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急性缺血性脑卒中患者血清IL-17A、25-(OH)D、MBL水平与神经功能损伤程度及短期预后的相关性
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作者 周桂娟 杨冬梅 +2 位作者 常艳双 李斌 王淞 《中国现代医学杂志》 2026年第1期41-47,共7页
目的 探讨急性缺血性脑卒中(AIS)患者血清白细胞介素-17A(IL-17A)、25-羟基维生素D[25-(OH)D]和甘露糖结合凝集素(MBL)水平与神经功能损伤程度及短期预后的相关性。方法 选取2022年1月-2023年12月唐山市人民医院神经内科接受治疗的200例... 目的 探讨急性缺血性脑卒中(AIS)患者血清白细胞介素-17A(IL-17A)、25-羟基维生素D[25-(OH)D]和甘露糖结合凝集素(MBL)水平与神经功能损伤程度及短期预后的相关性。方法 选取2022年1月-2023年12月唐山市人民医院神经内科接受治疗的200例AIS患者作为观察组,60例健康志愿者作为对照组。结合患者入院时美国国立卫生研究院卒中量表(NIHSS)评分,将其分为神经功能缺损轻度组70例、中度组80例和重度组50例;结合患者卒中后3个月改良Rankin量表(mRS)评分,将其分为预后良好组120例和预后不良组80例。在患者入院时采集空腹血清样本,并通过酶联免疫吸附试验测定血清IL-17A、25-(OH)D和MBL水平。采用单因素和多因素统计学方法评估这些生物标志物与神经功能损伤程度及短期预后之间的关系。结果 观察组IL-17A、MBL水平均高于对照组(P<0.05),观察组25-(OH)D水平低于对照组(P<0.05)。重度组血清25-(OH)D水平低于轻度组和中度组(P<0.05),血清IL-17A、MBL水平均高于轻度组和中度组(P<0.05)。轻度组与中度组患者,血清25-(OH)D、IL-17A和MBL水平比较,差异均无统计学意义(P >0.05)。预后不良组与预后良好组NIHSS评分、反复卒中史、近端血管狭窄/闭塞、糖尿病、高脂血症、高血压、血清IL-17A、25-(OH)D和MBL比较,差异均有统计学意义(P<0.05),预后不良组与预后良好组性别构成、年龄、BMI、后循环受累比较,差异均无统计学意义(P >0.05)。多因素一般Logistic回归分析,结果显示,NIHSS评分高[OR=4.776(95%CI:2.127,7.214)]、反复卒中史[OR=7.420(95%CI:1.852,12.478)]、近端血管狭窄/闭塞[OR=3.425(95%CI:2.165,5.418)]、糖尿病[OR=1.274(95%CI:1.023,1.586)]、高脂血症[OR=1.408(95%CI:1.062,1.876)]、高血压[OR=3.475(95%CI:1.763,5.847)]、25-(OH)D水平降低[OR=3.582(95%CI:1.425,6.987)]、MBL水平升高[OR=6.319(95%CI:2.010,8.764)]、IL-17A水平升高[OR=2.452(95%CI:1.785,4.361)]均为AIS患者短期预后不良的危险因素(P<0.05)。血清25-(OH)D水平、MBL、IL-17A对AIS患者预后评估的曲线下面积分别为0.733(95%CI:0.617,0.849)、0.828(95%CI:0.737,0.920)、0.782(95%CI:0.678,0.886),敏感性分别为62.52%(95%CI:0.518,0.714)、82.71%(95%CI:0.736,0.893)、63.48%(95%CI:0.530,0.728),特异性分别为75.22%(95%CI:0.663,0.827)、72.82%(95%CI:0.635,0.807)、82.83%(95%CI:0.747,0.889)。三者联合诊断的曲线下面积为0.884(95%CI:0.810,0.959),敏感性为78.84%(95%CI:0.692,0.862),特异性为73.81%(95%CI:0.650,0.813)。结论 血清IL-17A、25-(OH)D及MBL水平与急性缺血性脑卒中患者的神经功能缺损程度和短期预后密切相关,有望作为预测急性缺血性脑卒中病情和预后的潜在生物标志物,为临床干预和预后评估提供新的参考依据。 展开更多
关键词 急性缺血性脑卒中 白细胞介素-17A 25-羟基维生素D 甘露糖结合凝集素 神经功能缺损 短期预后
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A novel noise reduction technique for underwater acoustic signals based on complete ensemble empirical mode decomposition with adaptive noise,minimum mean square variance criterion and least mean square adaptive filter 被引量:9
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作者 Yu-xing Li Long Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2020年第3期543-554,共12页
Underwater acoustic signal processing is one of the research hotspots in underwater acoustics.Noise reduction of underwater acoustic signals is the key to underwater acoustic signal processing.Owing to the complexity ... Underwater acoustic signal processing is one of the research hotspots in underwater acoustics.Noise reduction of underwater acoustic signals is the key to underwater acoustic signal processing.Owing to the complexity of marine environment and the particularity of underwater acoustic channel,noise reduction of underwater acoustic signals has always been a difficult challenge in the field of underwater acoustic signal processing.In order to solve the dilemma,we proposed a novel noise reduction technique for underwater acoustic signals based on complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN),minimum mean square variance criterion(MMSVC) and least mean square adaptive filter(LMSAF).This noise reduction technique,named CEEMDAN-MMSVC-LMSAF,has three main advantages:(i) as an improved algorithm of empirical mode decomposition(EMD) and ensemble EMD(EEMD),CEEMDAN can better suppress mode mixing,and can avoid selecting the number of decomposition in variational mode decomposition(VMD);(ii) MMSVC can identify noisy intrinsic mode function(IMF),and can avoid selecting thresholds of different permutation entropies;(iii) for noise reduction of noisy IMFs,LMSAF overcomes the selection of deco mposition number and basis function for wavelet noise reduction.Firstly,CEEMDAN decomposes the original signal into IMFs,which can be divided into noisy IMFs and real IMFs.Then,MMSVC and LMSAF are used to detect identify noisy IMFs and remove noise components from noisy IMFs.Finally,both denoised noisy IMFs and real IMFs are reconstructed and the final denoised signal is obtained.Compared with other noise reduction techniques,the validity of CEEMDAN-MMSVC-LMSAF can be proved by the analysis of simulation signals and real underwater acoustic signals,which has the better noise reduction effect and has practical application value.CEEMDAN-MMSVC-LMSAF also provides a reliable basis for the detection,feature extraction,classification and recognition of underwater acoustic signals. 展开更多
