Clinical studies on trastuzumab deruxtecan for human epidermal growth factor receptor 2-positive brain metastases Several previous clinical studies have suggested significant intracranial activity of trastuzumab derux...Clinical studies on trastuzumab deruxtecan for human epidermal growth factor receptor 2-positive brain metastases Several previous clinical studies have suggested significant intracranial activity of trastuzumab deruxtecan(T-DXd)in brain metastases(BMs)of human epidermal growth factor receptor 2(HER2)-positive(HER2-positive)metastatic breast cancer(mBC).Pooled analyses from DESTINY-Breast(DB)01,02,and 03 showed that T-DXd outperformed controls in terms of intracranial overall response rate(ORR)and median progression-free survival(mPFS).展开更多
总结了已有的基于市场机制控制(Market Based Control,MBC)策略中的财富分配方式。财富分配方式不同直接会影响MBC算法的控制效果,根据结构反应特点,提出了两种财富分配方式:以结构剪力为优化目标的线性财富分配和以结构位移为优化目标...总结了已有的基于市场机制控制(Market Based Control,MBC)策略中的财富分配方式。财富分配方式不同直接会影响MBC算法的控制效果,根据结构反应特点,提出了两种财富分配方式:以结构剪力为优化目标的线性财富分配和以结构位移为优化目标的模态财富分配。对一安装有控制装置的20层结构进行了数值分析,比较了这两种财富分配下的MBC控制算法,并与经典LQR算法的控制效果进行了对比。研究表明,提出的两种财富分配方式能有效的控制结构响应,并验证了其合理性。展开更多
基金supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023-JKCS-23)the Special Research Fund for Central Universities,Peking Union Medical College(No.2022-I2M-C&T-A-014).
文摘Clinical studies on trastuzumab deruxtecan for human epidermal growth factor receptor 2-positive brain metastases Several previous clinical studies have suggested significant intracranial activity of trastuzumab deruxtecan(T-DXd)in brain metastases(BMs)of human epidermal growth factor receptor 2(HER2)-positive(HER2-positive)metastatic breast cancer(mBC).Pooled analyses from DESTINY-Breast(DB)01,02,and 03 showed that T-DXd outperformed controls in terms of intracranial overall response rate(ORR)and median progression-free survival(mPFS).
文摘总结了已有的基于市场机制控制(Market Based Control,MBC)策略中的财富分配方式。财富分配方式不同直接会影响MBC算法的控制效果,根据结构反应特点,提出了两种财富分配方式:以结构剪力为优化目标的线性财富分配和以结构位移为优化目标的模态财富分配。对一安装有控制装置的20层结构进行了数值分析,比较了这两种财富分配下的MBC控制算法,并与经典LQR算法的控制效果进行了对比。研究表明,提出的两种财富分配方式能有效的控制结构响应,并验证了其合理性。
