSC and 86.6%NSD,with significant gains in delineating complex organs such as the pancreas,colon,kidney,and brain tumours.The main novelty of our method consists of effectively combining the results of multiple point prompts into the medical segmentation pipeline so that single-point prompt methods are outperformed.Overall,the proposed model offers a straightforward yet effective approach to improve medical image segmentation performance while maintaining computational efficiency.展开更多
In contemporary computer vision,convolutional neural networks(CNNs)and vision transformers(ViTs)represent the two primary architectural paradigms for image recognition.While both approaches have been widely adopted in...In contemporary computer vision,convolutional neural networks(CNNs)and vision transformers(ViTs)represent the two primary architectural paradigms for image recognition.While both approaches have been widely adopted in medical imaging applications,they operate based on fundamentally different computational principles.This report attempts to provide brief application notes on ViTs and CNNs,particularly focusing on scenarios that guide the selection of one architecture over the other in practical medical implementations.Generally,CNNs rely on convolutional kernels,localized receptive fields,and weight sharing,enabling efficient hierarchical feature extraction.These properties contribute to strong performance in detecting spatially constrained patterns such as textures,edges,and anatomical boundaries,while maintaining relatively low computational requirements.ViTs,on the other hand,decompose images into smaller segments referred to as tokens and employ self-attention mechanisms to model relationships across the entire image.This global modeling capability allows ViTs to capture long-range dependencies that may be difficult for convolution-based architectures to learn.However,ViTs typically achieve optimal performance when trained on extremely large datasets or when supported by extensive pretraining,as their reduced inductive bias requires greater data exposure to learn robust representations.This report briefly examines the architectural structure,underlying mathematical foundations,and relative performance characteristics of CNNs and ViTs,drawing upon recent findings from contemporary research.Emphasis is placed on understanding how differences in data availability,computational resources,and task requirements influence model effectiveness across medical imaging domains.Most importantly,the report serves as a concise application guide for practitioners seeking informed implementation decisions between these two influential deep learning frameworks.展开更多
Objectives This study aimed to design and evaluate a detection system for the accidental dislodgement of head-and-neck medical supplies through hand position recognition and tracking in Intensive Care Unit(ICU)patient...Objectives This study aimed to design and evaluate a detection system for the accidental dislodgement of head-and-neck medical supplies through hand position recognition and tracking in Intensive Care Unit(ICU)patients.Methods We conducted a single-center,prospective,parallel-group feasibility randomized controlled trial.We recruited 80 participants using convenience sampling from the ICU of a hospital in Ningbo City,Zhejiang Province,between March 2025 and June 2025,and they were randomly assigned to either the control group(routine care)or the intervention group(routine care plus image recognition-based detection system).The system continuously tracked patients’hand positions via bedside cameras and generated real-time alarms when hands entered predefined risk zones,notifying on-duty nurses to enable early intervention.System stability was assessed by continuous system uptime;system performance and clinical feasibility were evaluated by the frequencies of risk actions and accidental dislodgement of medical supplies(ADMS).Results All 80 participants completed the intervention,with 40 patients in each group.The baseline characteristics and median observation time of the two groups were balanced(intervention group:48 h/patient vs.control group:49 h/patient).Compared with the control group,the intervention group showed fewer ADMS(2/40 vs.9/40)and detected more risk actions per 100 h(36 vs.25);all system-detected events had corroborating images with complete concordance on manual review,and all nurse-recorded hand-contact events were accurately captured.Conclusions The study demonstrated that the image recognition-based detection system can function stably in clinical settings,providing accurate and continuous surveillance while supporting the early detection of risk actions.By reducing the observation burden and offering real-time cognitive support,the system complements routine nursing care and serves as an additional safety measure in ICU practice.With further optimization and larger multicenter validation,this approach could have the potential to make a significant contribution to the development of smart ICUs and the broader digital transformation of nursing care.展开更多
Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of de...Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.展开更多
In recent years,with the accelerating aging process of the population,China has entered an aging society,and the number of elderly patients with chronic diseases has been increasing.The traditional medical and elderly...In recent years,with the accelerating aging process of the population,China has entered an aging society,and the number of elderly patients with chronic diseases has been increasing.The traditional medical and elderly care service models can no longer fully meet their needs.The integrated medical and elderly care model has emerged as the times require.It organically combines medical resources with elderly care resources to provide comprehensive and continuous health management services for the elderly,becoming an important approach to solving the problems of chronic disease management among the elderly.In this regard,this paper first elaborates on the role of integrated medical and elderly care in the management of chronic diseases among the elderly,and then puts forward application strategies of integrated medical and elderly care in the management of chronic diseases among the elderly,in order to provide certain reference for relevant researchers.展开更多
