The effects of internals on liquid mixing and gas-liquid mass transfer have rarely been investigated in bubble columns,and the commonly used measurement method overestimates significantly overall gas holdup.Firstly,ga...The effects of internals on liquid mixing and gas-liquid mass transfer have rarely been investigated in bubble columns,and the commonly used measurement method overestimates significantly overall gas holdup.Firstly,gas holdup measurement method is improved by conducting multi-point liquid level measurement and using net fluid volume instead of bed volume to calculate gas holdup.Then,a stable conductivity method for liquid macromixing has been established by shielding large bubbles using#16nylon mesh.Subsequently,the influences of internal coverage(=12.6%,18.9% and 25.1%) on macroscopic fluid dynamics in a bubble column with a free wall area are systematically investigated.It is found that the presence of internals has a notable effect on macroscopic fluid dynamics.The overall gas holdup and gas-liquid volumetric mass transfer coefficient decrease,and the macromixing time decreases with the increase of internal cross-sectional area coverage.These are mainly caused by the uneven distribution of airflow due to the low resistance in the free wall area.This design makes maintenance easier,but in reality,the reactor performance has decreased.Further improvements will be made to the reactor performance based on such a configuration through flow guidance using baffles.展开更多
Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,t...Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.展开更多
BACKGROUND The concept of macroscopic on-site evaluation(MOSE)was introduced in 2015 when the endoscopist observed better diagnostic yield when the macroscopically visible core on MOSE was superior to 4 mm.Recent stud...BACKGROUND The concept of macroscopic on-site evaluation(MOSE)was introduced in 2015 when the endoscopist observed better diagnostic yield when the macroscopically visible core on MOSE was superior to 4 mm.Recent studies suggest that MOSE by the endoscopist may be an excellent alternative to rapid on-site evaluation,and some classi-fications have been published.Few studies have assessed the adequacy of histologic cores in MOSE during endoscopic ultrasound-guided fine-needle aspiration/biopsy(EUS-FNA/FNB).AIM To evaluate the performance of MOSE during EUS-FNA/FNB.METHODS This multicentric prospective study was conducted in 16 centers in 3 countries(Egypt,Iraq,and Morocco)and included 1108 patients with pancreatic,biliary,or gastrointestinal pathology who were referred for EUS examination.We prospectively analyzed the MOSE in 1008 patients with available histopathological reports according to 2 classifications to determine the adequacy of the histological core samples.Data management and analysis were performed using a Statistical Package for Social Sciences(SPSS)version 27.RESULTS A total of 1074 solid lesions were biopsied in 1008 patients with available cytopathological reports.Mean age was 59 years,and 509 patients(50.5%)were male.The mean lesion size was 38 mm.The most frequently utilized needles were FNB-Franseen(74.5%)and 22 G(93.4%),with a median of 2 passes.According to 2 classifications,618 non-bloody cores(61.3%)and 964 good samples(95.6%)were adequate for histological evaluation.The overall diagnostic yield of cytopathology was 95.5%.The cytological examination confirmed the diagnosis of malignancy in 861 patients(85.4%),while 45 samples(4.5%)were inconclusive.Post-procedural adverse events occurred in 33 patients(3.3%).Statistical analysis showed a difference between needle types(P=0.035)with a high sensitivity of FNB(97%).The analysis of the relationship between the MOSE-score and the final diagnosis showed a significant difference between the different scores of the MOSE(P<0.001).CONCLUSION MOSE is a simple method that allows endoscopists to increase needle passes to improve sample quality.There is significantly higher FNB sensitivity and cytopathology diagnostic yield with good MOSE cores.展开更多
The macroscopic fundamental diagram（ MFD） is studied to obtain the aggregate behavior of traffic in cities. This paper investigates the existence and the characteristics of different types of daily MFD for the Shang...The macroscopic fundamental diagram（ MFD） is studied to obtain the aggregate behavior of traffic in cities. This paper investigates the existence and the characteristics of different types of daily MFD for the Shanghai urban expressway network. The existence of MFD in the Shanghai urban expressway network is proved based on two weeks＇ data.Moreover, the hysteresis phenomena is present in most days and the network exhibits different hysteresis loops under different traffic situations. The relationship between the hysteresis phenomena and the inhomogeneity of traffic distribution is verified. The MFDs in the years of 2009 and 2012 are compared. The hysteresis loop still exists in 2012, which further verifies the existence of the hysteresis phenomenon. The direct relationship between the length of the hysteresis loop（ ΔO） and the congestion is proved based on sufficient data. The width of the hysteresis loop, i. e., the drop in network flow（ ΔQ） has no relationship with the congestion, and it varies from day to day under different traffic situations.展开更多
The appearance of macroscopic segregation in ZL205A alloy castings bears a super resemblance to theappearance of shrinkage porosity, and the chemical composition of the segregation is Al2Cu whose microstructure isin t...The appearance of macroscopic segregation in ZL205A alloy castings bears a super resemblance to theappearance of shrinkage porosity, and the chemical composition of the segregation is Al2Cu whose microstructure isin the form of dentrite or skeleton crystal. According to the characteristic of nebulous segregation, the formationprocess could be divided into two steps by the eutectic temperature of Al2Cu. Then a criterion for each of the twosteps is brought forward on the basis of the shrinkage porosity criterion of low pressure casting.展开更多