关键词 Underwater acoustic signal Noise reduction Empirical mode decomposition(EMD) Ensemble EMD(EEMD) Complete EEMD with adaptive noise(CEEMDAN) minimum mean square variance criterion(MMSVC) Least mean square adaptive filter(LMSAF) Ship-radiated noise
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Arctic sea-ice extent: No record minimum in 2023 or recent years
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作者 Ola M.Johannessen Tor I.Olaussen 《Atmospheric and Oceanic Science Letters》 2025年第1期52-55,共4页
Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(mill.km^(2)). This was not a record low, which occurred in 2012, when the minimum ... Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(mill.km^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 mill.km^(2), 0.794 mill.km^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 mill.km^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability. 展开更多
关键词 Sea ice ARCTIC minimum ice CLIMATE
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The Minimum Spectral Radius of Graphs with Given Pendant Vertices
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作者 LI Hao LIU Chang LI Jianping 《数学进展》 北大核心 2025年第5期973-982,共10页
For a graph G,a vertex is said to be pendant if its neighborhood contains exactly one vertex.In this paper,we determine the extremal graphs among all n-vertex graphs with the minimum spectral radius andβpendant verti... For a graph G,a vertex is said to be pendant if its neighborhood contains exactly one vertex.In this paper,we determine the extremal graphs among all n-vertex graphs with the minimum spectral radius andβpendant vertices,whereβe{1,2,3,4,n-3,n-2,n-1}. 展开更多
关键词 minimum spectral radius pendant vertex extremal graph
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血清MBL、MASP1和MASP2检测在急性淋巴细胞白血病患者中的运用价值
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作者 刘媛 张宇 +2 位作者 宁燕 张娟莉 郭雅琼 《智慧健康》 2025年第21期37-39,共3页
目的 分析血清甘露糖结合凝集素(MBL)、甘露糖结合凝集素相关丝氨酸蛋白酶-1(MASP1)及甘露糖结合凝集素相关丝氨酸蛋白酶-2(MASP2)在急性淋巴细胞白血病临床治疗中的运用价值。方法 本研究所选研究对象为本院2019年1—12月收治的89例急... 目的 分析血清甘露糖结合凝集素(MBL)、甘露糖结合凝集素相关丝氨酸蛋白酶-1(MASP1)及甘露糖结合凝集素相关丝氨酸蛋白酶-2(MASP2)在急性淋巴细胞白血病临床治疗中的运用价值。方法 本研究所选研究对象为本院2019年1—12月收治的89例急性淋巴白血病患者,并将其设置为观察组,同时选择同期来本院接受健康体检的100例受试者为对照组,对比两组的MBL、MASP1及MASP2水平差异。结果 两组的血清MBL数值差异无统计学意义(P>0.05),观察组的血清MASP1数值低于对照组(P<0.05),且血清MASP2数值高于对照组(P<0.05);复发性白血病患者的血清MBL水平数值低于初发性白血病患者(P<0.05),血清MASP2水平数值高于初发性白血病患者(P<0.05),而二者之间的MASP1水平数值差异无统计学意义(P>0.05)。结论 经对比后发现,急性淋巴细胞白血病患者的血清MASP1降低明显而MASP2升高明显,对患者实施MBL、MASP1与MASP2水平检测有利于对病情发展情况进行分析,具有理想的应用价值。 展开更多
关键词 血清mbl 血清MASP1 血清MASP2 急性淋巴细胞白血病
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Discussion on Methods and Influence Factors for Minimum Propulsion Power Assessment
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作者 ZHAN Xing−yu MAO Xiao−fei LI Ting−qiu 《船舶力学》 北大核心 2025年第6期888-900,共13页
Currently,the International Maritime Organization(IMO)has approved and implemented the assessment requirement for Minimum Propulsion Power(MPP)of ships in adverse sea conditions.The assessment method and relevant infl... Currently,the International Maritime Organization(IMO)has approved and implemented the assessment requirement for Minimum Propulsion Power(MPP)of ships in adverse sea conditions.The assessment method and relevant influence factors will have a vital impact on ship's design and operation.On the other hand,MPP is essentially a criterion for manoeuvring safety at actual seas.However,the practical assessment methods adopted in IMO guidelines do not directly and accurately account for ship's coursekeeping ability in severe seas.A time-domain comprehensive method with supplementary course-keeping ability criteria has been proposed in the authors'preliminary research.Based on an updated mathematical model and criteria,this paper presents