“Shen”is one of the core contents in the basic theory of traditional Chinese medicine(TCM).Taoist philosophy plays an important role in promoting the theoretical shaping and medical transformation of“Shen”.Taking ...“Shen”is one of the core contents in the basic theory of traditional Chinese medicine(TCM).Taoist philosophy plays an important role in promoting the theoretical shaping and medical transformation of“Shen”.Taking the medical history as the thread and medical philosophy as the speculative dimension,this paper systematically sorts out the evolutionary trajectory of“Shen”in TCM from supernatural worship to philosophical abstraction,and then to medical embodiment,deeply analyzes the shaping effect of Taoist thought on the theoretical framework of“Shen”,and interprets its contemporary medical value.The research shows that Taoist philosophy provides a cosmological foundation,the core of the interdependence of essence,Qi,blood and Shen,and the guidance of spiritual inward concentration for“Shen”in TCM;Huangdi Neijing(Yellow Emperor’s Internal Classic)deeply integrates Taoist philosophy with medical practice,promoting the medical transformation of“Shen”.Its core ideas of“the unity of nature and man”and“the unity of form and Shen”provide traditional wisdom for modern psychosomatic medicine and systems medicine.The“Shen”theory,for which Taoist philosophy serves as an important intellectual source,is not only a crucial foundation for the inheritance and innovation of TCM theory,but also provides important ideological reference for the holistic development of modern medicine.展开更多
From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine)....From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine).Tracing its origin to the Song Dynasty,Longsha medicine has been handed down through successive generations,with numerous renowned physicians such as Xu Shuwei(许叔微)and Lu Wengui(陆文圭)making remarkable contributions to its development.A combination of favorable geographical location,superior ecological environment,an open cultural atmosphere,abundant local medicinal resources,and the unique physical constitutions of the local population comprehensively shaped the school’s distinct features and fueled its evolution.The core characteristics of Longsha medicine can be summarized as:emphasizing on inheritance and academic exploration,focusing on traditional Chinese medicine(TCM)classical theories and clinical practice,and embodying profound cultural connotations.As a regional and comprehensive TCM academic school,it originated in the Huashi area(historically known as Longsha)in Jiangyin County,Wuxi City,Jiangsu Province,gradually expanded to the areas surrounding Taihu Lake(太湖),and exerted far-reaching influence nationwide.Serving as a core representative of the TCM academic field in the Yangtze River Delta,Longsha medicine boasts a long history,solid cultural foundation,a galaxy of eminent physicians,classic works,distinct academic traits,unique diagnostic and therapeutic techniques,and vigorous dynamic inheritance.Contemporary in-depth research on Longsha medicine not only facilitates the dynamic inheritance of the core TCM theories such as Wu Yun Liu Qi(五运六气the five movements and six qi theory)in Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic)but also verifies the effectiveness and scientific validity of TCM classical theories in guiding the prevention and treatment of modern diseases.Thus,the study helps to protect regional medical-historical sources,enrich the doctrinal landscape of TCM,sustain distinctive academic techniques,catalyzes contemporary innovation,cultivates characteristic TCM talent,and enhances clinical service effectiveness.展开更多
Large language models(LLMs)show considerable potential to revolutionize healthcare through their performance across diverse clinical applications.Given the inherent constraints of LLMs and the critical nature of medic...Large language models(LLMs)show considerable potential to revolutionize healthcare through their performance across diverse clinical applications.Given the inherent constraints of LLMs and the critical nature of medical practice,a rigorous and systematic evaluation of their medical competence is imperative.This study presents a comprehensive review of the established methodologies and benchmarks for evaluating the medical competence of LLMs,encompassing a thorough analysis of current assessment practices across medical knowledge,clinical practice competence,and ethical-safety considerations.By integrating clinician competency assessment frameworks into LLMs evaluation,we propose a structured tri-dimensional framework that systematically organizes existing evaluation approaches according to medical theoretical knowledge,clinical practice ability,and ethical-safety considerations.Furthermore,this research provides critical insights into future developmental trajectories while establishing foundational frameworks and standardization protocols for the integration of LLMs into medical practice.展开更多
Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders,vision impairment,and ultimately myopia.China’s children and ...Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders,vision impairment,and ultimately myopia.China’s children and adolescents not only exhibit high myopia rates but also face increasingly prominent issues of younger onset and severe progression,which critically impact the nation’s future and require urgent attention.Myopia prevention constitutes a systematic project.Traditional Mongolian moxibustion therapy works by applying heat stimulation to specific acupoints to warm meridians,harmonize Qi-blood circulation,regulate elemental balance,thereby enhancing immunity for disease prevention.This holistic approach features non-invasive application with minimal side effects.However,current interventions in myopia management through this method still face challenges including inconsistent operational protocols and insufficiently systematic collaborative research.This paper reviews recent advancements in early intervention using Mongolian moxibustion therapy for myopia,providing insights to optimize myopia prevention strategies.展开更多