An industrial plant trial for optimizing the process parameters in a round billet continuous casting mold with electromagnetic stirring （M-EMS） was performed, in which the influences of stirring parameters with M-EM...An industrial plant trial for optimizing the process parameters in a round billet continuous casting mold with electromagnetic stirring （M-EMS） was performed, in which the influences of stirring parameters with M-EMS on the solidification macrostructure of high carbon steel were investigated. The results show that the billet quality is not well controlled under the condition of working current and frequency with EMS, in which the subsurface crack of grade 1.0-2.0 ups to 38.09%, the central pipe of grade 1.0-1.5 reaches to 14.28%, and the central porosity of grade 1.5 is 14.29%. The parameters of current 260 A and frequency 8 Hz as the final optimum scheme has a remarkable effect for improving the macroscopic quality of billet, in which the subsurface crack, central pipe and skin blowhole are all disappeared, and the central porosity and carbon segregation are also well improved.展开更多
Macroscopic supramolecular assembly(MSA)has been a recent progress in supramolecular chemistry.MSA mainly focuses on studies of the building blocks with a size beyond ten micrometers and the non-covalent interactions ...Macroscopic supramolecular assembly(MSA)has been a recent progress in supramolecular chemistry.MSA mainly focuses on studies of the building blocks with a size beyond ten micrometers and the non-covalent interactions between these interactive building blocks to form ordered structures.MSA is essential to realize the concept of"self-assembly at all scales"by bridging most supramolecular researches at molecular level and at macroscopic scale.This review summaries the development of MSA,the basic design principle and related strategies to achieve MSA and potential applications.Correspondingly,we try to elucidate the correlations and differences between"macroscopic assembly"and MSA based on intermolecular interactions;the design principle and the underlying assembly mechanism of MSA are proposed to understand the reported MSA behaviors;to demonstrate further applications of MSA,we introduce some methods to improve the ordered degree of the assembled structures from the point of precise assembly and thus envision some possible fields for the use of MSA.展开更多
Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and tw...Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and twodimensional graphene both possess remarkable mechanical properties. In the past years, a large amount of work have been done by using CNTs or graphene as building blocks for constructing novel, macroscopic, mechanically strong fibrous materials. In this review, we summarize the assembly approaches of CNT-based fibers and graphene-based fibers in chronological order, respectively. The mechanical performances of these fibrous materials are compared, and the critical influences on the mechanical properties are discussed. Personal perspectives on the fabrication methods of CNT-and graphene-based fibers are further presented.展开更多
A perimeter traffic signal control strategy is proposed based on the macroscopic fundamental diagram theory(MFD)to solve the signal control problem in oversaturated states.First,the MFD of a specific regional network ...A perimeter traffic signal control strategy is proposed based on the macroscopic fundamental diagram theory(MFD)to solve the signal control problem in oversaturated states.First,the MFD of a specific regional network can be derived using VSS IM simulation software.Secondly,the maximum number of cumulative vehicles that the network can accommodate is determined based on the MFD.Then,through monitoring the influx flow,the number of vehicles existing in and exiting from the network,a perimeter traffic control model is proposed to optimize the signal timing of the boundary intersections.Finally,a virtual network simulation model is established and three different kinds o f traffic demand are loaded into the network.Simulation results show that a fer the strategy implementation,the number o f vehicles accumulating in the network can be kept near the optimal value,while the number o f both entering and exiting vehicles increases significantly and the road network can be maintained at a large capacity.Simultaneously,the queue length at the approach of the border intersections is reasonably controlled and vehicles entering and exiting the network can maintain a more efficient and stable speed.The network performance indices such as the average traffic delay and average number of stops can be improved to a certain degree,thus verifying the effectiveness and feasibility of the perimeter control strategy.展开更多
In the presence of inhibitors, the macroscopical oxidation kinetics of calcium sulfite, the main byproduct in wet limestone scrubbing, was studied for the first time by adding different inhibitors and varying pH, conc...In the presence of inhibitors, the macroscopical oxidation kinetics of calcium sulfite, the main byproduct in wet limestone scrubbing, was studied for the first time by adding different inhibitors and varying pH, concentration of calcium sulfite, oxygen partial pressure, concentration of inhibitors and temperature. The mathematical model about the general oxidation reaction was established, which was controlled by three steps involving dissolution of calcium sulfite, mass transfer of oxygen and chemical reaction in the solution. It was concluded that the general reaction was controlled by mass transfer of oxygen under uncatalyzed conditions, while it was controlled by dissolution of calcium sulfite after adding three kinds of inhibitors. Thus, the theory was provided for investigating the mechanism and oxidation kinetics of sulfite. The beneficial references were also supplied for design of oxidation technics in the wet limestone scrubbing.展开更多