more detailed elaborations,results and discussions on the time-domain method,including the comparative analyses with a power line method and two steady-state equilibrium methods based on IMO guidelines and draft.Discussions on the influences of key factors,involving criterion conditions and calculation parameters,are also presented.The results indicate that different methods exhibit varying advantages and complexity in MPP assessment,thus constituting a multi-level assessment framework for MPP.In particular,the time-domain comprehensive assessment has a higher accuracy with more realistic description of manoeuvre behaviors,capable of offering a solution for the ships that cannot meet other assessments,or for the assessment requiring additional course-keeping ability.Furthermore,an expanded range of wave direction sets a stricter but potentially necessary requirement,while using the self-propulsion factors at low speeds can eliminate the unnecessary conservation of assessment result caused by those at design speed. 展开更多
关键词 manoeuvrability in actual seas minimum propulsion power comprehensive assessment manoeuvrability criterion course keeping
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M-Estimation-Based Minimum Error Entropy with Affine Projection Algorithm for Outlier Suppression in Spaceborne SAR System
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作者 WANG Weixin CHANG Xuelian OU Shifeng 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第5期615-628,共14页
Conventional adaptive filtering algorithms often exhibit performance degradation when processing multipath interference in raw echoes of spaceborne synthetic aperture radar(SAR)systems due to anomalous outliers,manife... Conventional adaptive filtering algorithms often exhibit performance degradation when processing multipath interference in raw echoes of spaceborne synthetic aperture radar(SAR)systems due to anomalous outliers,manifesting as insufficient convergence and low estimation accuracy.To address this issue,this study proposes a novel robust adaptive filtering algorithm,namely the M-estimation-based minimum error entropy with affine projection(APMMEE)algorithm.This algorithm inherits the joint multi-data-block update mechanism of the affine projection algorithm,enabling rapid adaptation to the dynamic characteristics of raw echoes and achieving fast convergence.Meanwhile,it incorporates the M-estimation-based minimum error entropy(MMEE)criterion,which weights error samples in raw echoes through M-estimation functions,effectively suppressing outlier interference during the algorithm update.Both the system identification simulations and practical multipath interference suppression experiments using raw echoes demonstrate that the proposed APMMEE algorithm exhibits superior filtering performance. 展开更多
关键词 radar signal adaptive filtering minimum error entropy M-ESTIMATION affine projection
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MINIMUM WAVE SPEED OF A REACTION-DIFFUSION DENGUE MODEL WITH ASYMPTOMATIC CARRIER TRANSMISSION
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作者 Qin XING Rui XU 《Acta Mathematica Scientia》 2025年第5期2088-2119,共32页
Dengue is a mosquito-borne disease that is rampant worldwide,with up to 70%of cases reported to be asymptomatic during epidemics.In this paper,a reaction-diffusion dengue model with asymptomatic carrier transmission i... Dengue is a mosquito-borne disease that is rampant worldwide,with up to 70%of cases reported to be asymptomatic during epidemics.In this paper,a reaction-diffusion dengue model with asymptomatic carrier transmission is investigated.We aim to study the existence,nonexistence and minimum wave speed of traveling wave solutions to the model.The results show that the existence and nonexistence of traveling wave solutions are fully determined by the threshold values,which are,the basic reproduction number R0 and critical wave speed c^(*)>0.Specifically,when R0>1 and the wave speed c≥c^(*),the existence of the traveling wave solution is obtained by using Schauder's fixed point theorem and Lyapunov functional.It is proven that the model has no nontrivial traveling wave solutions for R0≤1 or R0>1 and 0<c<c^(*)by employing comparison principle and limit theory.As a consequence,we conclude that the critical wave speed c^(*)is the minimum wave speed of the model.Finally,numerical simulations are carried out to illustrate the effects of several important parameters on the minimum wave speed. 展开更多