The Transformer has achieved great success in the field of medical image segmentation,but its quadratic computational complexity limits its application in dense medical image prediction.Recently,the receptance weighte...The Transformer has achieved great success in the field of medical image segmentation,but its quadratic computational complexity limits its application in dense medical image prediction.Recently,the receptance weighted key value(RWKV)architecture has garnered widespread attention due to its linear computational complexity and its capability of parallel computation during training.Despite the RWKV model's proficiency in addressing long-range modeling tasks with linear computational complexity,most current RWKV-based approaches employ static scanning patterns.These patterns may inadvertently incorporate biased prior knowledge into the model's predictions.To address this challenge,we propose a multi-head scan strategy combined with padding methods to effectively simulate spatial continuity in 2D images.Within the Feature Aggregation Attention(FAA)module,asymmetric convolutions are designed to aggregate 1D sequence features along a single dimension,thereby expanding effective receptive fields while preserving structural sparsity.Additionally,panoramic token shift(P-Shift)effectively models local dependency relationships by moving tokens from a wide receptive field.Extensive experiments conducted on the ISIC17/18 and ACDC datasets demonstrate that our method exhibits superior performance in dense medical image prediction tasks.展开更多
On October 18,2017,the 19th National Congress Report called for the implementation of the Healthy China Strategy.The development of biomedical data plays a pivotal role in advancing this strategy.Since the 18th Nation...On October 18,2017,the 19th National Congress Report called for the implementation of the Healthy China Strategy.The development of biomedical data plays a pivotal role in advancing this strategy.Since the 18th National Congress of the Communist Party of China,China has vigorously promoted the integration and implementation of the Healthy China and Digital China strategies.The National Health Commission has prioritized the development of health and medical big data,issuing policies to promote standardized applica-tions and foster innovation in"Internet+Healthcare."Biomedical data has significantly contributed to preci-sion medicine,personalized health management,drug development,disease diagnosis,public health monitor-ing,and epidemic prediction capabilities.展开更多
文摘The emergence of Medical Large Language Models has significantly transformed healthcare.Medical Large Language Models(Med-LLMs)serve as transformative tools that enhance clinical practice through applications in decision support,documentation,and diagnostics.This evaluation examines the performance of leading Med-LLMs,including GPT-4Med,Med-PaLM,MEDITRON,PubMedGPT,and MedAlpaca,across diverse medical datasets.It provides graphical comparisons of their effectiveness in distinct healthcare domains.The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making,documentation,drug discovery,research,patient interaction,and public health.The paper addresses deployment challenges of Medical-LLMs,emphasizing trustworthiness and explainability as essential requirements for healthcare AI.It presents current evaluation techniques that improve model transparency in high-stakes medical contexts and analyzes regulatory frameworks using benchmarking datasets such asMedQA,MedMCQA,PubMedQA,and MIMIC.By identifying ongoing challenges in biasmitigation,reliability,and ethical compliance,thiswork serves as a resource for selecting appropriate Med-LLMs and outlines future directions in the field.This analysis offers a roadmap for developing Med-LLMs that balance technological innovation with the trust and transparency required for clinical integration,a perspective often overlooked in existing literature.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-DDRSP2601).
文摘Generative Adversarial Networks(GANs)have become valuable tools in medical imaging,enabling realistic image synthesis for enhancement,augmentation,and restoration.However,their integration into clinical workflows raises concerns,particularly the risk of subtle distortions or hallucinations that may undermine diagnostic accuracy and weaken trust in AI-assisted decision-making.To address this challenge,we propose a hybrid deep learning framework designed to detect GAN-induced artifacts in medical images,thereby reinforcing the reliability of AI-driven diagnostics.The framework integrates low-level statistical descriptors,including high-frequency residuals and Gray-Level Co-occurrence Matrix(GLCM)texture features,with high-level semantic representations extracted from a pre-trained ResNet18.This dual-stream approach enables detection of both pixel-level anomalies and structural inconsistencies introduced by GAN-based manipulation.We validated the framework on a curated dataset of 10,000 medical images,evenly split between authentic and GAN-generated samples across four modalities:MRI,CT,X-ray,and fundus photography.To improve generalizability to real-world clinical settings,we incorporated domain adaptation strategies such as adversarial training and style transfer,reducing domain shift by 15%.Experimental results demonstrate robust performance,achieving 92.6%accuracy and an F1-score of 0.91 on synthetic test data,and maintaining strong performance on real-world GAN-modified images with 87.3%accuracy and an F1-score of 0.85.Additionally,the model attained an AUC of 0.96 and an average precision of 0.92,outperforming conventional GAN detection pipelines and baseline Convolutional Neural Network(CNN)architectures.These findings establish the proposed framework as an effective and reliable solution for detecting GAN-induced hallucinations in medical imaging,representing an important step toward building trustworthy and clinically deployable AI systems.
