In this paper, using the stochastic decomposition and renewal theory we provide the direct method for analysis the departure process of single sever M/G/1 queueing system, and further discuss the departure process of ...In this paper, using the stochastic decomposition and renewal theory we provide the direct method for analysis the departure process of single sever M/G/1 queueing system, and further discuss the departure process of GI/G/1 queueing system. The method provided in this paper is new and concise, which make us see dearly the structure of the departure process of a single server queueing system.展开更多
By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its s...By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its steady-state solution. We also show that the time-dependent queueing size at the departure point converges to the corresponding steady-state queueing size at the departure point.展开更多
In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on ...In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on the left real line and these results describe the point spectra of the operator. Then, we show that the essential growth bound of the C_0-semigroup generated by the operator is 0 and therefore it is not quasi compact, the essential spectral bound of the C_0-semigroup is equal to 1. Moreover, our results imply it is impossible that the time-dependent solution of the model exponentially converges to its steady-state solution.展开更多
It is well known, in queueing theory, that the system performance is greatly influenced by scheduling policy. No universal optimum scheduling strategy exists in systems where individual customer service demands are no...It is well known, in queueing theory, that the system performance is greatly influenced by scheduling policy. No universal optimum scheduling strategy exists in systems where individual customer service demands are not known a priori. However, if the distribution of job times is known, then the residual time (expected time remaining for a job), based on the service it has already received, can be calculated. Our particular research contribution is in exploring the use of this function to enhance system performance by increasing the probability that a job will meet its deadline. In a detailed discrete event simulation, we have tested many different distributions with a wide range of C2 and shapes, as well as for single and dual processor system. Results of four distributions are reported here. We compare with RR and FCFS, and find that in all distributions studied our algorithm performs best. In the study of the use of two slow servers versus one fast server, we have discovered that they provide comparable performance, and in a few cases the double server system does better.展开更多
The Distributed Queuing (DQ) algorithm is predicted as one of the solutions to the issues currently found in IoT networks over the use of Aloha based algorithms. Since recently, the algorithm has been of interest to m...The Distributed Queuing (DQ) algorithm is predicted as one of the solutions to the issues currently found in IoT networks over the use of Aloha based algorithms. Since recently, the algorithm has been of interest to many IoT researchers as a replacement of those Aloha variants for channel access. However, previous works analyzed and evaluated the DQ algorithm without any consideration of the stability of its queues, assuming it is stable for any given number of nodes in the network. In this paper, we define the DQ stability condition in a single-channel M2M environment considering a traffic model of periodic and urgent frames from each node in the network. Besides, a steady-state evaluation of the algorithm’s performance metrics is also presented. In general, the DQ algorithm, when it is stable, was observed not to efficiently use the contention slots for the collision resolution. In a single-channel environment, the DQ algorithm is found to outperform the Aloha based algorithms only in an idle-to-saturation scenario.展开更多
Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identifi...Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identified that C3 is primarily derived from periodontal fibroblasts.Subsequently,we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis.C3ar−/−mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice,characterized by mild gingival tissue damage and reduced alveolar bone loss.This reduction was associated with decreased production of proinflammatory mediators and reduced osteoclast infiltration in the periodontal tissues.Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation.Finally,by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis,we found that the results observed in mice were consistent with human data.Therefore,our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis,driven by macrophage M1 polarization and osteoclast differentiation.These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.展开更多
Objective:Aloin,the main active component in Aloe vera(L.)Burm.f.,has shown promising anti-tumor effects.This study investigated the impact of aloin in lung squamous cell carcinoma(LUSC)and explored its functional mec...Objective:Aloin,the main active component in Aloe vera(L.)Burm.f.,has shown promising anti-tumor effects.This study investigated the impact of aloin in lung squamous cell carcinoma(LUSC)and explored its functional mechanism.Methods:We analyzed the viability,migration,invasion,proliferation,and apoptosis of two LUSC cell lines after treatment with aloin.Target molecules of aloin and downstream target transcripts of nuclear receptor subfamily 3 group C member 2(NR3C2)were predicted by bioinformatics.The biological functions of NR3C2 and metallothionein 1M(MT1M)in the malignant properties of LUSC cells were determined.A co-culture system of LUSC cells with monocyte-derived macrophages was constructed.Mouse xenograft tumor models were generated to analyze the functions of aloin and NR3C2 in the tumorigenic activity of LUSC cells and macrophage polarization in vivo.Results:Aloin suppressed malignant properties of LUSC cells in vitro.However,these effects were negated by the silencing of NR3C2.NR3C2 was found to activate MT1M transcription by binding to its promoter.Additional upregulation of MT1M suppressed the malignant behavior of LUSC cells augmented by NR3C2 silencing.Analysis of the M1 and M2 markers/cytokines in the macrophages or the culture supernatant revealed that aloin treatment or MT1M overexpression in LUSC cells enhanced M1 polarization while suppressing M2 polarization of macrophages,whereas NR3C2 silencing led to reverse trends.Consistent findings were reproduced in vivo.Conclusion:This study demonstrated that aloin activates the NR3C2/MT1M axis to suppress the malignant behavior of LUSC cells and M2 macrophage polarization.Please cite this article as:Chen YN,Lu JY,Gao CF,Fang ZR,Zhou Y.Aloin blocks the malignant behavior of lung squamous cell carcinoma cells and M2 macrophage polarization by modulating the NR3C2/MT1M axis.展开更多
文摘In this paper, using the stochastic decomposition and renewal theory we provide the direct method for analysis the departure process of single sever M/G/1 queueing system, and further discuss the departure process of GI/G/1 queueing system. The method provided in this paper is new and concise, which make us see dearly the structure of the departure process of a single server queueing system.