Recent experiments revealed many new phenomena of the macroscopic domain patterns in the stress-induced phase transformation of a superelastic polycrystalline NiTi tube during tensile loading. The new phenomena includ...Recent experiments revealed many new phenomena of the macroscopic domain patterns in the stress-induced phase transformation of a superelastic polycrystalline NiTi tube during tensile loading. The new phenomena include deformation instability with the formation of a helical domain, domain topology transition from helix to cylinder, domain-front branching and loading-path dependence of domain patterns. In this paper, we model the polycrystal as an elastic continuum with nonconvex strain energy and adopt the non-local strain gradient energy to account for the energy of the diffusive domain front. We simulate the equilibrium domain patterns and their evolution in the tubes under tensile loading by a non-local Finite Element Method （FEM）. It is revealed that the observed loading-path dependence and topology transition of do- main patterns are due to the thermodynamic metastability of the tube system. The computation also shows that the tube-wall thickness has a significant effect on the domain patterns： with fixed material properties and interfacial energy density, a large tube-wall thickness leads to a long and slim helical domain and a severe branching of the cylindrical-domain front.展开更多
Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to ...Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.展开更多
Recently,metal-based carbon materials have been verified to be an effective persulfate activator,but secondary pollution caused by metal leaching is inevitable.Hence,a green metalfree 3D macroscopic N-doped porous car...Recently,metal-based carbon materials have been verified to be an effective persulfate activator,but secondary pollution caused by metal leaching is inevitable.Hence,a green metalfree 3D macroscopic N-doped porous carbon nanosheets(NPCN)was synthesized successfully.The obtained NPCN showed high adsorption capacity of tetracycline(TC)and excellent persulfate(PS)activation ability,especially when calcined at 700℃(NPCN-700).The maximum adsorption capacity of NPCN-700 was 121.51 mg/g by H-bonds interactions.Moreover,the adsorption process followed pseudo-second-order kinetics model and Langmuir adsorption isotherm.The large specific surface area(365.27 mg/g)and hierarchical porous structure of NPCN-700 reduced the mass transfer resistance and increased the adsorption capacity.About 96.39%of TC was removed after adding PS.The effective adsorption of the catalyst greatly shortened the time for the target organic molecules to migrate to the catalyst.Moreover,the NPCN-700 demonstrated high reusability with the TC removal rate of 80.23%after 4 cycles.Quenching experiment and electron paramagnetic resonance(EPR)test confirmed the non-radical mechanism dominated by ^(1)O_(2).More importantly,the C=O groups,defects and Graphitic N acted as active sites to generate ^(1)O_(2).Correspondingly,electrochemical measurement revealed the direct electron transfer pathway of TC degradation.Finally,multiple degradation intermediates were recognized by the LC-MS measurement and three possible degradation pathways were proposed.Overall,the prepared NPCN had excellent application prospects for removal of antibiotics due to its remarkable adsorption and catalytic degradation capabilities.展开更多
AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological sta...AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer.展开更多
Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)is an excellent investigation to diagnose pancreatic lesions and has shown high accuracy for its use in pathologic diagnosis.Recently,macroscopic on-site evaluat...Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)is an excellent investigation to diagnose pancreatic lesions and has shown high accuracy for its use in pathologic diagnosis.Recently,macroscopic on-site evaluation(MOSE)performed by an endoscopist was introduced as an alternative to rapid on-site cytologic evaluation to increase the diagnostic yield of EUS-FNB.The MOSE of the biopsy can estimate the adequacy of the sample directly by the macroscopic evaluation of the core tissue obtained from EUS-FNB.Isolated pancreatic tuberculosis is extremely rare and difficult to diagnose because of its non-specific signs and symptoms.Therefore,this challenging diagnosis is based on endoscopy,imaging,and the bacteriological and histological examination of tissue biopsies.This uncommon presentation of tuberculosis can be revealed as pancreatic mass mimicking cancer.EUS-FNB can be very useful in providing a valuable histopathological diagnosis.A calcified lesion with a cheesy core in MOSE must be suggestive of tuberculosis,leading to the request of the GeneXpert,which can detect Mycobacterium tuberculosis deoxyribonucleic acid and resistance to rifampicin.A decent diagnostic strategy is crucial to prevent unnecessary surgical resection and to supply conservative management with antitubercular therapy.展开更多
The evolution of gas bearing channels in the roof,and their spatial distribution,was studied.A complete consideration of gas flow changes through the stress-strain changes in the roof near a working face is made.The t...The evolution of gas bearing channels in the roof,and their spatial distribution,was studied.A complete consideration of gas flow changes through the stress-strain changes in the roof near a working face is made.The theoretical abutment pressure distribution using displacement monitors and borehole visual recording instruments allow a theoretical analysis.Field test research determined the conditions for formation of macroscopic gas channels.These appear along the working face roof,normally distributed to it.These results show that the coal rock stratification becomes a macroscopic gas channel boundary if its deformation is less than the lower layer,or greater than the layer above it.At the same time the stability is greater than the distance from the roof for hanging dew conditions.The working face advances and the roof gas channels experience a cycle of development.Microscopic channels dominate the initial stage then macroscopic gas channels form,develop,and close.The evolution of the macroscopic channels depends on the ratio between the distances from the new compaction area in the goaf to the initial stress area in front of the working face.The amount of daily advance of the face also affects channel development.The experimental observations in one mining area showed that the main gas channels are located about 2 and 6.2 m above the lower surface of the roof and that they have an evolution period 7 to 11 days long.展开更多