基金supported by Deanship of Research and Graduate Studies at King Khalid University for funding this work through Large Research Project under grant number RGP2/540/46.
文摘Over the years,Generative Adversarial Networks(GANs)have revolutionized the medical imaging industry for applications such as image synthesis,denoising,super resolution,data augmentation,and cross-modality translation.The objective of this review is to evaluate the advances,relevances,and limitations of GANs in medical imaging.An organised literature review was conducted following the guidelines of PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses).The literature considered included peer-reviewed papers published between 2020 and 2025 across databases including PubMed,IEEE Xplore,and Scopus.The studies related to applications of GAN architectures in medical imaging with reported experimental outcomes and published in English in reputable journals and conferences were considered for the review.Thesis,white papers,communication letters,and non-English articles were not included for the same.CLAIM based quality assessment criteria were applied to the included studies to assess the quality.The study classifies diverse GAN architectures,summarizing their clinical applications,technical performances,and their implementation hardships.Key findings reveal the increasing applications of GANs for enhancing diagnostic accuracy,reducing data scarcity through synthetic data generation,and supporting modality translation.However,concerns such as limited generalizability,lack of clinical validation,and regulatory constraints persist.This review provides a comprehensive study of the prevailing scenario of GANs in medical imaging and highlights crucial research gaps and future directions.Though GANs hold transformative capability for medical imaging,their integration into clinical use demands further validation,interpretability,and regulatory alignment.
基金supported in part by the National Natural Science Foundation of China under grant 52175556the Macao Science and Technology Development Fund under grant 0004/2022/AKP,0102/2022/A2,and 0078/2023/RIB3+1 种基金the Research Committee of the University of Macao under grants MYRG2022-00068-FST and MYRG-CRG202200004-FST-ICIthe Guangdong Basic and Applied Basic Research Foundation under grant 2023A1515011178。
文摘In recent years,the rising incidence of gastrointestinal(GI)cancer has triggered an urgent need for effective early intervention strategies.Traditional endoscopic techniques often cause patient discomfort,and it is difficult to navigate deep regions of complex organ structures.This work proposes a kind of bio-inspired magnetic soft robot(BMSR)to address these challenges.The design of the BMSRs is inspired by the rolling motion of the golden wheel spider.Two six-degree-of-freedom(6-DOF)robotic arms are used,where one arm is responsible for real-time manipulation of the BMSRs,and the other is dedicated to monitoring their status.Under the actuation of an external rotating magnetic field,the BMSRs can flexibly climb on inclined surfaces at any angle,involving the inverted surface.Through the powerful output force,the BMSRs can overcome the mobility barrier induced by different human organs,including mucus,folds,and height differences of up to 8 cm.Such an exceptional mobility enables the BMSRs to deliver drugs in the targeted complex GI environment.Moreover,in combination with an endoscope,it provides real-time visual feedback for precise navigation.In vitro animal experiments validate the feasibility of BMSRs,paving a way for their usage in minimally invasive GI treatment.This work advances the potential applications of magnetic soft robots in the biomedical field.
文摘BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.
基金supported by the National Natural Science Foundation of China(32171022,32221005,and 32401246).
文摘While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information,spatial omics technologies enable high-throughput molecular mapping across tissue microenvironments.These technologies are emerging as transformative tools in molecular diagnostics and medical research.By integrating histopathological morphology with spatial multi-omics profiling(genome,transcriptome,epigenome,and proteome),spatial omics technologies open an avenue for understanding disease progression,therapeutic resistance mechanisms,and precise diagnosis.It particularly enhances tumor microenvironment analysis by mapping immune cell distributions and functional states,which may greatly facilitate tumor molecular subtyping,prognostic assessment,and prediction of the radiotherapy and chemotherapy efficacy.Despite the substantial advancements in spatial omics,the translation of spatial omics into clinical applications remains challenging due to robustness,efficacy,clinical validation,and cost constraints.In this review,we summarize the current progress and prospects of spatial omics technologies,particularly in medical research and diagnostic applications.