关键词 DENGUE asymptomatic carriers REACTION-DIFFUSION traveling wave solutions minimum wave speed
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A robust MP-ADRC-based strategy for uncertain minimum phase systems
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作者 Josiel A.Gouvêa Alessandro R.L.Zachi +1 位作者 Lúcio M.Fernandes Tiago Roux Oliveira 《Control Theory and Technology》 2025年第3期345-363,共19页
This paper proposes an extension of the Modified-Plant ADRC(MP-ADRC)strategy to broaden its application to minimum phase dynamical systems.The main features of the MP-ADRC method are the inclusion of a constant gain i... This paper proposes an extension of the Modified-Plant ADRC(MP-ADRC)strategy to broaden its application to minimum phase dynamical systems.The main features of the MP-ADRC method are the inclusion of a constant gain in series with the plant output error and a linear filter in parallel with the overall error system.These structural changes do not influence the input/output dynamics of the original plant,but are intentionally introduced to modify the dynamics to be estimated by the extended state observer(ESO)and,thus,promote an increase in the robustness of the method.Some advantages can also be attributed to the proposed methodology,such as(i)the design procedures of both the controller and the ESO only require knowledge of the sign(±)of the plant input channel coefficient(or control gain);(ii)the plant control input is generated directly by a single ESO state variable.Despite the advantages and the characteristics of MP-ADRC mentioned earlier,closed-loop stability cannot be guaranteed when it is applied to dynamical systems that have finite zeros.To overcome this difficulty,this work introduces an extension in the MP-ADRC method.It basically consists of rewriting the minimum phase plant dynamics according to its relative order,and then follows with the design of the ESO by conveniently increasing the number of ESO state variables.The simulation results are also presented to illustrate the application of the proposed method. 展开更多
关键词 Modified-plant ADRC Uncertain systems minimum phase plants Robust control Extended state observer
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Investigation on Processing Technology of Minimum Quantity Lubrication Nozzle and Its Influence on Atomization Effect
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作者 LI Donghui ZHANG Tao +1 位作者 ZHENG Tao QI Wei 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第2期261-274,共14页
Minimum quantity lubrication(MQL)is a technique that achieves effective lubrication and cooling of the cutting zone by using a minimal amount of cutting fluid.This results in a decrease in the cutting temperature,exte... Minimum quantity lubrication(MQL)is a technique that achieves effective lubrication and cooling of the cutting zone by using a minimal amount of cutting fluid.This results in a decrease in the cutting temperature,extending the cutting tool life and improving the surface quality of the workpiece.Optimizing the nozzle settings can enhance the cooling and lubrication performance of MQL,leading to increased processing efficiency and product quality.Nozzles with different shapes are fabricated,and different outlet diameters and wall thicknesses are set.The cutting process takes into account the impact of spindle speed and feed rate.An experimental study is conducted to investigate the atomization cone angle and particle size distribution of different nozzles.The circular nozzle is more conducive to the concentrated injection of an atomized liquid beam.The atomization cone angle is the largest when the nozzle outlet diameter is 1.2 mm.Enlarging the nozzle outlet diameter will increase the diameter of the atomized droplets.The atomization cone angle increases while the droplet diameter decreases with the increase of outlet wall thickness.Properly increasing the outlet wall thickness is beneficial to improving the atomization quality.The droplet diameter increases firstly and then decreases with the increase of spindle speed and feed rate.Increasing the MQL gas supply pressure and reducing the lubricating oil flow rate will improve the atomization quality of the nozzle.Studies on the influence of the MQL nozzle processing technology on the atomization effect can help to enhance the cooling and lubrication performance of the MQL technology,leading to improved processing efficiency and quality. 展开更多