We have observed the macroscopic resonant tunneling of magnetic flux between macroscopically distinct quantum states in a superconducting flux qubit. The dependences of the macroscopic resonant tunneling on the barrie...We have observed the macroscopic resonant tunneling of magnetic flux between macroscopically distinct quantum states in a superconducting flux qubit. The dependences of the macroscopic resonant tunneling on the barrier height of the potential well, the flux bias and the initial state are investigated. Detailed measurements of the tunneling rate as a function of the flux bias reveal the feature of the quantum noise in the superconducting flux qubit.展开更多
A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new ma...A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new macroscopic traffic flow model based on the transition velocity distribution is proposed which characterizes traffic alignment under adverse weather conditions. Two examples are considered to illustrate the effect of the transition velocity behavior on traffic velocity and density. Simulation results are presented which show that this model provides a more accurate characterization of traffic flow behavior than the well known Payne-Whitham model. The proposed model can be used to reduce accidents and improve road safety during adverse weather conditions.展开更多
Hydrophobic interactions have been studied before in detail based on hydrophobic polymers,such as polystyrene(PS).Because fluorinated materials have relatively low surface energy,they often show both oleophobicity and...Hydrophobic interactions have been studied before in detail based on hydrophobic polymers,such as polystyrene(PS).Because fluorinated materials have relatively low surface energy,they often show both oleophobicity and hydrophobicity at the macroscopic level.However,it remains unknown how fluorination of hydrophobic polymer influences hydrophobicity at the microscopic level.We synthesized PS and fluorine-substituted PS(FPS)by employing the reversible addition-fragmentation chain transfer polymerization method.Contact angle measurements confirmed that FPS is more hydrophobic than PS at the macroscopic level due to the introduction of fluorine.However,single molecule force spectroscopy experiments showed that the forces required to unfold the PS and FPS nanoparticles in water are indistinguishable,indicating that the strength of the hydrophobic effect that drives the self-assembly of PS and FPS nanoparticles is the same at the microscopic level.The divergence of hydrophobic effect at the macroscopic and microscopic level may hint different underlying mechanisms:the hydrophobicity is dominated by the solvent hydration at the microscopic level and the surface-associated interaction at the macroscopic level.展开更多
We study the tunnelling dynamics of superfluid Fermi gases trapped in multi-well system along the BEC-BCS crossover. Within the hydrodynamical model and by using the multi-mode approximation, the self-trapping dynamic...We study the tunnelling dynamics of superfluid Fermi gases trapped in multi-well system along the BEC-BCS crossover. Within the hydrodynamical model and by using the multi-mode approximation, the self-trapping dynamics of superfluid Fermi gases in multi-well system are obtained numerically. We find that the self-trapping to diffusion transition strongly depends on the well number. When the well number is less than three, the self-trapped state takes place easier on the BEC side than that on the BCS side. However, when the well number is larger than three, the self-trapped state takes place easier on the BCS side instead of the BEC side. Furthermore, by considering a superfluid of 40K atoms, we obtain the zero-mode and π-mode Josephson frequencies of coherent atomic oscillations in double-well system. It is noteworthy that the Josephson mode, especially, the existence of π-mode frequency strongly depends on the atoms number on the BCS side.展开更多
基金National Natural Science Foundation of China(22178228,22378271)are gratefully acknowledged。
文摘The effects of internals on liquid mixing and gas-liquid mass transfer have rarely been investigated in bubble columns,and the commonly used measurement method overestimates significantly overall gas holdup.Firstly,gas holdup measurement method is improved by conducting multi-point liquid level measurement and using net fluid volume instead of bed volume to calculate gas holdup.Then,a stable conductivity method for liquid macromixing has been established by shielding large bubbles using#16nylon mesh.Subsequently,the influences of internal coverage(=12.6%,18.9% and 25.1%) on macroscopic fluid dynamics in a bubble column with a free wall area are systematically investigated.It is found that the presence of internals has a notable effect on macroscopic fluid dynamics.The overall gas holdup and gas-liquid volumetric mass transfer coefficient decrease,and the macromixing time decreases with the increase of internal cross-sectional area coverage.These are mainly caused by the uneven distribution of airflow due to the low resistance in the free wall area.This design makes maintenance easier,but in reality,the reactor performance has decreased.Further improvements will be made to the reactor performance based on such a configuration through flow guidance using baffles.
