报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检...报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。展开更多
Sister Mary Joseph’s结节(Sister Mary Joseph’s nodule,SMJN)是指腹腔内恶性肿瘤导致的脐部转移性结节,1949年由Hamilton Bailey命名以纪念St.Mary’s Hospital的护士Sister Joseph。SMJN并不多见,但个案报道屡屡见诸文献。这种脐...Sister Mary Joseph’s结节(Sister Mary Joseph’s nodule,SMJN)是指腹腔内恶性肿瘤导致的脐部转移性结节,1949年由Hamilton Bailey命名以纪念St.Mary’s Hospital的护士Sister Joseph。SMJN并不多见,但个案报道屡屡见诸文献。这种脐部转移可以与腹腔内肿瘤同时出现或异时出现,是预后极差的表现。SMJN最常见原发肿瘤为胃癌及卵巢癌,结肠癌特别是右侧结肠癌引起的SMJN极其罕见。另外右侧结肠癌转移至腹股沟淋巴结未见文献报道。本文报道一例右侧结肠癌同时伴有SMJN及腹股沟淋巴结转移,并对相关文献进行综述。展开更多
报告1例可能为胃癌转移的Sister Mary Joseph结节1例。患者男,44岁。脐部出现暗红色大小不等的结节7个月。皮损组织病理检查:真皮全层胶原束间散在呈腺样分化的肿瘤细胞,免疫组化染色:癌胚抗原(CEA)阳性、细胞角蛋白(CK)20阳性、CK7阳...报告1例可能为胃癌转移的Sister Mary Joseph结节1例。患者男,44岁。脐部出现暗红色大小不等的结节7个月。皮损组织病理检查:真皮全层胶原束间散在呈腺样分化的肿瘤细胞,免疫组化染色:癌胚抗原(CEA)阳性、细胞角蛋白(CK)20阳性、CK7阳性、甲状腺转录因子(TTF)-1阴性。糖链抗原(CA)19-9、CA72-4、CA24-2均升高。腹部B超检查示:胃幽门部胃壁增生性病变,肝右叶多发偏强回声结节,腹水。展开更多
The students were having an English class. "Today you can write a story about your family.I want you to tell me something about your parents and your brothers and sisters, "said Mr Shute. Mary raised her han...The students were having an English class. "Today you can write a story about your family.I want you to tell me something about your parents and your brothers and sisters, "said Mr Shute. Mary raised her hand."What kind of thing shall I write about my parents? "she asked. "Well,"said Mr Shute. "Write about展开更多
Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be di...Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be difficult to diagnose, due to the absence or misinterpretation of symptoms as pregnancy-related. Diagnostic aids, such as a basic chemistry panel and imaging techniques, may not show any abnormalities. We present a case of a 37-year-old pregnant patient whose umbilical nodule was the first presenting physical sign of gastric cancer, which had metastasized throughout the abdominal and pelvic regions.展开更多
Sister Mary Joseph's nodule(SMJN) refers to a metastatic tumor of the umbilicus.It is a rare entity which arises from a malignancy in the intra-abdominal cavity.We herein describe a patient who presented with SMJN...Sister Mary Joseph's nodule(SMJN) refers to a metastatic tumor of the umbilicus.It is a rare entity which arises from a malignancy in the intra-abdominal cavity.We herein describe a patient who presented with SMJN as his first sign of pancreatic cancer.It is an even more unusual case of SMJN.We therefore,suggest that pancreatic cancer should be included in the differential diagnosis when an umbilical mass is found.With the progress made in surgical procedures and other modalities,an early diagnosis will dramatically improve the prognosis of the patients.展开更多
Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant pe...Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case.展开更多
BACKGROUND Sister Mary Joseph’s nodule(SMJN)is rare and may occur independently or simultaneously with malignant tumors in the abdominal cavity.It has a poor prognosis.Endometrial carcinoma is the most common maligna...BACKGROUND Sister Mary Joseph’s nodule(SMJN)is rare and may occur independently or simultaneously with malignant tumors in the abdominal cavity.It has a poor prognosis.Endometrial carcinoma is the most common malignant tumor in the upper segment of the female reproductive tract;however,it rarely occurs with SMJN.We here report a case of endometrial carcinoma with SMJN.CASE SUMMARY A 75-year-old woman was diagnosed with endometrial cancer>2 years ago.After multiple cycles of chemotherapy,an obvious but painless umbilical mass was detected 2 wk before admission.The patient did not undergo surgical treatment but received chemotherapy,which was different from previous chemotherapy,for three consecutive cycles after discovery of umbilical metastases.Currently,the umbilical metastatic tumor has reduced,and the quality of life of the patient has significantly improved.CONCLUSION Once the umbilical mass is found,the possibility of SMJN should be considered.We should also take into account the poor prognosis of endometrial carcinoma complicated with umbilical metastasis,especially in patients with advanced tumors,and it is important to choose an appropriate treatment.展开更多