基金supported by the National Natural Science Foundation of China(11371303)Natural Science Foundation of Xinjiang(2012211A023)Science Foundation of Xinjiang University(XY110101)
文摘By studying the spectral properties of the underlying operator corresponding to the M/G/1 queueing model with optional second service we obtain that the time-dependent solution of the model strongly converges to its steady-state solution. We also show that the time-dependent queueing size at the departure point converges to the corresponding steady-state queueing size at the departure point.
基金Supported by the National Natural Science Foundation of China(Grant No.11801485)
文摘In this paper, we consider point spectra of the operator corresponding to the M/M/1 queueing model with working vacation and vacation interruption. We prove that the underlying operator has uncountable eigenvalues on the left real line and these results describe the point spectra of the operator. Then, we show that the essential growth bound of the C_0-semigroup generated by the operator is 0 and therefore it is not quasi compact, the essential spectral bound of the C_0-semigroup is equal to 1. Moreover, our results imply it is impossible that the time-dependent solution of the model exponentially converges to its steady-state solution.
文摘It is well known, in queueing theory, that the system performance is greatly influenced by scheduling policy. No universal optimum scheduling strategy exists in systems where individual customer service demands are not known a priori. However, if the distribution of job times is known, then the residual time (expected time remaining for a job), based on the service it has already received, can be calculated. Our particular research contribution is in exploring the use of this function to enhance system performance by increasing the probability that a job will meet its deadline. In a detailed discrete event simulation, we have tested many different distributions with a wide range of C2 and shapes, as well as for single and dual processor system. Results of four distributions are reported here. We compare with RR and FCFS, and find that in all distributions studied our algorithm performs best. In the study of the use of two slow servers versus one fast server, we have discovered that they provide comparable performance, and in a few cases the double server system does better.
文摘The Distributed Queuing (DQ) algorithm is predicted as one of the solutions to the issues currently found in IoT networks over the use of Aloha based algorithms. Since recently, the algorithm has been of interest to many IoT researchers as a replacement of those Aloha variants for channel access. However, previous works analyzed and evaluated the DQ algorithm without any consideration of the stability of its queues, assuming it is stable for any given number of nodes in the network. In this paper, we define the DQ stability condition in a single-channel M2M environment considering a traffic model of periodic and urgent frames from each node in the network. Besides, a steady-state evaluation of the algorithm’s performance metrics is also presented. In general, the DQ algorithm, when it is stable, was observed not to efficiently use the contention slots for the collision resolution. In a single-channel environment, the DQ algorithm is found to outperform the Aloha based algorithms only in an idle-to-saturation scenario.
基金supported by the National Key R&D Program of China(No.2022YFC2504200)the National Natural Science Foundation of China(Nos.82370936,81920108012,82471032).
文摘Complement C3 plays a critical role in periodontitis.However,its source,role and underlying mechanisms remain unclear.In our study,by analyzing single-cell sequencing data from mouse model of periodontitis,we identified that C3 is primarily derived from periodontal fibroblasts.Subsequently,we demonstrated that C3a has a detrimental effect in ligature-induced periodontitis.C3ar−/−mice exhibited significantly less destruction of periodontal support tissues compared to wild-type mice,characterized by mild gingival tissue damage and reduced alveolar bone loss.This reduction was associated with decreased production of proinflammatory mediators and reduced osteoclast infiltration in the periodontal tissues.Mechanistic studies suggested that C3a could promote macrophage polarization and osteoclast differentiation.Finally,by analyzing single-cell sequencing data from the periodontal tissues of patients with periodontitis,we found that the results observed in mice were consistent with human data.Therefore,our findings clearly demonstrate the destructive role of fibroblast-derived C3 in ligature-induced periodontitis,driven by macrophage M1 polarization and osteoclast differentiation.These data strongly support the feasibility of C3a-targeted interventions for the treatment of human periodontitis.
基金Financial support was provided by the Research Start-up Funding of Changzhou University(No.ZMF19020381)。
文摘Objective:Aloin,the main active component in Aloe vera(L.)Burm.f.,has shown promising anti-tumor effects.This study investigated the impact of aloin in lung squamous cell carcinoma(LUSC)and explored its functional mechanism.Methods:We analyzed the viability,migration,invasion,proliferation,and apoptosis of two LUSC cell lines after treatment with aloin.Target molecules of aloin and downstream target transcripts of nuclear receptor subfamily 3 group C member 2(NR3C2)were predicted by bioinformatics.The biological functions of NR3C2 and metallothionein 1M(MT1M)in the malignant properties of LUSC cells were determined.A co-culture system of LUSC cells with monocyte-derived macrophages was constructed.Mouse xenograft tumor models were generated to analyze the functions of aloin and NR3C2 in the tumorigenic activity of LUSC cells and macrophage polarization in vivo.Results:Aloin suppressed malignant properties of LUSC cells in vitro.However,these effects were negated by the silencing of NR3C2.NR3C2 was found to activate MT1M transcription by binding to its promoter.Additional upregulation of MT1M suppressed the malignant behavior of LUSC cells augmented by NR3C2 silencing.Analysis of the M1 and M2 markers/cytokines in the macrophages or the culture supernatant revealed that aloin treatment or MT1M overexpression in LUSC cells enhanced M1 polarization while suppressing M2 polarization of macrophages,whereas NR3C2 silencing led to reverse trends.Consistent findings were reproduced in vivo.Conclusion:This study demonstrated that aloin activates the NR3C2/MT1M axis to suppress the malignant behavior of LUSC cells and M2 macrophage polarization.Please cite this article as:Chen YN,Lu JY,Gao CF,Fang ZR,Zhou Y.Aloin blocks the malignant behavior of lung squamous cell carcinoma cells and M2 macrophage polarization by modulating the NR3C2/MT1M axis.