基金supported by the China Scholarship Council (CSC) (No.202206020149)the Academic Excellence Foundation of BUAA for PhD Students,the Funding Project of Science and Technology on Reliability and Environmental Engineering Laboratory (No.6142004210106).
文摘Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional properties.However,the material reliability is significantly affected by various microscopic defects.In this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and quantified.Molecular dynamics(MD)simulations are employed to observe the failure evolution of different microscopic defects.The dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation motion.At the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain points.The impact of defect types on the failure process is also discussed.Furthermore,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale model.The validity of the crack propagation model is confirmed through tensile tests.Finally,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD model.Our findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.
文摘BACKGROUND The concept of macroscopic on-site evaluation(MOSE)was introduced in 2015 when the endoscopist observed better diagnostic yield when the macroscopically visible core on MOSE was superior to 4 mm.Recent studies suggest that MOSE by the endoscopist may be an excellent alternative to rapid on-site evaluation,and some classi-fications have been published.Few studies have assessed the adequacy of histologic cores in MOSE during endoscopic ultrasound-guided fine-needle aspiration/biopsy(EUS-FNA/FNB).AIM To evaluate the performance of MOSE during EUS-FNA/FNB.METHODS This multicentric prospective study was conducted in 16 centers in 3 countries(Egypt,Iraq,and Morocco)and included 1108 patients with pancreatic,biliary,or gastrointestinal pathology who were referred for EUS examination.We prospectively analyzed the MOSE in 1008 patients with available histopathological reports according to 2 classifications to determine the adequacy of the histological core samples.Data management and analysis were performed using a Statistical Package for Social Sciences(SPSS)version 27.RESULTS A total of 1074 solid lesions were biopsied in 1008 patients with available cytopathological reports.Mean age was 59 years,and 509 patients(50.5%)were male.The mean lesion size was 38 mm.The most frequently utilized needles were FNB-Franseen(74.5%)and 22 G(93.4%),with a median of 2 passes.According to 2 classifications,618 non-bloody cores(61.3%)and 964 good samples(95.6%)were adequate for histological evaluation.The overall diagnostic yield of cytopathology was 95.5%.The cytological examination confirmed the diagnosis of malignancy in 861 patients(85.4%),while 45 samples(4.5%)were inconclusive.Post-procedural adverse events occurred in 33 patients(3.3%).Statistical analysis showed a difference between needle types(P=0.035)with a high sensitivity of FNB(97%).The analysis of the relationship between the MOSE-score and the final diagnosis showed a significant difference between the different scores of the MOSE(P<0.001).CONCLUSION MOSE is a simple method that allows endoscopists to increase needle passes to improve sample quality.There is significantly higher FNB sensitivity and cytopathology diagnostic yield with good MOSE cores.
基金The National Natural Science Foundation of China(No.51238008)
文摘The macroscopic fundamental diagram（ MFD） is studied to obtain the aggregate behavior of traffic in cities. This paper investigates the existence and the characteristics of different types of daily MFD for the Shanghai urban expressway network. The existence of MFD in the Shanghai urban expressway network is proved based on two weeks＇ data.Moreover, the hysteresis phenomena is present in most days and the network exhibits different hysteresis loops under different traffic situations. The relationship between the hysteresis phenomena and the inhomogeneity of traffic distribution is verified. The MFDs in the years of 2009 and 2012 are compared. The hysteresis loop still exists in 2012, which further verifies the existence of the hysteresis phenomenon. The direct relationship between the length of the hysteresis loop（ ΔO） and the congestion is proved based on sufficient data. The width of the hysteresis loop, i. e., the drop in network flow（ ΔQ） has no relationship with the congestion, and it varies from day to day under different traffic situations.
