G protein coupled receptor kinase 2 (GRK2) is a kinase that regulates cardiac signaling activity. Inhibiting GRK2 is a promising mechanism for the treatment of heart failure (HF). Further development and optimization ...G protein coupled receptor kinase 2 (GRK2) is a kinase that regulates cardiac signaling activity. Inhibiting GRK2 is a promising mechanism for the treatment of heart failure (HF). Further development and optimization of inhibitors targeting GRK2 are highly meaningful. Therefore, in order to design GRK2 inhibitors with better performance, the most active molecule was selected as a reference compound from a data set containing 4-pyridylhydrazone derivatives and triazole derivatives, and its scaffold was extracted as the initial scaffold. Then, a powerful optimization-based framework for de novo drug design, guided by binding affinity, was used to generate a virtual molecular library targeting GRK2. The binding affinity of each virtual compound in this dataset was predicted by our developed deep learning model, and the designed potential compound with high binding affinity was selected for molecular docking and molecular dynamics simulation. It was found that the designed potential molecule binds to the ATP site of GRK2, which consists of key amino acids including Arg199, Gly200, Phe202, Val205, Lys220, Met274 and Asp335. The scaffold of the molecule is stabilized mainly by H-bonding and hydrophobic contacts. Concurrently, the reference compound in the dataset was also simulated by docking. It was found that this molecule also binds to the ATP site of GRK2. In addition, its scaffold is stabilized mainly by H-bonding and π-cation stacking interactions with Lys220, as well as hydrophobic contacts. The above results show that the designed potential molecule has similar binding modes to the reference compound, supporting the effectiveness of our framework for activity-focused molecular design. Finally, we summarized the interaction characteristics of general GRK2 inhibitors and gained insight into their molecule-target binding mechanisms, thereby facilitating the expansion of lead to hit compound.展开更多
Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Appli...Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.展开更多
Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Appli...Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.展开更多
Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Appli...Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.展开更多
Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Appli...Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad felds of sciences and technology,scientists and engineers interested in mathematics.展开更多
Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Appli...Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.展开更多
To ameliorate the difficulties of on-site dynamic disaster control in the end-mining stage of traditional mining engineering,this paper introduces the mathematical research and engineering application of the end-minin...To ameliorate the difficulties of on-site dynamic disaster control in the end-mining stage of traditional mining engineering,this paper introduces the mathematical research and engineering application of the end-mining technology system with non-pillar in mines(ETSNM)in recent years.The petal warning criterion for the stability of the surrounding rock of the roadway at the end-mining stage was obtained by studying the inverse problem of the petal theorem.A conformal mathematical model of the end-mining stage was established using the conformal mapping method,and the limit theorem of the peak point of mine pressure(LTPPMP)in the end-mining stage was demonstrated.Based on the cross-fusion of the above basic mathematical theory and the LTPPMP,a new ETSNM model was proposed,which includes no coal pillar,no dedicated retracement roadways,and fast retracement equipment(NNF).The mathematical principles of engineering technology for height control,speed limit,and roof cutting in the end-mining stage with non-pillar were revealed.The scientific and application values of the ETSNM were confirmed through engineering applications.Based on this,a new non-pillar control technology for dynamic disasters in the end-mining stage was proposed.The above research will play an active role in promoting the engineering application of ETSNM driven by mathematical theory.展开更多
The increasing demand due to development and advancement in every field of life has caused the depletion of fossil fuels.This depleting fossil fuel reserve throughout the world has enforced to get energy from alternat...The increasing demand due to development and advancement in every field of life has caused the depletion of fossil fuels.This depleting fossil fuel reserve throughout the world has enforced to get energy from alternative/renewable sources.One of the economicalways to get energy is through the utilization of solar ponds.In this study,a mathematical model of a salt gradient solar pond under the Islamabad climatic conditions has been analyzed for the first time.The model uses a one-dimensional finite difference explicit method for optimization of different zone thicknesses.The model depicts that NCZ(Non-Convective Zone)thickness has a significant effect on LCZ(Lower Convective Zone)temperature and should be kept less than 1.7mfor the optimal temperature.It is also observed that for long-termoperation of a solar pond,heat should be extracted by keeping the mass flowrate of 17.3 kg/m^(2)/day.Themodel also suggests that when the bottom reflectivity is about 0.3,then only 24%of the radiation is absorbed in the pond.展开更多