关键词 minimum quantity lubrication(MQL) nozzle processing spray cone angle droplet diameter
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Dynamic modeling of minimum mass of pore-gas for triggering landslide in stable gentle soil slope
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作者 Xingyu Kang Zhongqi Quentin Yue 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期652-670,共19页
This paper presents a dynamic modeling method to test and examine the minimum mass of pressurized pore-gas for triggering landslides in stable gentle soil slopes.A stable gentle soil slope model is constructed with a ... This paper presents a dynamic modeling method to test and examine the minimum mass of pressurized pore-gas for triggering landslides in stable gentle soil slopes.A stable gentle soil slope model is constructed with a dry cement powder core,a saturated clay middle layer,and a dry sand upper layer.The test injects H_(2)O_(2)solution into the cement core to produce new pore-gas.The model test includes three identical H_(2)O_(2)injections.The small mass of generated oxygen gas(0.07%of slope soil mass and landslide body)from the first injection can build sufficient pore-gas pressure to cause soil upheaval and slide.Meanwhile,despite the first injection causing leak paths in the clay layer,the generated small mass of gas from the second and third injections can further trigger the landslide.A dynamic theoretical analysis of the slope failure is carried out and the required minimum pore-gas pressure for the landslide is calculated.The mass and pressure of generated gas in the model test are also estimated based on the calibration test for oxygen generation from H_(2)O_(2)solution in cement powder.The results indicate that the minimum mass of the generated gas for triggering the landslide is 2 ppm to 0.07%of the landslide body.Furthermore,the small mass of gas can provide sufficient pressure to cause soil upheaval and soil sliding in dynamic analysis. 展开更多
关键词 LANDSLIDE Gentle soil slope Physical model test minimum pore-gas mass Soil upheaval Dynamic modeling
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Minimum area of primitive broad-leaved Korean pine forest community based on biomass
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作者 Huibin Yang Qingxi Guo 《Journal of Forestry Research》 2025年第1期347-357,共11页
Based on the survey data of nine primitive broad-leaved Korean pine forest plots ranging from 1 to 10.4 ha in Heilongjiang Province,this study used the moving window method and GIS technology to analyze the variation ... Based on the survey data of nine primitive broad-leaved Korean pine forest plots ranging from 1 to 10.4 ha in Heilongjiang Province,this study used the moving window method and GIS technology to analyze the variation characteristics of the spatial distribution pattern of forest biomass in each plot.We explored the minimum area that can reflect the structural and functional characteristics of the primitive broad-leaved Korean pine forest,and used computer simulation random sampling method to verify the accuracy of the minimum area.The results showed that:(1)Through the analysis of the spatial distribution raster map of biomass deviation in the plots at various scales of 10−100 m,there is a minimum area(0.64 ha)for the critical range of biomass density variation in the primitive broad-leaved Korean pine forest.This minimum area based on biomass density can indirectly reflect the comprehensive characteristics of productivity level per unit area,structure,function,and environmental quality of the primitive broad-leaved Korean pine forest community.