The M-shaped multi-row pile foundation retaining structure represents an enhanced version of conventional multi-row anti-sliding support systems.To date,the implementation of M-shaped pile configurations in foundation...The M-shaped multi-row pile foundation retaining structure represents an enhanced version of conventional multi-row anti-sliding support systems.To date,the implementation of M-shaped pile configurations in foundation pit excavations has not been extensively investigated,with particularly scant research focusing on their load-bearing mechanisms and stress redistribution characteristics.Furthermore,numerical modeling methodologies for such geometrically optimized pile networks remain underdeveloped compared to practical engineering applications,creating a notable research-practice gap in geotechnical engineering.A comparative finite element analysis was systematically conducted using ABAQUS software to establish three distinct excavation support configurations:single-row cantilever retaining structures,three-row cantilever configurations,and M-shaped multi-row pile foundation systems.Subsequent numerical simulations enabled quantitative comparisons of critical performance indicators,including pile stress distribution patterns,lateral displacement profiles,and bending moment diagrams across different structural typologies.The parametric investigation revealed characteristic mechanical responses associated with each configuration,establishing corresponding mechanical principles governing the interaction between pile topology and soil-structure behavior towers.The findings of this study provide critical references for the design optimization of M-shaped multi-row pile foundation retaining systems.展开更多
Dear Editor,Iam Dr.Ping-Hong Lai,from the Jiangxi Eye Center,Jiangxi Provincial People＇s Hospital,Nanchang,Jiangxi Province,China.I would like to present the technique of subconjunctival M-shaped limbus incision for ...Dear Editor,Iam Dr.Ping-Hong Lai,from the Jiangxi Eye Center,Jiangxi Provincial People＇s Hospital,Nanchang,Jiangxi Province,China.I would like to present the technique of subconjunctival M-shaped limbus incision for a series of cases with hard cataracts.展开更多
Herein,an intense electrochemiluminescence(ECL)was achieved based on Pt hollow nanospheres/rubrene nanoleaves(Pt HNSs/Rub NLs)without the addition of any coreactant,which was employed for ultrasensitive detection of c...Herein,an intense electrochemiluminescence(ECL)was achieved based on Pt hollow nanospheres/rubrene nanoleaves(Pt HNSs/Rub NLs)without the addition of any coreactant,which was employed for ultrasensitive detection of carcinoembryonic antigen(CEA)coupled with an M-shaped DNA walker(M-DNA walker)as signal switch.Specifically,in comparison with platinum nanoparticles(Pt NPs),Pt HNSs revealed excellent catalytic performance and pore confinement-enhanced ECL,which could significantly amplify ECL intensity of Rub NLs/dissolved O_(2)(DO)binary system.Then,the tracks and M-DNA walker were confined on the Pt HNSs simultaneously to promote the reaction efficiency,whose M-structure boosted the interaction sites between walking strands and tracks and reduced the rigidity of their recognition.Once the CEA approached the sensing interface,the M-DNA walker was activated based on highly specific aptamer recognition to recover ECL intensity with the assistance of exonucleaseⅢ(ExoⅢ).As proof of concept,the“on-off-on”switch aptasensor was constructed for CEA detection with a low detection limit of 0.20 fg/m L.The principle of the constructed ECL aptasensor also enables a universal platform for sensitive detection of other tumor markers.展开更多
Background Nasal alarplasty is an important component of esthetic rhinoplasty in Asians.The two main surgical techniques that correct alar hypertrophy by reducing the height or length often leave external scars and ar...Background Nasal alarplasty is an important component of esthetic rhinoplasty in Asians.The two main surgical techniques that correct alar hypertrophy by reducing the height or length often leave external scars and are associated with a high relapse rate.Methods We developed a new technique,called three-dimensional(3D)M-shaped resection,which corrects both the nasal alar height and length and simultaneously minimizes external scarring.We performed this procedure from January 2013 to September 2016 in 49 consecutive female patients diagnosed with saddle nose and nasal alar hypertrophy.Their mean age was 28.6(range,18–40)years.All patients had previously undergone simple rhinoplasty.Nasal alar length and height,nostril length and width,and maximal nose width were analyzed preoperatively and postoperatively from photographs.Results After a mean of 9(range,3–24)months of follow-up,surgery was considered successful in 46 women(94%)with good cosmetic effects.In three patients,nasal alar hypertrophy recurred(6 months postoperatively).There were no early complications such as hematomas,infections,skin or mucosal necrosis,or wound dehiscence.The mean reductions postoperatively were 1.7 mm and 0.9 mm for nasal alar length and height,respectively,1.6 mm for both nostril length and width,and 3.5 mm for nose width.Conclusion The 3D M-shaped resection for nasal alar hypertrophy effectively reduced hypertrophy in 94%of patients for up to 24 months,producing minimal external scars and good cosmetic effects.It is a simple and convenient technique that is an effective and safe option for nasal alarplasty.展开更多
In this work two different fluorochromes （Alexa 594 and Alexa 680） are conjugated to the same monoclonal antibody （Cetuximab） for obtaining a characteristic M-shaped dual-peak spectrum. Dual-labeling of Cetuximab ...In this work two different fluorochromes （Alexa 594 and Alexa 680） are conjugated to the same monoclonal antibody （Cetuximab） for obtaining a characteristic M-shaped dual-peak spectrum. Dual-labeling of Cetuximab by mixing both fluorochromes before the conjugation step gives spectral results similar to those of mixing of fluorochrome-labeled Cetuximab after the conjugation step （P 〉 0.05）. In conclusion, both methods may be used equivalently for producing a dual-labeled single-antibody probe. Future studies may test whether the M-shaped spectrum may increase the diagnostic confidence in tumor-targeted multispectral optical imaging.展开更多
文摘The M-shaped multi-row pile foundation retaining structure represents an enhanced version of conventional multi-row anti-sliding support systems.To date,the implementation of M-shaped pile configurations in foundation pit excavations has not been extensively investigated,with particularly scant research focusing on their load-bearing mechanisms and stress redistribution characteristics.Furthermore,numerical modeling methodologies for such geometrically optimized pile networks remain underdeveloped compared to practical engineering applications,creating a notable research-practice gap in geotechnical engineering.A comparative finite element analysis was systematically conducted using ABAQUS software to establish three distinct excavation support configurations:single-row cantilever retaining structures,three-row cantilever configurations,and M-shaped multi-row pile foundation systems.Subsequent numerical simulations enabled quantitative comparisons of critical performance indicators,including pile stress distribution patterns,lateral displacement profiles,and bending moment diagrams across different structural typologies.The parametric investigation revealed characteristic mechanical responses associated with each configuration,establishing corresponding mechanical principles governing the interaction between pile topology and soil-structure behavior towers.The findings of this study provide critical references for the design optimization of M-shaped multi-row pile foundation retaining systems.