基金funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant No.(IFPDP-261-22).
文摘Medical imaging is essential in modern health care,allowing accurate diagnosis and effective treatment planning.These images,however,often demonstrate low contrast,noise,and brightness distortion that reduce their diagnostic reliability.This review presents a structured and comprehensive analysis of advanced histogram equalization(HE)-based techniques for medical image enhancement.Our review methodology encompasses:(1)classical HE approaches and related limitations in medical domains;(2)adaptive schemes like Adaptive Histogram Equalization(AHE)and Contrast Limited Adaptive Histogrma Equalization(CLAHE)and their advance variants;(3)brightnesspreserving schemes like BBHE and MMBEBHE and related algorithms;(4)dynamic and recursive histogram equalization methods incorporating DHE and RMSHE;(5)fuzzy logic-based enhancement methodologies addressing uncertainty and noise in medical images;and(6)hybrid optimization methodologies through the application of metaheuristic algorithms(World Cup Optimization,Particle Swarm Optimization,Genetic Algorithms,along with histogram-based methodologies.)There is also a comparative discussion given based on contrast improvement,image brightness preservation,noise management,and computational efficiency.Such advancements have better capabilities of improving image quality,which is more important for improved diagnosis and image analysis.
基金Science and Technology Innovation 2030 Major Project,Grant/Award Number:2023ZD0508506。
文摘Background:Artificial intelligence(AI)is transforming healthcare,demanding reevaluation of medical education.China's“New Medical Education”initiative urgently requires a standardized AI literacy framework for medical students to address fragmented standards,rapid technological evolution,and insufficient localized ethical norms.Objective:To establish a Chinese expert consensus defining core AI competencies and a multi-modal assessment framework for medical students.Methods:A multidisciplinary(including medical education,clinical medicine,medical AI,public health,and medical ethics)expert group(n=32)developed an initial competency list based on the“Knowledge-Skills-Attitude”Medical Competency Model.Two Delphi rounds(100%response rate;consensus threshold:mean≥4.0,CV≤0.25)refined the framework.Core competencies were prioritized via Analytic Hierarchy Process(AHP).The final consensus document was established after multiple expert group meetings.Results:The consensus defines AI literacy for medical students as a comprehensive attribute for integrating AI into profes-sional knowledge,clinical practice,research,and health management.It comprises a 21-item Competencies of AI Proficiency(CAIP)list across knowledge(eight indicators),skills(seven indicators),and attitude(six indicators)dimensions.Key com-petencies prioritized include understanding AI's role in multidisciplinary knowledge integration(CAIP3),identifying AI output biases(CAIP4),understanding health data governance(CAIP2),maintaining physician-led AI-assisted diagnosis(CAIP16),and identifying AI diagnostic biases(CAIP12).A multi-modal assessment framework is recommended,including paper-based/computerized tests for knowledge,situational judgment tests(SJTs)for attitudes,and objective structured clinical examinations(OSCEs)with a specific“AI Clinical Decision Conflict Scoring Scale”for skills.A multi-stage dynamic assessment system(“Pre-enrollment-Pre-clinical-Post-clinical”)is proposed for longitudinal tracking.Educational integration pathways emphasize embedding AI literacy modularly from early undergraduate years,constructing an integrated curriculum covering fundamental principles,advanced large model applications(e.g.,prompt engineering,agent development),and ethical considerations,supported by a"digital twin hospital platform."Conclusion:This consensus provides authoritative,China-specific guidance for defining and assessing medical students'AI literacy,adhering to national policies and regulations.It offers a core action framework for optimizing AI integration into medical education,fostering future healthcare professionals proficient in both AI technology and medical humanism,with a commitment to dynamic updating to adapt to evolving AI advancements.