(2)Using computer simulation random sampling,it was found that only by sampling in a specific plot larger than or equal to the minimum area can equivalent or similar results be achieved as random sampling within the plot,indicating that the minimum area determined by the moving window method is accurate.(3)The minimum area determined in this paper is an excellent indicator reflecting the complexity of community structure,which can be used for comparing changes in community structure and function before and after external disturbances,and has a good evaluation effect.This minimum area can also be used as a basis for scientific and reasonable setting of plot size in the investigation and monitoring work of broad-leaved Korean pine forests in this region,thereby achieving the goals of improving work efficiency and saving work costs. 展开更多
关键词 minimum area of community Community structure BIOMASS Spatial heterogeneity Broad-leaved Korean pine forest
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Predicting the minimum horizontal principal stress using genetic expression programming and borehole breakout data
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作者 Rui Zhang Jian Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第7期4227-4240,共14页
As a critical component of the in situ stress state,determination of the minimum horizontal principal stress plays a significant role in both geotechnical and petroleum engineering.To this end,a gene expression progra... As a critical component of the in situ stress state,determination of the minimum horizontal principal stress plays a significant role in both geotechnical and petroleum engineering.To this end,a gene expression programming(GEP)algorithm-based model,in which the data of borehole breakout size,vertical principal stress,and rock strength characteristics are used as the inputs,is proposed to predict the minimum horizontal principal stress.Seventy-nine(79)samples with seven features are collected to construct the minimum horizontal principal stress dataset used for training models.Twenty-four(24)GEP model hyperparameter sets were configured to explore the key parameter combinations among the inputs and their potential relationships with the minimum horizontal principal stresses.Model performance was evaluated using root mean squared error(RMSE),mean absolute error(MAE),mean absolute percentage error(MAPE),and coefficient of determination(R^(2)).By comparing predictive performance and parameter composition,two models were selected from 24 GEP models that demonstrated excellent predictive performance and simpler parameter composition.Compared with prevalent models,the results indicate that the two selected GEP models have better performance on the test set(R^(2)=0.9568 and 0.9621).Additionally,the results conducted by SHapley Additive exPlanations(SHAP)sensitivity analysis and Local Interpretable Model-agnostic Explanations(LIME)demonstrate that the vertical principal stress is the most influential parameter in both GEP models.The two GEP models have simple parameter compositions as well as stable and excellent prediction performance,which is a viable method for predicting the minimum horizontal principal stresses. 展开更多
关键词 Gene expression programming(GEP) In situ stresses minimum horizontal principal stresses Borehole breakout
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Improving PM_(2.5)simulation in the stable boundary layer over eastern China through parameterized minimum eddy diffusivity
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作者 Wen Lu Bin Zhu +3 位作者 Shuqi Yan Shuangshuang Shi Jie Li Zifa Wang 《Journal of Environmental Sciences》 2025年第12期254-264,共11页