Invisible Man is Ralph Ellison's most important work,the hero of which is confused by the problem of his identity.This thesis will discuss the transformation of Mary Rambo in the novel.At the beginning,Mary Rambo ...Invisible Man is Ralph Ellison's most important work,the hero of which is confused by the problem of his identity.This thesis will discuss the transformation of Mary Rambo in the novel.At the beginning,Mary Rambo was a symbol of hope and encouragement for the hero and a kind of salvation and redemption to him both materially and spiritually.But later,she changed from a savior to a restrictive mother.The hero became restive and guilty under her watchful and anxious care.Thus,the hero must escape her in order to continue his search for identity.展开更多
Mary Barton is Elizabeth Gaskell's first novel,published in 1848,depicted the fierce conflict between working class and capitalist.This novel reveals the fact that with the development of capitalism,capitalist hol...Mary Barton is Elizabeth Gaskell's first novel,published in 1848,depicted the fierce conflict between working class and capitalist.This novel reveals the fact that with the development of capitalism,capitalist hold the money worship of consumer cultural perspective,social spiritual slump and self lost.People enter the wasteland of spiritual life,result the imbalanced of mental spiritual.According to describing the disasters of industrial capitalism to human spiritual ecology that draws attention to imbalanced psychology ecology.And advocate to rethinking life significance.展开更多
BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced malignancy.SMJNs typically originate from intra-abdominal sources,rarely from breast cancer...BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced malignancy.SMJNs typically originate from intra-abdominal sources,rarely from breast cancer.Diagnosis suggests a poor prognosis with a median survival of approximately 8 mo after detection.Managing patients with SMJNs is challenging,as most receive limited palliative care only.The optimal strategy for long-term survival of these patients remains unclear.CASE SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical nodule.Thirteen years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph nodes.An umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional biopsy.Despite initial removal,the nodule recurred and grew,leading to her referral to our hospital.The patient underwent extensive excision of the umbilical tumor and immediate abdominal wall reconstruction.Endocrine therapy was continued postoperatively.Five years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN diagnosis.CONCLUSION This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive treatment.We presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment regimen.Our findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive therapy.This approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.展开更多
The acquisition of language ability is one of the most important milestones in early child development.The ability to communicate with others extends beyond the use of spoken words and includes tone of voice,facial ex...The acquisition of language ability is one of the most important milestones in early child development.The ability to communicate with others extends beyond the use of spoken words and includes tone of voice,facial expression,展开更多
The feminine spiritual figures of compassion, the Catholic Christian Virgin Mother Mary, and the Chinese Buddhist, Kuan Yin, share a number of traits and attributes in spite of their cultural differences. They also sh...The feminine spiritual figures of compassion, the Catholic Christian Virgin Mother Mary, and the Chinese Buddhist, Kuan Yin, share a number of traits and attributes in spite of their cultural differences. They also share a common history in the development of their devotional worship through two empresses who identified themselves with their respective cultural icon thereby enhancing their political roles while endearing themselves to the common people through their promotion of the spiritual figures of compassion. This paper seeks to show the parallels between the rise in devotion to the Virgin Mary under the Byzantine Empress Pulcheria （399-453） and the corresponding rise in the interest in, and feminization of, Avalokiteshvara/Kuan Yin under the Tang Dynasty Empress Wu Zetian （625-705）. While there has been a substantial amount written about how ancient political leaders used selected deities as vehicles for asserting their power, there are only a few that have looked at these two unique Empresses and none that compares their influence in the popularization of devotional worship to Mary and Kuan Yin. This study attempts to begin to fill that gap.展开更多
