This study determined growth and lipid accumulation in Nannochloropsis sp. MASCC 11 cultivated at different pH, temperatures, and CO2 concentrations in 10-day period. The suitability for biodiesel production was also ...This study determined growth and lipid accumulation in Nannochloropsis sp. MASCC 11 cultivated at different pH, temperatures, and CO2 concentrations in 10-day period. The suitability for biodiesel production was also evaluated based on the fatty acid profiles of microalgae lipid. Nannochloropsis sp. MASCC 11 showed an excellent tolerance to acidic pH(as low as 4.0), high temperatures(at least 40℃), and high CO2 concentrations(5%-15%), which are major stressed conditions in flue gas. The highest algal biomass was acquired at pH of 9.0(0.44 g L^-1), a temperature of 35℃(0.63 g L^-1), and a CO2 concentration of 5%(2.27 g L^-1). Maximum lipid production was obtained at p H of 6.0(108.2 mg L^-1), a temperature of 35℃(134.6 mg L^-1), and a CO2 concentration of 5%(782.7 mg L^-1). Synthesis of polyunsaturated fatty acids(PUFAs) in biomass was stimulated under high CO_2 concentrations, remaining above 80% of total fatty acids, mainly composed of C16:3, C18:2, and C18:3. This led to the algae-based biodiesel having a lower oxidation stability, better cold flow properties, and other parameters such as its kinematic viscosity, cetane number, and specific gravity complied with ASTM or EN 14214 biodiesel specifications. Therefore, the improvement of oxidative stability needs to be considered before Nannochloropsis sp. MASCC 11 lipid can be used for biodiesel production, even if this species can grow well under stressful conditions.展开更多
目的:分析粒细胞缺乏伴发热(febrile neutropenia,FN)的实体癌患者发生严重不良事件(serious adverse events,SAE)的危险因素,并对稳定发热性中性粒细胞减少症临床指数(clinical index of stable febrile neutropenia,CISNE)与多国癌症...目的:分析粒细胞缺乏伴发热(febrile neutropenia,FN)的实体癌患者发生严重不良事件(serious adverse events,SAE)的危险因素,并对稳定发热性中性粒细胞减少症临床指数(clinical index of stable febrile neutropenia,CISNE)与多国癌症支持治疗协会(Multinational Association of Supportive Care in Cancer,MASCC)风险分层模型的预测效能进行比较。方法:回顾性收集2016年1月至2021年6月重庆大学附属肿瘤医院诊治的所有经化疗后发生FN的实体癌患者。将患者分为SAE组和非SAE组,SAE的定义:①FN治疗期间出现感染性休克或脏器功能衰竭且必需转入ICU治疗;②FN发生后60 d内死亡。比较2组临床资料,采用二元logistic回归分析SAE的独立危险因素。计算患者CISNE评分和MASCC评分,比较CISNE、MASCC评分识别低危FN的效能。结果:共入选91例患者,其中SAE 18例(19.78%)。二元logistic回归分析发现SAE的独立危险因素为:ECOG评分≥2分、血钾<3.5 mmol/L、降钙素原(procalcitonin,PCT)≥0.5 ng/mL和单核细胞计数≤0.02×10^(9)个/L(OR=8.619、11.358、30.612、11.202,95%CI=1.124~66.094、1.696~76.047、5.013~186.947、1.889~66.440,P<0.05)。SAE组与非SAE组的CISNE、MASCC评分均具有统计学差异(P<0.05)。CISNE 0分(低危)与MASCC评分≥21分(低危)患者SAE的发生率明显低于非低危组(P<0.05)。CISNE 0分与MASCC≥21分识别低危FN的敏感性、特异性、阳性和阴性预测值分别为21.9%、100.0%、100.0%、24.0%和91.8%、38.9%、85.9%、53.8%。结论:ECOG评分≥2分、血钾<3.5 mmol/L、PCT≥0.5 ng/mL和单核细胞计数≤0.02×10^(9)个/L是FN患者发生SAE的独立危险因素。CISNE 0分比MASCC≥21分预测低危FN的特异性和阳性预测值更高。展开更多
The Annual Symposium of the Multinational Association of Supportive Care in Cancer （MASCC）/International Society of Oral Oncology （ISOO） was held in Vancouver, Canada,June 24-26, 2010. The symposium brought togeth...The Annual Symposium of the Multinational Association of Supportive Care in Cancer （MASCC）/International Society of Oral Oncology （ISOO） was held in Vancouver, Canada,June 24-26, 2010. The symposium brought together health care professionals from many countries and many fields of expertise for an excellent forum of ideas, lectures and collegial interactions,and discussed methods to minimize cancer-induced side effects, the symptoms and complications of its treatment, and psychosocial issues facing cancer patients and their families. Some ideas and studies selected from the presentations of different fields of supportive care in cancer presented in this symposium are introduced in this paper.展开更多
