Background Methane(CH_(4))emissions from ruminants significantly contribute to greenhouse gas effects and energy loss in livestock production.Methyl-coenzyme M reductase(MCR)is the key enzyme in methanogenesis,making ...Background Methane(CH_(4))emissions from ruminants significantly contribute to greenhouse gas effects and energy loss in livestock production.Methyl-coenzyme M reductase(MCR)is the key enzyme in methanogenesis,making it a promising target for CH_(4) mitigation.This study aimed to identify and validate plant-derived inhibitors by using molecular docking to screen compounds with strong binding affinity to the F430 active site of MCR and assessing their efficacy in reducing CH_(4) emissions.Results Molecular docking analysis identified salvianolic acid C(SAC)as a potent inhibitor of MCR,showing a strong binding affinity to the F430 active site(binding energy:-8.2 kcal/mol).Enzymatic inhibition assays confirmed its inhibitory effect,with a half-maximal inhibitory concentration(IC50)of 692.3μmol/L.In vitro rumen fermentation experiments demonstrated that SAC supplementation(1.5 mg/g DM)significantly reduced CH_(4)production(P<0.01)without negatively affecting major fermentation parameters.Microbial community analysis using 16S rRNA sequencing and metagenomics revealed that SAC selectively altered the rumen microbiota,increasing the relative abundance of Bacteroidota while significantly reducing Methanobrevibacter(P=0.04).Moreover,metagenomic analysis showed the downregulation of key methanogenesis-related genes(mcrA and rnfC),suggesting a dual mechanism involving direct enzymatic inhibition and microbial community modulation.Conclusions These findings indicate that SAC effectively reduces CH_(4)production by inhibiting MCR activity and reshaping the rumen microbial community.As a plant-derived compound with strong inhibitory effects on methanogenesis,SAC presents a promising and sustainable alternative to synthetic CH_(4) inhibitors,offering potential applications for mitigating CH_(4)emissions in livestock production.展开更多
“好房子”承载着千家万户对美好生活的向往,2025年被首次写入政府工作报告,住房城乡建设部及各地行业主管部门相继对“好房子”建设提出了一系列要求,并持续推动政策落地,建设“好房子”由此成为房地产领域产业转型发展的新赛道。在此...“好房子”承载着千家万户对美好生活的向往,2025年被首次写入政府工作报告,住房城乡建设部及各地行业主管部门相继对“好房子”建设提出了一系列要求,并持续推动政策落地,建设“好房子”由此成为房地产领域产业转型发展的新赛道。在此背景下,由贝壳集团旗下贝好家推出的C2M(Customer to Manufacturer,从消费者到制造者)全链解决方案,经过一段时间的探索和落地实践,已取得不错的实践成效和市场反馈。展开更多
In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Rese...In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Research(Ding et al.,2025),the title was incorrectly presented due to an error during the language polishing process.展开更多
This study systematically analyzed the spatiotemporal evolution characteristics of geomagnetic anomalies before and after the 2013 Sichuan Lushan M7.0 earthquake and the Gansu Minxian M6.6 earthquake by constructing a...This study systematically analyzed the spatiotemporal evolution characteristics of geomagnetic anomalies before and after the 2013 Sichuan Lushan M7.0 earthquake and the Gansu Minxian M6.6 earthquake by constructing a geomagnetic diurnal variation model based on Taylor polynomial fitting,combined with midnight mean values of the geomagnetic F component from China,s geomagnetic observatory network.The results reveal distinct differences in anomaly patterns,namely per-sistent positive anomalies were observed in the epicentral region of the Lushan earthquake,while significant negative anomalies characterized the Minxian earthquake zone.This differential response reveals the modulating effect of the electrical structure of the seismogenic medium on space electromagnetic disturbances,namely positive anomalies may correspond to the stage of stable stress accumulation in intact rock,while the expansion of negative anomalies may reflect an amplification of electromagnetic disturbances induced by fracture expansion.Further analysis demonstrates that both anomalies exhibit a three-stage evolutionary pattern,namely pre-seismic accumulation,co-seismic release,and post-seismic adjustment.The phase transitions in these anomalies are closely correlated with regional tectonic stress accumulation and destabilization processes.These findings not only provide new evidence for the physical interpretation of seismomagnetic precursors but also establish a theoretical foundation for developing earthquake prediction methods based on the dynamic evolution of geomagnetic anomalies.展开更多
