消化系统肿瘤在我国的发病率高且存活率低,尽管随着医学的不断发展,目前的治疗手段能够在一定程度上提高和改善患者的生存率及预后,但总的生存率仍没有达到人们预期。肿瘤微环境(TME)由多种免疫细胞组成,其中髓源抑制细胞(MDSCs)是起免...消化系统肿瘤在我国的发病率高且存活率低,尽管随着医学的不断发展,目前的治疗手段能够在一定程度上提高和改善患者的生存率及预后,但总的生存率仍没有达到人们预期。肿瘤微环境(TME)由多种免疫细胞组成,其中髓源抑制细胞(MDSCs)是起免疫抑制作用的重要组成部分,它通过抑制机体的免疫细胞如T细胞或者自然杀伤细胞(NK细胞)来帮助肿瘤细胞发生免疫逃逸。研究发现MDSCs的生成、分化、数量及凋亡与消化系统肿瘤的发生发展密切相关,并且靶向MDSCs可作为消化系统肿瘤靶向治疗的潜在靶点,因此本文就MDSCs在消化系统肿瘤中的作用及其靶向治疗的研究做一综述。The incidence rate of digestive system tumors in China is high and the survival rate is low. With the continuous development of medicine, the current treatment methods can improve the survival rate and prognosis of patients, but the overall survival rate still does not meet patient expected. The tumor microenvironment (TME) is composed of various immune cells, myeloid derived suppressor cells (MDSCs) are one kind of important immune suppression cells. They help tumor cells escape by inhibiting immune cells such as T cells or natural killer cells (NK cells). Research has found that the generation, differentiation, quantity, and apoptosis of MDSCs are closely related to the occurrence and development of digestive system tumors, and targeting MDSCs can be a potential point for targeted therapy. Therefore, this paper reviews the role of MDSCs in digestive system tumors and their targeted therapy research.展开更多
Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the patholog...Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and cancer.As individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by aging.This indicates that MDSC could serve as a potent inducer of immune senescence.Immune senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and tumors.To achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related diseases.Therefore,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting MDSC.This article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.展开更多
文摘消化系统肿瘤在我国的发病率高且存活率低,尽管随着医学的不断发展,目前的治疗手段能够在一定程度上提高和改善患者的生存率及预后,但总的生存率仍没有达到人们预期。肿瘤微环境(TME)由多种免疫细胞组成,其中髓源抑制细胞(MDSCs)是起免疫抑制作用的重要组成部分,它通过抑制机体的免疫细胞如T细胞或者自然杀伤细胞(NK细胞)来帮助肿瘤细胞发生免疫逃逸。研究发现MDSCs的生成、分化、数量及凋亡与消化系统肿瘤的发生发展密切相关,并且靶向MDSCs可作为消化系统肿瘤靶向治疗的潜在靶点,因此本文就MDSCs在消化系统肿瘤中的作用及其靶向治疗的研究做一综述。The incidence rate of digestive system tumors in China is high and the survival rate is low. With the continuous development of medicine, the current treatment methods can improve the survival rate and prognosis of patients, but the overall survival rate still does not meet patient expected. The tumor microenvironment (TME) is composed of various immune cells, myeloid derived suppressor cells (MDSCs) are one kind of important immune suppression cells. They help tumor cells escape by inhibiting immune cells such as T cells or natural killer cells (NK cells). Research has found that the generation, differentiation, quantity, and apoptosis of MDSCs are closely related to the occurrence and development of digestive system tumors, and targeting MDSCs can be a potential point for targeted therapy. Therefore, this paper reviews the role of MDSCs in digestive system tumors and their targeted therapy research.
基金supported by S&T Program of Hebei(No.23379902L).
文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and cancer.As individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by aging.This indicates that MDSC could serve as a potent inducer of immune senescence.Immune senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and tumors.To achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related diseases.Therefore,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting MDSC.This article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.