This article deals with the biochemical characteristics of varieties of Saint Mary’s Thistle such as Panacea, Debut and Samaryanka. Based on the studies, it was found that the highest oil content was found in the spe...This article deals with the biochemical characteristics of varieties of Saint Mary’s Thistle such as Panacea, Debut and Samaryanka. Based on the studies, it was found that the highest oil content was found in the species Debut (26%). <span style="font-family:Verdana;">The lowest oil content was observed in the variety </span><span style="font-family:Verdana;">Samaryanka</span><span style="font-family:Verdana;"> (19%). The highest protein content and the sum of total amino acids in the seeds of St. Mary’s Thistle varieties were found in the variety Debut (131.1), and the lowest indication was observed in the species Samaryanka (79.2). By the number of replaceable amino acids existing in the seeds of the species of St. Mary’s Thistle, it was found in the Varieties Debut (126.3), and the lowest indication was observed in the variety Samaryanka (112). Based on the results of studies and the noted biochemical characteristics and varietal differences of the St. Mary’s Thistle, the possibility and expediency of expanding the crops of this species in the soil and climatic conditions of the Khorezm region are suggested. The research was conducted 2017-2019 y.</span>展开更多
文摘报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。
文摘Sister Mary Joseph’s结节(Sister Mary Joseph’s nodule,SMJN)是指腹腔内恶性肿瘤导致的脐部转移性结节,1949年由Hamilton Bailey命名以纪念St.Mary’s Hospital的护士Sister Joseph。SMJN并不多见,但个案报道屡屡见诸文献。这种脐部转移可以与腹腔内肿瘤同时出现或异时出现,是预后极差的表现。SMJN最常见原发肿瘤为胃癌及卵巢癌,结肠癌特别是右侧结肠癌引起的SMJN极其罕见。另外右侧结肠癌转移至腹股沟淋巴结未见文献报道。本文报道一例右侧结肠癌同时伴有SMJN及腹股沟淋巴结转移,并对相关文献进行综述。
文摘报告1例可能为胃癌转移的Sister Mary Joseph结节1例。患者男,44岁。脐部出现暗红色大小不等的结节7个月。皮损组织病理检查:真皮全层胶原束间散在呈腺样分化的肿瘤细胞,免疫组化染色:癌胚抗原(CEA)阳性、细胞角蛋白(CK)20阳性、CK7阳性、甲状腺转录因子(TTF)-1阴性。糖链抗原(CA)19-9、CA72-4、CA24-2均升高。腹部B超检查示:胃幽门部胃壁增生性病变,肝右叶多发偏强回声结节,腹水。
文摘The students were having an English class. "Today you can write a story about your family.I want you to tell me something about your parents and your brothers and sisters, "said Mr Shute. Mary raised her hand."What kind of thing shall I write about my parents? "she asked. "Well,"said Mr Shute. "Write about
文摘Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be difficult to diagnose, due to the absence or misinterpretation of symptoms as pregnancy-related. Diagnostic aids, such as a basic chemistry panel and imaging techniques, may not show any abnormalities. We present a case of a 37-year-old pregnant patient whose umbilical nodule was the first presenting physical sign of gastric cancer, which had metastasized throughout the abdominal and pelvic regions.
基金Supported by National Natural Science Funds for Distinguished Young Scholar,No.30925033National Natural Science Funds of China,No.30801101 and No.81171884Innovation and High-Level Talent Training Program of Department of Health of Zhejiang
文摘Sister Mary Joseph's nodule(SMJN) refers to a metastatic tumor of the umbilicus.It is a rare entity which arises from a malignancy in the intra-abdominal cavity.We herein describe a patient who presented with SMJN as his first sign of pancreatic cancer.It is an even more unusual case of SMJN.We therefore,suggest that pancreatic cancer should be included in the differential diagnosis when an umbilical mass is found.With the progress made in surgical procedures and other modalities,an early diagnosis will dramatically improve the prognosis of the patients.
文摘Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case.
