BACKGROUND: Epidemiology investigation showed that no worker drunk Maotai liquor for nearly 30 years died of hepatic diseases, and no obvious hepatic fibrosis and cirrho- sis were found in 99 workers who had drunk Mao...BACKGROUND: Epidemiology investigation showed that no worker drunk Maotai liquor for nearly 30 years died of hepatic diseases, and no obvious hepatic fibrosis and cirrho- sis were found in 99 workers who had drunk Maotai liquor for a long period by epidemiology investigation and needle biopsy. The same finding was detected in rats that were drunk by Maotai liquor continued for 56 days. This study was to investigate the effects of Maotai liquor on the liver and its mechanism of preventing hepatic fibrosis. METHODS: After ingestion of Maotai for 56 consecutive days, male SD rats were killed for detecting the levels of metallothionein and malondialdehyde (MDA) in liver tis- sues. Rat hepatic stellate cells (HSCs) and human HSCs were cultured in vitro to observe the effect of Maotai on HSCs proliferation and collagen synthesis. After ingestion of Maotai for 14 consecutive weeks, the livers of male SD rats were harvested for pathohistological examination. RESULTS: The level of metallothionein in the liver of Mao- tai-induced rats increased by 22 folds, whereas the levels of hepatic lipid peroxide and MDA was decreased significantly ( P <0.05) in Maotai-induced animals suffering from CCl4. Maotai demonstrated obvious inhibitory effect on prolifera- tion of HSCs and the inhibition was concentration-depen- dent. Gene expression and protein secretion of collagens could also be inhibited by Maotai. In alcoholic group, typi- cal liver cirrhosis was observed. In Maotai group, however, though fatty degeneration of hepatocytes and mild fibrosis of the interstitium were observed, no obvious hepatic fibro- sis and cirrhosis were found. CONCLUSION: It might be an important mechanism of interfering the progress of hepatic fibrosis that Maotai in- creases the level of metallothionein in the liver and inhibits the activation of HSCs and the synthesis of collagen pro- teins.展开更多
Research in advanced water recycling technologies,nutrient recovery systems,and carbon capture methods can further enhance such projects,and studies on eco-metaverse applications and energy-efficient designs could pro...Research in advanced water recycling technologies,nutrient recovery systems,and carbon capture methods can further enhance such projects,and studies on eco-metaverse applications and energy-efficient designs could provide insights into optimizing industrial ecological initiatives·This project demonstrates innovative solutions for environmental challenges,equipping designers with strategies to align ecological goals with industrial and economic objectives and inspiring innovative and sustainable practices.展开更多
In China, the morbidity of alcoholic liver diseases （ALD） is increasing, which is the second cause of liver diseases after viral hepatitis. An epidemiological survey of 99 subjects in Kweichow Maotai Distillery who ...In China, the morbidity of alcoholic liver diseases （ALD） is increasing, which is the second cause of liver diseases after viral hepatitis. An epidemiological survey of 99 subjects in Kweichow Maotai Distillery who have drunk a lot of Maotai liquor for a long time showed that fatty livers were predominate and the incidence of hepatic fibrosis and cirrhosis was relatively low. Now, we carried out an animal experiment to investigate the mutation of P53 gene in liver tissues of primary hepatocellular carcinoma （HCC） induced by compound factors.展开更多
EVERYONE who likes to drink wine knows Guizhou’s Maotai, a well-known white spirit. It is the pride of the Guizhou people, because it has been elected as the most famous Chinese white spirit three times and honored a...EVERYONE who likes to drink wine knows Guizhou’s Maotai, a well-known white spirit. It is the pride of the Guizhou people, because it has been elected as the most famous Chinese white spirit three times and honored as the "state white spirit." Maotai tastes mellow and leaves a pleasing aftertaste. The good taste of this strong spirit benefits from its good water source and the skill of the masters. The Maotai Township is located by the limpid Chishui River, which has clear and sweet water. The method of making Maotai is complicated. It uses wheat展开更多
文摘BACKGROUND: Epidemiology investigation showed that no worker drunk Maotai liquor for nearly 30 years died of hepatic diseases, and no obvious hepatic fibrosis and cirrho- sis were found in 99 workers who had drunk Maotai liquor for a long period by epidemiology investigation and needle biopsy. The same finding was detected in rats that were drunk by Maotai liquor continued for 56 days. This study was to investigate the effects of Maotai liquor on the liver and its mechanism of preventing hepatic fibrosis. METHODS: After ingestion of Maotai for 56 consecutive days, male SD rats were killed for detecting the levels of metallothionein and malondialdehyde (MDA) in liver tis- sues. Rat hepatic stellate cells (HSCs) and human HSCs were cultured in vitro to observe the effect of Maotai on HSCs proliferation and collagen synthesis. After ingestion of Maotai for 14 consecutive weeks, the livers of male SD rats were harvested for pathohistological examination. RESULTS: The level of metallothionein in the liver of Mao- tai-induced rats increased by 22 folds, whereas the levels of hepatic lipid peroxide and MDA was decreased significantly ( P <0.05) in Maotai-induced animals suffering from CCl4. Maotai demonstrated obvious inhibitory effect on prolifera- tion of HSCs and the inhibition was concentration-depen- dent. Gene expression and protein secretion of collagens could also be inhibited by Maotai. In alcoholic group, typi- cal liver cirrhosis was observed. In Maotai group, however, though fatty degeneration of hepatocytes and mild fibrosis of the interstitium were observed, no obvious hepatic fibro- sis and cirrhosis were found. CONCLUSION: It might be an important mechanism of interfering the progress of hepatic fibrosis that Maotai in- creases the level of metallothionein in the liver and inhibits the activation of HSCs and the synthesis of collagen pro- teins.
文摘Research in advanced water recycling technologies,nutrient recovery systems,and carbon capture methods can further enhance such projects,and studies on eco-metaverse applications and energy-efficient designs could provide insights into optimizing industrial ecological initiatives·This project demonstrates innovative solutions for environmental challenges,equipping designers with strategies to align ecological goals with industrial and economic objectives and inspiring innovative and sustainable practices.
文摘In China, the morbidity of alcoholic liver diseases （ALD） is increasing, which is the second cause of liver diseases after viral hepatitis. An epidemiological survey of 99 subjects in Kweichow Maotai Distillery who have drunk a lot of Maotai liquor for a long time showed that fatty livers were predominate and the incidence of hepatic fibrosis and cirrhosis was relatively low. Now, we carried out an animal experiment to investigate the mutation of P53 gene in liver tissues of primary hepatocellular carcinoma （HCC） induced by compound factors.
文摘EVERYONE who likes to drink wine knows Guizhou’s Maotai, a well-known white spirit. It is the pride of the Guizhou people, because it has been elected as the most famous Chinese white spirit three times and honored as the "state white spirit." Maotai tastes mellow and leaves a pleasing aftertaste. The good taste of this strong spirit benefits from its good water source and the skill of the masters. The Maotai Township is located by the limpid Chishui River, which has clear and sweet water. The method of making Maotai is complicated. It uses wheat