Weak turbulence often occurs during heavy pollution events in eastern China(EC).However,existing mesoscale meteorology models cannot accurately simulate turbulent diffusion under weakened turbulence,particularly under... Weak turbulence often occurs during heavy pollution events in eastern China(EC).However,existing mesoscale meteorology models cannot accurately simulate turbulent diffusion under weakened turbulence,particularly under the nocturnal stable boundary layer(SBL),often leading to significant turbulent diffusivity underestimation and surface aerosol overestimation.In this study,a new parameterization of minimum turbulent diffusivity coefficient(Kz_(min))was tested and applied to PM_(2.5)simulations in EC under SBL conditions in WRF-Chem.The original model overestimated the PM_(2.5)simulation and the simulation performance can be improved by adding Kz_(min).Sensitivity experiments revealed different ranges of available Kz_(min)values over the northern(0.8 to 1.2 m^(2)/s)and southern(1.0 to 1.5 m^(2)/s)regions of EC.The geographically related Kz_(min)was parameterized by sensible heat flux(H)and latent heat flux(LE),which also exhibited regional differences related to the climate and underlying surface.Furthermore,we assign physical significance to the parameterized formula Kz_(min)and found that our proposed Kz_(min)scheme can reasonably yield dynamic Kz_(min)values over EC.The revised Kz_(min)scheme(EXP_(NEW))enhanced the turbulent diffusion(north:0.93 m^(2)/s,south:1.10 m^(2)/s on average)in the SBL,simultaneously improving the PM_(2.5)simulations on the surface(north:65.78 to 0.67μg/m^(3);south 30.48 to 12.86μg/m^(3))and upper SBL.A process analysis showed that vertical mixing was the key process for improving PM_(2.5)simulations on the surface in EXP_(NEW).This study highlighted the importance of improving turbulent diffusion in current mesoscale models under SBL and has great significance for aerosol simulation. 展开更多
关键词 WRF-Chem Stable boundary layer minimum turbulent diffusivity PM_(2.5)simulation Process analysis
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Monthly Reduced Time-Period Scheduling of Thermal Generators and Energy Storage Considering Daily Minimum Chargeable Energy of Energy Storage
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作者 Xingxu Zhu Shiye Wang +3 位作者 Gangui Yan Junhui Li Hongda Dong Chenggang Li 《Energy Engineering》 2025年第4期1469-1489,共21页
To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy stora... To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy storage,incorporating daily minimum chargeable energy constraints,was developed.Firstly,considering the variations in the frequency of unit start-ups and shutdowns under different levels of net load fluctuation,a method was proposed to reduce decision time periods for unit start-up and shut-down operations.This approach,based on the characteristics of net load fluctuations,minimizes the decision variables of units,thereby simplifying the monthly schedulingmodel.Secondly,the relationship between energy storage charging and discharging power,net load,and the total maximum/minimum output of units was analyzed.Based on this,daily minimum chargeable energy constraints were established to ensure the energy storage system meets charging requirements under extreme net load scenarios.Finally,taking into account the operational costs of thermal generators and energy storage,load loss costs,and operational constraints,the reduced time-period monthly schedulingmodel was constructed.Case studies demonstrate that the proposedmethod effectively generates economical monthly operation plans for thermal generators and energy storage,significantly reduces model solution time,and satisfies the charging requirements of energy storage under extreme net load conditions. 展开更多
关键词 Monthly scheduling thermal generators energy storage daily minimum chargeable energy decision time-period reduction unit start-up and shut-down unit commitment renewable energy
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金水宝胶囊对支气管哮喘患者血清MBL、IgE及FeNO的影响
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作者 方秀珍 唐金龙 管晓韧 《河南中医》 2025年第8期1274-1279,共6页
目的:观察金水宝胶囊对支气管哮喘(bronchial asthma,BA)患者血清甘露糖结合凝集素(mannose-binding lectin,MBL)、免疫球蛋白E(immunoglobulin E,IgE)及呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)的影响。方法:选取2023年... 目的:观察金水宝胶囊对支气管哮喘(bronchial asthma,BA)患者血清甘露糖结合凝集素(mannose-binding lectin,MBL)、免疫球蛋白E(immunoglobulin E,IgE)及呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)的影响。方法:选取2023年1月至2024年11月上饶市中心医院收治的BA患者92例,按随机数字表法分为对照组和观察组,每组各46例。对照组给予空气压泵法雾化吸入布地奈德气雾剂治疗,观察组在对照组治疗的基础上加用金水宝胶囊治疗。观察两组患者治疗前后中医证候积分、哮喘控制测试(asthma control test,ACT)调查表评分、第1秒用力呼气容积(forced expiratory volume at second 1,FEV1)、用力肺活量(forced vital capacity,FVC)、FEV1/FVC、MBL、IgE、FeNO变化情况及临床疗效。结果:观察组有效率为95.65%,对照组有效率为82.61%,观察组有效率高于对照组,差异有统计学意义(P<0.05);两组治疗后中医证候积分、MBL、IgE及FeNO水平均低于治疗前,且治疗后观察组低于对照组,差异有统计学意义(P<0.05);两组治疗后ACT评分、FEV1、FVC、FEV1/FVC均高于治疗前,且治疗后观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。结论:金水宝胶囊可能通过调节体内MBL、IgE和FeNO水平来改善BA患者症状和肺功能,缓解哮喘程度,从而提高治疗效果,且安全性良好。 展开更多