文摘Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstruction methods either compromise on accuracy with iterative algorithms or suffer from limited generalizability with task-specific deep learning approaches.Methods:We present LDM-PIR,a lightweight physics-conditioned diffusion multi-model for medical image reconstruction that addresses key challenges in magnetic resonance imaging(MRI),CT,and low-photon imaging.Unlike traditional iterative methods,which are computationally expensive,or task-specific deep learning approaches lacking generalizability,integrates three innovations.A physics-conditioned diffusion framework that embeds acquisition operators(Fourier/Radon transforms)and noise models directly into the reconstruction process.A multi-model architecture that unifies denoising,inpainting,and super-resolution via shared weight conditioning.A lightweight design(2.1M parameters)enabling rapid inference(0.8s/image on GPU).Through self-supervised fine-tuning with measurement consistency losses adapts to new imaging modalities using fewer annotated samples.Results:Achieves state-of-the-art performance on fastMRI(peak signal-to-noise ratio(PSNR):34.04 for single-coil/31.50 for multi-coil)and Lung Image Database Consortium and Image Database Resource Initiative(28.83 PSNR under Poisson noise).Clinical evaluations demonstrate superior preservation of anatomical structures,with SSIM improvements of 8.8%for single-coil and 4.36%for multi-coil MRI over uDPIR.Conclusion:It offers a flexible,efficient,and scalable solution for medical image reconstruction,addressing the challenges of noise,undersampling,and modality generalization.The model’s lightweight design allows for rapid inference,while its self-supervised fine-tuning capability minimizes reliance on large annotated datasets,making it suitable for real-world clinical applications.
基金supported by the Autonomous Government of Andalusia(Spain)under project UMA20-FEDERJA-108also by the Ministry of Science and Innovation of Spain,grant number PID2022-136764OA-I00+1 种基金It includes funds fromthe European Regional Development Fund(ERDF),It is also partially supported by the Fundación Unicaja(PUNI-003_2023)the Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND(ATECH-25-02).
文摘Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(MedSAM),have demonstrated strong performance but face challenges inmanymedical applications due to anatomical complexity and a limited domain-specific prompt.Thiswork introduces amethodology that enhances segmentation robustness and precision by automatically generating multiple informative point prompts,rather than relying on single inputs.The proposed approach randomly samples sets of spatially distributed point prompts based on image features,enabling MedSAM to better capture fine-grained anatomical structures and boundaries.During inference,probability maps are aggregated to reduce local misclassifications without additional model training.Extensive experiments on various computed tomography(CT)and magnetic resonance imaging(MRI)datasets demonstrate improvements in Dice Similarity Coefficient(DSC)and Normalized Surface Dice(NSD)metrics compared to baseline SAM and Scribble Prompt models.A semi-automatic point sampling version based on the ground truth segmentations yielded enhanced results,achieving up to 92.1%DSC and 86.6%NSD,with significant gains in delineating complex organs such as the pancreas,colon,kidney,and brain tumours.The main novelty of our method consists of effectively combining the results of multiple point prompts into the medical segmentation pipeline so that single-point prompt methods are outperformed.Overall,the proposed model offers a straightforward yet effective approach to improve medical image segmentation performance while maintaining computational efficiency.
文摘In contemporary computer vision,convolutional neural networks(CNNs)and vision transformers(ViTs)represent the two primary architectural paradigms for image recognition.While both approaches have been widely adopted in medical imaging applications,they operate based on fundamentally different computational principles.This report attempts to provide brief application notes on ViTs and CNNs,particularly focusing on scenarios that guide the selection of one architecture over the other in practical medical implementations.Generally,CNNs rely on convolutional kernels,localized receptive fields,and weight sharing,enabling efficient hierarchical feature extraction.These properties contribute to strong performance in detecting spatially constrained patterns such as textures,edges,and anatomical boundaries,while maintaining relatively low computational requirements.ViTs,on the other hand,decompose images into smaller segments referred to as tokens and employ self-attention mechanisms to model relationships across the entire image.This global modeling capability allows ViTs to capture long-range dependencies that may be difficult for convolution-based architectures to learn.However,ViTs typically achieve optimal performance when trained on extremely large datasets or when supported by extensive pretraining,as their reduced inductive bias requires greater data exposure to learn robust representations.This report briefly examines the architectural structure,underlying mathematical foundations,and relative performance characteristics of CNNs and ViTs,drawing upon recent findings from contemporary research.Emphasis is placed on understanding how differences in data availability,computational resources,and task requirements influence model effectiveness across medical imaging domains.Most importantly,the report serves as a concise application guide for practitioners seeking informed implementation decisions between these two influential deep learning frameworks.
