Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identifi...Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identified that C3 is primarily derived from periodontal fibroblasts.Subsequently,we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis.C3ar−/−mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice,characterized by mild gingival tissue damage and reduced alveolar bone loss.This reduction was associated with decreased production of proinflammatory mediators and reduced osteoclast infiltration in the periodontal tissues.Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation.Finally,by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis,we found that the results observed in mice were consistent with human data.Therefore,our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis,driven by macrophage M1 polarization and osteoclast differentiation.These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.展开更多
Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress vs.shear displacement behavior...Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress vs.shear displacement behaviors.The Barton-Bandis(B-B) joint model provides the most realistic prediction for the nonlinear shear behavior of rock joints.The B-B model accounts for asperity roughness and strength through the joint roughness coefficient(JRC) and joint wall compressive strength(JCS) parameters.Nevertheless,many computer codes for rock engineering analysis still use the constant shear strength parameters from the linear Mohr-Coulomb(M-C) model,which is only appropriate for smooth and non-dilatant joints.This limitation prevents fractured rock models from capturing the nonlinearity of joint shear behavior.To bridge the B-B and the M C models,this paper aims to provide a linearized implementation of the B-B model using a tangential technique to obtain the equivalent M-C parameters that can satisfy the nonlinear shear behavior of rock joints.These equivalent parameters,namely the equivalent peak cohesion,friction angle,and dilation angle,are then converted into their mobilized forms to account for the mobilization and degradation of JRC under shearing.The conversion is done by expressing JRC in the equivalent peak parameters as functions of joint shear displacement using proposed hyperbolic and logarithmic functions at the pre-and post-peak regions of shear displacement,respectively.Likewise,the pre-and post-peak joint shear stiffnesses are derived so that a complete shear stress-shear displacement relationship can be established.Verifications of the linearized implementation of the B-B model show that the shear stress-shear displacement curves,the dilation behavior,and the shear strength envelopes of rock joints are consistent with available experimental and numerical results.展开更多
It is well known that Landsat TM images are the most widely used remote sensing data in various fields.Usually,it has 7 different electromagnetic spectrum bands,among which the sixth one has much lower ground resoluti...It is well known that Landsat TM images are the most widely used remote sensing data in various fields.Usually,it has 7 different electromagnetic spectrum bands,among which the sixth one has much lower ground resolution compared with the other six bands.Nevertheless,it is useful in the study of rock spectrum reflection,geothermal resources exploration,etc.To improve the ground resolution of TM6 to the level as that of the other six bands is a problem .This paper presents an algorithm based on the combination of multivariate regression model with semivariogram function which can improve the ground resolution of TM6 by "fusing" the data of other six bands.It includes the following main steps: （1） testing the correlation between TM6 and one of TM15,7.If the correlation coefficient between TM6 and another one is greater than a given threshold value,then select the band to the regression analysis as an argument.（2） calculating the size of the template window within which some parameters needed by the regression model will be calculated; （3） replacing the original pixel values of TM6 by those obtained by regression analysis; （4） using image entropy as a measurement to evaluate the quality of the fused image of TM6.The basic mechanism of the algorithm is discussed and the V C ++ program for implementing this algorithm is also presented.A simple application example is given in the last part of this paper,showing the effectiveness of the algorithm.展开更多
In this paper, the existence, uniqueness, and asymptotic behavior of the solution of the density evolution equation for M/M/∞ model was studied by the semigroup theory of linear operators.