Improving the specific,technical,economic,and environmental characteristics of piston engines(ICE)operating on alternative gaseous fuels is a pressing task for the energy and mechanical engineering industries.The aim ...Improving the specific,technical,economic,and environmental characteristics of piston engines(ICE)operating on alternative gaseous fuels is a pressing task for the energy and mechanical engineering industries.The aim of the study was to optimize the parameters of the ICE working cycle after replacing the base fuel(propane-butane blend)with syngas from wood sawdust to improve its technical and economic performance based on mathematical modeling.The modeling results were verified through experimental studies(differences for key parameters did not exceed 4.0%).The object of the study was an electric generator based on a single-cylinder spark ignition engine with a power of 1 kW.The article describes the main approaches to creating a mathematical model of the engine working cycle,a test bench for modeling verification,physicochemical properties of the base fuel(propane-butane blend),and laboratory syngas.It was shown that replacing the fuel from a propane-butane blend to laboratory syngas caused a decrease in engine efficiency to 33%(the efficiency of the base ICE was 0.179 vs.the efficiency of 0.119 for the converted ICE for the 0.59 kW power mode).Engine efficiency was chosen as the key criterion for optimizing the working cycle.As a result of optimization,the efficiency of the converted syngas engine was 6.1%higher than that of the base engine running on the propane-butane blend,and the power drop did not exceed 8.0%.Thus,careful fine-tuning of the working cycle parameters allows increasing the technical and economic characteristics of the syngas engine to the level of ICEs running on traditional types of fuel.展开更多
Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.Thi...Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria.展开更多
Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Appli...Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.展开更多
With the development of educational digitalization,how to effectively apply digital animation technology to traditional classroom teaching has become an urgent problem to be solved.This study explores the application ...With the development of educational digitalization,how to effectively apply digital animation technology to traditional classroom teaching has become an urgent problem to be solved.This study explores the application of Manim in the course of Mathematical Methods for Physics.Taking the visualization of Fourier series,complex numbers,and other content as examples,it improves students’understanding of complex and abstract mathematical physics concepts through dynamic and visual teaching methods.The teaching effect shows that Manim helps to enhance students’learning experience,improve teaching efficiency and effectiveness,and has a positive impact on students’active learning ability.The research in this paper can provide references and inspiration for the educational digitalization of higher education.展开更多
The work considers the problem of gas hydrate dissociation in a porous medium using the two-term Forchheimer law,corresponding to high flow rates of reservoir fluids.Such rates can arise during the decomposition of ga...The work considers the problem of gas hydrate dissociation in a porous medium using the two-term Forchheimer law,corresponding to high flow rates of reservoir fluids.Such rates can arise during the decomposition of gas hydrates,since a large amount of gas is released.Intensive emissions of gases from the earth’s interior are observed on the ocean floor.They are also associated with a large number of subvertical geological structures under the ocean floor,coming to the surface in the formof local ring funnels(pockmarks).Many similar objects have also been found on land.Particular interest in this problemis caused by climate threats associated with the release of greenhouse gases.The movement of gas released fromthe hydrate to the breakthrough channel is similar to the gas inflow to the well(without hydrate),which is usually described by a two-term filtration law.In this work,a mathematical model of gas hydrate dissociation with a nonlinear Forchheimer-type law ofmotion is developed.The systemis split in two blocks by physical processes,taking into account the quadratic correction to the velocity in the filtration law.The first block is responsible for the convective transfer of saturation parameters in the model,water,gas and hydrate saturations are taken into account.The second block corresponds to the equation of dissipative piezoconductivity with a different number of thermodynamic degrees of freedom,taking into account heat and mass transfer in a porous medium.The performed splitting allows using explicit-implicit difference schemes when solving problems and avoiding strong refinement of the step in time and space.For numerical modeling,the support operator method is used,which makes it possible to discretize partial differential equations on irregular grids,which allows taking into account the complex geometry and lithology of the reservoir.A difference scheme based on the support operator method is developed,which,due to the mutually consistent approximation of vector analysis operations(divergence and gradient),allows to take into account the various flux laws between adjacent grid cells,including quadratic corrections to the velocity.Based on the developed numerical algorithms and their program implementations,calculations of gas hydrate dissociation are performed both in a reservoir of simple geometric structure and in a heterogeneous reservoir of complex configuration.The results obtained correspond to the physics of the processes under consideration.展开更多
Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over.With the disease targeted for elimination by 2030,assessing the impact of control strategies i...Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over.With the disease targeted for elimination by 2030,assessing the impact of control strategies in communities where there are human-cattle-wildlife interactions is therefore essential.A compartmental framework incorporating tsetse flies,humans,cattle,wildlife and various disease control strategies is developed and analyzed.The reproduction is derived and its sensitivity to different model parameters is investigated.Meanwhile,the optimal control theory is used to identify a combination of control strategies capable of minimizing the infected human and cattle population over time at minimal costs of implementation.The results indicates that tsetse fly mortality rate is strongly and negatively correlated to the reproduction number.It is also established that tsetse fly feeding rate in strongly and positively correlated to the reproduction number.Simulation results indicates that time dependent control strategies can significantly reduce the infections.Overall,the study shows that screening and treatment of humans may not lead to disease elimination.Combining this strategy with other strategies such as screening and treatment of cattle and vector control strategies will result in maximum reduction of tsetse fly population and disease elimination.展开更多
1 Summary Mathematical modeling has become a cornerstone in understanding the complex dynamics of infectious diseases and chronic health conditions.With the advent of more refined computational techniques,researchers ...1 Summary Mathematical modeling has become a cornerstone in understanding the complex dynamics of infectious diseases and chronic health conditions.With the advent of more refined computational techniques,researchers are now able to incorporate intricate features such as delays,stochastic effects,fractional dynamics,variable-order systems,and uncertainty into epidemic models.These advancements not only improve predictive accuracy but also enable deeper insights into disease transmission,control,and policy-making.Tashfeen et al.展开更多
This paper focuses on the ideological and political construction of the course“Probability Theory and Mathematical Statistics.”Aiming at the current situation in teaching where emphasis is placed on knowledge impart...This paper focuses on the ideological and political construction of the course“Probability Theory and Mathematical Statistics.”Aiming at the current situation in teaching where emphasis is placed on knowledge imparting while value guidance is neglected,and combined with the requirements of ideological and political education policies in the new era,this paper explores the integration path between professional courses and ideological and political education.Through literature analysis,case comparison,and empirical research,the study proposes a systematic implementation plan covering the design of teaching objectives,the reconstruction of teaching content,and the optimization of the evaluation system.The purpose is to cultivate students’sense of social responsibility and innovative awareness by excavating the ideological and political elements in mathematics.The research results provide practical reference for colleges and universities to deepen the reform of ideological and political education in courses,and promote the implementation of the fundamental task of fostering virtue through education in STEM education.展开更多
Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when deal...Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when dealing with color fundus images due to issues like non-uniformillumination,low contrast,and variations in vessel appearance,especially in the presence of different pathologies.Furthermore,the speed of the retinal vessel segmentation system is of utmost importance.With the surge of now available big data,the speed of the algorithm becomes increasingly important,carrying almost equivalent weightage to the accuracy of the algorithm.To address these challenges,we present a novel approach for retinal vessel segmentation,leveraging efficient and robust techniques based on multiscale line detection and mathematical morphology.Our algorithm’s performance is evaluated on two publicly available datasets,namely the Digital Retinal Images for Vessel Extraction dataset(DRIVE)and the Structure Analysis of Retina(STARE)dataset.The experimental results demonstrate the effectiveness of our method,withmean accuracy values of 0.9467 forDRIVE and 0.9535 for STARE datasets,aswell as sensitivity values of 0.6952 forDRIVE and 0.6809 for STARE datasets.Notably,our algorithmexhibits competitive performance with state-of-the-art methods.Importantly,it operates at an average speed of 3.73 s per image for DRIVE and 3.75 s for STARE datasets.It is worth noting that these results were achieved using Matlab scripts containing multiple loops.This suggests that the processing time can be further reduced by replacing loops with vectorization.Thus the proposed algorithm can be deployed in real time applications.In summary,our proposed system strikes a fine balance between swift computation and accuracy that is on par with the best available methods in the field.展开更多
Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory ca...Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.展开更多