文摘Dear Editor,Iam Dr.Ping-Hong Lai,from the Jiangxi Eye Center,Jiangxi Provincial People＇s Hospital,Nanchang,Jiangxi Province,China.I would like to present the technique of subconjunctival M-shaped limbus incision for a series of cases with hard cataracts.
基金financially supported by the National Natural Science Foundation(NNSF)of China(No.22022408)the Chongqing Talents Personnel Support Program(No.NCQYC201905067)the Fundamental Research Funds for the Central Universities(No.XDJK2019TJ002)。
文摘Herein,an intense electrochemiluminescence(ECL)was achieved based on Pt hollow nanospheres/rubrene nanoleaves(Pt HNSs/Rub NLs)without the addition of any coreactant,which was employed for ultrasensitive detection of carcinoembryonic antigen(CEA)coupled with an M-shaped DNA walker(M-DNA walker)as signal switch.Specifically,in comparison with platinum nanoparticles(Pt NPs),Pt HNSs revealed excellent catalytic performance and pore confinement-enhanced ECL,which could significantly amplify ECL intensity of Rub NLs/dissolved O_(2)(DO)binary system.Then,the tracks and M-DNA walker were confined on the Pt HNSs simultaneously to promote the reaction efficiency,whose M-structure boosted the interaction sites between walking strands and tracks and reduced the rigidity of their recognition.Once the CEA approached the sensing interface,the M-DNA walker was activated based on highly specific aptamer recognition to recover ECL intensity with the assistance of exonucleaseⅢ(ExoⅢ).As proof of concept,the“on-off-on”switch aptasensor was constructed for CEA detection with a low detection limit of 0.20 fg/m L.The principle of the constructed ECL aptasensor also enables a universal platform for sensitive detection of other tumor markers.
文摘Background Nasal alarplasty is an important component of esthetic rhinoplasty in Asians.The two main surgical techniques that correct alar hypertrophy by reducing the height or length often leave external scars and are associated with a high relapse rate.Methods We developed a new technique,called three-dimensional(3D)M-shaped resection,which corrects both the nasal alar height and length and simultaneously minimizes external scarring.We performed this procedure from January 2013 to September 2016 in 49 consecutive female patients diagnosed with saddle nose and nasal alar hypertrophy.Their mean age was 28.6(range,18–40)years.All patients had previously undergone simple rhinoplasty.Nasal alar length and height,nostril length and width,and maximal nose width were analyzed preoperatively and postoperatively from photographs.Results After a mean of 9(range,3–24)months of follow-up,surgery was considered successful in 46 women(94%)with good cosmetic effects.In three patients,nasal alar hypertrophy recurred(6 months postoperatively).There were no early complications such as hematomas,infections,skin or mucosal necrosis,or wound dehiscence.The mean reductions postoperatively were 1.7 mm and 0.9 mm for nasal alar length and height,respectively,1.6 mm for both nostril length and width,and 3.5 mm for nose width.Conclusion The 3D M-shaped resection for nasal alar hypertrophy effectively reduced hypertrophy in 94%of patients for up to 24 months,producing minimal external scars and good cosmetic effects.It is a simple and convenient technique that is an effective and safe option for nasal alarplasty.
文摘In this work two different fluorochromes （Alexa 594 and Alexa 680） are conjugated to the same monoclonal antibody （Cetuximab） for obtaining a characteristic M-shaped dual-peak spectrum. Dual-labeling of Cetuximab by mixing both fluorochromes before the conjugation step gives spectral results similar to those of mixing of fluorochrome-labeled Cetuximab after the conjugation step （P 〉 0.05）. In conclusion, both methods may be used equivalently for producing a dual-labeled single-antibody probe. Future studies may test whether the M-shaped spectrum may increase the diagnostic confidence in tumor-targeted multispectral optical imaging.
