【目的】系统探究柴达木盆地耕地耕层土壤盐碱化水平及养分状况,优化柴达木盆地耕地耕层土壤评价因子,构建评价与诊断模型,为区域粮食安全和生态可持续发展提供科学依据。【方法】以柴达木盆地耕作层土壤为对象,基于470个土壤样品的11...【目的】系统探究柴达木盆地耕地耕层土壤盐碱化水平及养分状况,优化柴达木盆地耕地耕层土壤评价因子,构建评价与诊断模型,为区域粮食安全和生态可持续发展提供科学依据。【方法】以柴达木盆地耕作层土壤为对象,基于470个土壤样品的11项土壤指标(全盐:TS、电导率:EC、全氮:TN、全磷:TP、速效氮:AN、速效磷:AP、pH、有机质:SOM、钠离子:Na^(+)、氯离子:Cl^(-)、硫酸根离子:SO_(4)^(2-)),通过主成分分析(PCA)与Norm值构建最小数据集(Minimum data set,MDS),结合多准则妥协解排序法(VIKOR法),系统评价土壤质量指数(Soil quality index,SQI)并诊断主要障碍因子。【结果】研究区土壤呈现显著盐碱化风险(TS均值2.449 g/kg,C_(V)=53.98%)和氮磷养分限制特征(TN均值为0.916 mg/kg,TP的C_(V)为118.38%);MDS筛选出TS、TN、TP、AP、Cl^(-)和SO_(4)^(2-)等6项核心指标,可替代全数据集(Total data set,TDS)精准评价土壤质量(R^(2)=0.904);VIKOR模型显示,格尔木和大柴旦地区土壤综合障碍度最高(群体效应值S>0.46),TP与SO_(4)^(2-)是主要限制因子,德令哈土壤质量最优(SQI=0.284)。【讨论】研究揭示了盐碱化与养分失衡对干旱区土壤质量的协同制约效应,为柴达木盆地耕地定向改良提供了科学依据。展开更多
S100 proteins govern cellular proliferation,differentiation,apoptosis,calcium homeostasis,energy metabolism,and inflammation.This heterodimeric calcium-binding protein,consisting of the S100A8 and S100A9 subunits,modu...S100 proteins govern cellular proliferation,differentiation,apoptosis,calcium homeostasis,energy metabolism,and inflammation.This heterodimeric calcium-binding protein,consisting of the S100A8 and S100A9 subunits,modulates myeloid cell development.展开更多
Infrastructure development within protected areas has become a critical concern in biodiversity conservation,particularly in ecologically sensitive regions like Bantimurung Bulusaraung National Park (TN Babul), Indone...Infrastructure development within protected areas has become a critical concern in biodiversity conservation,particularly in ecologically sensitive regions like Bantimurung Bulusaraung National Park (TN Babul), Indonesia. Thisstudy aims to evaluate the ecological, social, economic, institutional, and infrastructural sustainability of the Maros–Watampone road corridor that crosses TN Babul. Using a qualitative descriptive design, the research employed theMultidimensional Scaling (MDS) method supported by leverage and Monte Carlo analysis. Data were gathered fromkey stakeholders through purposive sampling and analyzed based on sustainability attributes across five dimensions.The findings reveal that environmental, institutional, and infrastructure dimensions scored in the "less sustainable"category, indicating high ecological risk and governance gaps. In contrast, economic and social dimensions weremoderately sustainable, reflecting emerging opportunities for inclusive growth. Sensitive attributes influencingsustainability include habitat fragmentation, road design, governance coordination, and community participation. Thestudy concludes that balancing development with conservation requires integrated, multi-stakeholder strategies andtargeted interventions that address the most vulnerable sustainability dimensions.展开更多
本研究旨在探讨骨髓增生异常综合征(MDS)患者袪铁治疗后红细胞生成素(EPO)、血红蛋白(Hb)、重组EPO(rEPO)的变化及EPO与血清铁蛋白(SF)的相关性。检测172例MDS患者及30例健康对照者SF、EPO浓度、血清铁(SI)、总铁结合力(TIBC)、C反应蛋...本研究旨在探讨骨髓增生异常综合征(MDS)患者袪铁治疗后红细胞生成素(EPO)、血红蛋白(Hb)、重组EPO(rEPO)的变化及EPO与血清铁蛋白(SF)的相关性。检测172例MDS患者及30例健康对照者SF、EPO浓度、血清铁(SI)、总铁结合力(TIBC)、C反应蛋白(CRP)、Hb;根据CRP值对SF进行调整。对34例低危组、SF>1 000 mg/L的患者给予袪铁胺治疗,比较治疗前后SF、EPO、SI、TIBC、Hb的变化。对58例低危组、EPO<1 000 U/L的患者给予rEPO治疗,比较铁过载组与非铁过载组袪铁治疗前后EPO抵抗的发生率。结果表明:非铁过载组EPO浓度高于正常对照组(997.44±473.48 vs 467.27±238.49)(P<0.05);铁过载组EPO浓度高于无铁过载组及正常对照组(3257.59±697.19 vs 997.44±473.48;3257.59±697.19 vs 467.27±238.49)(P均<0.05);铁过载组EPO抵抗发生率高于非铁过载组(18/35 vs 2/23)(P=0.001),铁过载组MDS患者EPO与SF呈显著正相关(r=0.310)(P=0.036)。袪铁治疗后SF、SI、TIBC及EPO浓度均较治疗前明显下降(3942.38±641.82 vs 2266.35±367.31;48.61±10.65 vs 28.52±12.61;59.84±12.62 vs 33.76±15.43;3808.01±750.22 vs 1954.78±473.18)(P均<0.05),Hb升高(35±18 vs 57±21)(P=0.046),部分EPO抵抗患者恢复疗效。结论:袪铁治疗能增强贫血MDS患者对EPO反应,缓解EPO抵抗,降低EPO病理性升高,提升Hb水平,减少输血依赖。展开更多