The global populationhas beenandwill continue to be severely impacted by theCOVID-19 epidemic.The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal...The global populationhas beenandwill continue to be severely impacted by theCOVID-19 epidemic.The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal conditions such as cancer,heart disease,and diabetes.Here,using ordinary differential equations(ODEs),two mathematical models are developed to explain the association between COVID-19 and cancer and between COVID-19 and diabetes and heart disease.After that,we highlight the stability assessments that can be applied to these models.Sensitivity analysis is used to examine how changes in certain factors impact different aspects of disease.The sensitivity analysis showed that many people are still nervous about seeing a doctor due to COVID-19,which could result in a dramatic increase in the diagnosis of various ailments in the years to come.The correlation between diabetes and cardiovascular illness is also illustrated graphically.The effects of smoking and obesity are also found to be significant in disease compartments.Model fitting is also provided for interpreting the relationship between real data and the results of thiswork.Diabetic people,in particular,need tomonitor their health conditions closely and practice heart health maintenance.People with heart diseases should undergo regular checks so that they can protect themselves from diabetes and take some precautions including suitable diets.The main purpose of this study is to emphasize the importance of regular checks,to warn people about the effects of COVID-19(including avoiding healthcare centers and doctors because of the spread of infectious diseases)and to indicate the importance of family history of cancer,heart diseases and diabetes.The provision of the recommendations requires an increase in public consciousness.展开更多
Heat integration is important for energy-saving in the process industry.It is linked to the persistently challenging task of optimal design of heat exchanger networks(HEN).Due to the inherent highly nonconvex nonlinea...Heat integration is important for energy-saving in the process industry.It is linked to the persistently challenging task of optimal design of heat exchanger networks(HEN).Due to the inherent highly nonconvex nonlinear and combinatorial nature of the HEN problem,it is not easy to find solutions of high quality for large-scale problems.The reinforcement learning(RL)method,which learns strategies through ongoing exploration and exploitation,reveals advantages in such area.However,due to the complexity of the HEN design problem,the RL method for HEN should be dedicated and designed.A hybrid strategy combining RL with mathematical programming is proposed to take better advantage of both methods.An insightful state representation of the HEN structure as well as a customized reward function is introduced.A Q-learning algorithm is applied to update the HEN structure using theε-greedy strategy.Better results are obtained from three literature cases of different scales.展开更多
基金supported by the National Natural Science Foundation of China Excellent Young Scientist Fund(22422801)the National Natural Science Foundation of China General Project(22278053)+1 种基金the National Natural Science Foundation of China General Project(22078041)Dalian High-level Talents Innovation Support Program(2023RQ059).
文摘G protein coupled receptor kinase 2 (GRK2) is a kinase that regulates cardiac signaling activity. Inhibiting GRK2 is a promising mechanism for the treatment of heart failure (HF). Further development and optimization of inhibitors targeting GRK2 are highly meaningful. Therefore, in order to design GRK2 inhibitors with better performance, the most active molecule was selected as a reference compound from a data set containing 4-pyridylhydrazone derivatives and triazole derivatives, and its scaffold was extracted as the initial scaffold. Then, a powerful optimization-based framework for de novo drug design, guided by binding affinity, was used to generate a virtual molecular library targeting GRK2. The binding affinity of each virtual compound in this dataset was predicted by our developed deep learning model, and the designed potential compound with high binding affinity was selected for molecular docking and molecular dynamics simulation. It was found that the designed potential molecule binds to the ATP site of GRK2, which consists of key amino acids including Arg199, Gly200, Phe202, Val205, Lys220, Met274 and Asp335. The scaffold of the molecule is stabilized mainly by H-bonding and hydrophobic contacts. Concurrently, the reference compound in the dataset was also simulated by docking. It was found that this molecule also binds to the ATP site of GRK2. In addition, its scaffold is stabilized mainly by H-bonding and π-cation stacking interactions with Lys220, as well as hydrophobic contacts. The above results show that the designed potential molecule has similar binding modes to the reference compound, supporting the effectiveness of our framework for activity-focused molecular design. Finally, we summarized the interaction characteristics of general GRK2 inhibitors and gained insight into their molecule-target binding mechanisms, thereby facilitating the expansion of lead to hit compound.
文摘Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.
文摘Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.
文摘Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.
文摘Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad felds of sciences and technology,scientists and engineers interested in mathematics.
文摘Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.
基金supported by the National Natural Science Foundation of China(No.12071047,51774289,52074291).
