Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China pa...Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China participated in this study.Their symptoms were investigated with the MDASI-C from November 2020 to February 2021,and the reliability and validity of this tool were evaluated,respectively.Cluster analysis and correlation analysis were also performed.Results The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880,respectively.Construct validity revealed a four-factor structure.The Kaiser—Meyer—Olkin value was 0.760.The Karnofsky Performance Status,treatment phase,and cancer stage of the patients were grouped,and the differences of scores within the groups were significant.In addition,the employment status,education level,and age of the patients were significantly correlated with the symptoms.The correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was increased.The top three symptoms were disturbed sleep(3.10±2.52),difficulty remembering(2.54±2.30),and fatigue(2.24±2.13).The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many symptoms.As the patients’BMI increased,the patients’pain,disturbed sleep,and difficulty remembering were aggravated,and numbness was alleviated.Conclusion The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in China.The symptoms are related to many clinical and biochemical indicators.展开更多
目的调查并分析晚期癌症患者年龄、性别因素对症状发生率及强度的影响。方法采用M.D安德森症状评估量表中文版(The Chinese version of the M.D Anderson Symptom Inventory,MDASI-C)对250例晚期癌症住院患者进行调查。使用Logistic回...目的调查并分析晚期癌症患者年龄、性别因素对症状发生率及强度的影响。方法采用M.D安德森症状评估量表中文版(The Chinese version of the M.D Anderson Symptom Inventory,MDASI-C)对250例晚期癌症住院患者进行调查。使用Logistic回归分析对症状进行检验以确定年龄、性别因素与症状发生率的关系,不同年龄及性别组间的症状强度比较先进行t检验再接受Bonferroni修正。结果疼痛、乏力及胃口差是最常见的症状。低龄组报告有更严重的疼痛、苦恼及悲伤感,以及更轻的健忘与更好的胃口(P<0.05);女性则有更严重的恶心症状(P=0.01)。Logistic回归分析显示低龄组发生悲伤感、苦恼、呕吐、疼痛、胃口差、恶心、睡眠不好的风险更高;男性在悲伤感、苦恼、睡眠不安以及胃口差上有更高的发生风险。结论晚期癌症患者在症状发生率及强度上存在着年龄与性别的差异,对其认识有助于理解症状的病理生理学特征及促进更加个体化的姑息治疗。展开更多
基金This work was supported by the National Natural Science Foundation of China(No.81672977).
文摘Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China participated in this study.Their symptoms were investigated with the MDASI-C from November 2020 to February 2021,and the reliability and validity of this tool were evaluated,respectively.Cluster analysis and correlation analysis were also performed.Results The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880,respectively.Construct validity revealed a four-factor structure.The Kaiser—Meyer—Olkin value was 0.760.The Karnofsky Performance Status,treatment phase,and cancer stage of the patients were grouped,and the differences of scores within the groups were significant.In addition,the employment status,education level,and age of the patients were significantly correlated with the symptoms.The correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was increased.The top three symptoms were disturbed sleep(3.10±2.52),difficulty remembering(2.54±2.30),and fatigue(2.24±2.13).The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many symptoms.As the patients’BMI increased,the patients’pain,disturbed sleep,and difficulty remembering were aggravated,and numbness was alleviated.Conclusion The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in China.The symptoms are related to many clinical and biochemical indicators.
文摘目的调查并分析晚期癌症患者年龄、性别因素对症状发生率及强度的影响。方法采用M.D安德森症状评估量表中文版(The Chinese version of the M.D Anderson Symptom Inventory,MDASI-C)对250例晚期癌症住院患者进行调查。使用Logistic回归分析对症状进行检验以确定年龄、性别因素与症状发生率的关系,不同年龄及性别组间的症状强度比较先进行t检验再接受Bonferroni修正。结果疼痛、乏力及胃口差是最常见的症状。低龄组报告有更严重的疼痛、苦恼及悲伤感,以及更轻的健忘与更好的胃口(P<0.05);女性则有更严重的恶心症状(P=0.01)。Logistic回归分析显示低龄组发生悲伤感、苦恼、呕吐、疼痛、胃口差、恶心、睡眠不好的风险更高;男性在悲伤感、苦恼、睡眠不安以及胃口差上有更高的发生风险。结论晚期癌症患者在症状发生率及强度上存在着年龄与性别的差异,对其认识有助于理解症状的病理生理学特征及促进更加个体化的姑息治疗。
