Modelling based on multi-agent system （MAS） was built for the current production management and process of Shenyang Songyang Paper Cup Co., Ltd. It can transmit the information instantly via order agent （OA）, mana...Modelling based on multi-agent system （MAS） was built for the current production management and process of Shenyang Songyang Paper Cup Co., Ltd. It can transmit the information instantly via order agent （OA）, manager agent （MA）, production agent （PA）, and service agent （SA）, and realize information sharing. The PA is also built on MAS, and it includes two agents, task agent （TA）, and resource agent （RA）. It has been found that the modelling is superior to the old one. It can improve the working flow and production efficiency, and shorten the time of delivery.展开更多
为探究考虑心理因素影响下我国城市潜在MaaS(Mobility as a Service)用户的套餐选择行为与支付意愿的影响因素,综合考虑了受访者个人属性、心理属性与套餐属性3个方面,分别在北京和大连开展了RP与SP调查。在此基础上,构建了结构方程模...为探究考虑心理因素影响下我国城市潜在MaaS(Mobility as a Service)用户的套餐选择行为与支付意愿的影响因素,综合考虑了受访者个人属性、心理属性与套餐属性3个方面,分别在北京和大连开展了RP与SP调查。在此基础上,构建了结构方程模型和离散选择模型,对受访者的MaaS套餐选择行为和支付意愿进行了定性与定量研究。研究结果显示:个人属性方面,北京样本中男性和收入为1万~2万元对MaaS套餐选择行为有显著正面影响;本科教育水平和家中儿童数为2个及以上有显著负面影响;大连样本中本科及以上教育水平、家中老人数为2个及以上、收入2万元及以上、工作有弹性等因素对MaaS套餐选择行为有显著正面影响;年龄在36~60岁、家中有私家车、家中有儿童等因素有显著负面影响。心理属性方面,行为态度对MaaS套餐选择行为具有显著影响,其中北京受访者表现尤为明显;套餐属性方面,套餐价格、公共交通次数及共享单车次数对MaaS套餐选择行为均有显著影响。支付意愿方面,北京和大连受访者对出租车和网约车支付意愿均最高,每增加一公里出租车或网约车均愿为套餐多花费1元。研究结果可为我国未来MaaS套餐的设计与推广提供理论支撑。展开更多
We previously found that the K141N mutation in heat shock protein B8 （HSPB8） was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a tr...We previously found that the K141N mutation in heat shock protein B8 （HSPB8） was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene, and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L, and consequently be suitable for use in studies of disease pathogenesis. Transgenic mice overexpressing K141N HSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system. PCR and western blot analysis confirmed integration of the KI41NHSPB8 gene and widespread expression in tissues of the transgenic mice. The K141N HSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination, but no obvious sensory disturbance at 6 months of age by behavioral assessment. Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased, but motor nerve conduction velocity remained normal at 6 months of age. Pathological analysis of the sciatic nerve showed reduced myelinated fiber density, notable axonal edema and vacuolar degeneration in K141N HSPB8 transgenic mice, suggesting axonal involvement in the peripheral nerve damage in these animals. These findings indicate that the KI4mHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease.展开更多
通过仿真实验进行演示、检验和评估,是研究信息化战场火力与指挥控制的有效方法。通过采用基于M A S的仿真方法,把火力战系统的内部组元直接映射成相应的A gen t,研究了基于M A S的火力战仿真建模过程,提出了基于M A S建模的火力战系统...通过仿真实验进行演示、检验和评估,是研究信息化战场火力与指挥控制的有效方法。通过采用基于M A S的仿真方法,把火力战系统的内部组元直接映射成相应的A gen t,研究了基于M A S的火力战仿真建模过程,提出了基于M A S建模的火力战系统总体框架与工作过程,并进一步研究了火力战A gen t的定义与工作原理,为未来信息化战场火力战相关项目技术演示提供平台基础。展开更多
文摘Modelling based on multi-agent system （MAS） was built for the current production management and process of Shenyang Songyang Paper Cup Co., Ltd. It can transmit the information instantly via order agent （OA）, manager agent （MA）, production agent （PA）, and service agent （SA）, and realize information sharing. The PA is also built on MAS, and it includes two agents, task agent （TA）, and resource agent （RA）. It has been found that the modelling is superior to the old one. It can improve the working flow and production efficiency, and shorten the time of delivery.
文摘为探究考虑心理因素影响下我国城市潜在MaaS(Mobility as a Service)用户的套餐选择行为与支付意愿的影响因素,综合考虑了受访者个人属性、心理属性与套餐属性3个方面,分别在北京和大连开展了RP与SP调查。在此基础上,构建了结构方程模型和离散选择模型,对受访者的MaaS套餐选择行为和支付意愿进行了定性与定量研究。研究结果显示:个人属性方面,北京样本中男性和收入为1万~2万元对MaaS套餐选择行为有显著正面影响;本科教育水平和家中儿童数为2个及以上有显著负面影响;大连样本中本科及以上教育水平、家中老人数为2个及以上、收入2万元及以上、工作有弹性等因素对MaaS套餐选择行为有显著正面影响;年龄在36~60岁、家中有私家车、家中有儿童等因素有显著负面影响。心理属性方面,行为态度对MaaS套餐选择行为具有显著影响,其中北京受访者表现尤为明显;套餐属性方面,套餐价格、公共交通次数及共享单车次数对MaaS套餐选择行为均有显著影响。支付意愿方面,北京和大连受访者对出租车和网约车支付意愿均最高,每增加一公里出租车或网约车均愿为套餐多花费1元。研究结果可为我国未来MaaS套餐的设计与推广提供理论支撑。
基金funded by the National Natural Science Foundation of China,No.81071001,30900805
文摘We previously found that the K141N mutation in heat shock protein B8 （HSPB8） was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene, and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L, and consequently be suitable for use in studies of disease pathogenesis. Transgenic mice overexpressing K141N HSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system. PCR and western blot analysis confirmed integration of the KI41NHSPB8 gene and widespread expression in tissues of the transgenic mice. The K141N HSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination, but no obvious sensory disturbance at 6 months of age by behavioral assessment. Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased, but motor nerve conduction velocity remained normal at 6 months of age. Pathological analysis of the sciatic nerve showed reduced myelinated fiber density, notable axonal edema and vacuolar degeneration in K141N HSPB8 transgenic mice, suggesting axonal involvement in the peripheral nerve damage in these animals. These findings indicate that the KI4mHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease.
文摘通过仿真实验进行演示、检验和评估,是研究信息化战场火力与指挥控制的有效方法。通过采用基于M A S的仿真方法,把火力战系统的内部组元直接映射成相应的A gen t,研究了基于M A S的火力战仿真建模过程,提出了基于M A S建模的火力战系统总体框架与工作过程,并进一步研究了火力战A gen t的定义与工作原理,为未来信息化战场火力战相关项目技术演示提供平台基础。