文摘To ameliorate the difficulties of on-site dynamic disaster control in the end-mining stage of traditional mining engineering,this paper introduces the mathematical research and engineering application of the end-mining technology system with non-pillar in mines(ETSNM)in recent years.The petal warning criterion for the stability of the surrounding rock of the roadway at the end-mining stage was obtained by studying the inverse problem of the petal theorem.A conformal mathematical model of the end-mining stage was established using the conformal mapping method,and the limit theorem of the peak point of mine pressure(LTPPMP)in the end-mining stage was demonstrated.Based on the cross-fusion of the above basic mathematical theory and the LTPPMP,a new ETSNM model was proposed,which includes no coal pillar,no dedicated retracement roadways,and fast retracement equipment(NNF).The mathematical principles of engineering technology for height control,speed limit,and roof cutting in the end-mining stage with non-pillar were revealed.The scientific and application values of the ETSNM were confirmed through engineering applications.Based on this,a new non-pillar control technology for dynamic disasters in the end-mining stage was proposed.The above research will play an active role in promoting the engineering application of ETSNM driven by mathematical theory.
文摘The increasing demand due to development and advancement in every field of life has caused the depletion of fossil fuels.This depleting fossil fuel reserve throughout the world has enforced to get energy from alternative/renewable sources.One of the economicalways to get energy is through the utilization of solar ponds.In this study,a mathematical model of a salt gradient solar pond under the Islamabad climatic conditions has been analyzed for the first time.The model uses a one-dimensional finite difference explicit method for optimization of different zone thicknesses.The model depicts that NCZ(Non-Convective Zone)thickness has a significant effect on LCZ(Lower Convective Zone)temperature and should be kept less than 1.7mfor the optimal temperature.It is also observed that for long-termoperation of a solar pond,heat should be extracted by keeping the mass flowrate of 17.3 kg/m^(2)/day.Themodel also suggests that when the bottom reflectivity is about 0.3,then only 24%of the radiation is absorbed in the pond.
基金the Ministry of Science and Higher Education of the Russian Federation(Ural Federal University Program of Development within the Priority-2030 Program)is gratefully acknowledged.
文摘Improving the specific,technical,economic,and environmental characteristics of piston engines(ICE)operating on alternative gaseous fuels is a pressing task for the energy and mechanical engineering industries.The aim of the study was to optimize the parameters of the ICE working cycle after replacing the base fuel(propane-butane blend)with syngas from wood sawdust to improve its technical and economic performance based on mathematical modeling.The modeling results were verified through experimental studies(differences for key parameters did not exceed 4.0%).The object of the study was an electric generator based on a single-cylinder spark ignition engine with a power of 1 kW.The article describes the main approaches to creating a mathematical model of the engine working cycle,a test bench for modeling verification,physicochemical properties of the base fuel(propane-butane blend),and laboratory syngas.It was shown that replacing the fuel from a propane-butane blend to laboratory syngas caused a decrease in engine efficiency to 33%(the efficiency of the base ICE was 0.179 vs.the efficiency of 0.119 for the converted ICE for the 0.59 kW power mode).Engine efficiency was chosen as the key criterion for optimizing the working cycle.As a result of optimization,the efficiency of the converted syngas engine was 6.1%higher than that of the base engine running on the propane-butane blend,and the power drop did not exceed 8.0%.Thus,careful fine-tuning of the working cycle parameters allows increasing the technical and economic characteristics of the syngas engine to the level of ICEs running on traditional types of fuel.
基金supported by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia[Grant No.KFU252959].
文摘Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria.
文摘Journal overview:Journal of Mathematical Research with Applications(JMRA),formerly Journal of Mathematical Research and Exposition(JMRE)created in 1981,one of the transactions of China Society for Industrial and Applied Mathematics,is a home for original research papers of the highest quality in all areas of mathematics with applications.The target audience comprises:pure and applied mathematicians,graduate students in broad fields of sciences and technology,scientists and engineers interested in mathematics.
基金supported by the Teaching Reform Research Project of Shaanxi University of Science&Technology(23Y083)the Project of National University Association for Mathematical Methods in Physics(JZW-23-SL-02)+3 种基金the Graduate Course Construction Project of Shaanxi University of Science&Technology(KC2024Y03)the 2024 National Higher Education University Physics Reform Research Project(2024PR064)the Teaching Reform Research Project of the International Office of Shaanxi University of Science&Technology(YB202410)Graduate Education and Teaching Reform Research Project of Shaanxi University of Science&Technology(JG2025Y18).