文摘The appearance of macroscopic segregation in ZL205A alloy castings bears a super resemblance to theappearance of shrinkage porosity, and the chemical composition of the segregation is Al2Cu whose microstructure isin the form of dentrite or skeleton crystal. According to the characteristic of nebulous segregation, the formationprocess could be divided into two steps by the eutectic temperature of Al2Cu. Then a criterion for each of the twosteps is brought forward on the basis of the shrinkage porosity criterion of low pressure casting.
基金supported by the Program for New Century Excellent Talents in University from the Ministry of Education of China (No.NCET-04-0285)
文摘An industrial plant trial for optimizing the process parameters in a round billet continuous casting mold with electromagnetic stirring （M-EMS） was performed, in which the influences of stirring parameters with M-EMS on the solidification macrostructure of high carbon steel were investigated. The results show that the billet quality is not well controlled under the condition of working current and frequency with EMS, in which the subsurface crack of grade 1.0-2.0 ups to 38.09%, the central pipe of grade 1.0-1.5 reaches to 14.28%, and the central porosity of grade 1.5 is 14.29%. The parameters of current 260 A and frequency 8 Hz as the final optimum scheme has a remarkable effect for improving the macroscopic quality of billet, in which the subsurface crack, central pipe and skin blowhole are all disappeared, and the central porosity and carbon segregation are also well improved.
文摘Macroscopic supramolecular assembly(MSA)has been a recent progress in supramolecular chemistry.MSA mainly focuses on studies of the building blocks with a size beyond ten micrometers and the non-covalent interactions between these interactive building blocks to form ordered structures.MSA is essential to realize the concept of"self-assembly at all scales"by bridging most supramolecular researches at molecular level and at macroscopic scale.This review summaries the development of MSA,the basic design principle and related strategies to achieve MSA and potential applications.Correspondingly,we try to elucidate the correlations and differences between"macroscopic assembly"and MSA based on intermolecular interactions;the design principle and the underlying assembly mechanism of MSA are proposed to understand the reported MSA behaviors;to demonstrate further applications of MSA,we introduce some methods to improve the ordered degree of the assembled structures from the point of precise assembly and thus envision some possible fields for the use of MSA.
基金supported by the National Natural Science Foundation of China (Nos. 21325417, 51533008)the MOST National Key Research and Development Plan (2016YFA0200200)+1 种基金the National Postdoctoral Program for Innovative Talents (No. BX201700209)the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University (No. LK1403)
文摘Nanocarbon-based materials, such as carbon nanotubes(CNTs) and graphene have been attached much attention by scientific and industrial community. As two representative nanocarbon materials, one-dimensional CNTs and twodimensional graphene both possess remarkable mechanical properties. In the past years, a large amount of work have been done by using CNTs or graphene as building blocks for constructing novel, macroscopic, mechanically strong fibrous materials. In this review, we summarize the assembly approaches of CNT-based fibers and graphene-based fibers in chronological order, respectively. The mechanical performances of these fibrous materials are compared, and the critical influences on the mechanical properties are discussed. Personal perspectives on the fabrication methods of CNT-and graphene-based fibers are further presented.
基金The National Natural Science Foundation of China(No.51308227)the Fundamental Research Funds for the Central Universities(No.201522087)+1 种基金the Science and Technology Planning Project of Guangdong Province(No.2016A030305001)the Project of Department of Communications of Guangdong Province(No.2015-02-070)
文摘A perimeter traffic signal control strategy is proposed based on the macroscopic fundamental diagram theory(MFD)to solve the signal control problem in oversaturated states.First,the MFD of a specific regional network can be derived using VSS IM simulation software.Secondly,the maximum number of cumulative vehicles that the network can accommodate is determined based on the MFD.Then,through monitoring the influx flow,the number of vehicles existing in and exiting from the network,a perimeter traffic control model is proposed to optimize the signal timing of the boundary intersections.Finally,a virtual network simulation model is established and three different kinds o f traffic demand are loaded into the network.Simulation results show that a fer the strategy implementation,the number o f vehicles accumulating in the network can be kept near the optimal value,while the number o f both entering and exiting vehicles increases significantly and the road network can be maintained at a large capacity.Simultaneously,the queue length at the approach of the border intersections is reasonably controlled and vehicles entering and exiting the network can maintain a more efficient and stable speed.The network performance indices such as the average traffic delay and average number of stops can be improved to a certain degree,thus verifying the effectiveness and feasibility of the perimeter control strategy.