Scour around bridge pier foundations is a complex phenomenon that can threaten structural stability.Accurate prediction of scour depth around compound piers remains challenging for bridge engineers.This study investig...Scour around bridge pier foundations is a complex phenomenon that can threaten structural stability.Accurate prediction of scour depth around compound piers remains challenging for bridge engineers.This study investigated the effect of foundation elevation on scour around compound piers and developed reliable scour depth prediction models for economical foundation design.Experiments were conducted under clear-water conditions using two circular piers:(1)a uniform pier(with a diameter of D)and(2)a compound pier consisting of a uniform pier resting on a circular foundation(with a foundation diameter(D_(f))of 2D)positioned at various elevations(Z)relative to the channel bed.Results showed that foundation elevation significantly affected scour depth.Foundations at or below the bed(Z/D≥0)reduced scour,while those projecting into the flow field(Z/D<0)increased scour.The optimal foundation elevation was found to be 0.1D below the bed level,yielding a 57%reduction in scour depth compared to the uniform pier due to its shielding effect against downflow and horseshoe vortices.In addition,regression,artificial neural network(ANN),and M5 model tree models were developed using experimental data from this and previous studies.The M5 model outperformed the traditional HEC-18 equation,regression,and ANN models,with a coefficient of determination greater than 0.85.Sensitivity analysis indicated that flow depth,foundation elevation,and diameter significantly influenced scour depth prediction,whereas sediment size had a lesser impact.展开更多
In 2018,a catastrophic high-altitude landslide occurred at Baige,located within the tectonic suture zone of the Upper Jinsha River.The failure mechanism of this event remains poorly understood.This study aims to eluci...In 2018,a catastrophic high-altitude landslide occurred at Baige,located within the tectonic suture zone of the Upper Jinsha River.The failure mechanism of this event remains poorly understood.This study aims to elucidate the deformation characteristics and failure mechanism of the Baige landslide by employing a comprehensive methodology,including field geological surveys,analysis of historical remote sensing imagery,high-density electrical resistivity surveys,and advanced displacement monitoring.Additionally,the physical modeling experiments were conducted to replicate the unique failure modes.The findings propose a novel perspective on the failure mechanism of the Baige landslide,which involves two critical stages:first,the brittle shear zone bypasses and fails at the lower locked segment,and second,the failure of the upper locked segment,combined with the shear zone's impact on the lower locked segment,triggers overall slope instability.Physical modeling experiments revealed a transition from initial acceleration to a rapid acceleration phase,particularly marked by a significant increase in velocity following the failure of the upper locked segment.The intensity of acoustic emission signals was found to correlate with the failure of the locked segments and the state of particle collisions post-failure.It offers new insights into the failure mechanisms of tectonic mélange belt large-scale landslides in suture zones,contributing to the broader field of landslide research.展开更多
The early precipitation process of Ni（75）Al（14）Mo（11） alloy was simulated by microscopic phase-field model at different temperatures.The microstructure of the alloy,the precipitation time of Llo structure and oc...The early precipitation process of Ni（75）Al（14）Mo（11） alloy was simulated by microscopic phase-field model at different temperatures.The microstructure of the alloy,the precipitation time of Llo structure and occupation probability of the three kinds of atoms were investigated.It is indicated that the non-stoichiometric Ll0（Ⅰ/Ⅱ） phases are found in the precipitation process.With the temperature increasing,the appearance time of Ll0 is brought forward.The Ll0（Ⅱ） structure always precipitates earlier than the Ll0（Ⅰ） structure.Compared with lower temperature,higher temperature brings the formation time of Ll0 phase forward and makes Ll0 phase have a higher order degree.But lower temperature shortens the process time of the Ll0 phase to the Ll2 phase.Al and Mo atoms tend to occupy γ site,Ni atom tends to occupy a and β sites.At the same temperature,Al atom has stronger occupation ability than Mo atom in the same site.Ni,Al and Mo collectively form the composited Ll2 structure.展开更多