文摘With the development of educational digitalization,how to effectively apply digital animation technology to traditional classroom teaching has become an urgent problem to be solved.This study explores the application of Manim in the course of Mathematical Methods for Physics.Taking the visualization of Fourier series,complex numbers,and other content as examples,it improves students’understanding of complex and abstract mathematical physics concepts through dynamic and visual teaching methods.The teaching effect shows that Manim helps to enhance students’learning experience,improve teaching efficiency and effectiveness,and has a positive impact on students’active learning ability.The research in this paper can provide references and inspiration for the educational digitalization of higher education.
基金the framework of the state assignment of Keldysh Institute of Applied Mathematics of RAS(Project No.125020701776-0)the Ministry of Education and Science of Russia for IO RAS(Project No.FMWE-2024-0018).
文摘The work considers the problem of gas hydrate dissociation in a porous medium using the two-term Forchheimer law,corresponding to high flow rates of reservoir fluids.Such rates can arise during the decomposition of gas hydrates,since a large amount of gas is released.Intensive emissions of gases from the earth’s interior are observed on the ocean floor.They are also associated with a large number of subvertical geological structures under the ocean floor,coming to the surface in the formof local ring funnels(pockmarks).Many similar objects have also been found on land.Particular interest in this problemis caused by climate threats associated with the release of greenhouse gases.The movement of gas released fromthe hydrate to the breakthrough channel is similar to the gas inflow to the well(without hydrate),which is usually described by a two-term filtration law.In this work,a mathematical model of gas hydrate dissociation with a nonlinear Forchheimer-type law ofmotion is developed.The systemis split in two blocks by physical processes,taking into account the quadratic correction to the velocity in the filtration law.The first block is responsible for the convective transfer of saturation parameters in the model,water,gas and hydrate saturations are taken into account.The second block corresponds to the equation of dissipative piezoconductivity with a different number of thermodynamic degrees of freedom,taking into account heat and mass transfer in a porous medium.The performed splitting allows using explicit-implicit difference schemes when solving problems and avoiding strong refinement of the step in time and space.For numerical modeling,the support operator method is used,which makes it possible to discretize partial differential equations on irregular grids,which allows taking into account the complex geometry and lithology of the reservoir.A difference scheme based on the support operator method is developed,which,due to the mutually consistent approximation of vector analysis operations(divergence and gradient),allows to take into account the various flux laws between adjacent grid cells,including quadratic corrections to the velocity.Based on the developed numerical algorithms and their program implementations,calculations of gas hydrate dissociation are performed both in a reservoir of simple geometric structure and in a heterogeneous reservoir of complex configuration.The results obtained correspond to the physics of the processes under consideration.
文摘Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over.With the disease targeted for elimination by 2030,assessing the impact of control strategies in communities where there are human-cattle-wildlife interactions is therefore essential.A compartmental framework incorporating tsetse flies,humans,cattle,wildlife and various disease control strategies is developed and analyzed.The reproduction is derived and its sensitivity to different model parameters is investigated.Meanwhile,the optimal control theory is used to identify a combination of control strategies capable of minimizing the infected human and cattle population over time at minimal costs of implementation.The results indicates that tsetse fly mortality rate is strongly and negatively correlated to the reproduction number.It is also established that tsetse fly feeding rate in strongly and positively correlated to the reproduction number.Simulation results indicates that time dependent control strategies can significantly reduce the infections.Overall,the study shows that screening and treatment of humans may not lead to disease elimination.Combining this strategy with other strategies such as screening and treatment of cattle and vector control strategies will result in maximum reduction of tsetse fly population and disease elimination.
文摘1 Summary Mathematical modeling has become a cornerstone in understanding the complex dynamics of infectious diseases and chronic health conditions.With the advent of more refined computational techniques,researchers are now able to incorporate intricate features such as delays,stochastic effects,fractional dynamics,variable-order systems,and uncertainty into epidemic models.These advancements not only improve predictive accuracy but also enable deeper insights into disease transmission,control,and policy-making.Tashfeen et al.
