Chinese American literature hasn＇t developed into a visible power until 1970＇s in the American literary world. David Henry Hwang is a dazzling star among Chinese-American writers. He is the first to perform his own ...Chinese American literature hasn＇t developed into a visible power until 1970＇s in the American literary world. David Henry Hwang is a dazzling star among Chinese-American writers. He is the first to perform his own works on Broadway as well as the first to get Tony Award. He is the most successful and reputable Asian American playwright in the history of American Drama. Hwang＇s masterpiece M. Butterfly inverts orientalism＇s constructing the relationship between the east and the west, subverts stereotypes of the oriental in the westerners＇ eyes, and cries out a distinctive voice of＂the other＂ to western hegemony culture. However~ as a Chinese-American writer of the second generation that receives white mainstream cultural education, Hwang＇s deconstructing the orientalism and subverting the fixed relationship between the east and west has its imperfection, which results from social and historical environment the author lives in, personal experiences as well as national culture identity. In addition, Hwang＇s M.Butterfly aims at appealing for the eastern and western cultures＇ learning from each other, communicating with each other in order to achieve the goal of cultural co-prosperity with a broader mind in a harmonious atmosphere.展开更多
[Abstrac]Through the analysis of both Madama Butterfly and M. Butterfly,this paper expores the gaze of the Occidental upon the Oriental especially the women. It analyzes the change of the Occi-dental gaze and gets the...[Abstrac]Through the analysis of both Madama Butterfly and M. Butterfly,this paper expores the gaze of the Occidental upon the Oriental especially the women. It analyzes the change of the Occi-dental gaze and gets the result that the misconception of the Oriental and its culture might form a big mockery to the Orientalism.展开更多
The wing of a butterfly consists of partially overlapping forewing and hindwing,and forewing sweeping can dynamically change the shape of the whole wing.In this work,the effect of forewing sweeping on aerodynamic perf...The wing of a butterfly consists of partially overlapping forewing and hindwing,and forewing sweeping can dynamically change the shape of the whole wing.In this work,the effect of forewing sweeping on aerodynamic performance of a butterfly like model is studied using a solver based on immersed boundary method and adaptive mesh.For aerodynamic performance,adding a"forward-backward-forward"sweeping motion to the forewing makes it more suitable for fast cruising flight,and compared to the situation without forewing sweeping,the drag is reduced by 46%and the lift to drag ratio is increased by 45%.On the contrary,adding a"backward-for ward-backward"sweeping motion to the forewing increases lift and makes it more suitable for climb flight.For downstroke and middle to late upstroke,the forewing sweeping affects the Leading-Edge Vortex(LEV)through two factors:sweeping velocity and forward sweeping angle,and their effects are coupled.A large forward sweeping velocity can enhance the strength of LEV,while a large forward sweeping angle can weaken it.For early upstroke,the forewing sweeping can affect the wake capture mechanism,sweeping backward can enhance it while sweeping forward can weaken it.The findings in this work provide insight into the design of butterfly like Micro AirVehicles(MAVs).展开更多
With the advancement of modern technology and the continuous development of science,research into flapping wing aircraft is becoming increasingly sophisticated.Addressing issues such as the large wingspan and heavy ma...With the advancement of modern technology and the continuous development of science,research into flapping wing aircraft is becoming increasingly sophisticated.Addressing issues such as the large wingspan and heavy mass of existing bionic butterfly aircraft,this paper proposes the design of a lightweight lithium battery power supply,a chip integrated into a small circuit board,and a reference to the natural characteristics of butterfly wings.The wings are simulated using 0.125 mm polyethylene terephthalate(PET)film to replicate their movement.The driving structure employs a double motor and a four-bar mechanism to achieve natural and smooth wing vibrations.The control system features a lightweight motor,battery,and a high-performance low-power microcontroller for precise control.Using 3D printing technology,a lightweight design is realized,successfully simulating the structure and movement characteristics of a specific butterfly,demonstrating the principles of mechatronics.Furthermore,the design process incorporates multidisciplinary knowledge,and a workshop combining competitive discipline events with innovation and entrepreneurship has been established.This initiative fosters the deep integration of innovation and entrepreneurship education with professional training,effectively cultivating application-oriented technical talents.展开更多
Cardiovascular disease prediction is a significant area of research in healthcare management systems(HMS).We will only be able to reduce the number of deaths if we anticipate cardiac problems in advance.The existing h...Cardiovascular disease prediction is a significant area of research in healthcare management systems(HMS).We will only be able to reduce the number of deaths if we anticipate cardiac problems in advance.The existing heart disease detection systems using machine learning have not yet produced sufficient results due to the reliance on available data.We present Clustered Butterfly Optimization Techniques(RoughK-means+BOA)as a new hybrid method for predicting heart disease.This method comprises two phases:clustering data using Roughk-means(RKM)and data analysis using the butterfly optimization algorithm(BOA).The benchmark dataset from the UCI repository is used for our experiments.The experiments are divided into three sets:the first set involves the RKM clustering technique,the next set evaluates the classification outcomes,and the last set validates the performance of the proposed hybrid model.The proposed RoughK-means+BOA has achieved a reasonable accuracy of 97.03 and a minimal error rate of 2.97.This result is comparatively better than other combinations of optimization techniques.In addition,this approach effectively enhances data segmentation,optimization,and classification performance.展开更多