In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on ...In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on the left real line and these results describe the point spectra of the operator. Then, we show that the essential growth bound of the C_0-semigroup generated by the operator is 0 and therefore it is not quasi compact, the essential spectral bound of the C_0-semigroup is equal to 1. Moreover, our results imply it is impossible that the time-dependent solution of the model exponentially converges to its steady-state solution.展开更多
Liver segmentation in CT images is an important step for liver volumetry and vascular evaluation in liver pre-surgical planning. In this paper, a segmentation method based on distance regularized level set evolution(D...Liver segmentation in CT images is an important step for liver volumetry and vascular evaluation in liver pre-surgical planning. In this paper, a segmentation method based on distance regularized level set evolution(DRLSE) model was proposed, which incorporated a distance regularization term into the conventional Chan-Vese (C-V) model. In addition, the region growing method was utilized to generate the initial liver mask for each slice, which could decrease the computation time for level-set propagation. The experimental results show that the method can dramatically decrease the evolving time and keep the accuracy of segmentation. The new method is averagely 15 times faster than the method based on conventional C-V model in segmenting a slice.展开更多
基于文献报道的实验数据,采用相图计算(CALPHAD:CALculation of PHAse Diagrams)方法对V-M(M=Li,Na,K,Sc,Ag)5个二元系进行相图热力学研究。通过热力学优化计算获得了一套描述液相、(V)、(Li)、(Na)、(K)、(αSc)、(βSc)和(Ag)相的热...基于文献报道的实验数据,采用相图计算(CALPHAD:CALculation of PHAse Diagrams)方法对V-M(M=Li,Na,K,Sc,Ag)5个二元系进行相图热力学研究。通过热力学优化计算获得了一套描述液相、(V)、(Li)、(Na)、(K)、(αSc)、(βSc)和(Ag)相的热力学参数。V-Li、V-Na和V-K体系中的气相视为由组元V、Li、Li2、Na、Na2、K和K2混合的理想气体。与实验相图数据对比表明,获得的热力学参数能够准确地描述实验相平衡数据。展开更多
Three-dimensional atom probe （3DAP） technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800℃. 3D images indicate that the radius of...Three-dimensional atom probe （3DAP） technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800℃. 3D images indicate that the radius of M23C6 carbide after ageing for 10 min is about 9 nm. Concentration profiles of alloy elements in the carbide are also obtained. Combined with PANDAT and Thermo-Calc software, attempts to model the early stages of precipitation are present. The calculated particle size and composition of M23C6 carbide is in good agreement with 3DAP data.展开更多
基金supported by the National Key R&D Program of China(No.2022YFC2504200)the National Natural Science Foundation of China(Nos.82370936,81920108012,82471032).
文摘Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identified that C3 is primarily derived from periodontal fibroblasts.Subsequently,we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis.C3ar−/−mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice,characterized by mild gingival tissue damage and reduced alveolar bone loss.This reduction was associated with decreased production of proinflammatory mediators and reduced osteoclast infiltration in the periodontal tissues.Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation.Finally,by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis,we found that the results observed in mice were consistent with human data.Therefore,our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis,driven by macrophage M1 polarization and osteoclast differentiation.These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.
基金support from the University Transportation Center for Underground Transportation Infrastructure at the Colorado School of Mines for partially funding this research under Grant No.69A3551747118 of the Fixing America's Surface Transportation Act(FAST Act) of U.S.DoT FY2016
文摘Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress vs.shear displacement behaviors.The Barton-Bandis(B-B) joint model provides the most realistic prediction for the nonlinear shear behavior of rock joints.The B-B model accounts for asperity roughness and strength through the joint roughness coefficient(JRC) and joint wall compressive strength(JCS) parameters.Nevertheless,many computer codes for rock engineering analysis still use the constant shear strength parameters from the linear Mohr-Coulomb(M-C) model,which is only appropriate for smooth and non-dilatant joints.This limitation prevents fractured rock models from capturing the nonlinearity of joint shear behavior.To bridge the B-B and the M C models,this paper aims to provide a linearized implementation of the B-B model using a tangential technique to obtain the equivalent M-C parameters that can satisfy the nonlinear shear behavior of rock joints.These equivalent parameters,namely the equivalent peak cohesion,friction angle,and dilation angle,are then converted into their mobilized forms to account for the mobilization and degradation of JRC under shearing.The conversion is done by expressing JRC in the equivalent peak parameters as functions of joint shear displacement using proposed hyperbolic and logarithmic functions at the pre-and post-peak regions of shear displacement,respectively.Likewise,the pre-and post-peak joint shear stiffnesses are derived so that a complete shear stress-shear displacement relationship can be established.Verifications of the linearized implementation of the B-B model show that the shear stress-shear displacement curves,the dilation behavior,and the shear strength envelopes of rock joints are consistent with available experimental and numerical results.