文摘Objectives This study aimed to design and evaluate a detection system for the accidental dislodgement of head-and-neck medical supplies through hand position recognition and tracking in Intensive Care Unit(ICU)patients.Methods We conducted a single-center,prospective,parallel-group feasibility randomized controlled trial.We recruited 80 participants using convenience sampling from the ICU of a hospital in Ningbo City,Zhejiang Province,between March 2025 and June 2025,and they were randomly assigned to either the control group(routine care)or the intervention group(routine care plus image recognition-based detection system).The system continuously tracked patients’hand positions via bedside cameras and generated real-time alarms when hands entered predefined risk zones,notifying on-duty nurses to enable early intervention.System stability was assessed by continuous system uptime;system performance and clinical feasibility were evaluated by the frequencies of risk actions and accidental dislodgement of medical supplies(ADMS).Results All 80 participants completed the intervention,with 40 patients in each group.The baseline characteristics and median observation time of the two groups were balanced(intervention group:48 h/patient vs.control group:49 h/patient).Compared with the control group,the intervention group showed fewer ADMS(2/40 vs.9/40)and detected more risk actions per 100 h(36 vs.25);all system-detected events had corroborating images with complete concordance on manual review,and all nurse-recorded hand-contact events were accurately captured.Conclusions The study demonstrated that the image recognition-based detection system can function stably in clinical settings,providing accurate and continuous surveillance while supporting the early detection of risk actions.By reducing the observation burden and offering real-time cognitive support,the system complements routine nursing care and serves as an additional safety measure in ICU practice.With further optimization and larger multicenter validation,this approach could have the potential to make a significant contribution to the development of smart ICUs and the broader digital transformation of nursing care.
基金funded by China Law Society 2025 Annual Legal Research,Project grant number:CLS(2025)Y04.
文摘Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.
文摘In recent years,with the accelerating aging process of the population,China has entered an aging society,and the number of elderly patients with chronic diseases has been increasing.The traditional medical and elderly care service models can no longer fully meet their needs.The integrated medical and elderly care model has emerged as the times require.It organically combines medical resources with elderly care resources to provide comprehensive and continuous health management services for the elderly,becoming an important approach to solving the problems of chronic disease management among the elderly.In this regard,this paper first elaborates on the role of integrated medical and elderly care in the management of chronic diseases among the elderly,and then puts forward application strategies of integrated medical and elderly care in the management of chronic diseases among the elderly,in order to provide certain reference for relevant researchers.
基金supported by the Tianjin Municipal Education Commission Scientific Research Plan Project(Grant No.2022ZD042).
文摘“Shen”is one of the core contents in the basic theory of traditional Chinese medicine(TCM).Taoist philosophy plays an important role in promoting the theoretical shaping and medical transformation of“Shen”.Taking the medical history as the thread and medical philosophy as the speculative dimension,this paper systematically sorts out the evolutionary trajectory of“Shen”in TCM from supernatural worship to philosophical abstraction,and then to medical embodiment,deeply analyzes the shaping effect of Taoist thought on the theoretical framework of“Shen”,and interprets its contemporary medical value.The research shows that Taoist philosophy provides a cosmological foundation,the core of the interdependence of essence,Qi,blood and Shen,and the guidance of spiritual inward concentration for“Shen”in TCM;Huangdi Neijing(Yellow Emperor’s Internal Classic)deeply integrates Taoist philosophy with medical practice,promoting the medical transformation of“Shen”.Its core ideas of“the unity of nature and man”and“the unity of form and Shen”provide traditional wisdom for modern psychosomatic medicine and systems medicine.The“Shen”theory,for which Taoist philosophy serves as an important intellectual source,is not only a crucial foundation for the inheritance and innovation of TCM theory,but also provides important ideological reference for the holistic development of modern medicine.
基金the grants from the second round of Construction Project of National Traditional Chinese Medicine Academic Schools Inheritance Studio of the State Administration of Traditional Chinese Medicine(No.62,2019)the Seventh Batch of National Projects for Inheriting Academic Experience of Veteran Traditional Chinese Medicine Experts(No.[2022]76)Construction Project of Lu Shu’s National Veteran Traditional Chinese Medicine Expert Inheritance Studio under the National Administration of Traditional Chinese Medicine(No.[2022]75).