In order to improve the reconstruction accuracy of magnetic resonance imaging(MRI),an accurate natural image compressed sensing(CS)reconstruction network is proposed,which combines the advantages of model-based and de...In order to improve the reconstruction accuracy of magnetic resonance imaging(MRI),an accurate natural image compressed sensing(CS)reconstruction network is proposed,which combines the advantages of model-based and deep learning-based CS-MRI methods.In theory,enhancing geometric texture details in linear reconstruction is possible.First,the optimization problem is decomposed into two problems:linear approximation and geometric compensation.Aimed at the problem of image linear approximation,the data consistency module is used to deal with it.Since the processing process will lose texture details,a neural network layer that explicitly combines image and frequency feature representation is proposed,which is named butterfly dilated geometric distillation network.The network introduces the idea of butterfly operation,skillfully integrates the features of image domain and frequency domain,and avoids the loss of texture details when extracting features in a single domain.Finally,a channel feature fusion module is designed by combining channel attention mechanism and dilated convolution.The attention of the channel makes the final output feature map focus on the more important part,thus improving the feature representation ability.The dilated convolution enlarges the receptive field,thereby obtaining more dense image feature data.The experimental results show that the peak signal-to-noise ratio of the network is 5.43 dB,5.24 dB and 3.89 dB higher than that of ISTA-Net+,FISTA and DGDN networks on the brain data set with a Cartesian sampling mask CS ratio of 10%.展开更多
Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apopt...Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr^(9)Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr^(9)Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr^(9)Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
文摘Chinese American literature hasn＇t developed into a visible power until 1970＇s in the American literary world. David Henry Hwang is a dazzling star among Chinese-American writers. He is the first to perform his own works on Broadway as well as the first to get Tony Award. He is the most successful and reputable Asian American playwright in the history of American Drama. Hwang＇s masterpiece M. Butterfly inverts orientalism＇s constructing the relationship between the east and the west, subverts stereotypes of the oriental in the westerners＇ eyes, and cries out a distinctive voice of＂the other＂ to western hegemony culture. However~ as a Chinese-American writer of the second generation that receives white mainstream cultural education, Hwang＇s deconstructing the orientalism and subverting the fixed relationship between the east and west has its imperfection, which results from social and historical environment the author lives in, personal experiences as well as national culture identity. In addition, Hwang＇s M.Butterfly aims at appealing for the eastern and western cultures＇ learning from each other, communicating with each other in order to achieve the goal of cultural co-prosperity with a broader mind in a harmonious atmosphere.
文摘[Abstrac]Through the analysis of both Madama Butterfly and M. Butterfly,this paper expores the gaze of the Occidental upon the Oriental especially the women. It analyzes the change of the Occi-dental gaze and gets the result that the misconception of the Oriental and its culture might form a big mockery to the Orientalism.
基金supported by the National Natural Science Foundation of China(No.52175277)The computations were conducted in Computing Center in Xi'an.The authors thankfully acknowledge these institutions.
文摘The wing of a butterfly consists of partially overlapping forewing and hindwing,and forewing sweeping can dynamically change the shape of the whole wing.In this work,the effect of forewing sweeping on aerodynamic performance of a butterfly like model is studied using a solver based on immersed boundary method and adaptive mesh.For aerodynamic performance,adding a"forward-backward-forward"sweeping motion to the forewing makes it more suitable for fast cruising flight,and compared to the situation without forewing sweeping,the drag is reduced by 46%and the lift to drag ratio is increased by 45%.On the contrary,adding a"backward-for ward-backward"sweeping motion to the forewing increases lift and makes it more suitable for climb flight.For downstroke and middle to late upstroke,the forewing sweeping affects the Leading-Edge Vortex(LEV)through two factors:sweeping velocity and forward sweeping angle,and their effects are coupled.A large forward sweeping velocity can enhance the strength of LEV,while a large forward sweeping angle can weaken it.For early upstroke,the forewing sweeping can affect the wake capture mechanism,sweeping backward can enhance it while sweeping forward can weaken it.The findings in this work provide insight into the design of butterfly like Micro AirVehicles(MAVs).