基金funded by the Integrated Demonstration of Scalable and Efficient Healthy Breeding for Cattle and Sheep(Grant No.2022YFD1301100)Instant Intelligent Diagnosis and Risk Warning Methods for Nutritional and Metabolic-Type Periparturient Cow Paralysis(Grant No.2024-YWF-ZYSQ-10)。
文摘Background Methane(CH_(4))emissions from ruminants significantly contribute to greenhouse gas effects and energy loss in livestock production.Methyl-coenzyme M reductase(MCR)is the key enzyme in methanogenesis,making it a promising target for CH_(4) mitigation.This study aimed to identify and validate plant-derived inhibitors by using molecular docking to screen compounds with strong binding affinity to the F430 active site of MCR and assessing their efficacy in reducing CH_(4) emissions.Results Molecular docking analysis identified salvianolic acid C(SAC)as a potent inhibitor of MCR,showing a strong binding affinity to the F430 active site(binding energy:-8.2 kcal/mol).Enzymatic inhibition assays confirmed its inhibitory effect,with a half-maximal inhibitory concentration(IC50)of 692.3μmol/L.In vitro rumen fermentation experiments demonstrated that SAC supplementation(1.5 mg/g DM)significantly reduced CH_(4)production(P<0.01)without negatively affecting major fermentation parameters.Microbial community analysis using 16S rRNA sequencing and metagenomics revealed that SAC selectively altered the rumen microbiota,increasing the relative abundance of Bacteroidota while significantly reducing Methanobrevibacter(P=0.04).Moreover,metagenomic analysis showed the downregulation of key methanogenesis-related genes(mcrA and rnfC),suggesting a dual mechanism involving direct enzymatic inhibition and microbial community modulation.Conclusions These findings indicate that SAC effectively reduces CH_(4)production by inhibiting MCR activity and reshaping the rumen microbial community.As a plant-derived compound with strong inhibitory effects on methanogenesis,SAC presents a promising and sustainable alternative to synthetic CH_(4) inhibitors,offering potential applications for mitigating CH_(4)emissions in livestock production.
文摘“好房子”承载着千家万户对美好生活的向往,2025年被首次写入政府工作报告,住房城乡建设部及各地行业主管部门相继对“好房子”建设提出了一系列要求,并持续推动政策落地,建设“好房子”由此成为房地产领域产业转型发展的新赛道。在此背景下,由贝壳集团旗下贝好家推出的C2M(Customer to Manufacturer,从消费者到制造者)全链解决方案,经过一段时间的探索和落地实践,已取得不错的实践成效和市场反馈。
文摘In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Research(Ding et al.,2025),the title was incorrectly presented due to an error during the language polishing process.
基金supported by a Collaborative Project of the National Natural Science Foundation of China on Technical Maintenance and Data Preprocessing of the GPS Observation Array for the Qiaojia Earthquake(No.0120603)the National Natural Science Foundation of China(No.41274079).
文摘This study systematically analyzed the spatiotemporal evolution characteristics of geomagnetic anomalies before and after the 2013 Sichuan Lushan M7.0 earthquake and the Gansu Minxian M6.6 earthquake by constructing a geomagnetic diurnal variation model based on Taylor polynomial fitting,combined with midnight mean values of the geomagnetic F component from China,s geomagnetic observatory network.The results reveal distinct differences in anomaly patterns,namely per-sistent positive anomalies were observed in the epicentral region of the Lushan earthquake,while significant negative anomalies characterized the Minxian earthquake zone.This differential response reveals the modulating effect of the electrical structure of the seismogenic medium on space electromagnetic disturbances,namely positive anomalies may correspond to the stage of stable stress accumulation in intact rock,while the expansion of negative anomalies may reflect an amplification of electromagnetic disturbances induced by fracture expansion.Further analysis demonstrates that both anomalies exhibit a three-stage evolutionary pattern,namely pre-seismic accumulation,co-seismic release,and post-seismic adjustment.The phase transitions in these anomalies are closely correlated with regional tectonic stress accumulation and destabilization processes.These findings not only provide new evidence for the physical interpretation of seismomagnetic precursors but also establish a theoretical foundation for developing earthquake prediction methods based on the dynamic evolution of geomagnetic anomalies.
