OBJECTIVE Dysfunction of the dopaminergic(DA)neurons is implicated in the pathogenesis of bipolar disorder(BPD).Hista⁃mine receptor 2(Hrh2)is highly expressed in DA neurons,and its antagonists have been reported to in...OBJECTIVE Dysfunction of the dopaminergic(DA)neurons is implicated in the pathogenesis of bipolar disorder(BPD).Hista⁃mine receptor 2(Hrh2)is highly expressed in DA neurons,and its antagonists have been reported to induce mania phase of BPD.However,whether Hrh2 on DA neurons contributes to BPD patho⁃genesis is unclear.The present study aims to explore the role of hrh2 on DA neurons in the pathology of BPD.METHODS AAV-FLEX-shHrh2 was injected into a targeted brain area of DAT-Cre mice,leading to a selective brain-regional loss of Hrh2 on DA neurons.A series of behavior tests were used to measure the sponta⁃neous activity,anxiety and depression level of Hrh2-deficient mice.RESULTS①In the open field test and home-cage activity test,Hrh2-defi⁃cient mice displayed increased spontaneous activity.②Hrh2-deficient mice showed reduced depression level in the tail suspension test,forced swimming test and sucrose preference test.③The anxiety level of Hrh2-deficient mice was decreased in the open field test.CONCLU⁃SION Hrh2 on DA neurons is closely related with mania-like behavior.展开更多
<strong>Background:</strong> Ictal psychosis without remarkable cognitive impairment is uncommon occurrence, presents diagnostic challenges to clinicians, often misdiagnosed as functional psychosis. <st...<strong>Background:</strong> Ictal psychosis without remarkable cognitive impairment is uncommon occurrence, presents diagnostic challenges to clinicians, often misdiagnosed as functional psychosis. <strong>Case Presentation:</strong> We present 3 cases of young adult men admitted to psychiatric ward as functional psychosis. They presented with irritability, physical aggression and mild cognitive impairment with intense emotional symptoms, and persecutory ideas and delusions. Two were wrongly diagnose as mania while the third was mimicking schizophrenia in its presentation. They received antipsychotic treatment and misdiagnosed as functional psychosis. They did not respond well to such treatment, until, series electroencephalograms were taken which revealed evidence of ictal psychosis. All, thence, responded well to addition of antiepileptic treatment. This, not only, proves to be effective, but also determined future management and prognosis. <strong>Conclusion: </strong>These cases shine light onto the role of the frontal cortex in the genesis of quasi-manic episodes and highlight the importance of EEG investigations in first episode of acute psychosis.展开更多
Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic infammation with pontine perivascular enhancement responsive to s...Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic infammation with pontine perivascular enhancement responsive to steroids （CLIPPERS） have been reported in the current literature. The following is a case of a 29-year-old patient with a previous major depressive episode comorbid with CLIPPERS. Following glucocorticosteroid therapy, the patient switched to mania-like presentation and was diagnosed with bipolar disorder due to another medical condition. So it is strongly suggested that high-dose corticosteroid pulse therapy could easily induce psychiatric disturbances for patients with previous psychiatric symptoms, and there may be potential links between bipolar disorder and CLIPPERS in the area of infammation.展开更多
目的探讨脑电图(Electroencephalogram,EEG)评估相位滞后指数(phase lag index,PLI)对双相情感障碍(bipolar disorder,BD)患儿躁狂发作后复发的预测价值。方法选取2021年4月—2023年11月期间于本院就诊的128例BD患儿,根据随访1年内是否...目的探讨脑电图(Electroencephalogram,EEG)评估相位滞后指数(phase lag index,PLI)对双相情感障碍(bipolar disorder,BD)患儿躁狂发作后复发的预测价值。方法选取2021年4月—2023年11月期间于本院就诊的128例BD患儿,根据随访1年内是否复发分为复发组(n=42)和未复发组(n=86)。收集患儿临床资料,使用EEG评估和计算δ(1~4 Hz)、θ(4~7 Hz)、α(8~13Hz)、β(14~30 Hz)、γ(30~45 Hz)5个频段的PLI,分析患儿复发的影响因素和不同频段PLI的预测价值。结果与未复发组相比较,复发组伴发精神病性症状占比更高,接受维持期治疗占比更低(P<0.05),θ和α频段的PLI明显更低(P<0.05)。多因素Logistic回归分析结果显示:伴发精神病性症状、θ频段PLI、α频段PLI是BD患儿复发的影响因素(P<0.05)。受试者工作特征(receiver operating characteristic,ROC)曲线结果发现,θ频段PLI、α频段PLI单独及联合预测BD患儿复发的曲线下面积(areas under curve,AUC)分别为0.740(0.645~0.867)、0.657(0.556~0.757)、0.782(0.696~0.867)。结论基于EEG评估的θ联合α频段PLI对预测BD患儿躁狂发作后的复发具有良好的价值。展开更多
Chinese companies pick up outbound mergers and acquisitions to expand into overseas markets 0verall, Chinese companies were responsible for 38 overseas M&A deals in 2009, with a combined
ACPAFFC delegation headed by its vice pres- ident Li Xiaolin made a working visit to Ro- mania and France from August 31 to September 8 at the invitation of the Romania-China Friendship Association (RCFA) and
Next time you're at an office[party],whip out your phone,open the App Store,and buy a title called Ocarina.Then hand the phone over to an iPhone skeptic and watch him figure it out.