关键词 支气管哮喘 金水宝胶囊 甘露糖结合凝集素 免疫球蛋白E 呼出气一氧化氮
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MBL EXON Ⅰ 54位基因突变检测方法的建立及初步应用 被引量:10
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作者 贾天军 李萍 +3 位作者 张庶民 张印则 张寅龙 雷殿良 《中国生物制品学杂志》 CAS CSCD 2003年第6期327-329,共3页
目的 建立MBL基因点突变的检测方法,探讨健康汉族人MBL 54位密码子基因突变的情况。方法 根据MBL基因序列设计引物,建立MBL的PCR-RFLP测定点突变的方法。结果 扩增产物测序结果与预期扩增的目的基因序列一致,检测灵敏度为80ng/ml,用其检... 目的 建立MBL基因点突变的检测方法,探讨健康汉族人MBL 54位密码子基因突变的情况。方法 根据MBL基因序列设计引物,建立MBL的PCR-RFLP测定点突变的方法。结果 扩增产物测序结果与预期扩增的目的基因序列一致,检测灵敏度为80ng/ml,用其检测58例健康献血员54位密码子的点突变情况,野生型为29例,占50%;突变杂合型为27,占46.55%;突变纯合子型为2例,占3.45%。基因频率A为0.732 8;B为0.267 2。结论 该方法是特异、灵敏的检测方法。 展开更多
关键词 基因突变 检测方法 汉族 基因频率 mbl
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MBL基因多态性与新疆汉族人群结核病易感性的研究 被引量:12
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作者 李宇 吴芳 +1 位作者 章乐 张万江 《中国人兽共患病学报》 CAS CSCD 北大核心 2011年第9期769-773,共5页
目的探讨MBL基因多态性与新疆汉族人群结核病高发的关系。方法采用病例-对照研究方法和引物序列特异性PCR扩增(PCR-SSP)技术对新疆地区的231例肺结核患者和226例健康志愿者的MBL基因H/L、P/Q和A/B 3个多态性位点进行基因及单倍体分型,... 目的探讨MBL基因多态性与新疆汉族人群结核病高发的关系。方法采用病例-对照研究方法和引物序列特异性PCR扩增(PCR-SSP)技术对新疆地区的231例肺结核患者和226例健康志愿者的MBL基因H/L、P/Q和A/B 3个多态性位点进行基因及单倍体分型,比较各等位基因及单倍体型的频率(f),并计算优势比(OR)。结果对照组MBL基因AA基因型频率显著高于肺结核病例组(χ2=4.576,OR=0.613,P<0.05);而肺结核病例组MBL基因AB基因型频率显著高于健康对照组(χ2=4.821,OR=1.673,P<0.05)。结论 MBL基因AA基因型与新疆汉族人群结核病负相关,其可能为当地汉族人群结核病的抵抗基因;而MBL基因AB基因型与新疆汉族人群结核病相关,其可能是当地汉族人群结核病的易感基因。 展开更多
关键词 mbl基因 结核病 基因频率 聚合酶链反应
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人CGT52TGTMBL突变体在CHO细胞中的表达及其产物分析 被引量:4
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作者 刘凤玲 左大明 +1 位作者 白志军 陈政良 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2005年第4期399-402,共4页
目的: 初步探索MBL基因CGT52TGT点突变引起调理吞噬缺损的机制。方法: 采用PCR技术, 从质粒pMBLm52中获取含CGT52TGT点突变的MBL基因, 将其插入真核表达载体pcDNA4 /HisMaxC中构建重组表达载体。经测序验证后, 电转染入CHO细胞。以800mg... 目的: 初步探索MBL基因CGT52TGT点突变引起调理吞噬缺损的机制。方法: 采用PCR技术, 从质粒pMBLm52中获取含CGT52TGT点突变的MBL基因, 将其插入真核表达载体pcDNA4 /HisMaxC中构建重组表达载体。经测序验证后, 电转染入CHO细胞。以800mg/LZeocin筛选转染后的CHO细胞30d; 随后的30d中, 维持Zeocin的浓度在200mg/L, 以获取稳定转染的细胞。以RT PCR分析其mRNA的表达情况。表达产物经Ni NTAagarose纯化后, 以非还原SDS PAGE和Westernblot对表达产物进行初步鉴定。结果:以PCR扩增的MBLm52基因片段长约750bp, 将其插入表达载体构建重组真核表达载体pcDNA4 /HisMaxC MBLm52, 测序验证序列正确后将其电转染入CHO细胞。从细胞培养上清中获得的纯化的表达产物, 主要为相对分子质量(Mr)约60 000的分子, 寡聚化程度明显低于重组人野生型MBL和从人血浆中分离的MBL。结论: MBL基因CGT52TGT点突变可能并不影响其表达产物向胞外分泌的过程, 但突变后产生的Cys可能形成新的二硫键, 影响MBL结构单位和/或寡聚分子的形成, 推测该突变MBL蛋白不能发挥正常的功能。 展开更多
关键词 甘露聚糖结合凝集素 CGT52TGT突变体 表达 52Cys突变mbl蛋白
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类风湿关节炎患者血清MBL、MASP-2、HsCRP与C_3水平的相关性 被引量:9
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作者 陈思 马宝良 +2 位作者 曹明强 于红娟 马兴铭 《南方医科大学学报》 CAS CSCD 北大核心 2016年第10期1340-1344,1356,共6页
目的研究类风湿关节炎(RA)患者血清中甘露糖结合凝集素(MBL)/MBL相关的丝氨酸蛋白酶-2(MASP-2)、Hs CRP和C3水平的相关性。方法收集50例RA患者(活动期和非活动期各25例)和40例健康对照者空腹静脉血,用酶联免疫吸附试验和免疫比浊试验分... 目的研究类风湿关节炎(RA)患者血清中甘露糖结合凝集素(MBL)/MBL相关的丝氨酸蛋白酶-2(MASP-2)、Hs CRP和C3水平的相关性。方法收集50例RA患者(活动期和非活动期各25例)和40例健康对照者空腹静脉血,用酶联免疫吸附试验和免疫比浊试验分别检测血清MBL、MASP-2、Hs CRP和C3的水平。结果 RA组活动期和非活动期患者血清中MBL水平均显著低于健康对照组(10.05±2.14 ng/m L vs 26.97±11.78 ng/m L;14.79±3.93 ng/m L vs 26.97±11.78 ng/m L,P<0.05);RA组活动期和非活动期患者血清中MASP-2水平均显著低于健康对照组(75.90±9.21 ng/m L vs 251.78±34.50 ng/m L;107.8±14.90 ng/m L vs251.78±34.50 ng/m L)(P<0.05);RA组活动期和非活动期患者血清中Hs CRP水平显著高于健康对照组(40.53±34.81 mg/L vs1.42±1.70 mg/L;2.97±2.51 mg/L vs 1.42±1.70 mg/L,P<0.05),C3水平3组无差异;双变量Pearson相关性分析,RA患者组MBL与MASP-2含量均呈显著正相关(r=0.550,P=0.001)、与Hs CRP含量呈低度负性相关(r=-0.323,P=0.022);与C3含量无相关(r=0.022,P=0.882)。RA组MASP-2与Hs CRP含量呈低度负性相关(r=-0.453,P=0.001);与C3含量无相关(r=0.049,P=0.738)。经ROC曲线分析,Hs CRP曲线下面积最大(0.844,P=0.001),MASP-2和MBL曲线下面积较小(0.025,P=0.001;0.266,P=0.001),Hs CRP(84%)对RA诊断的敏感性高于MBL(10%)、MASP-2(40%)。结论 MBL与MASP-2水平与Hs CRP呈负相关关系,RA患者关节的炎症损伤程度越重,则血清MBL与MASP-2水平越低,提示MBL与MASP-2参与RA病理损伤过程,但二者的敏感性均较低,不能做为RA诊断及疾病活动程度评价的独立指标。 展开更多
关键词 类风湿关节炎 甘露糖结合凝集素 mbl相关的丝氨酸蛋白酶-2 补体系统 超敏C反应蛋白 补体C3
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