基金supported by the National Key Technology R&D Programme (No. 2011BAD14B04)。
文摘This study determined growth and lipid accumulation in Nannochloropsis sp. MASCC 11 cultivated at different pH, temperatures, and CO2 concentrations in 10-day period. The suitability for biodiesel production was also evaluated based on the fatty acid profiles of microalgae lipid. Nannochloropsis sp. MASCC 11 showed an excellent tolerance to acidic pH(as low as 4.0), high temperatures(at least 40℃), and high CO2 concentrations(5%-15%), which are major stressed conditions in flue gas. The highest algal biomass was acquired at pH of 9.0(0.44 g L^-1), a temperature of 35℃(0.63 g L^-1), and a CO2 concentration of 5%(2.27 g L^-1). Maximum lipid production was obtained at p H of 6.0(108.2 mg L^-1), a temperature of 35℃(134.6 mg L^-1), and a CO2 concentration of 5%(782.7 mg L^-1). Synthesis of polyunsaturated fatty acids(PUFAs) in biomass was stimulated under high CO_2 concentrations, remaining above 80% of total fatty acids, mainly composed of C16:3, C18:2, and C18:3. This led to the algae-based biodiesel having a lower oxidation stability, better cold flow properties, and other parameters such as its kinematic viscosity, cetane number, and specific gravity complied with ASTM or EN 14214 biodiesel specifications. Therefore, the improvement of oxidative stability needs to be considered before Nannochloropsis sp. MASCC 11 lipid can be used for biodiesel production, even if this species can grow well under stressful conditions.
文摘目的:分析粒细胞缺乏伴发热(febrile neutropenia,FN)的实体癌患者发生严重不良事件(serious adverse events,SAE)的危险因素,并对稳定发热性中性粒细胞减少症临床指数(clinical index of stable febrile neutropenia,CISNE)与多国癌症支持治疗协会(Multinational Association of Supportive Care in Cancer,MASCC)风险分层模型的预测效能进行比较。方法:回顾性收集2016年1月至2021年6月重庆大学附属肿瘤医院诊治的所有经化疗后发生FN的实体癌患者。将患者分为SAE组和非SAE组,SAE的定义:①FN治疗期间出现感染性休克或脏器功能衰竭且必需转入ICU治疗;②FN发生后60 d内死亡。比较2组临床资料,采用二元logistic回归分析SAE的独立危险因素。计算患者CISNE评分和MASCC评分,比较CISNE、MASCC评分识别低危FN的效能。结果:共入选91例患者,其中SAE 18例(19.78%)。二元logistic回归分析发现SAE的独立危险因素为:ECOG评分≥2分、血钾<3.5 mmol/L、降钙素原(procalcitonin,PCT)≥0.5 ng/mL和单核细胞计数≤0.02×10^(9)个/L(OR=8.619、11.358、30.612、11.202,95%CI=1.124~66.094、1.696~76.047、5.013~186.947、1.889~66.440,P<0.05)。SAE组与非SAE组的CISNE、MASCC评分均具有统计学差异(P<0.05)。CISNE 0分(低危)与MASCC评分≥21分(低危)患者SAE的发生率明显低于非低危组(P<0.05)。CISNE 0分与MASCC≥21分识别低危FN的敏感性、特异性、阳性和阴性预测值分别为21.9%、100.0%、100.0%、24.0%和91.8%、38.9%、85.9%、53.8%。结论:ECOG评分≥2分、血钾<3.5 mmol/L、PCT≥0.5 ng/mL和单核细胞计数≤0.02×10^(9)个/L是FN患者发生SAE的独立危险因素。CISNE 0分比MASCC≥21分预测低危FN的特异性和阳性预测值更高。
文摘The Annual Symposium of the Multinational Association of Supportive Care in Cancer （MASCC）/International Society of Oral Oncology （ISOO） was held in Vancouver, Canada,June 24-26, 2010. The symposium brought together health care professionals from many countries and many fields of expertise for an excellent forum of ideas, lectures and collegial interactions,and discussed methods to minimize cancer-induced side effects, the symptoms and complications of its treatment, and psychosocial issues facing cancer patients and their families. Some ideas and studies selected from the presentations of different fields of supportive care in cancer presented in this symposium are introduced in this paper.