文摘Scour around bridge pier foundations is a complex phenomenon that can threaten structural stability.Accurate prediction of scour depth around compound piers remains challenging for bridge engineers.This study investigated the effect of foundation elevation on scour around compound piers and developed reliable scour depth prediction models for economical foundation design.Experiments were conducted under clear-water conditions using two circular piers:(1)a uniform pier(with a diameter of D)and(2)a compound pier consisting of a uniform pier resting on a circular foundation(with a foundation diameter(D_(f))of 2D)positioned at various elevations(Z)relative to the channel bed.Results showed that foundation elevation significantly affected scour depth.Foundations at or below the bed(Z/D≥0)reduced scour,while those projecting into the flow field(Z/D<0)increased scour.The optimal foundation elevation was found to be 0.1D below the bed level,yielding a 57%reduction in scour depth compared to the uniform pier due to its shielding effect against downflow and horseshoe vortices.In addition,regression,artificial neural network(ANN),and M5 model tree models were developed using experimental data from this and previous studies.The M5 model outperformed the traditional HEC-18 equation,regression,and ANN models,with a coefficient of determination greater than 0.85.Sensitivity analysis indicated that flow depth,foundation elevation,and diameter significantly influenced scour depth prediction,whereas sediment size had a lesser impact.
基金supported by the National Major Scientific Instruments and Equipment Development Projects of China(No.41827808)the Major Program of the National Natural Science Foundation of China(No.42090055)Supported by Science and Technology Projects of Xizang Autonomous Region,China(No.XZ202402ZD0001)。
文摘In 2018,a catastrophic high-altitude landslide occurred at Baige,located within the tectonic suture zone of the Upper Jinsha River.The failure mechanism of this event remains poorly understood.This study aims to elucidate the deformation characteristics and failure mechanism of the Baige landslide by employing a comprehensive methodology,including field geological surveys,analysis of historical remote sensing imagery,high-density electrical resistivity surveys,and advanced displacement monitoring.Additionally,the physical modeling experiments were conducted to replicate the unique failure modes.The findings propose a novel perspective on the failure mechanism of the Baige landslide,which involves two critical stages:first,the brittle shear zone bypasses and fails at the lower locked segment,and second,the failure of the upper locked segment,combined with the shear zone's impact on the lower locked segment,triggers overall slope instability.Physical modeling experiments revealed a transition from initial acceleration to a rapid acceleration phase,particularly marked by a significant increase in velocity following the failure of the upper locked segment.The intensity of acoustic emission signals was found to correlate with the failure of the locked segments and the state of particle collisions post-failure.It offers new insights into the failure mechanisms of tectonic mélange belt large-scale landslides in suture zones,contributing to the broader field of landslide research.
基金Project(51275486)supported by the National Natural Science Foundation of China
文摘The early precipitation process of Ni（75）Al（14）Mo（11） alloy was simulated by microscopic phase-field model at different temperatures.The microstructure of the alloy,the precipitation time of Llo structure and occupation probability of the three kinds of atoms were investigated.It is indicated that the non-stoichiometric Ll0（Ⅰ/Ⅱ） phases are found in the precipitation process.With the temperature increasing,the appearance time of Ll0 is brought forward.The Ll0（Ⅱ） structure always precipitates earlier than the Ll0（Ⅰ） structure.Compared with lower temperature,higher temperature brings the formation time of Ll0 phase forward and makes Ll0 phase have a higher order degree.But lower temperature shortens the process time of the Ll0 phase to the Ll2 phase.Al and Mo atoms tend to occupy γ site,Ni atom tends to occupy a and β sites.At the same temperature,Al atom has stronger occupation ability than Mo atom in the same site.Ni,Al and Mo collectively form the composited Ll2 structure.