文摘From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine).Tracing its origin to the Song Dynasty,Longsha medicine has been handed down through successive generations,with numerous renowned physicians such as Xu Shuwei(许叔微)and Lu Wengui(陆文圭)making remarkable contributions to its development.A combination of favorable geographical location,superior ecological environment,an open cultural atmosphere,abundant local medicinal resources,and the unique physical constitutions of the local population comprehensively shaped the school’s distinct features and fueled its evolution.The core characteristics of Longsha medicine can be summarized as:emphasizing on inheritance and academic exploration,focusing on traditional Chinese medicine(TCM)classical theories and clinical practice,and embodying profound cultural connotations.As a regional and comprehensive TCM academic school,it originated in the Huashi area(historically known as Longsha)in Jiangyin County,Wuxi City,Jiangsu Province,gradually expanded to the areas surrounding Taihu Lake(太湖),and exerted far-reaching influence nationwide.Serving as a core representative of the TCM academic field in the Yangtze River Delta,Longsha medicine boasts a long history,solid cultural foundation,a galaxy of eminent physicians,classic works,distinct academic traits,unique diagnostic and therapeutic techniques,and vigorous dynamic inheritance.Contemporary in-depth research on Longsha medicine not only facilitates the dynamic inheritance of the core TCM theories such as Wu Yun Liu Qi(五运六气the five movements and six qi theory)in Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic)but also verifies the effectiveness and scientific validity of TCM classical theories in guiding the prevention and treatment of modern diseases.Thus,the study helps to protect regional medical-historical sources,enrich the doctrinal landscape of TCM,sustain distinctive academic techniques,catalyzes contemporary innovation,cultivates characteristic TCM talent,and enhances clinical service effectiveness.
基金Guangzhou Science and Technology Program,Grant/Award Numbers:2025B03J0110,2024A03J1074,2024A03J0927。
文摘Large language models(LLMs)show considerable potential to revolutionize healthcare through their performance across diverse clinical applications.Given the inherent constraints of LLMs and the critical nature of medical practice,a rigorous and systematic evaluation of their medical competence is imperative.This study presents a comprehensive review of the established methodologies and benchmarks for evaluating the medical competence of LLMs,encompassing a thorough analysis of current assessment practices across medical knowledge,clinical practice competence,and ethical-safety considerations.By integrating clinician competency assessment frameworks into LLMs evaluation,we propose a structured tri-dimensional framework that systematically organizes existing evaluation approaches according to medical theoretical knowledge,clinical practice ability,and ethical-safety considerations.Furthermore,this research provides critical insights into future developmental trajectories while establishing foundational frameworks and standardization protocols for the integration of LLMs into medical practice.
文摘Mongolian medicine posits that disruptions to the natural balance of the three roots and seven elements within the human body may lead to ocular disorders,vision impairment,and ultimately myopia.China’s children and adolescents not only exhibit high myopia rates but also face increasingly prominent issues of younger onset and severe progression,which critically impact the nation’s future and require urgent attention.Myopia prevention constitutes a systematic project.Traditional Mongolian moxibustion therapy works by applying heat stimulation to specific acupoints to warm meridians,harmonize Qi-blood circulation,regulate elemental balance,thereby enhancing immunity for disease prevention.This holistic approach features non-invasive application with minimal side effects.However,current interventions in myopia management through this method still face challenges including inconsistent operational protocols and insufficiently systematic collaborative research.This paper reviews recent advancements in early intervention using Mongolian moxibustion therapy for myopia,providing insights to optimize myopia prevention strategies.
基金Supported by Zhejiang Provincial Natural Science Foundation of China(LY22F020025)the National Natural Science Foundation of China(62072126)。
文摘The Transformer has achieved great success in the field of medical image segmentation,but its quadratic computational complexity limits its application in dense medical image prediction.Recently,the receptance weighted key value(RWKV)architecture has garnered widespread attention due to its linear computational complexity and its capability of parallel computation during training.Despite the RWKV model's proficiency in addressing long-range modeling tasks with linear computational complexity,most current RWKV-based approaches employ static scanning patterns.These patterns may inadvertently incorporate biased prior knowledge into the model's predictions.To address this challenge,we propose a multi-head scan strategy combined with padding methods to effectively simulate spatial continuity in 2D images.Within the Feature Aggregation Attention(FAA)module,asymmetric convolutions are designed to aggregate 1D sequence features along a single dimension,thereby expanding effective receptive fields while preserving structural sparsity.Additionally,panoramic token shift(P-Shift)effectively models local dependency relationships by moving tokens from a wide receptive field.Extensive experiments conducted on the ISIC17/18 and ACDC datasets demonstrate that our method exhibits superior performance in dense medical image prediction tasks.
文摘On October 18,2017,the 19th National Congress Report called for the implementation of the Healthy China Strategy.The development of biomedical data plays a pivotal role in advancing this strategy.Since the 18th National Congress of the Communist Party of China,China has vigorously promoted the integration and implementation of the Healthy China and Digital China strategies.The National Health Commission has prioritized the development of health and medical big data,issuing policies to promote standardized applica-tions and foster innovation in"Internet+Healthcare."Biomedical data has significantly contributed to preci-sion medicine,personalized health management,drug development,disease diagnosis,public health monitor-ing,and epidemic prediction capabilities.
