The current Internet has evolved during the last decade to a global provider of diverse applications. However, the underlying structure of routing and addressing has not evolved in the same pace and is somewhat inflex...The current Internet has evolved during the last decade to a global provider of diverse applications. However, the underlying structure of routing and addressing has not evolved in the same pace and is somewhat inflexible. How to provide diverse routing services, support emerging communication paradigms based on limited and definite network resources has become an urgent challenge. This paper investigates the adaptive matching between routing and application through network function decomposition and composition, and proposes a polymorphic routing model to support diverse applications and emerging communication paradigms. The model splits complex routing functions into its constituents, and derives customized routing mechanisms supporting various applications by composing the routing constituents. The derivation process is modeled as a Markov Decision Process (MDP), and a polymorphic derivation algorithm is also proposed to derive customized routing instances for diverse applications. The model enables the network to self-adjust routing services dynamically to adapt to the different requirements of applications, supports coexistence of multiple routing modes and communication paradigms, and provides a feasible solution for the network compatibility and evolvement. We describe the key design and demonstrate the feasibility of polymorphic derivation by simulations. We also present case studies that demonstrate key functionalities the polymorphic routing model enables.展开更多
The study was to investigate the role of pinhole single photon emission computed tomography (SPECT), the human pulmonary adenocarcinoma bone-seeking metastasis cell line SPC-A-1BM was used.These cells form typical ost...The study was to investigate the role of pinhole single photon emission computed tomography (SPECT), the human pulmonary adenocarcinoma bone-seeking metastasis cell line SPC-A-1BM was used.These cells form typical osteolytic bone metastases when inoculated into the arterial circulation of NIH-Beige-Nude-XD (BNX) mice via the left ventricle.In order to evaluate the irradiation impact of ^(99m)Tc-MDP versus X-ray on cells growth,we used six groups of SPC-A-1BM cells in our imaging scheme and irradiated by various doses of ^(99m)Tc-MDP (37,74,111, 370,740 MBq) and X-ray(40 kV,2 mA,6 s) respectively.The cell's number of each group was well recorded in different exposure time(4,8,12,24,48,72,96 hours).After that,SPC-A-1BM cells(1×106) were inoculated into the mice via left ventricle.We compared the results obtained with those different doses of ^(99m)Tc-MDP using pinhole SPECT and conventional X-ray skeletal surveys.The data show that the cell-survival number of 111 MBq group has insignificant difference with that of X-ray and the dose is adequate to have an ideal image.Besides,it is important that the chromosome of the cells in the group of 111 MBq showed no irradiation-related damages in our test.These results implied that ^(99m)Tc-MDP pinhole SPECT may provide another way other than conventional X-ray skeletal surveys in detecting bone metastasis of pulmonary adenocarcinoma in BNX mice.展开更多
基金supported in part by the Cernet Network (NGII20160103)National Natural Science Foundation of China, National Natural Science Foundation of China(No.61672471)+3 种基金Fundamental Research Funds for the He’nan Province University (No.17KYYWF0202)He’nan Province University science and technology innovation team(No.18IRTSTHN012)Plan For Scientific Innovation Talent of Henan Province (No.184200510010)Zhengzhou University of Light Industry Doctoral Fund (2016BSJJ041) funding
文摘The current Internet has evolved during the last decade to a global provider of diverse applications. However, the underlying structure of routing and addressing has not evolved in the same pace and is somewhat inflexible. How to provide diverse routing services, support emerging communication paradigms based on limited and definite network resources has become an urgent challenge. This paper investigates the adaptive matching between routing and application through network function decomposition and composition, and proposes a polymorphic routing model to support diverse applications and emerging communication paradigms. The model splits complex routing functions into its constituents, and derives customized routing mechanisms supporting various applications by composing the routing constituents. The derivation process is modeled as a Markov Decision Process (MDP), and a polymorphic derivation algorithm is also proposed to derive customized routing instances for diverse applications. The model enables the network to self-adjust routing services dynamically to adapt to the different requirements of applications, supports coexistence of multiple routing modes and communication paradigms, and provides a feasible solution for the network compatibility and evolvement. We describe the key design and demonstrate the feasibility of polymorphic derivation by simulations. We also present case studies that demonstrate key functionalities the polymorphic routing model enables.
基金Supported by the Key Project for Basicl Research in Shanghai Science and Technology Commission,China (Grant No.071409011)
文摘The study was to investigate the role of pinhole single photon emission computed tomography (SPECT), the human pulmonary adenocarcinoma bone-seeking metastasis cell line SPC-A-1BM was used.These cells form typical osteolytic bone metastases when inoculated into the arterial circulation of NIH-Beige-Nude-XD (BNX) mice via the left ventricle.In order to evaluate the irradiation impact of ^(99m)Tc-MDP versus X-ray on cells growth,we used six groups of SPC-A-1BM cells in our imaging scheme and irradiated by various doses of ^(99m)Tc-MDP (37,74,111, 370,740 MBq) and X-ray(40 kV,2 mA,6 s) respectively.The cell's number of each group was well recorded in different exposure time(4,8,12,24,48,72,96 hours).After that,SPC-A-1BM cells(1×106) were inoculated into the mice via left ventricle.We compared the results obtained with those different doses of ^(99m)Tc-MDP using pinhole SPECT and conventional X-ray skeletal surveys.The data show that the cell-survival number of 111 MBq group has insignificant difference with that of X-ray and the dose is adequate to have an ideal image.Besides,it is important that the chromosome of the cells in the group of 111 MBq showed no irradiation-related damages in our test.These results implied that ^(99m)Tc-MDP pinhole SPECT may provide another way other than conventional X-ray skeletal surveys in detecting bone metastasis of pulmonary adenocarcinoma in BNX mice.