文摘【目的】系统探究柴达木盆地耕地耕层土壤盐碱化水平及养分状况,优化柴达木盆地耕地耕层土壤评价因子,构建评价与诊断模型,为区域粮食安全和生态可持续发展提供科学依据。【方法】以柴达木盆地耕作层土壤为对象,基于470个土壤样品的11项土壤指标(全盐:TS、电导率:EC、全氮:TN、全磷:TP、速效氮:AN、速效磷:AP、pH、有机质:SOM、钠离子:Na^(+)、氯离子:Cl^(-)、硫酸根离子:SO_(4)^(2-)),通过主成分分析(PCA)与Norm值构建最小数据集(Minimum data set,MDS),结合多准则妥协解排序法(VIKOR法),系统评价土壤质量指数(Soil quality index,SQI)并诊断主要障碍因子。【结果】研究区土壤呈现显著盐碱化风险(TS均值2.449 g/kg,C_(V)=53.98%)和氮磷养分限制特征(TN均值为0.916 mg/kg,TP的C_(V)为118.38%);MDS筛选出TS、TN、TP、AP、Cl^(-)和SO_(4)^(2-)等6项核心指标,可替代全数据集(Total data set,TDS)精准评价土壤质量(R^(2)=0.904);VIKOR模型显示,格尔木和大柴旦地区土壤综合障碍度最高(群体效应值S>0.46),TP与SO_(4)^(2-)是主要限制因子,德令哈土壤质量最优(SQI=0.284)。【讨论】研究揭示了盐碱化与养分失衡对干旱区土壤质量的协同制约效应,为柴达木盆地耕地定向改良提供了科学依据。
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82170160 and 32000604)the Provincial Natural Science Foundation of Hunan(Grant Nos.2021JJ30163 and 2022JJ20021)+3 种基金the Changsha Municipal Natural Science Foundation(Grant No.kq2007053)the Global Research Award from American Society of Hematology to Y.Mpartially supported by the National Natural Science Foundation of China(Grant No.82470145)Mount Taishan Scholar Young Expert of Shandong Province(Grant No.tsqn202103167)to S.X。
文摘S100 proteins govern cellular proliferation,differentiation,apoptosis,calcium homeostasis,energy metabolism,and inflammation.This heterodimeric calcium-binding protein,consisting of the S100A8 and S100A9 subunits,modulates myeloid cell development.
文摘Infrastructure development within protected areas has become a critical concern in biodiversity conservation,particularly in ecologically sensitive regions like Bantimurung Bulusaraung National Park (TN Babul), Indonesia. Thisstudy aims to evaluate the ecological, social, economic, institutional, and infrastructural sustainability of the Maros–Watampone road corridor that crosses TN Babul. Using a qualitative descriptive design, the research employed theMultidimensional Scaling (MDS) method supported by leverage and Monte Carlo analysis. Data were gathered fromkey stakeholders through purposive sampling and analyzed based on sustainability attributes across five dimensions.The findings reveal that environmental, institutional, and infrastructure dimensions scored in the "less sustainable"category, indicating high ecological risk and governance gaps. In contrast, economic and social dimensions weremoderately sustainable, reflecting emerging opportunities for inclusive growth. Sensitive attributes influencingsustainability include habitat fragmentation, road design, governance coordination, and community participation. Thestudy concludes that balancing development with conservation requires integrated, multi-stakeholder strategies andtargeted interventions that address the most vulnerable sustainability dimensions.
文摘本研究旨在探讨骨髓增生异常综合征(MDS)患者袪铁治疗后红细胞生成素(EPO)、血红蛋白(Hb)、重组EPO(rEPO)的变化及EPO与血清铁蛋白(SF)的相关性。检测172例MDS患者及30例健康对照者SF、EPO浓度、血清铁(SI)、总铁结合力(TIBC)、C反应蛋白(CRP)、Hb;根据CRP值对SF进行调整。对34例低危组、SF>1 000 mg/L的患者给予袪铁胺治疗,比较治疗前后SF、EPO、SI、TIBC、Hb的变化。对58例低危组、EPO<1 000 U/L的患者给予rEPO治疗,比较铁过载组与非铁过载组袪铁治疗前后EPO抵抗的发生率。结果表明:非铁过载组EPO浓度高于正常对照组(997.44±473.48 vs 467.27±238.49)(P<0.05);铁过载组EPO浓度高于无铁过载组及正常对照组(3257.59±697.19 vs 997.44±473.48;3257.59±697.19 vs 467.27±238.49)(P均<0.05);铁过载组EPO抵抗发生率高于非铁过载组(18/35 vs 2/23)(P=0.001),铁过载组MDS患者EPO与SF呈显著正相关(r=0.310)(P=0.036)。袪铁治疗后SF、SI、TIBC及EPO浓度均较治疗前明显下降(3942.38±641.82 vs 2266.35±367.31;48.61±10.65 vs 28.52±12.61;59.84±12.62 vs 33.76±15.43;3808.01±750.22 vs 1954.78±473.18)(P均<0.05),Hb升高(35±18 vs 57±21)(P=0.046),部分EPO抵抗患者恢复疗效。结论:袪铁治疗能增强贫血MDS患者对EPO反应,缓解EPO抵抗,降低EPO病理性升高,提升Hb水平,减少输血依赖。