文摘OBJECTIVE Dysfunction of the dopaminergic(DA)neurons is implicated in the pathogenesis of bipolar disorder(BPD).Hista⁃mine receptor 2(Hrh2)is highly expressed in DA neurons,and its antagonists have been reported to induce mania phase of BPD.However,whether Hrh2 on DA neurons contributes to BPD patho⁃genesis is unclear.The present study aims to explore the role of hrh2 on DA neurons in the pathology of BPD.METHODS AAV-FLEX-shHrh2 was injected into a targeted brain area of DAT-Cre mice,leading to a selective brain-regional loss of Hrh2 on DA neurons.A series of behavior tests were used to measure the sponta⁃neous activity,anxiety and depression level of Hrh2-deficient mice.RESULTS①In the open field test and home-cage activity test,Hrh2-defi⁃cient mice displayed increased spontaneous activity.②Hrh2-deficient mice showed reduced depression level in the tail suspension test,forced swimming test and sucrose preference test.③The anxiety level of Hrh2-deficient mice was decreased in the open field test.CONCLU⁃SION Hrh2 on DA neurons is closely related with mania-like behavior.
文摘<strong>Background:</strong> Ictal psychosis without remarkable cognitive impairment is uncommon occurrence, presents diagnostic challenges to clinicians, often misdiagnosed as functional psychosis. <strong>Case Presentation:</strong> We present 3 cases of young adult men admitted to psychiatric ward as functional psychosis. They presented with irritability, physical aggression and mild cognitive impairment with intense emotional symptoms, and persecutory ideas and delusions. Two were wrongly diagnose as mania while the third was mimicking schizophrenia in its presentation. They received antipsychotic treatment and misdiagnosed as functional psychosis. They did not respond well to such treatment, until, series electroencephalograms were taken which revealed evidence of ictal psychosis. All, thence, responded well to addition of antiepileptic treatment. This, not only, proves to be effective, but also determined future management and prognosis. <strong>Conclusion: </strong>These cases shine light onto the role of the frontal cortex in the genesis of quasi-manic episodes and highlight the importance of EEG investigations in first episode of acute psychosis.
文摘Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic infammation with pontine perivascular enhancement responsive to steroids （CLIPPERS） have been reported in the current literature. The following is a case of a 29-year-old patient with a previous major depressive episode comorbid with CLIPPERS. Following glucocorticosteroid therapy, the patient switched to mania-like presentation and was diagnosed with bipolar disorder due to another medical condition. So it is strongly suggested that high-dose corticosteroid pulse therapy could easily induce psychiatric disturbances for patients with previous psychiatric symptoms, and there may be potential links between bipolar disorder and CLIPPERS in the area of infammation.
文摘Chinese companies pick up outbound mergers and acquisitions to expand into overseas markets 0verall, Chinese companies were responsible for 38 overseas M&A deals in 2009, with a combined
文摘ACPAFFC delegation headed by its vice pres- ident Li Xiaolin made a working visit to Ro- mania and France from August 31 to September 8 at the invitation of the Romania-China Friendship Association (RCFA) and
文摘Next time you're at an office[party],whip out your phone,open the App Store,and buy a title called Ocarina.Then hand the phone over to an iPhone skeptic and watch him figure it out.