基金The National Basic Research Program(973) of China(No. JK00020)
文摘In the presence of inhibitors, the macroscopical oxidation kinetics of calcium sulfite, the main byproduct in wet limestone scrubbing, was studied for the first time by adding different inhibitors and varying pH, concentration of calcium sulfite, oxygen partial pressure, concentration of inhibitors and temperature. The mathematical model about the general oxidation reaction was established, which was controlled by three steps involving dissolution of calcium sulfite, mass transfer of oxygen and chemical reaction in the solution. It was concluded that the general reaction was controlled by mass transfer of oxygen under uncatalyzed conditions, while it was controlled by dissolution of calcium sulfite after adding three kinds of inhibitors. Thus, the theory was provided for investigating the mechanism and oxidation kinetics of sulfite. The beneficial references were also supplied for design of oxidation technics in the wet limestone scrubbing.
文摘Recent experiments revealed many new phenomena of the macroscopic domain patterns in the stress-induced phase transformation of a superelastic polycrystalline NiTi tube during tensile loading. The new phenomena include deformation instability with the formation of a helical domain, domain topology transition from helix to cylinder, domain-front branching and loading-path dependence of domain patterns. In this paper, we model the polycrystal as an elastic continuum with nonconvex strain energy and adopt the non-local strain gradient energy to account for the energy of the diffusive domain front. We simulate the equilibrium domain patterns and their evolution in the tubes under tensile loading by a non-local Finite Element Method （FEM）. It is revealed that the observed loading-path dependence and topology transition of do- main patterns are due to the thermodynamic metastability of the tube system. The computation also shows that the tube-wall thickness has a significant effect on the domain patterns： with fixed material properties and interfacial energy density, a large tube-wall thickness leads to a long and slim helical domain and a severe branching of the cylindrical-domain front.
文摘Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.
基金supported by the Major special projects of Science and Technology Department of Sichuan Province(No.2020ZDZX0020)the Key R&D projects of Sichuan Science and Technology Department(No.2019YFG0056)。
文摘Recently,metal-based carbon materials have been verified to be an effective persulfate activator,but secondary pollution caused by metal leaching is inevitable.Hence,a green metalfree 3D macroscopic N-doped porous carbon nanosheets(NPCN)was synthesized successfully.The obtained NPCN showed high adsorption capacity of tetracycline(TC)and excellent persulfate(PS)activation ability,especially when calcined at 700℃(NPCN-700).The maximum adsorption capacity of NPCN-700 was 121.51 mg/g by H-bonds interactions.Moreover,the adsorption process followed pseudo-second-order kinetics model and Langmuir adsorption isotherm.The large specific surface area(365.27 mg/g)and hierarchical porous structure of NPCN-700 reduced the mass transfer resistance and increased the adsorption capacity.About 96.39%of TC was removed after adding PS.The effective adsorption of the catalyst greatly shortened the time for the target organic molecules to migrate to the catalyst.Moreover,the NPCN-700 demonstrated high reusability with the TC removal rate of 80.23%after 4 cycles.Quenching experiment and electron paramagnetic resonance(EPR)test confirmed the non-radical mechanism dominated by ^(1)O_(2).More importantly,the C=O groups,defects and Graphitic N acted as active sites to generate ^(1)O_(2).Correspondingly,electrochemical measurement revealed the direct electron transfer pathway of TC degradation.Finally,multiple degradation intermediates were recognized by the LC-MS measurement and three possible degradation pathways were proposed.Overall,the prepared NPCN had excellent application prospects for removal of antibiotics due to its remarkable adsorption and catalytic degradation capabilities.
文摘AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer.
文摘Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)is an excellent investigation to diagnose pancreatic lesions and has shown high accuracy for its use in pathologic diagnosis.Recently,macroscopic on-site evaluation(MOSE)performed by an endoscopist was introduced as an alternative to rapid on-site cytologic evaluation to increase the diagnostic yield of EUS-FNB.The MOSE of the biopsy can estimate the adequacy of the sample directly by the macroscopic evaluation of the core tissue obtained from EUS-FNB.Isolated pancreatic tuberculosis is extremely rare and difficult to diagnose because of its non-specific signs and symptoms.Therefore,this challenging diagnosis is based on endoscopy,imaging,and the bacteriological and histological examination of tissue biopsies.This uncommon presentation of tuberculosis can be revealed as pancreatic mass mimicking cancer.EUS-FNB can be very useful in providing a valuable histopathological diagnosis.A calcified lesion with a cheesy core in MOSE must be suggestive of tuberculosis,leading to the request of the GeneXpert,which can detect Mycobacterium tuberculosis deoxyribonucleic acid and resistance to rifampicin.A decent diagnostic strategy is crucial to prevent unnecessary surgical resection and to supply conservative management with antitubercular therapy.