文摘It is well known that Landsat TM images are the most widely used remote sensing data in various fields.Usually,it has 7 different electromagnetic spectrum bands,among which the sixth one has much lower ground resolution compared with the other six bands.Nevertheless,it is useful in the study of rock spectrum reflection,geothermal resources exploration,etc.To improve the ground resolution of TM6 to the level as that of the other six bands is a problem .This paper presents an algorithm based on the combination of multivariate regression model with semivariogram function which can improve the ground resolution of TM6 by "fusing" the data of other six bands.It includes the following main steps: （1） testing the correlation between TM6 and one of TM15,7.If the correlation coefficient between TM6 and another one is greater than a given threshold value,then select the band to the regression analysis as an argument.（2） calculating the size of the template window within which some parameters needed by the regression model will be calculated; （3） replacing the original pixel values of TM6 by those obtained by regression analysis; （4） using image entropy as a measurement to evaluate the quality of the fused image of TM6.The basic mechanism of the algorithm is discussed and the V C ++ program for implementing this algorithm is also presented.A simple application example is given in the last part of this paper,showing the effectiveness of the algorithm.
文摘In this paper, the existence, uniqueness, and asymptotic behavior of the solution of the density evolution equation for M/M/∞ model was studied by the semigroup theory of linear operators.
基金Supported by the National Natural Science Foundation of China(Grant No.11801485)
文摘In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on the left real line and these results describe the point spectra of the operator. Then, we show that the essential growth bound of the C_0-semigroup generated by the operator is 0 and therefore it is not quasi compact, the essential spectral bound of the C_0-semigroup is equal to 1. Moreover, our results imply it is impossible that the time-dependent solution of the model exponentially converges to its steady-state solution.
文摘Liver segmentation in CT images is an important step for liver volumetry and vascular evaluation in liver pre-surgical planning. In this paper, a segmentation method based on distance regularized level set evolution(DRLSE) model was proposed, which incorporated a distance regularization term into the conventional Chan-Vese (C-V) model. In addition, the region growing method was utilized to generate the initial liver mask for each slice, which could decrease the computation time for level-set propagation. The experimental results show that the method can dramatically decrease the evolving time and keep the accuracy of segmentation. The new method is averagely 15 times faster than the method based on conventional C-V model in segmenting a slice.
文摘基于文献报道的实验数据,采用相图计算(CALPHAD:CALculation of PHAse Diagrams)方法对V-M(M=Li,Na,K,Sc,Ag)5个二元系进行相图热力学研究。通过热力学优化计算获得了一套描述液相、(V)、(Li)、(Na)、(K)、(αSc)、(βSc)和(Ag)相的热力学参数。V-Li、V-Na和V-K体系中的气相视为由组元V、Li、Li2、Na、Na2、K和K2混合的理想气体。与实验相图数据对比表明,获得的热力学参数能够准确地描述实验相平衡数据。
基金supported by the National Natural Science Foundation of China (Nos. 50971137 and 50934011)
文摘Three-dimensional atom probe （3DAP） technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800℃. 3D images indicate that the radius of M23C6 carbide after ageing for 10 min is about 9 nm. Concentration profiles of alloy elements in the carbide are also obtained. Combined with PANDAT and Thermo-Calc software, attempts to model the early stages of precipitation are present. The calculated particle size and composition of M23C6 carbide is in good agreement with 3DAP data.