基金Innovation and Entrepreneurship Training Project for College Students in Hunan Province in 2024:Design of Small Bionic Butterfly Machine Under the Background of Innovation and Integration(Project No.S202413809022)2023 Innovation and Entrepreneurship Training Project of Hunan College Students:Tiger Butterfly—Bionic Manufacturing and Morphology Research(Project No.S202313809022)。
文摘With the advancement of modern technology and the continuous development of science,research into flapping wing aircraft is becoming increasingly sophisticated.Addressing issues such as the large wingspan and heavy mass of existing bionic butterfly aircraft,this paper proposes the design of a lightweight lithium battery power supply,a chip integrated into a small circuit board,and a reference to the natural characteristics of butterfly wings.The wings are simulated using 0.125 mm polyethylene terephthalate(PET)film to replicate their movement.The driving structure employs a double motor and a four-bar mechanism to achieve natural and smooth wing vibrations.The control system features a lightweight motor,battery,and a high-performance low-power microcontroller for precise control.Using 3D printing technology,a lightweight design is realized,successfully simulating the structure and movement characteristics of a specific butterfly,demonstrating the principles of mechatronics.Furthermore,the design process incorporates multidisciplinary knowledge,and a workshop combining competitive discipline events with innovation and entrepreneurship has been established.This initiative fosters the deep integration of innovation and entrepreneurship education with professional training,effectively cultivating application-oriented technical talents.
基金supported by the Research Incentive Grant 23200 of Zayed University,United Arab Emirates.
文摘Cardiovascular disease prediction is a significant area of research in healthcare management systems(HMS).We will only be able to reduce the number of deaths if we anticipate cardiac problems in advance.The existing heart disease detection systems using machine learning have not yet produced sufficient results due to the reliance on available data.We present Clustered Butterfly Optimization Techniques(RoughK-means+BOA)as a new hybrid method for predicting heart disease.This method comprises two phases:clustering data using Roughk-means(RKM)and data analysis using the butterfly optimization algorithm(BOA).The benchmark dataset from the UCI repository is used for our experiments.The experiments are divided into three sets:the first set involves the RKM clustering technique,the next set evaluates the classification outcomes,and the last set validates the performance of the proposed hybrid model.The proposed RoughK-means+BOA has achieved a reasonable accuracy of 97.03 and a minimal error rate of 2.97.This result is comparatively better than other combinations of optimization techniques.In addition,this approach effectively enhances data segmentation,optimization,and classification performance.
基金the National Natural Science Foundation of China(No.61962032)。
文摘In order to improve the reconstruction accuracy of magnetic resonance imaging(MRI),an accurate natural image compressed sensing(CS)reconstruction network is proposed,which combines the advantages of model-based and deep learning-based CS-MRI methods.In theory,enhancing geometric texture details in linear reconstruction is possible.First,the optimization problem is decomposed into two problems:linear approximation and geometric compensation.Aimed at the problem of image linear approximation,the data consistency module is used to deal with it.Since the processing process will lose texture details,a neural network layer that explicitly combines image and frequency feature representation is proposed,which is named butterfly dilated geometric distillation network.The network introduces the idea of butterfly operation,skillfully integrates the features of image domain and frequency domain,and avoids the loss of texture details when extracting features in a single domain.Finally,a channel feature fusion module is designed by combining channel attention mechanism and dilated convolution.The attention of the channel makes the final output feature map focus on the more important part,thus improving the feature representation ability.The dilated convolution enlarges the receptive field,thereby obtaining more dense image feature data.The experimental results show that the peak signal-to-noise ratio of the network is 5.43 dB,5.24 dB and 3.89 dB higher than that of ISTA-Net+,FISTA and DGDN networks on the brain data set with a Cartesian sampling mask CS ratio of 10%.
基金supported by the National Natural Science Foundation of China,Nos.32271043(to ZW)and 82171047(to YM)the both Science and Technology Major Project of Shanghai,No.2018SHZDZX01 and ZJLabShanghai Center for Brain Science and Brain-Inspired Technology(to ZW)。
文摘Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr^(9)Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr^(9)Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr^(9)Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