基金provided by the State Key BasicResearch Program of China(No.2011CB201204)the National Natural Science Foundation of China(Nos.51204187 and 51234005)
文摘The evolution of gas bearing channels in the roof,and their spatial distribution,was studied.A complete consideration of gas flow changes through the stress-strain changes in the roof near a working face is made.The theoretical abutment pressure distribution using displacement monitors and borehole visual recording instruments allow a theoretical analysis.Field test research determined the conditions for formation of macroscopic gas channels.These appear along the working face roof,normally distributed to it.These results show that the coal rock stratification becomes a macroscopic gas channel boundary if its deformation is less than the lower layer,or greater than the layer above it.At the same time the stability is greater than the distance from the roof for hanging dew conditions.The working face advances and the roof gas channels experience a cycle of development.Microscopic channels dominate the initial stage then macroscopic gas channels form,develop,and close.The evolution of the macroscopic channels depends on the ratio between the distances from the new compaction area in the goaf to the initial stress area in front of the working face.The amount of daily advance of the face also affects channel development.The experimental observations in one mining area showed that the main gas channels are located about 2 and 6.2 m above the lower surface of the roof and that they have an evolution period 7 to 11 days long.
基金Project supported by the New Century Excellent Talents in University,Chinathe National Natural Science Foundation of China(Grant Nos. 11074114 and 10874074)the National Basic Research Program of China (Grant No. 2011CBA00200)
文摘We have observed the macroscopic resonant tunneling of magnetic flux between macroscopically distinct quantum states in a superconducting flux qubit. The dependences of the macroscopic resonant tunneling on the barrier height of the potential well, the flux bias and the initial state are investigated. Detailed measurements of the tunneling rate as a function of the flux bias reveal the feature of the quantum noise in the superconducting flux qubit.
基金Project supported by Higher Education Commission,Pakistan/National Center of Big Data and Cloud Computing
文摘A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new macroscopic traffic flow model based on the transition velocity distribution is proposed which characterizes traffic alignment under adverse weather conditions. Two examples are considered to illustrate the effect of the transition velocity behavior on traffic velocity and density. Simulation results are presented which show that this model provides a more accurate characterization of traffic flow behavior than the well known Payne-Whitham model. The proposed model can be used to reduce accidents and improve road safety during adverse weather conditions.
基金supported by the National Key R&D Program of China(Grant No.2020YFA0908100)。
文摘Hydrophobic interactions have been studied before in detail based on hydrophobic polymers,such as polystyrene(PS).Because fluorinated materials have relatively low surface energy,they often show both oleophobicity and hydrophobicity at the macroscopic level.However,it remains unknown how fluorination of hydrophobic polymer influences hydrophobicity at the microscopic level.We synthesized PS and fluorine-substituted PS(FPS)by employing the reversible addition-fragmentation chain transfer polymerization method.Contact angle measurements confirmed that FPS is more hydrophobic than PS at the macroscopic level due to the introduction of fluorine.However,single molecule force spectroscopy experiments showed that the forces required to unfold the PS and FPS nanoparticles in water are indistinguishable,indicating that the strength of the hydrophobic effect that drives the self-assembly of PS and FPS nanoparticles is the same at the microscopic level.The divergence of hydrophobic effect at the macroscopic and microscopic level may hint different underlying mechanisms:the hydrophobicity is dominated by the solvent hydration at the microscopic level and the surface-associated interaction at the macroscopic level.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10975114 and 10774120the Natural Science Foundation of Gansu Province of China under Grant No. 1010RJZA012+1 种基金the Natural Science Foundation of Northwest Normal University of China under Grant No. NWNU-KJCXGC-03-48the Youthy Teacher Scientific Research Foundation of Northwest Normal University of China under Grant No. NWNU-LKQN-09-10
文摘We study the tunnelling dynamics of superfluid Fermi gases trapped in multi-well system along the BEC-BCS crossover. Within the hydrodynamical model and by using the multi-mode approximation, the self-trapping dynamics of superfluid Fermi gases in multi-well system are obtained numerically. We find that the self-trapping to diffusion transition strongly depends on the well number. When the well number is less than three, the self-trapped state takes place easier on the BEC side than that on the BCS side. However, when the well number is larger than three, the self-trapped state takes place easier on the BCS side instead of the BEC side. Furthermore, by considering a superfluid of 40K atoms, we obtain the zero-mode and π-mode Josephson frequencies of coherent atomic oscillations in double-well system. It is noteworthy that the Josephson mode, especially, the existence of π-mode frequency strongly depends on the atoms number on the BCS side.