文摘BACKGROUND Sister Mary Joseph’s nodule(SMJN)is rare and may occur independently or simultaneously with malignant tumors in the abdominal cavity.It has a poor prognosis.Endometrial carcinoma is the most common malignant tumor in the upper segment of the female reproductive tract;however,it rarely occurs with SMJN.We here report a case of endometrial carcinoma with SMJN.CASE SUMMARY A 75-year-old woman was diagnosed with endometrial cancer>2 years ago.After multiple cycles of chemotherapy,an obvious but painless umbilical mass was detected 2 wk before admission.The patient did not undergo surgical treatment but received chemotherapy,which was different from previous chemotherapy,for three consecutive cycles after discovery of umbilical metastases.Currently,the umbilical metastatic tumor has reduced,and the quality of life of the patient has significantly improved.CONCLUSION Once the umbilical mass is found,the possibility of SMJN should be considered.We should also take into account the poor prognosis of endometrial carcinoma complicated with umbilical metastasis,especially in patients with advanced tumors,and it is important to choose an appropriate treatment.
文摘Invisible Man is Ralph Ellison's most important work,the hero of which is confused by the problem of his identity.This thesis will discuss the transformation of Mary Rambo in the novel.At the beginning,Mary Rambo was a symbol of hope and encouragement for the hero and a kind of salvation and redemption to him both materially and spiritually.But later,she changed from a savior to a restrictive mother.The hero became restive and guilty under her watchful and anxious care.Thus,the hero must escape her in order to continue his search for identity.
文摘Mary Barton is Elizabeth Gaskell's first novel,published in 1848,depicted the fierce conflict between working class and capitalist.This novel reveals the fact that with the development of capitalism,capitalist hold the money worship of consumer cultural perspective,social spiritual slump and self lost.People enter the wasteland of spiritual life,result the imbalanced of mental spiritual.According to describing the disasters of industrial capitalism to human spiritual ecology that draws attention to imbalanced psychology ecology.And advocate to rethinking life significance.
文摘BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced malignancy.SMJNs typically originate from intra-abdominal sources,rarely from breast cancer.Diagnosis suggests a poor prognosis with a median survival of approximately 8 mo after detection.Managing patients with SMJNs is challenging,as most receive limited palliative care only.The optimal strategy for long-term survival of these patients remains unclear.CASE SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical nodule.Thirteen years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph nodes.An umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional biopsy.Despite initial removal,the nodule recurred and grew,leading to her referral to our hospital.The patient underwent extensive excision of the umbilical tumor and immediate abdominal wall reconstruction.Endocrine therapy was continued postoperatively.Five years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN diagnosis.CONCLUSION This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive treatment.We presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment regimen.Our findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive therapy.This approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.
文摘The acquisition of language ability is one of the most important milestones in early child development.The ability to communicate with others extends beyond the use of spoken words and includes tone of voice,facial expression,
文摘The feminine spiritual figures of compassion, the Catholic Christian Virgin Mother Mary, and the Chinese Buddhist, Kuan Yin, share a number of traits and attributes in spite of their cultural differences. They also share a common history in the development of their devotional worship through two empresses who identified themselves with their respective cultural icon thereby enhancing their political roles while endearing themselves to the common people through their promotion of the spiritual figures of compassion. This paper seeks to show the parallels between the rise in devotion to the Virgin Mary under the Byzantine Empress Pulcheria （399-453） and the corresponding rise in the interest in, and feminization of, Avalokiteshvara/Kuan Yin under the Tang Dynasty Empress Wu Zetian （625-705）. While there has been a substantial amount written about how ancient political leaders used selected deities as vehicles for asserting their power, there are only a few that have looked at these two unique Empresses and none that compares their influence in the popularization of devotional worship to Mary and Kuan Yin. This study attempts to begin to fill that gap.
文摘This article deals with the biochemical characteristics of varieties of Saint Mary’s Thistle such as Panacea, Debut and Samaryanka. Based on the studies, it was found that the highest oil content was found in the species Debut (26%). <span style="font-family:Verdana;">The lowest oil content was observed in the variety </span><span style="font-family:Verdana;">Samaryanka</span><span style="font-family:Verdana;"> (19%). The highest protein content and the sum of total amino acids in the seeds of St. Mary’s Thistle varieties were found in the variety Debut (131.1), and the lowest indication was observed in the species Samaryanka (79.2). By the number of replaceable amino acids existing in the seeds of the species of St. Mary’s Thistle, it was found in the Varieties Debut (126.3), and the lowest indication was observed in the variety Samaryanka (112). Based on the results of studies and the noted biochemical characteristics and varietal differences of the St. Mary’s Thistle, the possibility and expediency of expanding the crops of this species in the soil and climatic conditions of the Khorezm region are suggested. The research was conducted 2017-2019 y.</span>