基金Shaanxi Provincial 14th Five-Year Plan for Educational Science Research(SGH24Q481)。
文摘This paper focuses on the ideological and political construction of the course“Probability Theory and Mathematical Statistics.”Aiming at the current situation in teaching where emphasis is placed on knowledge imparting while value guidance is neglected,and combined with the requirements of ideological and political education policies in the new era,this paper explores the integration path between professional courses and ideological and political education.Through literature analysis,case comparison,and empirical research,the study proposes a systematic implementation plan covering the design of teaching objectives,the reconstruction of teaching content,and the optimization of the evaluation system.The purpose is to cultivate students’sense of social responsibility and innovative awareness by excavating the ideological and political elements in mathematics.The research results provide practical reference for colleges and universities to deepen the reform of ideological and political education in courses,and promote the implementation of the fundamental task of fostering virtue through education in STEM education.
文摘Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood vessels.The task is particularly challenging when dealing with color fundus images due to issues like non-uniformillumination,low contrast,and variations in vessel appearance,especially in the presence of different pathologies.Furthermore,the speed of the retinal vessel segmentation system is of utmost importance.With the surge of now available big data,the speed of the algorithm becomes increasingly important,carrying almost equivalent weightage to the accuracy of the algorithm.To address these challenges,we present a novel approach for retinal vessel segmentation,leveraging efficient and robust techniques based on multiscale line detection and mathematical morphology.Our algorithm’s performance is evaluated on two publicly available datasets,namely the Digital Retinal Images for Vessel Extraction dataset(DRIVE)and the Structure Analysis of Retina(STARE)dataset.The experimental results demonstrate the effectiveness of our method,withmean accuracy values of 0.9467 forDRIVE and 0.9535 for STARE datasets,aswell as sensitivity values of 0.6952 forDRIVE and 0.6809 for STARE datasets.Notably,our algorithmexhibits competitive performance with state-of-the-art methods.Importantly,it operates at an average speed of 3.73 s per image for DRIVE and 3.75 s for STARE datasets.It is worth noting that these results were achieved using Matlab scripts containing multiple loops.This suggests that the processing time can be further reduced by replacing loops with vectorization.Thus the proposed algorithm can be deployed in real time applications.In summary,our proposed system strikes a fine balance between swift computation and accuracy that is on par with the best available methods in the field.
基金supported by the National Natural Science Foundation of China(11871238,11931019,12371486)。
文摘Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.
文摘The global populationhas beenandwill continue to be severely impacted by theCOVID-19 epidemic.The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal conditions such as cancer,heart disease,and diabetes.Here,using ordinary differential equations(ODEs),two mathematical models are developed to explain the association between COVID-19 and cancer and between COVID-19 and diabetes and heart disease.After that,we highlight the stability assessments that can be applied to these models.Sensitivity analysis is used to examine how changes in certain factors impact different aspects of disease.The sensitivity analysis showed that many people are still nervous about seeing a doctor due to COVID-19,which could result in a dramatic increase in the diagnosis of various ailments in the years to come.The correlation between diabetes and cardiovascular illness is also illustrated graphically.The effects of smoking and obesity are also found to be significant in disease compartments.Model fitting is also provided for interpreting the relationship between real data and the results of thiswork.Diabetic people,in particular,need tomonitor their health conditions closely and practice heart health maintenance.People with heart diseases should undergo regular checks so that they can protect themselves from diabetes and take some precautions including suitable diets.The main purpose of this study is to emphasize the importance of regular checks,to warn people about the effects of COVID-19(including avoiding healthcare centers and doctors because of the spread of infectious diseases)and to indicate the importance of family history of cancer,heart diseases and diabetes.The provision of the recommendations requires an increase in public consciousness.
基金The financial support provided by the Project of National Natural Science Foundation of China(U22A20415,21978256,22308314)“Pioneer”and“Leading Goose”Research&Development Program of Zhejiang(2022C01SA442617)。
文摘Heat integration is important for energy-saving in the process industry.It is linked to the persistently challenging task of optimal design of heat exchanger networks(HEN).Due to the inherent highly nonconvex nonlinear and combinatorial nature of the HEN problem,it is not easy to find solutions of high quality for large-scale problems.The reinforcement learning(RL)method,which learns strategies through ongoing exploration and exploitation,reveals advantages in such area.However,due to the complexity of the HEN design problem,the RL method for HEN should be dedicated and designed.A hybrid strategy combining RL with mathematical programming is proposed to take better advantage of both methods.An insightful state representation of the HEN structure as well as a customized reward function is introduced.A Q-learning algorithm is applied to update the HEN structure using theε-greedy strategy.Better results are obtained from three literature cases of different scales.
